A one-pot synthesis of 3,3′-methylenebis(2-arylamino-4H-chromen-4-one) from C-(4-oxo-4H-1-benzopyran-3-yl)-N-arylnitrone

Tetrahedron Letters

Volumn 50, Issue 27, 2009, Pages 3966-3969

  Maiti, Sourav ^a   Panja, Suman Kalyan ^a   Bandyopadhyay, Chandrakanta ^a  

^a RAMAKRISHNA MISSION VIVEKANANDA CENTENARY COLLEGE   (India)

Author keywords

1 Benzopyran; 3 Formylchromone; Bischromones; Deformylation; Mannich reaction; Nitrones

Indexed keywords

12H CHROMENO[2,3 B]QUINOLIN 12 ONE; AMINE; CHROMENE DERIVATIVE; DIETHYLAMINE; FORMALDEHYDE; PIPERIDINE; QUINOLINE DERIVATIVE; SARCOSINE; UNCLASSIFIED DRUG;

ARTICLE; MANNICH REACTION; ONE POT SYNTHESIS; STRUCTURE ANALYSIS;

EID: 65549133717     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2009.04.087     Document Type: Article

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24. ++Na).
25. 2 = aryl) (1 mmol) was heated under reflux in ethanol (25 mL) for 2 h and complete conversion of 2 to 3 was observed by TLC. Under this condition, piperidine (85 mg, 1 mmol) and 37% aqueous formaldehyde solution (1.5 mL) were added to the reaction mixture and heated under reflux for another 3 h, when a white solid separated out. The solid was filtered and crystallized from benzene-petroleum ether (10:1) to afford 8 in 80-90% yields.