Perioperative drug therapy in elderly patients

Anesthesiology

Volumn 110, Issue 5, 2009, Pages 1176-1181

  Rivera, Richard ^a   Antognini, Joseph F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANESTHETIC AGENT; ATENOLOL; ATRACURIUM; BENZODIAZEPINE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CISATRACURIUM; DIAZEPAM; DOXACURIUM; ESMOLOL; ETOMIDATE; FENTANYL; FLUMAZENIL; ISOPRENALINE; KETAMINE; LIDOCAINE; METOPROLOL; MIDAZOLAM; MORPHINE; MUSCLE RELAXANT AGENT; PANCURONIUM; PROPOFOL; PROPRANOLOL; REMIFENTANIL; ROCURONIUM; SUFENTANIL; SUXAMETHONIUM; THIOPENTAL; UNINDEXED DRUG; VECURONIUM; DRUG;

AGED; AGING; CLINICAL PRACTICE; COMORBIDITY; CREATININE CLEARANCE; DELIRIUM; DISEASE PREDISPOSITION; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG DOSE REDUCTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG ISOLATION; DRUG MECHANISM; DRUG METABOLISM; DRUG SENSITIVITY; GLOMERULUS FILTRATION RATE; HUMAN; HYPOTENSION; KIDNEY; KIDNEY FUNCTION; LIVER BLOOD FLOW; LIVER METABOLISM; LIVER SIZE; LOW DRUG DOSE; MENTAL DETERIORATION; MINIMUM LUNG ALVEOLUS CONCENTRATION; NOTE; OXIDATIVE STRESS; PERIOPERATIVE PERIOD; PHARMACODYNAMICS; PHYSIOLOGY; PRIORITY JOURNAL; SENESCENCE; TREATMENT RESPONSE; DRUG EFFECT; METABOLISM; METHODOLOGY; REVIEW;

AGED; AGED, 80 AND OVER; AGING; HUMANS; PERIOPERATIVE CARE; PHARMACEUTICAL PREPARATIONS;

EID: 65549124065     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0b013e3181a10207     Document Type: Note

References (22)

1. McLean AJ, Le Couteur DG: Aging biology and geriatric clinical pharmacology. Pharmacol Rev 2004; 56:163-84
2. Gafni A: Structural modifications of proteins during aging. J Am Geriatr Soc 1997; 45:871-80
3. Lakatta EG: Age-associated cardiovascular changes in health: Impact on cardiovascular disease in older persons. Heart Fail Rev 2002; 7:29-49
4. Turnheim K: When drug therapy gets old: Pharmacokinetics and pharma-codynamics in the elderly. Exp Gerontol 2003; 38:843-53
5. Sprung J, Gajic O, Warner DO: Review article: Age related alterations in respiratory function anesthetic considerations. Can J Anaesth 2006; 53: 1244-57
6. Monk TG, Weldon BC, Garvan CW, Dede DE, van der Aa MT, Heilman KM, Gravenstein JS: Predictors of cognitive dysfunction after major noncardiac surgery. ANESTHESIOLOGY 2008; 108:18-30
7. Lortat-Jacob B, Servin F: Pharmacology of intravenous drugs in the elderly, Geriatric Anesthesia. Edited by Sieber FE. New York, McGraw-Hill, 2006, pp 91-103
8. Mauriz JL, Tabernero B, Garcia-Lopez J, Jorquera F, Villa JG, GonzalezGallego J: Physical exercise and improvement of liver oxidative metabolism in the elderly. Eur J Appl Physiol 2000; 81:62-6
9. Le Couteur DG, McLean AJ: The aging liver: Drug clearance and an oxygen diffusion barrier hypothesis. Clin Pharmacokinet 1998; 34:359-73
10. Yu ZY, Wang W, Fritschy JM, Witte OW, Redecker C: Changes in neocortical and hippocampal GABAA receptor subunit distribution during brain maturation and aging. Brain Res 2006; 1099:73-81
11. Eger EI: Age, minimum alveolar anesthetic concentration, and minimum alveolar anesthetic concentration-awake. Anesth Analg 2001; 93:947-53
12. Arden JR, Holley FO, Stanski DR: Increased sensitivity to etomidate in the elderly: Initial distribution versus altered brain response. ANESTHESIOLOGY 1986; 65:19-27
13. Stanski DR, Maitre PO: Population pharmacokinetics and pharmacodynamics of thiopental: The effect of age revisited. ANESTHESIOLOGY 1990; 72:412-22
14. Schnider TW, Minto CF, Shafer SL, Gambus PL, Andresen C, Goodale DB, Youngs EJ: The inuence of age on propofol pharmacodynamics. ANESTHESIOLOGY 1999; 90:1502-16
15. Aronow WS, Frishman WH, Cheng-Lai A: Cardiovascular drug therapy in the elderly. Cardiol Rev 2007; 15:195-215
16. Scott JC, Stanski DR: Decreased fentanyl and alfentanil dose requirements with age: A simultaneous pharmacokinetic and pharmacodynamic evaluation. J Pharmacol Exp Ther 1987; 240:159-66
17. Minto CF, Schnider TW, Shafer SL: Pharmacokinetics and pharmacodynamics of remifentanil, II: Model application. ANESTHESIOLOGY 1997; 86:24-33
18. Owen JA, Sitar DS, Berger L, Brownell L, Duke PC, Mitenko PA: Age-related morphine kinetics. Clin Pharmacol Ther 1983; 34:364-8
19. Koscielniak-Nielsen ZJ, Bevan JC, Popovic V, Baxter MR, Donati F, Bevan DR: Onset of maximum neuromuscular block following succinylcholine or vecuronium in four age groups. ANESTHESIOLOGY 1993; 79:229-34
20. Parker CJ, Hunter JM, Snowdon SL: Effect of age, sex and anaesthetic technique on the pharmacokinetics of atracurium. Br J Anaesth 1992; 69:439-43
21. Donati F: Onset of action of relaxants. Can J Anaesth 1988; 35:S52-8
22. Bouchon JP: 1 2 3 ou comment tenter dǎ™etre efficace en geriatrie. Rev Prat 1984; 34:888-9