ACE-gene polymorphism is associated with the development of allograft vascular disease in heart transplant recipients

Journal of Heart and Lung Transplantation

Volumn 19, Issue 12, 2000, Pages 1175-1182

  Pethig, Klaus ^a   Heublein, Bernd ^a   Hoffmann, Andrea ^b   Borlak, Jürgen ^b   Wahlers, Thorsten ^a   Haverich, Axel ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; CAPTOPRIL; CYCLOSPORIN; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; FOSINOPRIL; LISINOPRIL; PREDNISOLONE;

ADULT; ALLOGRAFT; ANGIOGRAPHY; ARTERY INTIMA PROLIFERATION; ARTICLE; CLINICAL TRIAL; DISEASE COURSE; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENOTYPE; HEART GRAFT; HLA MATCHING; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK FACTOR; ULTRASOUND; VASCULAR DISEASE;

ACTUARIAL ANALYSIS; ADULT; ALLELES; ANALYSIS OF VARIANCE; CHI-SQUARE DISTRIBUTION; COHORT STUDIES; CORONARY DISEASE; DISEASE PROGRESSION; ENVIRONMENT; FEMALE; FOLLOW-UP STUDIES; GENE DELETION; GENE FREQUENCY; GENOTYPE; HEART TRANSPLANTATION; HUMANS; INTRONS; LOGISTIC MODELS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; MUTAGENESIS, INSERTIONAL; PEPTIDYL-DIPEPTIDASE A; PHENOTYPE; POLYMORPHISM, GENETIC; SURVIVAL ANALYSIS; TRANSPLANTATION, HOMOLOGOUS;

EID: 0033638310     PISSN: 10532498     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1053-2498(00)00213-8     Document Type: Article

References (39)

1. Genetic dissection of complex traits
2. Genetics of interventional cardiology
3. Angiotensin converting enzyme gene deletion allele is independently and strongly associated with coronary atherosclerosis and myocardial infarction
4. Angiotensin-I converting enzyme genotype DD is a risk factor for coronary artery disease
5. A meta-analysis of the association of the deletion allele of the angiotensin-converting enzyme gene with myocardial infarction
6. Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction
7. Insertion/deletion polymorphism in the angiotensin converting enzyme gene and risk of restenosis after coronary angioplasty
8. D allele of the angiotensin I-converting enzyme is a major risk factor for restenosis after coronary stenting
9. Plasma activity and insertion/deletion polymorphism of angiotensin I-converting enzyme
10. The spectrum of coronary artery pathologic findings in human cardiac allografts
11. Cardiac allograft vasculopathy. A review
12. The registry of the International Society for Heart and Lung Transplantation; thirteenth official report-1996
13. Transplant coronary disease; nonimmunologic risk factors
14. Cardiac allograft vasculopathy; relationship with acute cellular rejection and histocompatibility
15. Impact of plaque burden on compensatory enlargement of coronary arteries in cardiac allograft vasculopathy
16. PCR detection of the insertion/deletion polymorphism of the human angiotension converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1)
17. Mistyping ACE heterozygotes
18. A sensitive fluorimetric assay for serum angiotensin-converting enzyme
19. Cardiac transplantation in man:VII:cardiac allograft pathology
20. Cardiac allograft vasculopathy; current concepts, recent developments, and future directions
21. Detection of coronary atherosclerosis in young adult hearts using intravascular ultrasound
22. Syndromes of accelerated atherosclerosis; role of vascular injury and smooth muscle cell proliferation
23. Cell biology and genetics of angiotensin in cardiovascular disease
24. Angiotensin II induces smooth muscle cell proliferation in the normal and injured rat arterial wall
25. Induction of angiotensin converting enzyme in the neointima after vascular injury; possible role on restenosis
26. Inhibitors of angiotensin-converting enzyme prevent myointimal proliferation after vascular injury
27. Potential importance of tissue angiotensin-converting enzyme inhibition in preventing neointima formation
28. An intravascular ultrasound study of the influence of angiotensin-converting enzyme inhibitors and calcium entry blockers on the development of cardiac allograft vasculopathy
29. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half of the variance of serum enzyme levels
30. Identification of new polymorphisms of the angiotensin I-converting enzyme (ACE) gene, and study of their relationship to plasma ACE levels by two-QTL segregation-linkage analysis
31. Angiotensin-converting enzyme (ACE) gene polymorphism in patients characterised by coronary angiography
32. Tissue angiotensin system in cardiovascular medicine. A paradigm shift?
33. Donor ACE gene polymorphism; a genetic risk factor for accelerated coronary sclerosis following cardiac implantation
34. Polymorphisms for angiotensin converting enzyme, angiotensinogen, nitric oxide synthase, and endothelin and their association with cardiac allograft vasculopathy in the first year posttransplant
35. Functional significance of intimal thickening as detected by intravascular ultrasound early and late after cardiac transplantation
36. Incidence and severity of transplant coronary artery disease early and up to 15 years after transplantation as detected by intravascular ultrasound
37. Intracoronary ultrasound in cardiac transplant recipients. In vivo evidence of 'angiographically silent' intimal thickening
38. Mechanism of luminal narrowing in cardiac allograft vasculopathy; inadequate remodeling rather than intimal hyperplasia is the major predictor of coronary artery stenosis