An improved large scale synthesis of the Schöllkopf chiral auxiliaries: (2R)-and (2S)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine

Organic Process Research and Development

Volumn 9, Issue 2, 2005, Pages 185-187

  Chen, Jianxie ^a   Corbin, Scott P ^a   Holman, Nicholas J ^a  

^a ALBANY MOLECULAR RESEARCH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,5 DIHYDRO 3,6 DIMETHOXY 2 ISOPROPYLPYRAZINE; PHOSGENE; PYRAZINE DERIVATIVE; TOXIC SUBSTANCE; TRIPHOSGENE; UNCLASSIFIED DRUG; VALINE;

ARTICLE; CHEMICAL REACTION; CHIRALITY; LOW TEMPERATURE; REACTION ANALYSIS; SYNTHESIS; TECHNIQUE;

EID: 17444391747     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op049777t     Document Type: Article

References (22)

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21. Intermediate 4 was obtained in 45% yield when the reaction was carried out on 40 g scale.
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