Recipient Genotype Is a Predictor of Allograft Cytokine Expression and Outcomes After Pediatric Cardiac Transplantation

Journal of the American College of Cardiology

Volumn 53, Issue 20, 2009, Pages 1909-1917

  Auerbach, Scott R ^a   Manlhiot, Cedric ^b   Reddy, Sushma ^a   Kinnear, Caroline ^a   Richmond, Marc E ^a   Gruber, Dorota ^a   McCrindle, Brian W ^b   Deng, Liyong ^a   Chen, Jonathan M ^a   Addonizio, Linda J ^a   Chung, Wendy K ^a   Mital, Seema ^b  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b Labatt Family Heart Centre   (Canada)

Author keywords

angiotensin; cardiac transplantation; cytokines; genetics; polymorphism

Indexed keywords

AZATHIOPRINE; CYCLOSPORIN; CYTOKINE; INTERLEUKIN 6; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; TACROLIMUS; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ACE D GENE; ADULT; AGT G GENE; AGTR1 C GENE; ALLELE; ARTICLE; BIOPSY; CARDIAC GRAFT REJECTION; CMA A GENE; COHORT ANALYSIS; CYP11B2 G GENE; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG DOSE TITRATION; DRUG SUBSTITUTION; FEMALE; GENE; GENETIC POLYMORPHISM; GENOTYPE; GRAFT DYSFUNCTION; GRAFT RECIPIENT; GRAFT SURVIVAL; HEART FUNCTION; HEART TRANSPLANTATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LINEAR REGRESSION ANALYSIS; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MORTALITY; OUTCOME ASSESSMENT; PREDICTOR VARIABLE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RETRANSPLANTATION; TREATMENT OUTCOME; UPREGULATION; VASCULAR DISEASE;

BIOPSY; CARDIOMYOPATHIES; CHILD; DNA; ECHOCARDIOGRAPHY; FEMALE; FOLLOW-UP STUDIES; GENE EXPRESSION REGULATION; GENOTYPE; GRAFT REJECTION; HEART DEFECTS, CONGENITAL; HEART TRANSPLANTATION; HUMANS; INTERLEUKIN-6; MALE; MYOCARDIUM; POLYMERASE CHAIN REACTION; RETROSPECTIVE STUDIES; RISK FACTORS; TIME FACTORS; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA; TRANSPLANTATION, HOMOLOGOUS;

EID: 65549112600     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2009.02.027     Document Type: Article

References (31)

1. Boucek M.M., Edwards L.B., Keck B.M., Trulock E.P., Taylor D.O., and Hertz M.I. Registry of the International Society for Heart and Lung Transplantation: eighth official pediatric report-2005. J Heart Lung Transplant 24 (2005) 968-982
2. Wilhelmi M., Pethig K., Wilhelmi M., Nguyen H., Struber M., and Haverich A. Heart transplantation: echocardiographic assessment of morphology and function after more than 10 years of follow-up. Ann Thorac Surg 74 (2002) 1075-1079 discussion 1079.
3. Pahl E., Naftel D.C., Kuhn M.A., et al. The impact and outcome of transplant coronary artery disease in a pediatric population: a 9-year multi-institutional study. J Heart Lung Transplant 24 (2005) 645-651
4. Diet F., Graf C., Mahnke N., et al. ACE and angiotensinogen gene genotypes and left ventricular mass in athletes. Eur J Clin Invest 31 (2001) 836-842
5. Hao J., Wang B., Jones S.C., Jassal D.S., and Dixon I.M.C. Interaction between angiotensin II and SMAD proteins in fibroblasts in failing heart and in vitro. Am J Physiol Heart Circ Physiol 279 (2000) H3020-H3030
6. Kaufman B.D., Auerbach S., Reddy S., et al. RAAS gene polymorphisms influence progression of pediatric hypertrophic cardiomyopathy. Hum Genet 122 (2007) 515-523
7. Yamani M.H., Cook D.J., Rodriguez E.R., et al. Increased expression of angiotensin II type 1 receptor (AGTR1) in heart transplant recipients with recurrent rejection. J Heart Lung Transplant 25 (2006) 1283-1289
8. Abdallah A.N., Billes M.A., Attia Y., Doutremepuich C., Cassaigne A., and Iron A. Evaluation of plasma levels of tumour necrosis factor alpha and interleukin-6 as rejection markers in a cohort of 142 heart-grafted patients followed by endomyocardial biopsy. Eur Heart J 18 (1997) 1024-1029
9. Campbell S.E., and Katwa L.C. Angiotensin II stimulated expression of transforming growth factor-beta1 in cardiac fibroblasts and myofibroblasts. J Mol Cell Cardiol 29 (1997) 1947-1958
10. Kranzhofer R., Browatzki M., Schmidt J., and Kubler W. Angiotensin II activates the proinflammatory transcription factor nuclear factor-[kappa]B in human monocytes. Biochem Biophys Res Commun 257 (1999) 826-828
11. Kurland L.M.H., Karlsson J., Kahan T., et al. Polymorphisms in the angiotensinogen and angiotensin II type 1 receptor gene are related to change in left ventricular mass during antihypertensive treatment: results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA) trial. J Hypertens 20 (2002) 657-663
12. McNamara D.M., Holubkov R., Postava L., et al. Pharmacogenetic interactions between angiotensin-converting enzyme inhibitor therapy and the angiotensin-converting enzyme deletion polymorphism in patients with congestive heart failure. J Am Coll Cardiol 44 (2004) 2019-2026
13. Pethig K.H.B., Hoffmann A., Borlak J., Wahlers T., and Haverich A. ACE-gene polymorphism is associated with the development of allograft vascular disease in heart transplant recipients. J Heart Lung Transplant 19 (2000) 1175-1182
14. Yousufuddin M.H.S., Starling R.C., Tuzcu E.M., et al. Cardiac angiotensin II receptors as predictors of transplant coronary artery disease following heart transplantation. Eur Heart J 25 (2004) 377-385
15. Ortlepp J.R., Vosberg H.P., Reith S., et al. Genetic polymorphisms in the renin-angiotensin-aldosterone system associated with expression of left ventricular hypertrophy in hypertrophic cardiomyopathy: a study of five polymorphic genes in a family with a disease causing mutation in the myosin binding protein C gene. Heart 87 (2002) 270-275
16. Stewart S., Winters G.L., Fishbein M.C., et al. Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection. J Heart Lung Transplant 24 (2005) 1710-1720
17. Law Y., Boyle G., Miller S., et al. Restrictive hemodynamics are present at the time of diagnosis of allograft coronary artery disease in children. Pediatr Transplant 10 (2006) 948-952
18. Eun L.Y., Gajarski R.J., Graziano J.N., and Ensing G.J. Relation of left ventricular diastolic function as measured by echocardiography and pulmonary capillary wedge pressure to rejection in young patients (< or = 31 years) after heart transplantation. Am J Cardiol 96 (2005) 857-860
19. Gao S.Z., Alderman E.L., Schroeder J.S., Silverman J.F., and Hunt S.A. Accelerated coronary vascular disease in the heart transplant patient: coronary arteriographic findings. J Am Coll Cardiol 12 (1988) 334-340
20. Perkins M.J., Van Driest S.L., Ellsworth E.G., et al. Gene-specific modifying effects of pro-LVH polymorphisms involving the renin-angiotensin-aldosterone system among 389 unrelated patients with hypertrophic cardiomyopathy. Eur Heart J 26 (2005) 2457-2462
21. Ternstrom L., Jeppsson A., Ricksten A., and Nilsson F. Tumor necrosis factor gene polymorphism and cardiac allograft vasculopathy. J Heart Lung Transplant 24 (2005) 433-438
22. Densem C.G., Ray M., Hutchinson I.V., Yonan N., and Brooks N.H. Interleukin-6 polymorphism: a genetic risk factor for cardiac transplant related coronary vasculopathy?. J Heart Lung Transplant 24 (2005) 559-565
23. Zakrzewski-Jakubiak M., de Denus S., Dube M.-P., Belanger F., White M., and Turgeon J. Ten renin-angiotensin system-related gene polymorphisms in maximally treated Canadian Caucasian patients with heart failure. Br J Clin Pharmacol 65 (2008) 742-751
24. Bloem L.J., Manatunga A.K., Tewksbury D.A., and Pratt J.H. The serum angiotensinogen concentration and variants of the angiotensinogen gene in white and black children. J Clin Invest 95 (1995) 948-953
25. Kim H.-S., Lee M.-M., Oh B.-H., et al. Synergistic effect of angiotensin-converting enzyme and angiotensinogen gene on cardiac hypertrophy. Int J Cardiol 72 (2000) 151-161
26. van Rijn M.J.E., Bos M.J., Isaacs A., et al. Polymorphisms of the renin angiotensin system are associated with blood pressure, atherosclerosis and cerebral white matter pathology. J Neurol Neurosurg Psychiatry 78 (2007) 1083-1087
27. Cunningham D.A., Crisp S.J., Barbir M., Lazem F., Dunn M.J., and Yacoub M.H. Donor ACE gene polymorphism: a genetic risk factor for accelerated coronary sclerosis following cardiac transplantation. Eur Heart J 19 (1998) 319-325
28. Ayed K., Ayed-Jendoubi S., Ben Abdallah T., et al. Polymorphism of the renin-angiotensin-aldosterone system in patients with chronic allograft dysfunction. Transpl Immunol 15 (2006) 303-309
29. Prasad G.V.R., Pinnaduwage D., Parkes R.K., et al. Angiotensinogen M235T genotype predicts progression in chronic renal allograft dysfunction. Transplant 75 (2003) 209-216
30. Weis M., and von Scheidt W. Cardiac allograft vasculopathy: a review. Circulation 96 (1997) 2069-2077
31. Bleumink G.S., Schut A.F., Sturkenboom M.C., et al. Mortality in patients with hypertension on angiotensin-I converting enzyme (ACE)-inhibitor treatment is influenced by the ACE insertion/deletion polymorphism. Pharmacogenet Genomics 15 (2005) 75-81