Complementary three-dimensional quantitative structure-activity relationship modeling of binding affinity and functional potency: A study on α4β2 nicotinic ligands

Journal of Medicinal Chemistry

Volumn 52, Issue 8, 2009, Pages 2311-2316

  Tosco, Paolo ^a   Ahring, Philip K ^b   Dyhring, Tino ^b   Peters, Dan ^b   Harpsøe, Kasper ^c   Liljefors, Tommy ^c   Balle, Thomas ^c  

^a UNIVERSITY OF TURIN   (Italy)

^b NEUROSEARCH A S   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

NICOTINIC AGENT; NICOTINIC RECEPTOR ALPHA4BETA2;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING ASSAY; CHEMICAL BOND; DRUG POTENCY; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LIGAND BINDING; MOLECULAR MODEL; MOLECULAR SIZE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SEQUENCE ALIGNMENT; STEREOSPECIFICITY; STRUCTURE ANALYSIS; TECHNIQUE;

BINDING SITES; CALCIUM; CELL LINE; DRUG PARTIAL AGONISM; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NICOTINE; NICOTINIC AGONISTS; PYRIDINES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECEPTORS, NICOTINIC;

EID: 65449161400     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm801060h     Document Type: Article

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