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Volumn 18, Issue 11, 2009, Pages 2032-2044

Reproductive and epigenetic outcomes associated with aging mouse oocytes

Author keywords

[No Author keywords available]

Indexed keywords

DNA METHYLTRANSFERASE;

EID: 65549089592     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddp127     Document Type: Article
Times cited : (62)

References (61)
  • 2
    • 0346417263 scopus 로고
    • Reproductive aging in females: An etiological perspective updated
    • Nelson, J.F. and Felicio, L.S. (1987) Reproductive aging in females: An etiological perspective updated. Rev. Biol. Res. Aging, 3, 359-381.
    • (1987) Rev. Biol. Res. Aging , vol.3 , pp. 359-381
    • Nelson, J.F.1    Felicio, L.S.2
  • 3
    • 0020615526 scopus 로고
    • Imminent oocyte exhaustion and reduced follicular recruitment mark the transition to acyclicity in aging C57BL/6J mice
    • Gosden, R.G., Laing, S.C., Felicio, L.S., Nelson, J.F. and Finch, C.E. (1983) Imminent oocyte exhaustion and reduced follicular recruitment mark the transition to acyclicity in aging C57BL/6J mice. Biol. Reprod., 28, 255-260.
    • (1983) Biol. Reprod , vol.28 , pp. 255-260
    • Gosden, R.G.1    Laing, S.C.2    Felicio, L.S.3    Nelson, J.F.4    Finch, C.E.5
  • 4
    • 0034971810 scopus 로고    scopus 로고
    • Cellular and morphological traits of oocytes retrieved from aging mice after exogenous ovarian stimulation
    • Tarin, J.J., Perez-Albala, S. and Cano, A. (2001) Cellular and morphological traits of oocytes retrieved from aging mice after exogenous ovarian stimulation. Biol. Reprod., 65, 141-150.
    • (2001) Biol. Reprod , vol.65 , pp. 141-150
    • Tarin, J.J.1    Perez-Albala, S.2    Cano, A.3
  • 7
    • 0019451971 scopus 로고
    • Altered profiles of estradiol and progesterone associated with prolonged estrous cycles and persistent vaginal cornification in aging C57BL/6J mice
    • Nelson, J.F., Felicio, L.S., Osterburg, H.H. and Finch, C.E. (1981) Altered profiles of estradiol and progesterone associated with prolonged estrous cycles and persistent vaginal cornification in aging C57BL/6J mice. Biol. Reprod., 24, 784-794.
    • (1981) Biol. Reprod , vol.24 , pp. 784-794
    • Nelson, J.F.1    Felicio, L.S.2    Osterburg, H.H.3    Finch, C.E.4
  • 8
    • 0020318864 scopus 로고
    • Age effects on luteinizing hormone, progesterone and prolactin in proestrous and acyclic C57BL/6j mice
    • Flurkey, K., Gee, D.M., Sinha, Y.N., Wisner, J.R. Jr. and Finch, C.E. (1982) Age effects on luteinizing hormone, progesterone and prolactin in proestrous and acyclic C57BL/6j mice. Biol. Reprod., 26, 835-846.
    • (1982) Biol. Reprod , vol.26 , pp. 835-846
    • Flurkey, K.1    Gee, D.M.2    Sinha, Y.N.3    Wisner Jr., J.R.4    Finch, C.E.5
  • 9
    • 0029863560 scopus 로고    scopus 로고
    • Reproductive aging: Accelerated ovarian follicular development associated with a monotropic follicle-stimulating hormone rise in normal older women
    • Klein, N.A., Battaglia, D.E., Fujimoto, V.Y., Davis, G.S., Bremner, W.J. and Soules, M.R. (1996) Reproductive aging: Accelerated ovarian follicular development associated with a monotropic follicle-stimulating hormone rise in normal older women. J. Clin. Endocrinol. Metab., 81, 1038-1045.
    • (1996) J. Clin. Endocrinol. Metab , vol.81 , pp. 1038-1045
    • Klein, N.A.1    Battaglia, D.E.2    Fujimoto, V.Y.3    Davis, G.S.4    Bremner, W.J.5    Soules, M.R.6
  • 10
    • 2942662048 scopus 로고    scopus 로고
    • Age-related analysis of inhibin A, inhibin B, and activin a relative to the intercycle monotropic follicle-stimulating hormone rise in normal ovulatory women
    • Klein, N.A., Houmard, B.S., Hansen, K.R., Woodruff, T.K., Sluss, P.M., Bremner, W.J. and Soules, M.R. (2004) Age-related analysis of inhibin A, inhibin B, and activin a relative to the intercycle monotropic follicle-stimulating hormone rise in normal ovulatory women. J. Clin. Endocrinol. Metab., 89, 2977-2981.
    • (2004) J. Clin. Endocrinol. Metab , vol.89 , pp. 2977-2981
    • Klein, N.A.1    Houmard, B.S.2    Hansen, K.R.3    Woodruff, T.K.4    Sluss, P.M.5    Bremner, W.J.6    Soules, M.R.7
  • 11
    • 0016606074 scopus 로고
    • Hormonal characteristics of the human menstrual cycle throughout reproductive life
    • Sherman, B.M. and Korenman, S.G. (1975) Hormonal characteristics of the human menstrual cycle throughout reproductive life. J. Clin. Invest. 55, 699-706.
    • (1975) J. Clin. Invest , vol.55 , pp. 699-706
    • Sherman, B.M.1    Korenman, S.G.2
  • 12
    • 49449126080 scopus 로고    scopus 로고
    • Reyes, F.I., Winter, J.S. and Faiman, C. (1977) Pituitary-ovarian relationships preceding the menopause. I. A cross-sectional study of serum follicle-stimulating hormone, luteinizing hormone, prolactin, estradiol, and progesterone levels. Am. J. Obstet. Gynecol., 129, 557-564.
    • Reyes, F.I., Winter, J.S. and Faiman, C. (1977) Pituitary-ovarian relationships preceding the menopause. I. A cross-sectional study of serum follicle-stimulating hormone, luteinizing hormone, prolactin, estradiol, and progesterone levels. Am. J. Obstet. Gynecol., 129, 557-564.
  • 13
    • 0023885803 scopus 로고
    • Progressive changes in LH and FSH and LH: FSH ratio in women throughout reproductive life
    • Lenton, E.A., Sexton, L., Lee, S. and Cooke, I.D. (1988) Progressive changes in LH and FSH and LH: FSH ratio in women throughout reproductive life. Maturitas, 10, 35-43.
    • (1988) Maturitas , vol.10 , pp. 35-43
    • Lenton, E.A.1    Sexton, L.2    Lee, S.3    Cooke, I.D.4
  • 14
    • 0029899167 scopus 로고    scopus 로고
    • Decreased inhibin B secretion is associated with the monotropic FSH rise in older, ovulatory women: A study of serum and follicular fluid levels of dimeric inhibin A and B in spontaneous menstrual cycles
    • Klein, N.A., Illingworth, P.J., Groome, N.P., McNeilly, A.S., Battaglia, D.E. and Soules, M.R. (1996) Decreased inhibin B secretion is associated with the monotropic FSH rise in older, ovulatory women: A study of serum and follicular fluid levels of dimeric inhibin A and B in spontaneous menstrual cycles. J. Clin. Endocrinol. Metab., 81, 2742-2745.
    • (1996) J. Clin. Endocrinol. Metab , vol.81 , pp. 2742-2745
    • Klein, N.A.1    Illingworth, P.J.2    Groome, N.P.3    McNeilly, A.S.4    Battaglia, D.E.5    Soules, M.R.6
  • 15
    • 0017356459 scopus 로고
    • Age-related changes in the decidual response of the C57BL/6J mouse uterus
    • Holinka, C.F. and Finch, C.E. (1977) Age-related changes in the decidual response of the C57BL/6J mouse uterus. Biol. Reprod., 16, 385-393.
    • (1977) Biol. Reprod , vol.16 , pp. 385-393
    • Holinka, C.F.1    Finch, C.E.2
  • 16
    • 0019417535 scopus 로고
    • Effect of age upon uterine response to deciduagenic stimulus
    • Craig, S.S. (1981) Effect of age upon uterine response to deciduagenic stimulus. Acta Anat. (Basel), 110, 146-158.
    • (1981) Acta Anat. (Basel) , vol.110 , pp. 146-158
    • Craig, S.S.1
  • 17
    • 0018770362 scopus 로고
    • Reproductive aging in C57BL/6J mice: Plasma progesterone, viable embryos and resorption frequency throughout pregnancy
    • Holinka, C.F., Tseng, Y.C. and Finch, C.E. (1979) Reproductive aging in C57BL/6J mice: Plasma progesterone, viable embryos and resorption frequency throughout pregnancy. Biol. Reprod., 20, 1201-1211.
    • (1979) Biol. Reprod , vol.20 , pp. 1201-1211
    • Holinka, C.F.1    Tseng, Y.C.2    Finch, C.E.3
  • 18
    • 0026636519 scopus 로고
    • Delayed childbearing and risk of adverse perinatal outcome. A population-based study
    • Cnattingius, S., Forman, M.R., Berendes, H.W. and Isotalo, L. (1992) Delayed childbearing and risk of adverse perinatal outcome. A population-based study. JAMA, 268, 886-890.
    • (1992) JAMA , vol.268 , pp. 886-890
    • Cnattingius, S.1    Forman, M.R.2    Berendes, H.W.3    Isotalo, L.4
  • 19
    • 0028329110 scopus 로고
    • Delayed childbearing - are there any risks?
    • Roberts, C.L., Algert, C.S. and March, L.M. (1994) Delayed childbearing - are there any risks? Med. J. Aust., 160, 539-544.
    • (1994) Med. J. Aust , vol.160 , pp. 539-544
    • Roberts, C.L.1    Algert, C.S.2    March, L.M.3
  • 21
    • 0024947496 scopus 로고
    • Nocodazole sensitivity, age-related aneuploidy, and alterations in the cell cycle during maturation of mouse oocytes
    • Eichenlaub-Ritter, U. and Boll, I. (1989) Nocodazole sensitivity, age-related aneuploidy, and alterations in the cell cycle during maturation of mouse oocytes. Cytogenet. Cell Genet., 52, 170-176.
    • (1989) Cytogenet. Cell Genet , vol.52 , pp. 170-176
    • Eichenlaub-Ritter, U.1    Boll, I.2
  • 22
    • 38549107664 scopus 로고    scopus 로고
    • Human female meiosis: What makes a good egg go bad?
    • Hunt, P.A. and Hassold, T.J. (2008) Human female meiosis: What makes a good egg go bad? Trends Genet., 24, 86-93.
    • (2008) Trends Genet , vol.24 , pp. 86-93
    • Hunt, P.A.1    Hassold, T.J.2
  • 23
    • 0028153551 scopus 로고
    • Age-related decline in female fertility is not due to diminished capacity of the uterus to sustain embryo implantation
    • Navot, D., Drews, M.R., Bergh, P.A., Guzman, I., Karstaedt, A., Scott, R.T. Jr., Garrisi, G.J. and Hofmann, G.E. (1994) Age-related decline in female fertility is not due to diminished capacity of the uterus to sustain embryo implantation. Fertil. Steril., 61, 97-101.
    • (1994) Fertil. Steril , vol.61 , pp. 97-101
    • Navot, D.1    Drews, M.R.2    Bergh, P.A.3    Guzman, I.4    Karstaedt, A.5    Scott Jr., R.T.6    Garrisi, G.J.7    Hofmann, G.E.8
  • 24
    • 0031783838 scopus 로고    scopus 로고
    • The impact of age on reproductive potential: Lessons learned from oocyte donation
    • Sauer, M.V. (1998) The impact of age on reproductive potential: Lessons learned from oocyte donation. Maturitas, 30, 221-225.
    • (1998) Maturitas , vol.30 , pp. 221-225
    • Sauer, M.V.1
  • 26
    • 41149148487 scopus 로고    scopus 로고
    • Age-associated increase in aneuploidy and changes in gene expression in mouse eggs
    • Pan, H., Ma, P., Zhu, W. and Schultz, R.M. (2008) Age-associated increase in aneuploidy and changes in gene expression in mouse eggs. Dev. Biol., 316, 397-407.
    • (2008) Dev. Biol , vol.316 , pp. 397-407
    • Pan, H.1    Ma, P.2    Zhu, W.3    Schultz, R.M.4
  • 27
    • 0033753779 scopus 로고    scopus 로고
    • The DNA methyltransferases of mammals
    • Bestor, T.H. (2000) The DNA methyltransferases of mammals. Hum. Mol. Genet., 9, 2395-2402.
    • (2000) Hum. Mol. Genet , vol.9 , pp. 2395-2402
    • Bestor, T.H.1
  • 28
    • 0035839126 scopus 로고    scopus 로고
    • Epigenetic reprogramming in mammalian development
    • Reik, W., Dean, W. and Walter, J. (2001) Epigenetic reprogramming in mammalian development. Science, 293, 1089-1093.
    • (2001) Science , vol.293 , pp. 1089-1093
    • Reik, W.1    Dean, W.2    Walter, J.3
  • 29
    • 0034801809 scopus 로고    scopus 로고
    • DNA methylation in genomic imprinting, development, and disease
    • Paulsen, M. and Ferguson-Smith, A.C. (2001) DNA methylation in genomic imprinting, development, and disease. J. Pathol., 195, 97-110.
    • (2001) J. Pathol , vol.195 , pp. 97-110
    • Paulsen, M.1    Ferguson-Smith, A.C.2
  • 30
    • 1942421683 scopus 로고    scopus 로고
    • Gene-specific timing and epigenetic memory in oocyte imprinting
    • Lucifero, D., Mann, M.R., Bartolomei, M.S. and Trasler, J.M. (2004) Gene-specific timing and epigenetic memory in oocyte imprinting. Hum. Mol. Genet., 13, 839-849.
    • (2004) Hum. Mol. Genet , vol.13 , pp. 839-849
    • Lucifero, D.1    Mann, M.R.2    Bartolomei, M.S.3    Trasler, J.M.4
  • 32
    • 0344012003 scopus 로고    scopus 로고
    • Methylation imprints of the imprint control region of the SNRPN-gene in human gametes and preimplantation embryos
    • Geuns, E., De Rycke, M., Van Steirteghem, A. and Liebaers, I. (2003) Methylation imprints of the imprint control region of the SNRPN-gene in human gametes and preimplantation embryos. Hum. Mol. Genet., 12 2873-2879.
    • (2003) Hum. Mol. Genet , vol.12 , pp. 2873-2879
    • Geuns, E.1    De Rycke, M.2    Van Steirteghem, A.3    Liebaers, I.4
  • 33
    • 33645148785 scopus 로고    scopus 로고
    • Oocyte growth-dependent progression of maternal imprinting in mice
    • Hiura, H., Obata, Y., Komiyama, J., Shirai, M. and Kono, T. (2006) Oocyte growth-dependent progression of maternal imprinting in mice. Genes Cells, 11, 353-361.
    • (2006) Genes Cells , vol.11 , pp. 353-361
    • Hiura, H.1    Obata, Y.2    Komiyama, J.3    Shirai, M.4    Kono, T.5
  • 34
    • 15744401773 scopus 로고    scopus 로고
    • Eukaryotic cytosine methyltransferases
    • Goll, M.G. and Bestor, T.H. (2005) Eukaryotic cytosine methyltransferases. Annu. Rev. Biochem., 74, 481-514.
    • (2005) Annu. Rev. Biochem , vol.74 , pp. 481-514
    • Goll, M.G.1    Bestor, T.H.2
  • 36
    • 0035930660 scopus 로고    scopus 로고
    • Dnmt3L and the establishment of maternal genomic imprints
    • Bourc'his, D., Xu, G.L., Lin, C.S., Bollman, B. and Bestor, T.H. (2001) Dnmt3L and the establishment of maternal genomic imprints. Science 294, 2536-2539.
    • (2001) Science , vol.294 , pp. 2536-2539
    • Bourc'his, D.1    Xu, G.L.2    Lin, C.S.3    Bollman, B.4    Bestor, T.H.5
  • 37
    • 0036333103 scopus 로고    scopus 로고
    • Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice
    • Hata, K., Okano, M., Lei, H. and Li, E. (2002) Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. Development, 129, 1983-1993.
    • (2002) Development , vol.129 , pp. 1983-1993
    • Hata, K.1    Okano, M.2    Lei, H.3    Li, E.4
  • 38
    • 3042584653 scopus 로고    scopus 로고
    • Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting
    • Kaneda, M., Okano, M., Hata, K., Sado, T., Tsujimoto, N., Li, E. and Sasaki, H. (2004) Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting. Nature, 429, 900-903.
    • (2004) Nature , vol.429 , pp. 900-903
    • Kaneda, M.1    Okano, M.2    Hata, K.3    Sado, T.4    Tsujimoto, N.5    Li, E.6    Sasaki, H.7
  • 39
    • 34548037672 scopus 로고    scopus 로고
    • Oocyte developmental competence in a bovine model of reproductive aging
    • Malhi, P.S., Adams, G.P., Mapletoft, R.J. and Singh, J. (2007) Oocyte developmental competence in a bovine model of reproductive aging. Reproduction, 134, 233-239.
    • (2007) Reproduction , vol.134 , pp. 233-239
    • Malhi, P.S.1    Adams, G.P.2    Mapletoft, R.J.3    Singh, J.4
  • 41
  • 42
    • 33750167928 scopus 로고    scopus 로고
    • Deficit of mitochondria-derived ATP during oxidative stress impairs mouse MII oocyte spindles
    • Zhang, X., Wu, X.Q., Lu, S., Guo, Y.L. and Ma, X. (2006) Deficit of mitochondria-derived ATP during oxidative stress impairs mouse MII oocyte spindles. Cell Res., 16, 841-850.
    • (2006) Cell Res , vol.16 , pp. 841-850
    • Zhang, X.1    Wu, X.Q.2    Lu, S.3    Guo, Y.L.4    Ma, X.5
  • 43
    • 0023280827 scopus 로고
    • Fetal and placental growth in young, primiparous and old, multiparous rats
    • Rahima, A. and Bruce, N.W. (1987) Fetal and placental growth in young, primiparous and old, multiparous rats. Exp. Gerontol., 22, 257-261.
    • (1987) Exp. Gerontol , vol.22 , pp. 257-261
    • Rahima, A.1    Bruce, N.W.2
  • 44
    • 0642375197 scopus 로고    scopus 로고
    • The effects of maternal age and parity on placental and fetal development in the mare
    • Wilsher, S. and Allen, W.R. (2003) The effects of maternal age and parity on placental and fetal development in the mare. Equine Vet. J. 35, 476-483.
    • (2003) Equine Vet. J , vol.35 , pp. 476-483
    • Wilsher, S.1    Allen, W.R.2
  • 45
    • 33751364987 scopus 로고    scopus 로고
    • Genomic imprinting in mammals: Emerging themes and established theories
    • Wood, A.J. and Oakey, R.J. (2006) Genomic imprinting in mammals: emerging themes and established theories. PLoS Genet., 2, e147.
    • (2006) PLoS Genet , vol.2
    • Wood, A.J.1    Oakey, R.J.2
  • 46
    • 0033615717 scopus 로고    scopus 로고
    • DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
    • Okano, M., Bell, D.W., Haber, D.A. and Li, E. (1999) DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell, 99, 247-257.
    • (1999) Cell , vol.99 , pp. 247-257
    • Okano, M.1    Bell, D.W.2    Haber, D.A.3    Li, E.4
  • 47
    • 0027378582 scopus 로고
    • Role for DNA methylation in genomic imprinting
    • Li, E., Beard, C. and Jaenisch, R. (1993) Role for DNA methylation in genomic imprinting. Nature, 366, 362-365.
    • (1993) Nature , vol.366 , pp. 362-365
    • Li, E.1    Beard, C.2    Jaenisch, R.3
  • 48
    • 44349166369 scopus 로고    scopus 로고
    • Superovulation alters the expression of imprinted genes in the midgestation mouse placenta
    • Fortier, A.L., Lopes, F.L., Darricarrere, N., Martel, J. and Trasler, J.M. (2008) Superovulation alters the expression of imprinted genes in the midgestation mouse placenta. Hum. Mol. Genet., 17, 1653-1665.
    • (2008) Hum. Mol. Genet , vol.17 , pp. 1653-1665
    • Fortier, A.L.1    Lopes, F.L.2    Darricarrere, N.3    Martel, J.4    Trasler, J.M.5
  • 50
    • 37549048600 scopus 로고    scopus 로고
    • Manipulations of mouse embryos prior to implantation result in aberrant expression of imprinted genes on day 9.5 of development
    • Rivera, R.M., Stein, P., Weaver, J.R., Mager, J., Schultz, R.M. and Bartolomei, M.S. (2008) Manipulations of mouse embryos prior to implantation result in aberrant expression of imprinted genes on day 9.5 of development. Hum. Mol. Genet., 17, 1-14.
    • (2008) Hum. Mol. Genet , vol.17 , pp. 1-14
    • Rivera, R.M.1    Stein, P.2    Weaver, J.R.3    Mager, J.4    Schultz, R.M.5    Bartolomei, M.S.6
  • 51
    • 0036757811 scopus 로고    scopus 로고
    • Infrequent occurrence of age-dependent changes in CpG island methylation as detected by restriction landmark genome scanning
    • Tra, J., Kondo, T., Lu, Q., Kuick, R., Hanash, S. and Richardson, B. (2002) Infrequent occurrence of age-dependent changes in CpG island methylation as detected by restriction landmark genome scanning. Mech. Ageing Dev., 123, 1487-1503.
    • (2002) Mech. Ageing Dev , vol.123 , pp. 1487-1503
    • Tra, J.1    Kondo, T.2    Lu, Q.3    Kuick, R.4    Hanash, S.5    Richardson, B.6
  • 53
  • 55
    • 0023664725 scopus 로고
    • Genomic 5-methyldeoxycytidine decreases with age
    • Wilson, V.L., Smith, R.A., Ma, S. and Cutler, R.G. (1987) Genomic 5-methyldeoxycytidine decreases with age. J. Biol. Chem., 262 9948-9951.
    • (1987) J. Biol. Chem , vol.262 , pp. 9948-9951
    • Wilson, V.L.1    Smith, R.A.2    Ma, S.3    Cutler, R.G.4
  • 56
    • 0021139979 scopus 로고
    • Cell lineage-specific undermethylation of mouse repetitive DNA
    • Chapman, V., Forrester, L., Sanford, J., Hastie, N. and Rossant, J. (1984) Cell lineage-specific undermethylation of mouse repetitive DNA. Nature, 307, 284-286.
    • (1984) Nature , vol.307 , pp. 284-286
    • Chapman, V.1    Forrester, L.2    Sanford, J.3    Hastie, N.4    Rossant, J.5
  • 57
    • 0022965187 scopus 로고
    • Undermethylation of structural gene sequences in extraembryonic lineages of the mouse
    • Rossant, J., Sanford, J.P., Chapman, V.M. and Andrews, G.K. (1986) Undermethylation of structural gene sequences in extraembryonic lineages of the mouse. Dev. Biol., 117, 567-573.
    • (1986) Dev. Biol , vol.117 , pp. 567-573
    • Rossant, J.1    Sanford, J.P.2    Chapman, V.M.3    Andrews, G.K.4
  • 58
    • 0042862983 scopus 로고    scopus 로고
    • Disruption of imprinted gene methylation and expression in cloned preimplantation stage mouse embryos
    • Mann, M.R., Chung, Y.G., Nolen, L.D., Verona, R.I., Latham, K.E. and Bartolomei, M.S. (2003) Disruption of imprinted gene methylation and expression in cloned preimplantation stage mouse embryos. Biol. Reprod., 69, 902-914.
    • (2003) Biol. Reprod , vol.69 , pp. 902-914
    • Mann, M.R.1    Chung, Y.G.2    Nolen, L.D.3    Verona, R.I.4    Latham, K.E.5    Bartolomei, M.S.6
  • 60
    • 33846107211 scopus 로고    scopus 로고
    • Evaluation of a quantitative DNA methylation analysis technique using methylation-sensitive/dependent restriction enzymes and real-time PCR
    • Oakes, C.C., La Salle, S., Robaire, B. and Trasler, J.M. (2006) Evaluation of a quantitative DNA methylation analysis technique using methylation-sensitive/dependent restriction enzymes and real-time PCR. Epigenetics, 1, 146-152.
    • (2006) Epigenetics , vol.1 , pp. 146-152
    • Oakes, C.C.1    La Salle, S.2    Robaire, B.3    Trasler, J.M.4
  • 61
    • 0036311364 scopus 로고    scopus 로고
    • Restriction landmark genome scanning
    • Costello, J.F., Smiraglia, D.J. and Plass, C. (2002) Restriction landmark genome scanning. Methods, 27, 144-149.
    • (2002) Methods , vol.27 , pp. 144-149
    • Costello, J.F.1    Smiraglia, D.J.2    Plass, C.3


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