Coupled with uncouplers: The curious case of lifespan

American Journal of Physiology - Endocrinology and Metabolism

Volumn 296, Issue 4, 2009, Pages

  Lockie, Sarah Haas ^a   Müller, Timo D ^a   Tschöp, Matthias H ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MANGANESE SUPEROXIDE DISMUTASE; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 3; ION CHANNEL; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN 2; SUPEROXIDE DISMUTASE;

EDITORIAL; LIFESPAN; LONGEVITY; METABOLIC RATE; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; TRANSGENE; WILD TYPE; ANIMAL; DROSOPHILA; GENETICS; HUMAN; MOUSE; MOUSE MUTANT; NOTE; PHYSIOLOGY; RAT; SIGNAL TRANSDUCTION;

ANIMALS; DROSOPHILA; HUMANS; ION CHANNELS; LONGEVITY; MICE; MICE, KNOCKOUT; MITOCHONDRIAL PROTEINS; RATS; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE;

EID: 65649087939     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00060.2009     Document Type: Editorial

References (20)

1. Andrews ZB, Horvath TL. Uncoupling protein-2 regulates lifespan in mice. Am J Physiol Endocrinol Metab (January 13, 2009).
2. Andrews ZB, Liu ZW, Walllingford N, Erion DM, Borok E, Friedman JM, Tschöp MH, Shanabrough M, Cline G, Shulman GI, Coppola A, Gao XB, Horvath TL, Diano S. UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals. Nature 454: 846-851, 2008.
3. Anedda A, Rial E, Gonzalez-Barroso MM. Metformin induces oxidative stress in white adipocytes and raises uncoupling protein 2 level J Endocrinol 199: 33-40, 2008.
4. Bishop NA, Guarente L. Genetic links between diet and lifespan: shared mechanisms from yeast to humans. Nat Rev Genet 8: 835-844, 2007. (Pubitemid 47609089)
5. Brand MD. Uncoupling to survive? The role of mitochondrial inefficiency in ageing. In: Biological Aging. Euroconference on Molecular, Cellular and Tissue Gerontology. Spa, Belgium: 2000.
6. Buffenstein R. The naked mole-rat? A new long-living model for human aging research. J Gerontol A Biol Sci Med Sci 60: 1369-1377, 2005. (Pubitemid 41798442)
7. da Silva CC, Cerqueira FM, Barbosa LF, Medeiros MH, Kowaltowski AJ. Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity. Aging Cell 7: 552-560, 2008.
8. Echtay KS, Roussel D, St-Pierre J, Jekabsons MB, Cadenas S, Stuart JA, Harper JA, Roebuck SJ, Morrison A, Pickering S, Clapham JC, Brand MD. Superoxide activates mitochondrial uncoupling proteins. Nature 415: 96-99, 2002. (Pubitemid 34062457)
9. Harman D. The aging process. Proc Natl Acad Sci USA Biol Sci 78: 7124-7128, 1981.
10. Holloszy JO, Smith EK, Vining M, Adams S. Effect of voluntary exercise on longevity of rats. J Appl Physiol 59: 826-831, 1985. (Pubitemid 16214146)
11. Hulbert AJ, Beard LA, Grigg GC. The exceptional longevity of an egg-laying mammal, the short-beaked echidna (Tachyglossus aculeatus) is associated with peroxidation-resistant membrane composition. Exper Gerontol 43: 729-733, 2008.
12. Hulbert AJ, Pamplona R, Buffenstein R, Buttemer WA. Life and death: Metabolic rate, membrane composition, and life span of animals. Physiol Rev 87: 1175-1213, 2007. (Pubitemid 350033823)
13. Hulbert AJ, Clancy DJ, Mair W, Braeckman BP, Gems D, Partridge L. Metabolic rate is not reduced by dietary-restriction or by lowered insulin/IGF-1 signalling and is not correlated with individual lifespan in Drosophila melanogaster. Exper Gerontol 39: 1137-1143, 2004. (Pubitemid 39024363)
14. Korshunov SS, Skulachev VP, Starkov AA. High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria. FEBS Lett 416: 15-18, 1997.
15. Lebovitz RM, Zhang H, Vogel H, Cartwright J Jr, Dionne L, Lu N, Huang S, Matzuk MM. Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice. Proc Natl Acad Sci USA 93: 9782-9787, 1996. (Pubitemid 26296686)
16. McDonald RB, Walker KM, Warman DB, Griffey SM, Warden CH, Ramsey JJ, Horwitz BA. Characterization of survival and phenotype throughout the life span in UCP2/UCP3 genetically altered mice. Exper Gerontol 43: 1061-1068, 2008.
17. Parton LE, Ye CP, Coppari R, Enriori PJ, Choi B, Zhang CY, Xu C, Vianna CR, Balthasar N, Lee CE, Elmquist JK, Cowley MA, Lowell BB. Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature 449: 228-U7, 2007. (Pubitemid 47402365)
18. Speakman JR, Talbot DA, Selman C, Snart S, McLaren JS, Redman P, Krol E, Jackson DM, Johnson MS, Brand MD. Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer. Aging Cell 3: 87-95, 2004. (Pubitemid 40246671)
19. Turturro A, Witt WW, Lewis S, Hass BS, Lipman RD, Hart RW. Growth curves and survival characteristics of the animals used in the biomarkers of aging program. J Gerontol A Biol Sci Med Sci 54: B492-B501, 1999. (Pubitemid 30017610)
20. Zhang CY, Parton LE, Ye CP, Krauss S, Shen R, Lin CT, Porco JA Jr, Lowell BB. Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets. Cell Metab 3: 417-427, 2006. (Pubitemid 43811776)