Mefloquine pharmacokinetics and mefloquine-artesunate effectiveness in Peruvian patients with uncomplicated Plasmodium falciparum malaria

Malaria Journal

Volumn 8, Issue 1, 2009, Pages

  Gutman, Julie ^a,b   Green, Michael ^a   Durand, Salomon ^d   Rojas, Ofelia Villalva ^d   Ganguly, Babita ^a   Quezada, Wilmer Marquĩo ^d   Utz, Gregory C ^c   Slutsker, Laurence ^a   Ruebush, Trenton K ^a   Bacon, David J ^c  

^a CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Virology Program   (Peru)

^d INSTITUTO NACIONAL DE SALUD   (Peru)

Author keywords

[No Author keywords available]

Indexed keywords

ARTESUNATE; MEFLOQUINA AC; MEFLOQUINE; UNCLASSIFIED DRUG; ANTIMALARIAL AGENT; ARTEMISININ DERIVATIVE;

ADULT; ANXIETY; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG HALF LIFE; DRUG WITHDRAWAL; FEMALE; HUMAN; IN VIVO STUDY; INSOMNIA; MALARIA FALCIPARUM; MALE; MAXIMUM PLASMA CONCENTRATION; MENINGOENCEPHALITIS; PARANOIA; PERU; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; TREATMENT RESPONSE; ADOLESCENT; ANIMAL; DRUG ADMINISTRATION; DRUG EFFECT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOLATION AND PURIFICATION; MIDDLE AGED; ORAL DRUG ADMINISTRATION; PARASITEMIA; PARASITOLOGY; PLASMODIUM FALCIPARUM; TIME; TREATMENT OUTCOME;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; ANIMALS; ANTIMALARIALS; ARTEMISININS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; MALARIA, FALCIPARUM; MALE; MEFLOQUINE; MIDDLE AGED; PARASITEMIA; PERU; PLASMODIUM FALCIPARUM; TIME FACTORS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 65449189517     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-8-58     Document Type: Article

References (32)

1. Antimalarial drug combination therapy: Report of WHO technical consultation. World Health Organization, WHO/CDS/RBM/200135 2001
2. The use of antimalarial drugs. Report of a WHO Informal Consultation. World Health Organization, WHO/CDS/RBM/200133 2001
3. Artemisinin-based combination treatment of falciparum malaria. F Nosten NJ White, Am J Trop Med Hyg 2007 77 181 192 18165491
4. Lack of bioequivalence of a generic mefloquine tablet with the standard product. E Weidekamm G Rusing H Caplain F Sorgel C Crevoisier, Eur J Clin Pharmacol 1998 54 615 619 10.1007/s002280050523 9860148 (Pubitemid 28531422)
5. Pharmacokinetics and bioequivalence evaluation of three commercial tablet formulations of mefloquine when given in combination with dihydroartemisinin in patients with acute uncomplicated falciparum malaria. K Na-Bangchang J Karbwang PA Palacios R Ubalee S Saengtertsilapachai WH Wernsdorfer, Eur J Clin Pharmacol 2000 55 743 748 10.1007/s002280050008 10663453 (Pubitemid 30077570)
6. Falciparum malaria in eastern Thailand: a randomized trial of the efficacy of a single dose of mefloquine. AL Fontanet BD Johnston AM Walker Y Bergqvist U Hellgren W Rooney, Bull World Health Organ 1994 72 73 78 8131253 (Pubitemid 24090720)
7. High-dose mefloquine in the treatment of multidrug-resistant falciparum malaria. FO ter Kuile F Nosten M Thieren C Luxemburger MD Edstein T Chongsuphajaisiddhi L Phaipun HK Webster NJ White, J Infect Dis 1992 166 1393 1400 1431257
8. Efficacy of mefloquine and a mefloquine-artesunate combination therapy for the treatment of uncomplicated Plasmodium falciparum malaria in the Amazon Basin of Peru. W Marquino M Huilca C Calampa E Falconi C Cabezas R Naupay TK Ruebush II, Am J Trop Med Hyg 2003 68 608 612 12812355 (Pubitemid 38240503)
9. Therapeutic efficacy test in malaria falciparum in Antioquia, Colombia. S Blair J Carmona-Fonseca JG Pineros A Rios T Alvarez G Alvarez A Tobon, Malar J 2006 5 14 16504002 10.1186/1475-2875-5-14
10. [An efficacy and tolerance study of oral artesunate alone and in combination with mefloquine in the treatment of uncomplicated falciparum malaria in an endemic area of Para, Brazil]. S Cardoso Bda HV Dourado C Pinheiro Mda JA Crescente WW Amoras J Baena S Saraty, Rev Soc Bras Med Trop 1996 29 251 257 8701045
11. Randomised efficacy and safety study of two 3-day artesunate rectal capsule/mefloquine regimens versus artesunate alone for uncomplicated malaria in Ecuadorian children. EA Gomez MH Jurado N Cambon, Acta Trop 2003 89 47 53 10.1016/j.actatropica.2003.09.003 14636982 (Pubitemid 37421416)
12. Efficacy of mefloquine and mefloquine-artesunate for the treatment of uncomplicated Plasmodium falciparum malaria in the Amazon region of Bolivia. JC Avila R Villaroel W Marquino J Zegarra R Mollinedo TK Ruebush, Trop Med Int Health 2004 9 217 221 10.1046/j.1365-3156.2003.01184.x 15040558 (Pubitemid 38250808)
13. Efficacy of chloroquine, sulfadoxine-pyrimethamine, and mefloquine for the treatment of uncomplicated Plasmodium falciparum malaria on the North Coast of Peru. W Marquino JR Macarthur LM Barat FE Oblitas M Arrunategui G Garavito ML Chafloque B Pardave S Gutierrez N Arrospide C Carillo C Cabezas TK Ruebush 2nd, Am J Trop Med Hyg 2003 68 120 123 12557836 (Pubitemid 38234860)
14. In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up. K Stepniewska WR Taylor M Mayxay R Price F Smithuis JP Guthmann K Barnes HY Myint M Adjuik P Olliaro S Pukrittayakamee S Looareesuwan TT Hien J Farrar F Nosten NPJ Day NJ White, Antimicrob Agents Chemother 2004 48 4271 4280 15504852 10.1128/AAC.48.11.4271-4280.2004 (Pubitemid 39434886)
15. Efficacy of sulfadoxine-pyrimethamine and mefloquine for the treatment of uncomplicated Plasmodium falciparum malaria in the Amazon basin of Peru. AJ Magill J Zegarra C Garcia W Marquino TK Ruebush 2nd, Rev Soc Bras Med Trop 2004 37 279 281 10.1590/S0037-86822004000300015 15330070 (Pubitemid 38797094)
16. In vivo efficacy of mefloquine for the treatment of Falciparum malaria in Brazil. C Cerutti Jr RR Durlacher FE de Alencar AA Segurado LW Pang, J Infect Dis 1999 180 2077 2080 10.1086/315141 10558975
17. [RIII mefloquine resistance in children with falciparum malaria in Manaus, AM, Brazil]. E Noronha MG Alecrim GA Romero V Macedo, Rev Soc Bras Med Trop 2000 33 201 205 10881135 (Pubitemid 30241498)
18. Absence of nucleotide polymorphism in a Plasmodium vivax multidrug resistance gene after failure of mefloquine prophylaxis in French Guyana. S Picot S Brega P Gerome G Velut F de Monbrison V Cheminel F Peyron, Trans R Soc Trop Med Hyg 2005 99 234 237 10.1016/j.trstmh.2004.09.007 15653127 (Pubitemid 40104024)
19. Assessment and monitoring of antimalarial drug efficacy for the treatment of uncomplicated falciparum malaria. World Health Organization, WHO/HTM/RBM/200350 Geneva: World Health Organization 2003
20. Approximate is better than "exact" for interval estimation of binomial proportions. A Agresti BA Coull, The American Statistician 1998 52 119 126 10.2307/2685469 (Pubitemid 128113559)
21. Improved validated assay for the determination of mefloquine and its carboxy metabolite in plasma, serum and whole blood using solid-phase extraction and high-performance liquid chromatography. MD Green Y Bergqvist DL Mount S Corbett MJ D'Souza, J Chromatogr B Biomed Sci Appl 1999 727 159 165 10.1016/S0378-4347(99)00080-8 10360435 (Pubitemid 29189288)
22. Biopharmaceutics and clinical pharmacokinetics. M Gibaldi, UK: Lea and Febiger 4 1991 2039681
23. Pharmacokinetics of Mefloquine Combined with Artesunate in Children with Acute Falciparum Malaria. R Price JA Simpson P Teja-Isavatharm MM Than C Luxemburger HD Gray T Chongsuphajaisiddhi F Nosten NJ White, Antimicrob Agents Chemother 1999 43 341 6 9925529 (Pubitemid 29079169)
24. Divided-dose kinetics of mefloquine in man. G Franssen B Rouveix J Lebras J Bauchet F Verdier C Michon F Bricaire, Br J Clin Pharmacol 1989 28 179 184 2789071 (Pubitemid 19201410)
25. Logarithmic transformation in bioequivalence: application with two formulations of perphenazine. KK Midha ED Ormsby JW Hubbard G McKay EM Hawes L Gavalas IJ McGilveray, J Pharm Sci 1993 82 138 144 10.1002/jps.2600820205 8445525 (Pubitemid 23147739)
26. Clinical Pharmacokinetics of Mefloquine. J Karbwang NJ White, Clin Pharmacokinet 1990 19 264 279 10.2165/00003088-199019040-00002 2208897 (Pubitemid 20283426)
27. Long-term malaria prophylaxis with weekly mefloquine. HO Lobel M Miani T Eng KW Bernard AW Hightower CC Campbell, Lancet 1993 341 848 851 10.1016/0140-6736(93)93058-9 8096560 (Pubitemid 23094508)
28. The bioequivalence of highly variable drugs and drug products. KK Midha MJ Rawson JW Hubbard, Int J Clin Pharmacol Ther 2005 43 485 98 16240706 (Pubitemid 41448423)
29. Mefloquine pharmacokinetic-pharmacodynamic models: implications for dosing and resistance. JA Simpson ER Watkins RN Price L Aarons DE Kyle NJ White, Antimicrob Agents Chemother 2000 44 3414 3424 11083649 10.1128/AAC.44.12.3414- 3424.2000 (Pubitemid 33009503)
30. Risk factors for gametocyte carriage in uncomplicated falciparum malaria. R Price F Nosten JA Simpson C Luxemburger L Phaipun F ter Kuile M van Vugt T Chongsuphajaisiddhi NJ White, Am J Trop Med Hyg 1999 60 1019 1023 10403336 (Pubitemid 29296230)
31. The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailand. RN Price C Cassar A Brockman M Duraisingh M van Vugt NJ White F Nosten S Krishna, Antimicrob Agents Chemother 1999 43 2943 2949 10582887
32. Factors contributing to anemia after uncomplicated falciparum malaria. RN Price JA Simpson F Nosten C Luxemburger L Hkirjaroen F ter Kuile T Chongsuphajaisiddhi NJ White, Am J Trop Med Hyg 2001 65 614 622 11716124 (Pubitemid 33134602)