Detection of human papillomavirus and cellular regulators p16 INK4a, p53, and NF-κB in penile cancer cases in Kenya

Acta Virologica

Volumn 53, Issue 1, 2009, Pages 43-48

  Senba, M ^a   Buziba, N ^b   Mori, N ^c   Wada, A ^a   Irie, S ^a   Toriyama, K ^d  

^a NAGASAKI UNIVERSITY   (Japan)

^b MOI UNIVERSITY   (Kenya)

^c UNIVERSITY OF THE RYUKYUS   (Japan)

^d Japanese Red Cross Nagasaki Atomic Bomb Hospital Nagasaki   (Japan)

Author keywords

Human papillomavirus; Kenya; NF B; p53; Penile cancer

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN P53; VIRUS DNA;

ADULT; AGED; ARTICLE; CANCER LOCALIZATION; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CYTOPLASM; HUMAN; HUMAN TISSUE; IMMUNOCHEMISTRY; IN SITU HYBRIDIZATION; KENYA; MALE; NUCLEUS ACCUMBENS; PAPILLOMAVIRUS INFECTION; PENIS CANCER; PROTEIN EXPRESSION; VIRUS DETECTION; WART VIRUS; BIOSYNTHESIS; CELL NUCLEUS; CHEMISTRY; IMMUNOHISTOCHEMISTRY; ISOLATION AND PURIFICATION; MIDDLE AGED; PAPILLOMA VIRUS; PATHOLOGY; PENIS TUMOR; VIROLOGY;

HUMAN PAPILLOMAVIRUS;

ADULT; AGED; AGED, 80 AND OVER; CELL NUCLEUS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYTOPLASM; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KENYA; MALE; MIDDLE AGED; NF-KAPPA B; PAPILLOMAVIRIDAE; PENILE NEOPLASMS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 65549091469     PISSN: 0001723X     EISSN: None     Source Type: Journal    
DOI: 10.4149/av_2009_01_43     Document Type: Article

References (30)

1. Cubilla AL, Reuter VE, Gregoire L, Ayala G, Ocampos S, Lancaster WD, Fair W (1998): Basaloid squamous cell carcinoma: A distinctive human papilloma virus-related penile neoplasm. A report of 20 cases. Am. J. Surg. Pathol. 22, 755-761. doi:10.1097/00000478-199806000-00014 PMid:9630184
2. Cupp MR, Malek RS, Goellner JR, Smith TF, Espy MJ (1995): The detection of human papillomavirus deoxyribonucleic acid in intraepithelial, in situ, verrucous and invasive carcinoma of the penis. J. Urol. 154, 1024-1029. doi:10.1016/S0022-5347(01)66967-2 PMid:7637047
3. Dehn D, Torkko K, Shroyer KR (2007): Human papillomavirus testing and molecular markers of cervical dysplasia and carcinoma. Cancer 111, 1-14. doi:10.1002/cncr.22425 PMid:17219448 (Pubitemid 46281079)
4. Ferreux E, Lont AP, Horenblas S, Gallee MP, Raaphorst FM, von Knebel Doeberitz M, Meijer CJ, Snijders PJ (2003): Evidence for at least three alternative mechanisms targeting the p16INK4a/cyclin D/Rb pathway in penile carcinoma, one of which is mediated by high-risk human papillomavirus. J. Pathol. 201, 109-118. doi:10.1002/path.1394 PMid:12950023
5. Gregoire L, Cubilla AL, Reuter VE, Haas GP, Lancaster WD (1995): Preferential association of human papillomavirus with high-grade histologic variants of penile invasive squamous cell carcinoma. J. Natl. Cancer Inst. 87, 1705-1709. doi:10.1093/jnci/87.22.1705 PMid:7473819
6. Gross G, Pfister H (2004): Role of human papillomavirus in penile cancer, penile intraepithelial squamous cell neoplasias and in genital warts. Med. Microbiol. Immunol. 193, 35-44. doi:10.1007/s00430-003-0181-2 PMid:12838415
7. Havard L, Delvenne P, Frare P, Boniver J, Giannini SL (2002): Differential production of cytokines and activation of NF-κB in HPV transformed keratinocytes. Virology 298, 271-285. doi:10.1006/viro.2002.1468 PMid:12127790
8. Havard L, Rahmouni S, Boniver J, Delvenne P (2005): High levels of p105 (NF-κB1) and p100 (NF-κB2) proteins in HPV 16-transformed keratinocytes: Role of E6 and E7 oncoproteins. Virology 331, 357-366. doi:10.1016/j.virol.2004.10.030 PMid:15629778
9. Humbey O, Cairey-Remonnay S, Guerrini JS, Algros MP, Mougin C, Bittard H, Aubin F (2003): Detection of the human papillomavirus and analysis of the TP53 polymorphism of exon 4 at codon 72 in penile squamous cell carcinoma. Eur. J. Cancer 39, 684-690. doi:10.1016/S0959-8049(02)00835-3 PMid:12628849
10. James MA, Lee JH, Klingelhutz AJ (2006): Human papillomavirus type 16 E6 activates NF-κB, induces cIAP-2 expression, and protects against apoptosis in a PDZ binding motif-dependent manner. J. Virol. 80, 5301-5307. doi:10.1128/JVI.01942-05 PMid:16699010 PMCid:1472131
11. Kalof AN, Evans MF, Simmons-Arnold L, Beatty BG, Cooper K (2005): p16INK4a immunoexpression and HPV in situ hybridization signal patterns: Potential markers of high-grade cervical intraepithelial neoplasia. Am. J. Surg. Pathol. 29, 674-679.
12. Kiriakidis S, Andreakos E, Monaco C, Foxwell B, Feldmann M, Paleolog E (2003): VEGF expression in human macrophages is NF-κB-dependent: Studies using adenoviruses expressing the endogenous NF-κB inhibitor IkkappaB-alpha and a kinase-defective form of the IkkappaB kinase 2. J. Cell Sci. 116, 665-674. doi:10.1242/jcs.00286 PMid:12538767
13. Klaes R, Friedrich T, Spitkovsky D, Ridder R, Rudy W, Petry U, Dallenbach-Hellweg G, Schmidt D, von Knebel Doeberitz M (2001): Overexpression of p16NIK4a as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri. Int. J. Cancer 92, 276-284. doi:10.1002/ijc.1174
14. Lam KY, Chan KW (1999): Molecular pathology and clinicopathologic features of penile tumors: With special reference to analyses of p21 and p53 expression and unusual histologic features. Arch. Pathol. Lab. Med. 123, 895-904.
15. Lopes A, Bezerra AL, Pino CA, Serrano SV, Mello CA, Villa LL (2002): p53 as a new prognostic factor for lymph node metastasis in penile carcinoma: Analysis of 82 patients treated with amputation and bilateral lymphadenectomy. J. Urol. 168, 81-86. doi:10.1016/S0022-5347(05)64836-7 PMid:12050497 (Pubitemid 34640788)
16. Milde-Langosch K, Riethdorf S, Kraus-Poppinghaus A, Riethdorf L, Loning T (2001): Expression of cyclin-dependent kinase inhibitors p16MTS1, p21WAF1, and p27KIP1 in HPV-positive and HPV-negative cervical adenocarcinomas. Virchows Arch. 439, 55-61. doi:10.1007/s004280100439 PMid:11499840 (Pubitemid 32662518)
17. Mishra A, Bharti AC, Varghese P, Saluja D, Das BC (2006): Differential expression and activation of NF-κB family proteins during oral carcinogenesis: Role of high risk human papillomavirus infection. Int. J. Cancer 119, 2840-2850. doi:10.1002/ijc.22262 (Pubitemid 44846236)
18. Munger K, Baldwin A, Edwards KM, Hayakawa H, Nguyen CL, Owens M, Grace M, Huh K (2004): Mechanisms of human papillomavirus-induced oncogenesis. J. Virol. 78, 11451-11460. doi:10.1128/JVI.78.21.11451-11460.2004 PMid:15479788 PMCid:523272
19. Nees M, Geoghegan JM, Hyman T, Frank S, Miller L, Woodworth CD (2001): Papillomavirus type 16 oncogenes downregulate expression of interferon- responsive genes and upregulate proliferation-associated and NF-κB-responsive genes in cervical keratinocytes. J. Virol. 75, 4283-4296. doi:10.1128/JVI.75.9.4283-4296.2001 PMid:11287578 PMCid:114174
20. Picconi MA, Eijan AM, Distefano AL, Pueyo S, Alonio LV, Gorostidi S, Teyssie AR, Gasabe A (2000): Human papillomavirus (HPV) DNA in penile carcinomas in Argentina: Analysis of primary tumors and lymph nodes. J. Med. Virol. 61, 65-69. doi:10.1002/(SICI)1096-9071(200005)61:1〈65::AID-JMV10〉3.0.CO;2- Z PMid:10745234
21. Prowse DM, Ktori EN, Chandrasekaran D, Prapa A, Baithun S (2008): Human papillomavirus-associated increase in p16INK4a expression in penile lichen sclerosus and squamous cell carcinoma. Br. J. Dermatol. 158, 261-265.
22. Rubin MA, Kleter B, Zhou M, Ayala G, Cubilla AL, Quint WG, Pirog EC (2001): Detection and typing of human papillomavirus DNA in penile carcinoma: Evidence for multiple independent pathways of penile carcinogenesis. Am. J. Pathol. 159, 1211-1218.
23. Sano T, Oyama T, Kashiwabara K, Fukuda T, Nakajima T (1998): Expression status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesions. Am. J. Pathol. 153, 1741-1748.
24. Sarkar FH, Miles BJ, Plieth DH, Crissman JD (1992): Detection of human papillomavirus in squamous neoplasm of the penis. J. Urol. 147, 389-392.
25. Senba M, Kumatori A, Fujita S, Jutavijittum P, Yousukh A, Moriuchi T, Nakamura T, Toriyama K (2006): The prevalence of human papillomavirus genotypes in penile cancers from northern Thailand. J. Med Virol. 78, 1341-1346. doi:10.1002/jmv.20703 PMid:16927292
26. Spitkovsky D, Hehner SP, Hofmann TG, Moller A, Schmitz ML (2002): The human papillomavirus oncoprotein E7 attenuates NF-κB activation by targeting IκB kinase complex. J. Biol. Chem. 277, 25576-25582. doi:10.1074/jbc.M201884200 PMid:11986318
27. Tornesello ML, Buonaguro FM, Beth-Giraldo E, Kyalwazi SK, Giraldo G (1992): Human papillomavirus (HPV) DNA in penile carcinomas and in two cell lines from high-incidence areas for genital cancers in Africa. Int. J. Cancer 51, 587-592. doi:10.1002/ijc.2910510414
28. Tornesello ML, Duraturo ML, Losito S, Botti G, Pilotti S, Stefanon B, De Palo G, Gallo A, Buonaguro L, Buonaguro FM (2008): Human papillomavirus genotypes and HPV 16 variants in penile carcinoma. Int. J. Cancer 122, 132-137. doi:10.1002/ijc.23062
29. Zhang HS, Postigo AA, Dean DC (1999): Active transcriptional repression by the Rb-E2F complex mediates G1 arrest triggered by p16INK4a, TGFb, and contact inhibition. Cell 97, 53-61. doi:10.1016/S0092-8674(00)80714-X PMid:10199402
30. Zielinski GD, Snijders PJ, Rozendaal L, Daalmeijer NF, Risse EK, Voorhorst FJ, Jiwa NM, Linden HC, Schipper FA, Runsink AP, Meijier CJ (2003): The presence of high-risk HPV combined with specific p53 and p16INK4a expression patterns points to high-risk HPV as the main causative agent for adenocarcinoma in situ and adenocarcinoma of the cervix. J. Pathol. 201, 535-543. doi:10.1002/path.1480 PMid:14648656