Follow-up of pregnant women with autoimmune hepatitis: The disease behavior along with maternal and fetal outcomes

Journal of Clinical Gastroenterology

Volumn 43, Issue 4, 2009, Pages 350-356

  Terrabuio, Debora Raquel B ^a   Abrantes Lemos, Clarice Pires ^a   Carrilho, Flair José ^a   Cançado, Eduardo Luiz R ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Autoimmune disease; Autoimmune hepatitis; Azathioprine; Congenital malformation; Miscarriage; Pregnancy

Indexed keywords

AMINOTRANSFERASE; AZATHIOPRINE; PREDNISONE; TACROLIMUS; URSODEOXYCHOLIC ACID; IMMUNOSUPPRESSIVE AGENT;

ADOLESCENT; ADULT; AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; AUTOIMMUNE HEPATITIS; BREAST FEEDING; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FETUS DISTRESS; HUMAN; MEDICAL INFORMATION; PREGNANCY; PREGNANT WOMAN; PREMATURE LABOR; PRIORITY JOURNAL; CONGENITAL DISORDER; IMMUNOLOGY; NEWBORN; PREGNANCY COMPLICATION; PREGNANCY OUTCOME; PREMATURITY; PROGNOSIS; RISK FACTOR; SPONTANEOUS ABORTION; STILLBIRTH;

ABORTION, SPONTANEOUS; ADOLESCENT; ADULT; AZATHIOPRINE; CONGENITAL ABNORMALITIES; FEMALE; HEPATITIS, AUTOIMMUNE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFANT, NEWBORN; INFANT, PREMATURE; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY OUTCOME; PREMATURE BIRTH; PROGNOSIS; RISK FACTORS; STILLBIRTH; YOUNG ADULT;

EID: 65449190482     PISSN: 01920790     EISSN: None     Source Type: Journal    
DOI: 10.1097/MCG.0b013e318176b8c5     Document Type: Article

References (49)

1. McFarlane IG. Autoimmune hepatitis, diagnostic criteria, subclassifications, and clinical features. Clin Liver Dis. 2002; 6:605-621.
2. Thiele DL. Autoimmune hepatitis. Clin Liver Dis. 2005;9: 635-646.
3. Lee WM. Pregnancy in patients with chronic liver disease. Gastroenterol Clin North Am. 1992;21:889-903. (Pubitemid 23003441)
4. Krawitt E. Autoimmune Hepatitis. N Engl J Med. 2006;354: 54-66.
5. Garcia-Tsao G. Portal hypertension. Curr Opin Gastroenterol. 2006;22:254-262.
6. López-Méndez E, Avila-Escobedo L. Pregnancy and portal hypertension a pathology view of physiologic changes. Ann Hepatol. 2006;5:219-223. (Pubitemid 44435368)
7. Steven MM, Buckley JD, Mackay IR. Pregnancy in chronic active hepatitis. Q J Med. 1979;192:519-531.
8. Whelton MJ, Sherlock S. Pregnancy in patients with hepatic cirrhosis. Management and outcome. Lancet. 1968;2:995-999.
9. Alvarez F, Berg PA, Bianchi FB, et al. International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis. J Hepatol. 1999;31: 929-938. (Pubitemid 29514229)
10. Schramm C, Herkel J, Beuers U, et al. Pregnancy in autoimmune hepatitis: outcome and risk factors. Am J Gastroenterol. 2006;101:556-560. (Pubitemid 43340932)
11. Heneghan MA, Norris SM, O'Grady JG, et al. Management and outcome of pregnancy in autoimmune hepatitis. Gut. 2001;48:97-102. (Pubitemid 32042648)
12. Colle I, Hautekeete M. Remission of autoimmune hepatitis during pregnancy: a report of two cases. Liver. 1999;19:55-57. (Pubitemid 29034112)
13. Muratori P, Loffreda S, Muratori L, et al. Spontaneous remission of autoimmune hepatitis during pregnancy. Dig Liver Dis. 2002;34:608-609. (Pubitemid 35023646)
14. Levine AB. Autoimmune hepatitis in pregnancy. Obstet Gynecol. 2000;95(6 Pt 2):1033.
15. Primo J, Ramos M, Julve R. The remission of autoimmune hepatitis during the pregnancy. Gastroenterol Hepatol. 2000;23: 24-25.
16. Meehan RT, Dorsey JK. Pregnancy among patients with systemic lupus erythematosus receiving immunosuppressive therapy. J Rheumatol. 1987;14:252-258. (Pubitemid 17113932)
17. Francella A, Dyan A, Bodian C, et al. The safety of 6- mercaptopurine for childbearing patients with inflammatory bowel disease: a retrospective cohort study. Gastroenterology. 2003;124:9-17. (Pubitemid 36055333)
18. Ville Y, Fernandez H, Samuel D, et al. Pregnancy in liver transplant recipients: course and outcome in 19 cases. Am J Obstet Gynecol. 1993;168:896-902. (Pubitemid 23096016)
19. Ahman E, Shah I. Unsafe abortion: worldwide estimates for 2000. Reprod Health Matters. 2002;10:13-17.
20. Guedes AC. Abortion in Brazil: legislation, reality and options. Reprod Health Matters. 2000;8:66-76.
21. Martins IR, Costa SH, Freitas SRS, et al. Induced abortion among low income women: dimensions of the problem. Cad Saude Publica. 1991;7:251-266.
22. Aragão VM, da Silva AA, de Aragão LF, et al. Risk factors for preterm births in São Luís, Maranhão, Brazil. Cad Saude Publica. 2004;20:57-63.
23. Uribe M, Chavez-Tapia NC, Mendez-Sanchez N. Pregnancy and autoimmune hepatitis. Ann Hepatol. 2006;5:187-189.
24. Candia L, Marquez J, Espinoza LR. Autoimmune hepatitis and pregnancy: a rheumatologist's dilemma. Semin Arthritis Rheum. 2005;35:49-56. (Pubitemid 41111471)
25. Benjaminov FS, Heathcote J. Liver disease in pregnancy. Am J Gastroenterol. 2004;99:2479-2488.
26. Mezzomo CLS, Garcias GL, Sclowitz ML, et al. Prevention of neural tube defects: prevalence of folic acid supplementation during pregnancy and associated factors in Pelotas, Rio Grande do Sul State, Brazil. Cad Saúde Pública. 2007;23:2716-2726.
27. Best RG, Anencephaly 2007. Available at: http://www.emedicine. com/neuro/topic639.htm.
28. Gilbert-Barness E. Potter's Pathology of the Fetus and Infant. St Louis, MO: Mosby Inc; 1997.
29. Mishra PC, Baveja R. Congenital malformations in the newborn: a prospective study. Indian Pediatr. 1989;26:32-36.
30. Kallen K. Maternal smoking and urinary organ malformations. Int J Epidemiol. 1997;26:571-574. (Pubitemid 27267778)
31. Noronha L, Reichert A, Martins VDM, et al. Study of urinary tract congenital malformation: analysis of 6245 pediatric necropsies. J Bras Patol Med Lab. 2003;39:237-243.
32. Golding A, Haque UJ, Giles JT. Rheumatoid arthritis and Reproduction. Rheum Dis Clin North Am. 2007;33:319-343.
33. Buchel E, Van Steenbergen W, Nevens F, et al. Improvement of autoimmune hepatitis during pregnancy followed by flare-up after delivery. Am J Gastroenterol. 2002;97: 3160-3165. (Pubitemid 35424590)
34. Elsing C, Stremmel W, Herrmann T. Spontaneous remission of autoimmune hepatitis in pregnancy and postpartum flare. Indian J Gastroenterol. 2007;26:104. (Pubitemid 46910523)
35. Yip L, McCluskey J, Sinclair R. Immunological aspects of pregnancy. Clin Dermatol. 2006;24:84-87.
36. H2 phenomenon? Immunol Today. 1993;14:353-356.
37. Wilder RL. Hormones, pregnancy and autoimmune diseases. Ann NY Acad Sci. 1998;840:45-50.
38. Aagaard-Tillery KM, Silver R, Dalton J. Immunology of normal pregnancy. Semin Fetal Neonatal Med. 2006;11: 279-295.
39. Megan EB, Clowse MD. Lupus activity in pregnancy. Rheum Dis Clin North Am. 2007;33:237-252.
40. Chambers CD, Tutuncu ZN, Johnson D, et al. Human pregnancy safety for agents used to treat rheumatoid arthritis: adequacy of available information and strategies for developing post-marketing data. Arthritis Res Ther. 2006; 8:215. (Pubitemid 44363221)
41. de Boer NKH, Jarbandhan VAS, de Graaf P, et al. Azathioprine use during pregnancy: unexpected intrauterine exposure to metabolites. Am J Gastroenterol. 2006;101: 1390-1392.
42. Goldstein LH, Dolinsky G, Greenberg R, et al. Pregnancy outcome of women exposed to azathioprine during pregnancy. Birth Defects Res A Clin Mol Teratol. 2007;79: 696-701. (Pubitemid 47584193)
43. Chan GI, Erdmann GR, Gruber SA, et al. Azathioprine metabolism: pharmacokinetics of 6-mercaptopurine, 6-thiouric acid and 6-thioguanine nucleotides in renal transplant patients. J Clin Pharmacol. 1990;30:358-363.
44. Gross A, Fein A, Serr DM, et al. The effect or Imuran on implantation and early embryonic development in rats. Obstet Gynecol. 1977;50:713-718. (Pubitemid 8237056)
45. Githens JH, Rosenkrantz JG, Tunnock SM. Teratogenic effects of AZP (Imuran). J Pediatr. 1965;66:959-961.
46. Nørgård B, Pedersen L, Fonager K, et al. Azathioprine, mercaptopurine and birth outcome: a population-based cohort study. Aliment Pharmacol Ther. 2003;17:827-834. (Pubitemid 36418880)
47. Langagergaard V, Pedersen L, Gislum M, et al. Birth outcome in women treated with azathioprine or mercaptopurine during pregnancy: a Danish nationwide cohort study. Aliment Pharmacol Ther. 2007;25:73-81. (Pubitemid 44902866)
48. Werner M, Björnsson E, Prytz H, et al. Autoimmune hepatitis among fertile women: strategies during pregnancy and breastfeeding? Scand J Gastroenterol. 2007;42:986-991.
49. Sau A, Clarke S, Bass J, et al. Azathioprine and breastfeeding: is it safe? BJOG. 2007;114:498-501.