Fetal cerebral blood flow, electrocorticographic activity, and oxygenation: Responses to acute hypoxia

Journal of Physiology

Volumn 587, Issue 9, 2009, Pages 2033-2047

  Lee, Stephen J ^a   Hatran, Douglas P ^a   Tomimatsu, Takuji ^a   Peña, Jorge Pereyra ^a   Mcauley, Grant ^a   Longo, Lawrence D ^a  

^a LOMA LINDA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL GAS; ARTERIAL OXYGEN TENSION; ARTERIAL PRESSURE; ARTICLE; BLOOD FLOW VELOCITY; BRAIN BLOOD FLOW; BRAIN METABOLISM; BRAIN OXYGEN TENSION; CONTROLLED STUDY; ELECTROCORTICOGRAPHY; FEMALE; FETUS; FETUS HEART RATE; HYPOXIA; LASER DOPPLER FLOWMETRY; METABOLIC RATE; NONHUMAN; PRIORITY JOURNAL; SHEEP; TISSUE OXYGENATION; ANIMAL TISSUE; BRAIN CORTEX; BRAIN OXYGEN CONSUMPTION; ELECTROCORTICOGRAPH ELECTRODE; ELECTRODE; EWE; FETUS CIRCULATION; MOLECULAR PROBE; PRENATAL STRESS;

ANIMALS; BLOOD FLOW VELOCITY; BRAIN; CEREBROVASCULAR CIRCULATION; ELECTROENCEPHALOGRAPHY; FEMALE; FETAL HYPOXIA; HYPOXIA, BRAIN; OXYGEN; PREGNANCY; PREGNANCY, ANIMAL; SHEEP;

EID: 65449143958     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2009.166983     Document Type: Article

References (58)

1. Bell AH, McClure BG, McCullah PJ & McClelland RJ (1991). Spectral edge frequency of the EEG in healthy neonates and variation with behavioural state. Biol Neonate 60, 69-74.
2. Bishai JM, Blood AB, Hunter CJ, Longo LD & Power GG (2003). Fetal lamb cerebral blood flow (CBF) and oxygen tensions during hypoxia: A comparison of laser Doppler and microsphere measurements of CBF. J Physiol 546, 869-878.
3. Bocking AD, Gagnon R, Milne KM & White SE (1988). Behavioral activity during prolonged hypoxemia in fetal sheep. J Appl Physiol 65, 2420-2426.
4. Bocking AD & Harding R (1986). Effects of reduced uterine blood flow on electrocortical activity, breathing, and skeletal muscle activity in fetal sheep. Am J Obstet Gynecol 154, 655-662.
5. Boddy K, Dawes GS, Fisher R, Pinter S & Robinson JS (1974). Foetal respiratory movements, electrocortical and cardiovascular responses to hypoxaemia and hypercapnia in sheep. J Physiol 243, 599-618.
6. Clapp JF III, Szeto HH, Abrams R, Larrow R & Mann LI (1980). Physiologic variability and fetal electrocortical activity. Am J Obstet Gynecol 136, 1045-1050.
7. Clewlow F, Dawes GS, Johnston BM & Walker DW (1983). Changes in breathing, electrocortical and muscle activity in unanaesthetized fetal lambs with age. J Physiol 341, 463-476.
8. Czikk MJ, Sweeley JC, Homan JH, Milley JR & Richardson BS (2003). Cerebral leucine uptake and protein synthesis in the near-term ovine fetus: Relation to fetal behavioral state. Am J Physiol Regul Integr Comp Physiol 284, R200-R207.
9. Dawes GS, Fox HE, Leduc BM, Liggins GC & Richards RT (1972). Respiratory movements and rapid eye movement sleep in the foetal lamb. J Physiol 220, 119-143.
10. Fraser M, Bennet L, Gunning M, Williams C, Gluckman PD, George S & Gunn AJ (2005). Cortical electroencephalogram suppression is associated with post-ischemic cortical injury in 0.65 gestation fetal sheep. Brain Res Dev Brain Res 154, 45-55.
11. Gasser T, Bächer P & Möcks J (1982). Transformations towards the normal distribution of broad band spectral parameters of the EEG. Electroencephalogr Clin Neurophysiol 53, 119-124.
12. George S, Gunn AJ, Westgate JA, Brabyn C, Guan J & Bennet L (2004). Fetal heart rate variability and brain stem injury after asphyxia in preterm fetal sheep. Am J Physiol Regul Integr Comp Physiol 287, R925-R933.
13. Grant DA, Franzini C, Wild J, Eede KJ & Walker AM (2005). Autoregulation of the cerebral circulation during sleep in newborn lambs. J Physiol 564, 923-930.
14. Harding R, Poore ER & Cohen GL (1981). The effect of brief episodes of diminished uterine blood flow on breathing movements, sleep states and heart rate in fetal sheep. J Dev Physiol 3, 231-243.
15. Inder TE, Buckland L, Williams CE, Spencer C, Gunning MI, Darlow BA, Volpe JJ & Gluckman PD (2003). Lowered electroencephalographic spectral edge frequency predicts the presence of cerebral white matter injury in premature infants. Pediatrics 111, 27-33.
16. Isler JR, Garland M, Stark RI & Grieve PG (2005). Local coherence oscillations in the EEG during development in the fetal baboon. Clin Neurophysiol 116, 2121-2128.
17. Jones MD Jr, Rosenberg AA, Simmons MA, Molteni RA, Koehler RC & Traystman RJ (1982). Oxygen delivery to the brain before and after birth. Science 216, 324-325.
18. Jones MD Jr & Traystman RJ (1984). Cerebral oxygenation of the fetus, newborn, and adult. Semin Perinatol 8, 205-216.
19. Jost RG, Quilligan EJ, Yeh S-Y & Anderson G (1972). Intrauterine electroencephalogram of the sheep fetus. Am J Obstet Gynecol 114, 535-539.
20. Koos BJ, Matsuda K & Power GG (1988). Fetal breathing and sleep state responses to graded carboxyhemoglobinemia in sheep. J Appl Physiol 65, 2118-2123.
21. Koos BJ & Sameshima H (1988). Effects of hypoxaemia and hypercapnia on breathing movements and sleep state in sinoaortic-denervated fetal sheep. J Dev Physiol 10, 131-144.
22. Koos BJ, Sameshima H & Power GG (1986). Fetal breathing movement, sleep state and cardiovascular responses to an inhibitor of mitochondrial ATPase in sheep. J Dev Physiol 8, 67-75.
23. Lotgering FK, Gilbert RD & Longo LD (1983). Exercise responses in pregnant sheep: Blood gases, temperatures, and fetal cardiovascular system. J Appl Physiol 55, 842-850.
24. MacLachlan JN, Hemstreet S, Matushewski B, McCallum JD & Richardson BS (2008). Induced hyper and hypo amino acidemia in the ovine fetus near term: Effects on electrocortical activity. Reprod Sci 15, 710-719.
25. Mann LI (1970). Fetal brain function and metabolism. Clin Obstet Gynecol 13, 638-651.
26. Mann LI, Duchin S & Weiss RR (1974). Fetal EEG sleep stages and physiologic variability. Am J Obstet Gynecol 119, 533-538.
27. Marks GA, Shaffery JP, Oksenberg A, Speciale SG & Roffwarg HP (1995). A functional role for REM sleep in brain maturation. Behav Brain Res 69, 1-11.
28. Mirmiran M (1986). The importance of fetal/neonatal REM sleep. Eur J Obstet Gynecol Reprod Biol 21, 283-291.
29. Mirmiran M (1995). The function of fetal/neonatel rapid eye movement sleep. Behav Brain Res 69, 13-22.
30. Morrison JL, Carmichael L, Homan J, White S & Richardson BS (2005). Cerebral blood flow during spontaneous and cholinergically induced behavioral states in the sheep fetus. Pediatr Res 57, 667-673.
31. Morrissey MJ, Duntley SP, Anch AM & Nonneman R (2004). Active sleep and its role in the prevention of apoptosis in the developing brain. Med Hypotheses 62, 876-879.
32. Natale R, Clewlow F & Dawes GS (1981). Measurement of fetal forelimb movements in the lamb in utero. Am J Obstet Gynecol 140, 545-551.
33. Osredkar D, Toet MC, van Rooij LGM, van Huffelen AC, Groenendaal F & de Vries LS (2005). Sleep-wake cycling on amplitude-integrated electroencephalography in term newborns with hypoxic-ischemic encephalopathy. Pediatrics 115, 327-332.
34. Pereyra Peña J, Tomimatsu T, Hatran DP, McGill LL & Longo LD (2007). Cerebral blood flow and oxygenation in ovine fetus: Responses to superimposed hypoxia at both low an high altitude. J Physiol 578, 359-370.
35. Pulgar VM, Zhang J, Massmann A & Figueroa JP (2006). Prolonged mild hypoxia alters fetal sheep electrocorticogram activity. J Soc Gynecol Investig 13, 404-411.
36. Richardson BS, Caetano H, Homan J & Carmichael L (1994). Regional brain blood flow in the ovine fetus during transition to the low-voltage electrocortical state. Brain Res Dev Brain Res 81, 10-16.
37. Richardson BS, Carmichael L, Homan J & Gagnon R (1989). Cerebral oxidative metabolism in lambs during perinatal period: Relationship to electrocortical state. Am J Physiol Regul Integr Comp Physiol 257, R1251-R1257.
38. Richardson BS, Carmichael L, Homan J & Patrick JE (1992). Electrocortical activity, electroocular activity, and breathing movements in fetal sheep with prolonged and graded hypoxemia. Am J Obstet Gynecol 167, 553-558.
39. Richardson BS, Patrick JE & Abduljabbar H (1985). Cerebral oxidative metabolism in the fetal lamb: Relationship to electrocortical state. Am J Obstet Gynecol 153, 426-431.
40. Roffwarg HP, Muzio JN & Dement WC (1966). Ontogenetic development of the human sleep-dream cycle. The prime role of "dreaming sleep" in early life may be in the development of the central nervous system. Science 152, 604-619.
41. Ruckebusch Y (1972). Development of sleep and wakefulness in the foetal lamb. Electroencephalogr Clin Neurophysiol 32, 119-128.
42. Ruckebusch Y, Gaujoux M & Eghbali B (1977). Sleep cycles and kinesis in the foetal lamb. Electroencephalogr Clin Neurophysiol 42, 226-237.
43. Scher MS, Steppe DA & Banks DL (1996). Prediction of lower developmental performances of healthy neonates by neonatal EEG-sleep measures. Pediatr Neurol 14, 137-144.
44. Scher MS, Steppe DA, Beggarly ME, Salerno DG & Banks DL (2002). Neonatal EEG-sleep disruption mimicking hypoxic-ischemic encephalopathy after intrapartum asphyxia. Sleep Med 3, 411-415.
45. Shinozuka N & Nathanielsz PW (1998). Electorcortical activity in fetal sheep in the last seven days of gestation. J Physiol 513, 273-281.
46. Spitzer NC (2006). Electrical activity in early neuronal development. Nature 444, 707-712.
47. Stark RI, Haiken J, Nordli D & Myers MM (1991). Characterization of electroencephalographic state in fetal baboons. Am J Physiol Regul Integr Comp Physiol 261, R496-R500.
48. Szeto HH (1990). Spectral edge frequency as a simple quantitative measure of the maturation of electrocortical activity. Pediatr Res 27, 289-292.
49. Szeto HH & Hinman DJ (1985). Prenatal development of sleep-wake patterns in sheep. Sleep 8, 347-355.
50. Szeto HH, Vo TDH, Dwyer G, Dogramajian ME, Cox MJ & Senger G (1985). The ontogeny of fetal lamb electrocortical activity: A power spectral analysis. Am J Obstet Gynecol 153, 462-466.
51. Takahashi T, Sugawara J, Chisaka H, Imai N, Saito M, Murakami T, Kimura Y & Okamura K (2006). Appearance of abnormal electrocorticogram patterns during umbilical cord compression in sheep fetus. Tohoku J Exp Med 208, 9-17.
52. Ter Horst HJ, Sommer C, Bergman KA, Fock JM, Van Weerden TW & Bos AF (2004). Prognostic significance of amplitude-integrated EEG during the first 72 hours after birth in severely asphyxiated neonates. Pediatr Res 55, 1026-1033.
53. Thaler I, Boldes R & Timor-Tritsch I (2000). Real-time spectral analysis of the fetal EEG: A new approach to monitoring sleep states and fetal condition during labor. Pediatr Res 48, 340-345.
54. Thornberg E & Thiringer K (1990). Normal pattern of the cerebral function monitor trace in term and preterm neonates. Acta Paediatr Scand 79, 20-25.
55. Tomimatsu T, Pereyra Peña J & Longo LD (2006). Fetal hypercapnia and cerebral tissue oxygenation: Studies in near-term sheep. Pediatr Res 60, 711-716.
56. Walker AM, Fleming J, Smolich J, Stunden R, Horne R & Maloney J (1984). Fetal oxygen consumption, umbilical circulation and electrocortical activity transitions in fetal lambs. J Dev Physiol 6, 267-274.
57. Watanabe K, Hayakawa F & Okumura A (1999). Neonatal EEG: A powerful tool in the assessment of brain damage in preterm infants. Brain Dev 21, 361-372.
58. Williams CE, Gunn AJ, Mallard C & Gluckman PD (1992). Outcome after ishemia in the developing sheep brain: An electroencephalographic and histological study. Ann Neurol 31, 14-21.