Leptin in horses: Tissue localization and relationship between peripheral concentrations of leptin and body condition

Journal of Animal Science

Volumn 80, Issue 11, 2002, Pages 2942-2948

  Buff, P R ^a   Dodds, A C ^a   Morrison, C D ^a   Whitley, N C ^b   McFadin, E L ^a   Daniel, J A ^a   Djiane, J ^c   Keisler, D H ^d  

^a UNIVERSITY OF MISSOURI   (United States)

^b UNIVERSITY OF MARYLAND EASTERN SHORE   (United States)

^c CEMAGREF   (France)

^d 160 Animal Science Research Center ^*  (United States)

Author keywords

Body Condition; Horses; Leptin

Indexed keywords

ANIMALIA; EQUIDAE; EQUUS CABALLUS;

CELL SURFACE RECEPTOR; COMPLEMENTARY DNA; LEPTIN; LEPTIN RECEPTOR; MESSENGER RNA;

ADIPOSE TISSUE; ANIMAL; ANIMAL DISEASE; ARTICLE; BLOOD; BODY COMPOSITION; CHEMISTRY; FEMALE; GENETICS; HORSE; HORSE DISEASE; MALE; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; OBESITY; PHYSIOLOGY; RADIOIMMUNOASSAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEX DIFFERENCE;

ADIPOSE TISSUE; ANIMALS; BASE SEQUENCE; BODY COMPOSITION; DNA, COMPLEMENTARY; FEMALE; HORSE DISEASES; HORSES; LEPTIN; MALE; MOLECULAR SEQUENCE DATA; OBESITY; RADIOIMMUNOASSAY; RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEX FACTORS;

EID: 0036834975     PISSN: 00218812     EISSN: None     Source Type: Journal    
DOI: 10.2527/2002.80112942x     Document Type: Article

References (21)

1. Barb, C. R., X. Yan, M. J. Azain, R. R. Kraeling, G. B. Rampacek, and T. G. Ramsay. 1998. Recombinant porcine leptin reduces feed intake and stimulates growth hormone secretion in swine. Domest. Anim. Endocrinol. 15:77-86.
2. Cioffi, J. A., A. W. Shafer, T. J. Zupancic, J. Smith-Gbur, A. Mikhail, D. Plantika, and H. R. Snodgrass. 1996. Novel B219/OB receptor isoforms: Possible role of leptin in hematopoiesis and reproduction. Nat. Med. 2:585-589.
3. Delavaud, C., F. Bocquier, Y. Chilliard, D. H. Keisler, A. Gertler, and G. Kann. 2000. Plasma leptin determination in ruminants: effect of nutritional status and body fatness on plasma leptin concentration assessed by a specific RIA in sheep. J. Endocrinol. 165:519-526.
4. Dyer, C. J., J. M. Simmons, R. L. Matteri, and D. H. Keisler. 1997a. cDNA cloning and tissue-specific gene expression of ovine leptin, NPY-Y1 receptor and NPY-Y2 receptor. Domest. Anim. Endocrinol. 14:295-303.
5. Dyer, C. J., J. M. Simmons, R. L. Matteri, and D. H. Keisler. 1997b. Leptin receptor mRNA is expressed in ewe anterior pituitary and adipose tissues and is differentially expressed in hypothalamic regions of well-fed and feed-restricted ewes. Domest. Anim. Endocrinol. 14:119-128.
6. Gertler, A., J. Simmons, and D. H. Keisler. 1998. Large-scale preparation of biologically active recombinant ovine obese protein (leptin). FEBS Letters. 422:137-140.
7. Harris, R. B. S. 2000. Leptin-much more than a satiety signal. Annu. Rev. Nutr. 20:45-75
8. Henneke, D. R., G. D. Potter, J. L. Kreider, and B. F. Yeates. 1983. Relationship between condition score, physical measurements and body fat percentage in mares. Equine Vet. J. 15:371-372.
9. Henry, B. A., J. W. Goding, W. S. Alexander, A. J. Tilbrook, B. J. Canny, F. Dunshea, A. Rao, A. Mansell, and I. J. Clarke. 1999. Central administration of leptin to ovariectomized ewes inhibits food intake without affecting the secretion of hormones from the pituitary gland: evidence for a dissociation of effects on appetite and neuroendocrine function. Endocrinology 140:1175-1182.
10. Houseknecht, K. L., C. A. Baile, R. L. Matteri, and M. E. Spurlock. 1998. The biology of leptin: A review. J. Anim. Sci. 76:1405-1420.
11. Lee, G., R. Proence, J. M. Montez, K. M. Carroll, J. G. Darvishzadeh, J. I. Lee, and J. M. Friedman. 1996. Abnormal splicing of the leptin receptor in diabetic mice. Nature (Lond.) 379:632-635.
12. Morrison, C. D., J. A. Daniel, B. J. Holmberg, J. Djiane, N. Raver, A. Gertler, and D. H. Keisler. 2002. Central infusion of leptin into well-fed and undernourished ewe lambs: effects on feed intake and serum concentration of growth hormone and luteinizing hormone. J. Endocrinol. 168 (In press)
13. Nagatani, S., Y. Zeng, D. H. Keisler, and D. L. Foster. 2000. Leptin regulates pulsatile luteinizing hormone and growth hormone secretion in the sheep. Endocrinology 141:3965-3975.
14. Neuenschwander, S., G. Rotenberger, E. Meijerink, H. Jorg, and G. Stranzinger. 1996. Partial characterization of porcine obesity gene (OBS) and its localization to chromosome 18 by somatic cell hybrids. Anim. Genet. 27:275-278.
15. Ostlund, R. E., J. W. Yang, S. Klein, and R. Gingerich. 1996. Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates. J. Clin. Endocrinol. Metab. 81:3909-3913.
16. Pfister-Genskow, M. A., H. Hayes, A. Eggen, and M. D. Bishop. 1996. Chromosomal localization of the bovine obese (OB) gene. Mamm. Genome 7:398-399.
17. Pfister-Genskow, M. A., H. Hayes, A. Eggen, and M. D. Bishop. 1997. The leptin receptor (LEPR) gene maps to bovine chromosome 3q33. Mamm. Genome 8:227.
18. Schwartz, M. W., S. C. Woods, D. Porte, R. L. Seeley, and D. G. Baskin. 2000. Central nervous system control of food intake. Nature (Lond.) 400:661-671.
19. Tartaglia, L. A., M. Dembski, X. Weng, N. Deng, J. Culpepper, R. Deros, G. J. Richards, L. A. Campfield, F. T. Clark, J. Deeds, C. Muir, S. Sanker, A. Moriarty, K. J. Moore, J. S. Smutko, G. G. Mays, E. A. Wolf, C. A. Monroe, and R. I. Tepper. 1995. Identification and expression cloning of a leptin receptor, OB-R. Cell 83:1263-1271.
20. Woods, S. C., M. W. Schwartz, D. G. Baskin, and R. J. Seeley. 2000. Food intake and the regulation of body weight. Annu. Rev. Psychol. 51:255-277.
21. Zhang, Y., R. Proenca, M. Maffei, M. Barone, L. Leopold, and J. M. Friedman. 1994. Positional cloning of the mouse obese gene and its human homologue. Nature (Lond.) 372:425-432.