Real-time quantitation of renal ischemia using targeted microbubbles: In-vivo measurement of p-selectin expression

Journal of Endourology

Volumn 23, Issue 3, 2009, Pages 373-378

  Andonian, Sero ^a   Coulthard, Tonya ^b   Smith, Arthur D ^a   Singhal, Pravin S ^c   Lee, Benjamin R ^a,d  

^a The Arthur Smith Institute for Urology   (United States)

^b VisualSonics   (Canada)

^c School of Medicine ^*  (United States)

^d TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PADGEM PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD FLOW VELOCITY; BLOOD VOLUME; C57BL 6 MOUSE; COLOR; COMPARATIVE STUDY; COMPUTER PROGRAM; CONTROLLED STUDY; DIGITAL SUBTRACTION ANGIOGRAPHY; DOPPLER ECHOGRAPHY; FEMALE; IN VIVO STUDY; KIDNEY BLOOD FLOW; KIDNEY CORTEX; KIDNEY ISCHEMIA; KIDNEY MEDULLA; KIDNEY VEIN; LIGATION; MICROTUBULE; MOUSE; NON INVASIVE MEASUREMENT; NONHUMAN; PERFUSION; PILOT STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RENAL ARTERY; REPERFUSION INJURY; SHAM PROCEDURE; ANIMAL; BLOOD FLOW; ECHOGRAPHY; ISCHEMIA; KIDNEY; KIDNEY DISEASE; METABOLISM; MICROBUBBLE; PATHOLOGY; TIME; VASCULARIZATION;

ANIMALS; FEMALE; ISCHEMIA; KIDNEY; KIDNEY DISEASES; LIGATION; MICE; MICROBUBBLES; P-SELECTIN; REGIONAL BLOOD FLOW; TIME FACTORS;

EID: 65549115478     PISSN: 08927790     EISSN: None     Source Type: Journal    
DOI: 10.1089/end.2008.0229     Document Type: Article

References (21)

1. Linehan WM, Zbar B, Bates SE, Zelefsky MJ, Yang JC. Cancer of the kidney and ureter. In: DeVita VT Jr, Hellman S, Rosenberg SA, eds. Cancer: Principles and Practice of Oncology. 6th ed. Philadelphia: Lippincott Williams & Wilkins, 2001, pp. 1362-1396.
2. McDougall EM, Clayman RV, Anderson K. Laparoscopic wedge resection of a renal tumor: Initial experience. J Laparoendosc Surg 1993;3:577-581.
3. Winfield HN, Donovan JF, Godet AS, Clayman RV. Laparoscopic partial nephrectomy: initial case report for benign disease. J Endourol 1993;7:521-526.
4. Uzzo RG, Novick AC. Nephron sparing surgery for renal tumors: Indications, techniques and outcomes. J Urol 2001; 166:6-18.
5. McKiernan J, Simmons R, Katz J, Russo P. Natural history of chronic renal insufficiency after partial and radical nephrectomy. Urology 2002;59:816-820.
6. Gill IS, Matin SF, Desai MM, et al. Comparative analysis of laparoscopic versus open partial nephrectomy for renal tumors in 200 patients. J Urol 2003;170:64-68.
7. Novick AC. Renal hypothermia: In vivo and ex vivo . Urol Clin North Am 1983;10:637-644.
8. Orvieto MA, Zorn KC, Mendiola F, et al. Recovery of renal function after complete renal hilar versus artery alone clamping during open and laparoscopic surgery. J Urol 2007; 177:2371-2374.
9. Johnson KJ, Weinberg JM. Postischemic renal injury due to oxygen radicals. Curr Opin Nephrol Hypertens 1993;2:625-635.
10. Klibanov AL. Ligand-carrying gas-filled microbubbles: Ultrasound contrast agents for targeted molecular imaging. Bioconjug Chem 2005;16:9-17.
11. Rouschop KM, Roelofs JJ, Claessen N, et al. Protection against renal ischemia reperfusion injury by CD44 disruption. J Am Soc Nephrol 2005;16:2034-2043.
12. Bevilacqua MP, Nelson RM. Selectins. J Clin Invest 1993;91: 379-387.
13. Kanwar S, Smith CW, Kubes P. An absolute requirement for P-selectin in ischemia/reperfusion-induced leukocyte recruitment in cremaster muscle. Microcirculation 1998;5:281-287.
14. Lange-Sperandio B, Cachat F, Thornhill BA, Chevalier RL. Selectins mediate macrophage infiltration in obstructive nephropathy in newborn mice. Kidney Int 2002;61:516-524.
15. Singbartl K, Green SA, Ley K. Blocking P-selectin protects from ischemia/reperfusion-induced acute renal failure. FASEB J 2000;14:48-54.
16. Wu P, Li X, Zhou T, et al. Role of P-selectin and anti-P-selectin monoclonal antibody in apoptosis during hepatic/ renal ischemia reperfusion injury. World J Gastroenterol 2000;6:244-247.
17. Fuller TF, Sattler B, Binder L, et al. Reduction of severe ischemia/reperfusion injury in rat kidney grafts by a soluble P-selectin glycoprotein ligand. Transplantation 2001;72:216-222.
18. Lindner JR. Molecular imaging with contrast ultrasound and targeted microbubbles. J Nucl Cardiol 2004;11:215-221.
19. Lindner JR, Song J, Jayaweera AR, et al. Microvascular rheology of Definity microbubbles after intra-arterial and intravenous administration. J Am Soc Echocardiogr 2002; 15:396-403.
20. Lindner JR, Song J, Christiansen J, et al. Ultrasound assessment of inflammation and renal tissue injury with microbubbles targeted to P-selectin. Circulation 2001;104:2107-2112.
21. Reilly MP, Delanty N, Roy L, et al. Increased formation of the isoprostanes IPF2alpha-I and 8-epi-prostaglandin F2al-pha in acute coronary angioplasty: Evidence for oxidant stress during coronary reperfusion in humans. Circulation 1997;96:3314-3320.