Evidence for reverse flux through pyruvate kinase in skeletal muscle

American Journal of Physiology - Endocrinology and Metabolism

Volumn 296, Issue 4, 2009, Pages

  Jin, Eunsook S ^a,b,e   Sherry, A Dean ^a,b,c   Malloy, Craig R ^a,b,d  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS AT DALLAS   (United States)

^d VA NORTH TEXAS HEALTH CARE SYSTEM   (United States)

^e Advanced Imaging Research Center   (United States)

Author keywords

Glyconeogenesis; Nuclear magnetic resonance; Phosphoenolpyruvate carboxykinase; Pyruvate kinase; Skeletal muscle

Indexed keywords

CARBON; CARBON 13; GLUCOSE; GLUTAMIC ACID; GLUTAMINE; GLYCOGEN; LACTIC ACID; PROPIONIC ACID; PYRUVATE CARBOXYLASE; PYRUVATE DEHYDROGENASE; PYRUVATE KINASE; TRICARBOXYLIC ACID;

ANIMAL EXPERIMENT; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CITRIC ACID CYCLE; CONTROLLED STUDY; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLYCOGEN LIVER LEVEL; GLYCOGEN MUSCLE LEVEL; GLYCOGEN SYNTHESIS; LABELING INDEX; MALE; METABOLISM; MUSCLE TISSUE; MYOTUBE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; RAT; SKELETAL MUSCLE; ANIMAL; BIOLOGICAL MODEL; CELL CULTURE; CHEMISTRY; LIVER; MOUSE; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; BLOOD GLUCOSE; CELLS, CULTURED; GLUCOSE; GLYCOGEN; LIVER; MALE; MICE; MODELS, BIOLOGICAL; MUSCLE, SKELETAL; PYRUVATE KINASE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 65649095251     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.90935.2008     Document Type: Article

References (22)

1. Boden G, Chen X, Ruiz J, White JV, Rossetti L. Mechanisms of fatty acid-induced inhibition of glucose uptake. J Clin Inve 93: 2438-2446, 1994. (Pubitemid 24177157)
2. Chandramouli V, Ekberg K, Schumann WC, Wahren J, Landau BR. Origins of the hydrogen bound to carbon 1 of glucose in fasting: significance in gluconeogenesis quantitation. Am J Physiol Endocrinol Metab 277: E717-E723, 1999. (Pubitemid 29522625)
3. Cline GW, Petersen KF, Krssak M, Shen J, Hundal RS, Trajanoski Z, Inzucchi S, Dresner A, Rothman DL, Shulman GI. Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes. N Engl J Med 341: 240-246, 1999. (Pubitemid 29334522)
4. Connett RJ. Glyconeogenesis from lactate in frog striated muscle. Am J Physiol Cell Physiol 237: C231-C236, 1979.
5. Dobson GP, Hitchins S, Teague WE Jr. Thermodynamics of the pyruvate kinase reaction and the reversal of glycolysis in heart and skeletal muscle. J Biol Chem 277: 27176-27182, 2002.
6. Donovan CM, Pagliassotti MJ. Quantitative assessment of pathways for lactate disposal in skeletal muscle fiber types. Med Sci Sports Exerc 32: 772-777, 2000.
7. Dyson RD, Cardenas JM, Barsotti RJ. The reversibility of skeletal muscle pyruvate kinase and an assessment of its capacity to support glyconeogenesis. J Biol Chem 250: 3316-3321,1975.
8. Fairchild TJ, Armstrong AA, Rao A, Liu H, Lawrence S, Fournier PA. Glycogen synthesis in muscle fibers during active recovery from intense exercise. Med Sci Sports Exerc 35: 595-602, 2003. (Pubitemid 36417849)
9. Hiatt HH, Goldstein M, Lareau J, Horecker BL. The pathway of hexose synthesis from pyruvate in muscle. J Biol Chem 231: 303-307, 1958.
10. Jin ES, Jones JG, Merritt M, Burgess SC, Malloy CR, Sherry AD. Glucose production, gluconeogenesis, and hepatic tricarboxylic acid cycle fluxes measured by nuclear magnetic resonance analysis of a single glucose derivative. Anal Biochem 327: 149-155, 2004. (Pubitemid 38402182)
11. 13C-labeled lactate. J Biol Chem 268: 25509-25521, 1993.
12. Krebs HA, Hems R, Weidemann MJ, Speake RN. The fate of isotopic carbon in kidney cortex synthesizing glucose from lactate. Biochem J 101: 242-249, 1966.
13. Krimsky I. Phosphorylation of pyruvate by the pyruvate kinase reaction and reversal of glycolysis in a reconstructed system. J Biol Chem 234: 232-236, 1959.
14. Lardy HA, Ziegler JA. The enzymatic synthesis of phosphopyruvate from pyruvate. J Biol Chem 159: 343-351, 1945.
15. Magnusson I, Schumann WC, Bartsch GE, Chandramouli V, Kumaran K, Wahren J, Landau BR. Noninvasive tracing of Krebs cycle metabolism in liver. J Biol Chem 266: 6975-6984, 1991. (Pubitemid 21906320)
16. McQuate JT, Utter MF. Equilibrium and kinetic studies of the pyruvic kinase reaction. J Biol Chem 234: 2151-2157, 1959.
17. Meyerhof O, Ohlmeyer P, Gentner W, Maier-Leibnitz H. Studies on the intermediate reactions of glycolysis with the aid of radioactive phosphorus. Biochem Z 298: 396-406, 1938.
18. Moriwaki T, Landau BR. Sources of the carbon atoms of liver glycogen formed by cortisol administration to rats in vivo. Endocrinology 72: 134-145, 1963.
19. Shieh JJ, Pan CJ, Mansfield BC, Chou JY. Potential new role for muscle in blood glucose homeostasis. J Biol Chem 279: 26215-26219, 2004.
20. Shulman GI, Rossetti L, Rothman DL, Blair JB, Smith D. Quantitative analysis of glycogen repletion by nuclear magnetic resonance spectroscopy in the conscious rat. J Clin Invest 80: 387-393, 1987.
21. Stryer WH. Biochemistry (4th ed.). New York, NY: Freeman, 1995, p. 571.
22. Tucker R, Kayser B, Rae E, Raunch L, Bosch A, Noakes T. Hyperoxia improves 20 km cycling time trial performance by increasing muscle activation levels while perceived exertion stays the same. Eur J Appl Physiol 101: 771-781, 2007. (Pubitemid 47604016)