Effects of natalizumab, an α4 integrin inhibitor, on fertility in male and female guinea pigs

Birth Defects Research Part B - Developmental and Reproductive Toxicology

Volumn 86, Issue 2, 2009, Pages 108-116

  Wehner, Nancy G ^a,e   Skov, Michael ^a   Shopp, George ^b   Rocca, Meredith S ^c   Clarke, Janet ^d  

^a ELAN PHARMACEUTICALS   (United States)

^b Shopp Nonclinical Consulting LLC   (United States)

^c TherImmune Research Corporation   (United States)

^d BIOGEN   (United States)

^e Flan Pharmaceuticals Inc   (United States)

Author keywords

4 integrin; Guinea pig; Mating fertility; Monoclonal antibody; Natalizumab; Safety assessment

Indexed keywords

NATALIZUMAB; ALPHA4 INTEGRIN; MONOCLONAL ANTIBODY; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPSY; CONTROLLED STUDY; DRUG EFFECT; DRUG EXPOSURE; DRUG MEGADOSE; EPIDIDYMIS; FEMALE; FEMALE FERTILITY; GESTATION PERIOD; GUINEA PIG; HISTOLOGY; LOW DRUG DOSE; MALE; MALE FERTILITY; MATING; NONHUMAN; ORGAN WEIGHT; OVARY WEIGHT; PREGNANCY; PREGNANCY RATE; PRIORITY JOURNAL; SPERM; TESTIS; UTERUS WEIGHT; ANIMAL; ANTIBODY PRODUCTION; BLOOD; BODY WEIGHT; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; DOSE RESPONSE; DRUG SCREENING; EMBRYO DEVELOPMENT; FEMALE INFERTILITY; FERTILITY; FERTILIZATION; FETUS; IMMUNOLOGY; NIDATION; PHYSIOLOGY; PRENATAL DEVELOPMENT; RANDOMIZATION; SPERMATOGENESIS; SPERMATOZOON MOTILITY;

CAVIA;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIBODIES, MONOCLONAL; ANTIBODY FORMATION; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; EMBRYO IMPLANTATION; EMBRYONIC DEVELOPMENT; FEMALE; FERTILITY; FERTILIZATION; FETUS; GUINEA PIGS; INFERTILITY, FEMALE; INTEGRIN ALPHA4; MALE; PREGNANCY; PREGNANCY RATE; RANDOM ALLOCATION; SPERM MOTILITY; SPERMATOGENESIS;

EID: 65549091168     PISSN: 15429733     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdrb.20191     Document Type: Article

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