Low cholesterol along with inflammation predicts morbidity and mortality in hemodialysis patients

Hemodialysis International

Volumn 13, Issue 2, 2009, Pages 197-204

  Tsirpanlis, George ^a,e   Boufidou, Fotini ^b   Zoga, Margarita ^b   Triantafyllis, George ^a   Fatourou, Alexandra ^a   Stamatelou, Kyriaki ^c   Bleta, Aliki ^d   Petrihou, Christiana ^a   Chatzipanagiotou, Stylianos ^b   Nicolaou, Chrysoula ^b  

^a KAT HOSPITAL   (Greece)

^b NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS   (Greece)

^c Blue Cross Hospital   (Greece)

^d Dragini Clinic   (Greece)

^e NONE   (Greece)

Author keywords

C reactive protein; Interleukin 10; Interleukin 6; Lipids; Renal failure; Reverse epidemiology

Indexed keywords

ACETYLSALICYLIC ACID; ANGIOTENSIN RECEPTOR ANTAGONIST; C REACTIVE PROTEIN; CALCIUM CHANNEL BLOCKING AGENT; CHOLESTEROL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GLYCOPROTEIN GP 130; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERLEUKIN 10; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OXIDIZED LOW DENSITY LIPOPROTEIN; SEVELAMER; TRIACYLGLYCEROL;

ADULT; ARTICLE; CARDIOVASCULAR RISK; CAUSE OF DEATH; CHOLESTEROL BLOOD LEVEL; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; FEMALE; HEMODIALYSIS; HEMODIALYSIS PATIENT; HOSPITALIZATION; HUMAN; HYPERCHOLESTEROLEMIA; HYPOCHOLESTEROLEMIA; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MORTALITY; PREDICTOR VARIABLE; PROGNOSIS; SURVIVAL RATE;

ADULT; AGED; C-REACTIVE PROTEIN; CHOLESTEROL; FEMALE; FOLLOW-UP STUDIES; HOSPITALIZATION; HUMANS; INFLAMMATION; INTERLEUKIN-10; INTERLEUKIN-6; KAPLAN-MEIERS ESTIMATE; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; MORBIDITY; PREDICTIVE VALUE OF TESTS; RENAL DIALYSIS;

EID: 65449167214     PISSN: 14927535     EISSN: 15424758     Source Type: Journal    
DOI: 10.1111/j.1542-4758.2009.00356.x     Document Type: Article

References (17)

1. Kalantar-Zadeh K, Block G, Humphreys MH, Kopple JD. Reverse epidemiology of cardiovascular risk factors in maintenance dialysis patients. Kidney Int. 2003; 63: 793-808.
2. Liu Y, Coresh J, Eustace JA, et al. Association between cholesterol level and mortality in dialysis patients: Role of inflammation and malnutrition. JAMA. 2004; 291: 451-459.
3. Kilpatrick RD, McAllister CJ, Kovesdy CP, Derose SF, Kopple JD, Kalantar-Zadeh K. Association between seum lipids and survival in hemodialysis patients and impact of race. J Am Soc Nephrol. 2007; 18: 293-303.
4. Kovesdy CP, Anderson JE, Kalantar-Zadeh K. Paradoxical association between body mass index and mortality in men with CKD not yet on dialysis. Am J Kidney Dis. 2007; 49: 581-591.
5. Jones SA, Horiuchi S, Topley N, et al. The soluble interleukin 6 receptor: Mechanisms of production and implications in disease. FASEB J. 2001; 15: 43-58.
6. Jostock T, Mullberg J, Ozbek S, et al. Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses. Eur J Biochem. 2001; 268: 160-167.
7. Tsirpanlis G, Bagos P, Ioannou D, et al. The variability and accurate assessment of microinflammation in haemodialysis patients. Nephrol Dial Transplant. 2004; 19: 150-157.
8. Tsirpanlis G, Chatzipanagiotou S, Ioannidis A, et al. Serum and peripheral blood mononuclear cells infectious burden: Correlation to inflammation and atherosclerosis in haemodialysis patients. Nephrology (Caltron). 2005; 10: 256-263.
9. Kovesdy CP, Anderson JE, Kalantar-Zadeh K. Inverse association between lipid levels and mortality in men with chronic kidney disease who are not yet on dialysis: Effects of case mix and the malnutrition-cachexia syndrome. J Am Soc Nephrology. 2007; 18: 304-311.
10. Curtis JP, Selter JG, Wang Y, et al. The obesity paradox: Body mass index and outcomes in patients with heart failure. Arch Intern Med. 2005; 165: 55-61.
11. Cano NJ, Pichard C, Roth H, et al. C-reactive protein and body mass index predict outcome in end-stage respiratory failure. Chest. 2004; 126: 540-546.
12. Escalante A, Haas RW, del Rincon I. Paradoxical effect of body mass index on survival in rheumatoid arthritis: Role of comorbidity and systemic inflammation. Arch Intern Med. 2005; 165: 1624-1629.
13. Tsirpanlis G. The pattern of inflammation and a potential new clinical meaning and usefulness of C-reactive protein in end-stage renal failure patients. Kidney Blood Press Res. 2005; 28: 55-61.
14. Stenvinkel P, Heimburger O, Lindholm B. Wasting, but not malnutrition, predicts cardiovascular mortality in end-stage renal disease. Nephrol Dial Transplant. 2004; 19: 2181-2183.
15. Tsirpanlis G, Chatzipanagiotou S, Boufidou F, et al. Release of interleukin-6 and its soluble receptors by activated peripheral blood monocytes is elevated in hypocholesterolemic hemodialysis patients. Am J Nephrol. 2005; 25: 484-490.
16. Tsirpanlis G, Chatzipanagiotou S, Nicolaou C. Microinflammation versus inflammation in chronic renal failure patients. Kidney Int. 2004; 66: 2093-2094.
17. Tsirpanlis G, Alevizaki F, Triantafyllis G, et al. C-reactive protein: "Cutoff" point and clinical applicability. Am J Kidney Dis. 2005; 46: 368.