A history of medical reports on the boston marathon: 112 years and still running

Medicine and Science in Sports and Exercise

Volumn 41, Issue 2, 2009, Pages 257-264

  Thompson, Paul D ^a   Venero, Carmelo V ^a  

^a HARTFORD HOSPITAL   (United States)

Author keywords

Athlete's heart; Cardiomegaly; Endurance; Exercise; Troponin

Indexed keywords

VASOPRESSIN;

ANGINA PECTORIS; BLOOD PRESSURE; CARDIOVASCULAR RISK; EXERCISE PHYSIOLOGY; HEART FAILURE; HEART INFARCTION; HUMAN; MARATHON RUNNER; REVIEW; UNITED STATES; ARTICLE; ENDURANCE; HEART; HISTORY; PHYSIOLOGY; RUNNING;

BOSTON; HEART; HISTORY, 19TH CENTURY; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HUMANS; PHYSICAL ENDURANCE; PHYSIOLOGY; RUNNING;

EID: 65449190091     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/MSS.0b013e3181878067     Document Type: Review

References (84)

1. Adner MM, Castelli WP. Elevated high-density lipoprotein levels in marathon runners. JAMA. 1980;243:534-6.
2. Adner MM, Gembarowicz R, Casey J, et al. Point-of-care biochemical monitoring of boston marathon runners: a comparison of prerace and postrace controls to runners requiring on-site medical attention. Point of Care: The Journal of Near-Patient Testing & Technology. 2002;1:237-40.
3. Adner MM, Scarlet JJ, Casey J, Robinson W, Jones BH. The Boston Marathon Medical Care Team: Ten years of experience. The Physican and Sports Medicine. 1988;16:99-106.
4. Almond CS, Shin AY, Fortescue EB, et al. Hyponatremia among runners in the Boston Marathon. N Engl J Med. 2005;352:1550-6.
5. Behrman RA. Urinary findings before and after a marathon race. N Engl J Med. 1941;225:801-2.
6. Blake JB, Larrabee RC. Observations upon long-distance runners. Boston Medical and Surgical Journal. 1903;148:195-206.
7. Bock AV. The circulation of a marathoner. J Sports Med Phys Fitness. 1963;168:80-6.
8. Buskirk ER, Beetham WP Jr. Dehydration and body temperature as a result of marathon running. Medicina Sportiva. 1960;14:493-506.
9. Conlay LA, Sabounjian LA, Wurtman RJ. Exercise and neuromodulators: choline and acetylcholine in marathon runners. Int J Sports Med. 1992;13(Suppl 1):S141-2.
10. Conlay LA, Wurtman RJ, Blusztajn K, Coviella IL, Maher TJ, Evoniuk GE. Decreased plasma choline concentrations in marathon runners. N Engl J Med. 1986;315:892.
11. Conlay LA, Wurtman RJ, Lopez G-C, et al. Effects of running the Boston marathon on plasma concentrations of large neutral amino acids. J Neural Transm. 1989;76:65-71.
12. Costill DL, Bowers R, Branam G, Sparks K. Muscle glycogen utilization during prolonged exercise on successive days. J Appl Physiol. 1971;31:834-8.
13. Costill DL, Fox EL. Energetics of Marathon Running. Medicine and Science in Sports. 1969;1:81-6.
14. Currens JH, White PD. Half a century of running. Clinical, physiologic and autopsy findings in the case of Clarence DeMar ("Mr. Marathon"). N Engl J Med. 1961;265:988-93.
15. Derderian T. Boston Marathon: The First Century of the World's Premier Running Event. Champaign, IL Human Kinetics 1995.
16. Dill DB. Marathoner DeMar: physiological studies. J Natl Cancer Inst. 1965;35:185-91.
17. Douglas PS, O'Toole ML, Hiller WD, Hackney K, Reichek N. Cardiac fatigue after prolonged exercise. Circulation. 1987;76:1206-13.
18. Edmondstone WM. Cardiac chest pain: does body language help the diagnosis. BMJ. 1995;311:1660-1.
19. Ely MR, Cheuvront SN, Montain SJ. Neither Cloud Cover nor Low Solar Loads Are Associated with Fast Marathon Performance. Med Sci Sports Exerc. 2007;39:2029-35.
20. Ely MR, Cheuvront SN, Roberts WO, Montain SJ. Impact of weather on marathon-running performance. Med Sci Sports Exerc. 2007;39:487-93.
21. Farkas TA, Zane RD. Comminuted femur fracture secondary to stress during the Boston marathon. J Emerg Med. 2006;31:79-82.
22. Fortescue EB, Shin AY, Greenes DS et al. Cardiac Troponin Increases Among Runners in the Boston Marathon. Ann Emerg Med. 2006;49:137-43.
23. Gilligan DR, Altschule MD, Katersky EM. Physiological Intravascular Hemolysis of Exercise. Hemoglobinemia and Hemoglobinuria Following Cross-Country Runs. Journal of Clinical Investigation. 1943;22:859-69.
24. Gordon B. The Effect of Effort on the Size of the Heart. Observations on Animals and Marathon Runners. American Journal of Roentgenology. 1925;14:424-6.
25. Gordon B. Effect of Exercise on the Circulation, Sugar Metabolism and Other Factors. Northwest Medicine. 1926;25:376-9.
26. Gordon B. Effects of Exercise on Circulation and Respiration. Journal of the Medical Society of New Jersey. 1930;672-4.
27. Gordon B, Kohn LA, Levine SA, Matton M, Scriver WdM, Whiting WB. Sugar content of the blood in runners following a marathon race with special reference to the prevention of hypoglycemia: further observations. Journal of the American Medical Association. 1925;85:508-9.
28. Gordon B, Levine SA, Wilmaers A. Observations on a group of marathon runners with special reference to the circulation. Archives of Internal Medicine. 1924;33:425-34.
29. Green LH, Cohen SI, Kurland G. Fatal myocardial infarction in marathon racing. Ann Intern Med. 1976;84:704-6.
30. Irving RA, Noakes TD, Buck R, et al. Evaluation of renal function and fluid homeostasis during recovery from exercise-induced hyponatremia. J Appl Physiol. 1991;70:342-8.
31. Isaacs R, Gordon B. The effect of exercise on the distribution of corpuscles in the blood stream. American Journal Physiology. 1924;71:106-11.
32. Jessen N, Goodyear LJ. Contraction signaling to glucose transport in skeletal muscle. J Appl Physiol. 2005;99:330-7.
33. Kavanagh T, Shephard RH, Pandit V. Marathon running after myocardial infarction. JAMA. 1974;229:1602-5.
34. Knapp PC, Thomas JJ. The Reflexes in Long-Distance Runners. A Study of the Influence of Fatigue upon Certain Reflexes. Journal Nervous and Mental Disease. 1904;31:94-9.
35. Kratz A, Lewandrowski KB, Siegel AJ, et al. Effect of marathon running on hematologic and biochemical laboratory parameters, including cardiac markers. Am J Clin Pathol. 2002;118:856-63.
36. Kratz A, Lewandrowski KB, Siegel AJ, et al. Effect of marathon running on total and free serum prostate-specific antigen concentrations. Arch Pathol Lab Med. 2003;127:345-8.
37. Kratz A, Siegel AJ, Verbalis JG, et al. Sodium status of collapsed marathon runners. Arch Pathol Lab Med. 2005;129:227-30.
38. Kratz A, Wood MJ, Siegel AJ, Hiers JR, Van Cott EM. Effects of marathon running on platelet activation markers: direct evidence for in vivo platelet activation. Am J Clin Pathol. 2006;125:296-300.
39. Kyriakos R, Siewert B, Kato E, Sosna J, Kruskal JB. CT findings in runner's colitis. Abdom Imaging. 2006;31:54-6.
40. Larrabee R, . Leucocytosis after violent exercise. Journal of Medical Research. 1902;7:76-82.
41. Levine SA. The myth of strict bed rest in the treatment of heart disease. Am Heart J. 1951;42:406-13.
42. Levine SA, Gordon B, Derick CL. Some changes in the chemical constituents of the blood following a marathon race with special reference to the development of hypoglycemia. Journal of the American Medical Association. 1924;82:1778-9.
43. Lucas W, Schroy PC III. Reversible ischemic colitis in a high endurance athlete. Am J Gastroenterol. 1998;93:2231-4.
44. Maresh CM, Allison TG, Noble BJ, Drash A, Kraemer WJ. Substrate and hormone responses to exercise following a marathon run. Int J Sports Med. 1989;10:101-6.
45. McMahon LF, JrRyan MJ, Larson D, Fisher RL. Occult gastrointestinal blood loss in marathon runners. Ann Intern Med. 1984;100:846-7.
46. Melanson SE, Green SM, Wood MJ, Neilan TG, Lewandrowski EL. Elevation of myeloperoxidase in conjunction with cardiac-specific markers after marathon running. Am J Clin Pathol. 2006;126:888-93.
47. Myers KJ. Marathon running and vision. J Am Optom Assoc. 1976;47:515-20.
48. Neilan TG, Januzzi JL, Lee-Lewandrowski E, et al. Myocardial injury and ventricular dysfunction related to training levels among nonelite participants in the Boston marathon. Circulation. 2006;114:2325-33.
49. Neilan TG, Yoerger DM, Douglas PS, et al. Persistent and reversible cardiac dysfunction among amateur marathon runners. Eur Heart J. 2006;27:1079-84.
50. Newmark ST, Himathongkam T, Martin RP, Cooper KH, Rose LI. Adrenocortical response to marathon running. J Clin Endocrinol Metab. 1976;42:393-4.
51. Noakes TD, Goodwin N, Rayner BL, Branken T, Taylor RK. Water intoxication: a possible complication during endurance exercise. Med Sci Sports Exerc. 1985;17:370-5.
52. Noble BJ, Maresh CM, Allison TG, Drash A. Cardio-respiratory and perceptual recovery from a marathon run. Medicine and Science in Sports. 1979;11:239-43.
53. O'Donnell TF Jr. The hemodynamic and metabolic alterations associated with acute heat stress injury in marathon runners. Ann N Y Acad Sci. 1977;301:262-9.
54. Pedersen BK. IL-6 signalling in exercise and disease. Biochem Soc Trans. 2007;35:1295-7.
55. Poortmans J, Jeanloz RW. Quantitative immunological determination of 12 plasma proteins excreted in human urine collected before and after exercise. J Clin Invest. 1968;47:386-93.
56. Roberts WO. Heat and cold: what does the environment do to marathon injury. Sports Med. 2007;37:400-3.
57. Rose LI, Carroll DR, Lowe SL, Peterson EW, Cooper KH. Serum electrolyte changes after marathon running. J Appl Physiol. 1970;29:449-51.
58. Rubin CT, Pratt GW, Porter AL, Lanyon LE, Poss R. The use of ultrasound in vivo to determine acute change in the mechanical properties of bone following intense physical activity. J Biomech. 1987;20:723-7.
59. Saenz AJ, Lee-Lewandrowski E, Wood MJ, et al. Measurement of a plasma stroke biomarker panel and cardiac troponin T in marathon runners before and after the 2005 Boston marathon. Am J Clin Pathol. 2006;126:185-9.
60. Sanchez LD, Tracy JA, Berkoff D, Pedrosa I. Ischemic colitis in marathon runners: a case-based review. J Emerg Med. 2006;30:321-6.
61. Shin AY, Almond CS, Mannix RC, et al. The Boston Marathon Study: a novel approach to research during residency. Pediatrics. 2006;117:1818-22.
62. Siegel AJ, Hennekens CH, Solomon HS, Van Boeckel B. Exercise-related hematuria. Findings in a group of marathon runners. JAMA. 1979;241:391-2.
63. Siegel AJ, Lewandrowski EL, Chun KY, Sholar MB, Fischman AJ, Lewandrowski KB. Changes in cardiac markers including B-natriuretic peptide in runners after the Boston marathon. Am J Cardiol. 2001;88:920-3.
64. Siegel AJ, Lewandrowski KB, Strauss HW, Fischman AJ, Yasuda T. Normal post-race antimyosin myocardial scintigraphy in asymptomatic marathon runners with elevated serum creatine kinase MB isoenzyme and troponin T levels. Evidence against silent myocardial cell necrosis. Cardiology. 1995;86:451-6.
65. Siegel AJ, Sholar M, Yang J, Dhanak E, Lewandrowski KB. Elevated serum cardiac markers in asymptomatic marathon runners after competition: is the myocardium stunned. Cardiology. 1997;88:487-91.
66. Siegel AJ, Silverman LM, Evans WJ. Elevated skeletal muscle creatine kinase MB isoenzyme levels in marathon runners. JAMA. 1983;250:2835-7.
67. Siegel AJ, Silverman LM, Holman BL. Elevated creatine kinase MB isoenzyme levels in marathon runners. Normal myocardial scintigrams suggest noncardiac source. JAMA. 1981;246:2049-51.
68. Siegel AJ, Silverman LM, Holman BL. Normal results of post-race thallium-201 myocardial perfusion imaging in marathon runners with elevated serum MB creatine kinase levels. Am J Med. 1985;79:431-4.
69. Siegel AJ, Silverman LM, Lopez RE. Creatine kinase elevations in marathon runners: relationship to training and competition. Yale J Biol Med. 1980;53:275-9.
70. Siegel AJ, Stec JJ, Lipinska I, et al. Effect of marathon running on inflammatory and hemostatic markers. Am J Cardiol. 2001;88:918-20, A9.
71. Siegel AJ, Stewart EL, Barone B. Body image assessment and eating attitudes in marathon runners: inverse findings to patients with anorexia nervosa. Annals of Sports Medicine. 1990;5:67-70.
72. Siegel AJ, Verbalis JG, Clement S, et al. Hyponatremia in marathon runners due to inappropriate arginine vasopressin secretion. Am J Med. 2007;120:461-7.
73. Takahashi M, Lee L, Shi Q, Gawad Y, Jackowski G. Use of enzyme immunoassay for measurement of skeletal troponin-I utilizing isoform-specific monoclonal antibodies. Clin Biochem. 1996;29:301-8.
74. Thijssen DH, Vos JB, Verseyden C, et al. Haematopoietic stem cells and endothelial progenitor cells in healthy men: effect of aging and training. Aging Cell. 2006;5:495-503.
75. Thomas D. Echocardiographic findings in athletes. In: Thompson PD. Exercise and Sports Cardiology. New YorkMcGraw-Hill. 2000;43-701.
76. Thompson PD. D. Bruce Dill Historical lecture. Historical concepts of the athlete's heart. Med Sci Sports Exerc. 2004;36:363-70.
77. Thompson PD, Apple FS, Wu A. Marathoner's heart. Circulation. 2006;114:2306-8.
78. Trapasso LM, Cooper JD. Record performances at the Boston Marathon: biometeorological factors. Int J Biometeorol. 1989;33:233-7.
79. Warhol MJ, Siegel AJ, Evans WJ, Silverman LM. Skeletal muscle injury and repair in marathon runners after competition. Am J Pathol. 1985;118:331-9.
80. White P. Bradycardia (below rate of 40) in athletes, especially long distance runners. JAMA. 1942;120:642.
81. White PD. The Pulse after a Marathon Race. Journal of American Medical Association. 1918;71:1047-8.
82. Willett W, Hennekens CH, Siegel AJ, Adner MM, Castelli WP. Alcohol consumption and high density lipoprotein cholesterol in marathon runners. N Engl J Med. 1980;303:1159-61.
83. Williams H, Arnold H. The Effects of violent and prolonged muscular exercise upon the heart. The Philadelphia Medical Journal. 1899;1233-9.
84. Wood PD, Haskell W, Klein H, Lewis S, Stern MP, Farquhar JW. The distribution of plasma lipoproteins in middle-aged male runners. Metabolism. 1976;25:1249-57.