Up-Regulation of Endothelin Type A Receptor in Human and Rat Radiation Proctitis: Preclinical Therapeutic Approach With Endothelin Receptor Blockade

International Journal of Radiation Oncology Biology Physics

Volumn 74, Issue 2, 2009, Pages 528-538

  Jullien, Nicolas ^a   Blirando, Karl ^a   Milliat, Fabien ^a   Sabourin, Jean Christophe ^c   Benderitter, Marc ^a,b   François, Agnès ^a  

^a SRBE   (France)

^b Unité Propre de Recherche de l'Enseignement Supérieur Equipe   (France)

^c ROUEN UNIVERSITY HOSPITAL   (France)

Author keywords

atrasentan; bosentan; Endothelin; radiation fibrosis; rectum

Indexed keywords

ATRASENTAN; BOSENTAN; ENDOTHELIN; RADIATION FIBROSIS; RECTUM;

ANIMALS; BIOLOGICAL RADIATION EFFECTS; CHEMICAL MODIFICATION; RADIATION DAMAGE;

RADIATION;

ATRASENTAN; BOSENTAN; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; ENDOTHELIN RECEPTOR ANTAGONIST; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIGESTIVE SYSTEM INJURY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MORNING DOSAGE; NONHUMAN; PELVIS TUMOR; PRIORITY JOURNAL; PROCTITIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RADIATION EXPOSURE; RADIATION HAZARD; RADIATION INJURY; RAT;

ANIMALS; HUMANS; MALE; PROCTITIS; PYRROLIDINES; RADIATION INJURIES; RADIATION-PROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; RECEPTORS, ENDOTHELIN; RECTUM; RNA, MESSENGER; SULFONAMIDES; UP-REGULATION;

EID: 65449159085     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2008.12.086     Document Type: Article

References (37)

1. Nguyen N.P., Antoine J.E., Dutta S., et al. Current concepts in radiation enteritis and implications for future clinical trials. Cancer 95 (2002) 1151-1163
2. Zheng H., Wang J., Koteliansky V.E., et al. Recombinant soluble transforming growth factor beta type II receptor ameliorates radiation enteropathy in mice. Gastroenterology 119 (2000) 1286-1296
3. Clozel M., and Salloukh H. Role of endothelin in fibrosis and anti-fibrotic potential of bosentan. Ann Med 37 (2005) 2-12
4. Leask A., and Abraham D.J. TGF-beta signaling and the fibrotic response. FASEB J 18 (2004) 816-827
5. Yanagisawa M., Kurihara H., Kimura S., et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332 (1988) 411-415
6. Rubanyi G.M., and Polokoff M.A. Endothelins:molecular biology, biochemistry, pharmacology, physiology, and pathophysiology. Pharmacol Rev 46 (1994) 325-415
7. Kahaleh M.B. Endothelin, an endothelial-dependent vasoconstrictor in scleroderma. Enhanced production and profibrotic action. Arthritis Rheum 34 (1991) 978-983
8. Vancheeswaran R., Azam A., Black C., et al. Localization of endothelin-1 and its binding sites in scleroderma skin. J Rheumatol 21 (1994) 1268-1276
9. Cambrey A.D., Harrison N.K., Dawes K.E., et al. Increased levels of endothelin-1 in bronchoalveolar lavage fluid from patients with systemic sclerosis contribute to fibroblast mitogenic activity in vitro. Am J Respir Cell Mol Biol 11 (1994) 439-445
10. Abraham D.J., Vancheeswaran R., Dashwood M.R., et al. Increased levels of endothelin-1 and differential endothelin type A and B receptor expression in scleroderma-associated fibrotic lung disease. Am J Pathol 151 (1997) 831-841
11. Garcia de la Pena-Lefebvre P., Rodriguez Rubio S., Valero Exposito M., et al. Long-term experience of bosentan for treating ulcers and healed ulcers in systemic sclerosis patients. Rheumatology (Oxford) 47 (2008) 464-466
12. Leask A. Targeting the TGFbeta, endothelin-1 and CCN2 axis to combat fibrosis in scleroderma. Cell Signal 20 (2008) 1409-1414
13. Rockey D.C., and Chung J.J. Endothelin antagonism in experimental hepatic fibrosis. Implications for endothelin in the pathogenesis of wound healing. J Clin Investig 98 (1996) 1381-1388
14. Thirunavukkarasu C., Yang Y., Subbotin V.M., et al. Endothelin receptor antagonist TAK-044 arrests and reverses the development of carbon tetrachloride induced cirrhosis in rats. Gut 53 (2004) 1010-1019
15. Boffa J.J., Tharaux P.L., Dussaule J.C., et al. Regression of renal vascular fibrosis by endothelin receptor antagonism. Hypertension 37 (2001) 490-496
16. Ammarguellat F., Larouche I., and Schiffrin E.L. Myocardial fibrosis in DOCA-salt hypertensive rats:effect of endothelin ET(A) receptor antagonism. Circulation 103 (2001) 319-324
17. Park S.H., Saleh D., Giaid A., et al. Increased endothelin-1 in bleomycin-induced pulmonary fibrosis and the effect of an endothelin receptor antagonist. Am J Respir Crit Care Med 156 (1997) 600-608
18. Opgenorth T.J., Adler A.L., Calzadilla S.V., et al. Pharmacological characterization of A-127722: An orally active and highly potent ETA-selective receptor antagonist. J Pharmacol Exp Ther 276 (1996) 473-481
19. Langberg C.W., Sauer T., Reitan J.B., et al. Relationship between intestinal fibrosis and histopathologic and morphometric changes in consequential and late radiation enteropathy. Acta Oncol 35 (1996) 81-87
20. Milliat F., Francois A., Isoir M., et al. Influence of endothelial cells on vascular smooth muscle cells phenotype after irradiation: implication in radiation-induced vascular damages. Am J Pathol 169 (2006) 1484-1495
21. Boerma M., Wang J., Kulkarni A., et al. Influence of endothelin 1 receptor inhibition on functional, structural and molecular changes in the rat heart after irradiation. Radiat Res 170 (2008) 275-283
22. Iwasa S., Fan J., Shimokama T., et al. Increased immunoreactivity of endothelin-1 and endothelin B receptor in human atherosclerotic lesions. A possible role in atherogenesis. Atherosclerosis 146 (1999) 93-100
23. Balyakina E.V., Chen D., Lawrence M.L., et al. ET-1 receptor gene expression and distribution in L1 and L2 cells from hypertensive sheep pulmonary artery. Am J Physiol Lung Cell Mol Physiol 283 (2002) L42-51
24. Wendel M., Petzold A., Koslowski R., et al. Localization of endothelin receptors in bleomycin-induced pulmonary fibrosis in the rat. Histochem Cell Biol 122 (2004) 507-517
25. Drimal J., Mislovicova M., Ismail A., et al. Detrimental subtype-specific endothelin-1 (ET-1) signaling in myocardial cells: The ET(A) mediated proliferation and ET(B)receptor down-regulation. Physiol Res 48 (1999) 9-19
26. Luscher T.F., and Barton M. Endothelins and endothelin receptor antagonists: therapeutic considerations for a novel class of cardiovascular drugs. Circulation 102 (2000) 2434-2440
27. Zidovetzki R., Wang J.L., Kim J.A., et al. Endothelin-1 enhances plasminogen activator inhibitor-1 production by human brain endothelial cells via protein kinase C-dependent pathway. Arterioscler Thromb Vasc Biol 19 (1999) 1768-1775
28. Milliat F., Sabourin J.C., Tarlet G., et al. Essential role of plasminogen activator inhibitor type-1 in radiation enteropathy. Am J Pathol 172 (2008) 691-701
29. Hocher B., Schwarz A., Fagan K.A., et al. Pulmonary fibrosis and chronic lung inflammation in ET-1 transgenic mice. Am J Respir Cell Mol Biol 23 (2000) 19-26
30. Shi-Wen X., Denton C.P., Dashwood M.R., et al. Fibroblast matrix gene expression and connective tissue remodeling: role of endothelin-1. J Investig Dermatol 116 (2001) 417-425
31. Rodriguez-Vita J., Ruiz-Ortega M., Ruperez M., et al. Endothelin-1, via ETA receptor and independently of transforming growth factor-beta, increases the connective tissue growth factor in vascular smooth muscle cells. Circ Res 97 (2005) 125-134
32. Horstmeyer A., Licht C., Scherr G., et al. Signalling and regulation of collagen I synthesis by ET-1 and TGF-beta1. FEBS Lett J 272 (2005) 6297-6309
33. Shi-Wen X., Renzoni E.A., Kennedy L., et al. Endogenous endothelin-1 signaling contributes to type I collagen and CCN2 overexpression in fibrotic fibroblasts. Matrix Biol 26 (2007) 625-632
34. Shi-wen X., Kennedy L., Renzoni E.A., et al. Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts. Arthritis Rheum 56 (2007) 4189-4194
35. Maurer M., Wedemeyer J., Metz M., et al. Mast cells promote homeostasis by limiting endothelin-1-induced toxicity. Nature 432 (2004) 512-516
36. Boerma M., Wang J., Wondergem J., et al. Influence of mast cells on structural and functional manifestations of radiation-induced heart disease. Cancer Res 65 (2005) 3100-3107
37. Zheng H., Wang J., and Hauer-Jensen M. Role of mast cells in early and delayed radiation injury in rat intestine. Radiat Res 153 (2000) 533-539