Cerebral leucine uptake and protein synthesis in the near-term ovine fetus: Relation to fetal behavioral state

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 284, Issue 1 53-1, 2003, Pages

  Czikk, Marie J ^a,b   Sweeley, John C ^a,b   Homan, Jacobus H ^a,b   Milley, J Ross ^a,b   Richardson, Bryan S ^a,b,c  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c ST JOSEPH S HEALTH CENTRE   (Canada)

Author keywords

Brain development; Leucine metabolism

Indexed keywords

LEUCINE; PEPTIDE HORMONE;

AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BRAIN DEVELOPMENT; BRAIN GROWTH; BRAIN METABOLISM; BRAIN TISSUE; CONTROLLED STUDY; ELECTRIC POTENTIAL; HYPOPHYSIS; NONHUMAN; NONREM SLEEP; OXIDATION; PREGNANCY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM; PROTEIN SYNTHESIS; SHEEP; SLEEP STAGE;

EID: 0037215559     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00190.2002     Document Type: Article

References (27)

1. Abrams RM, Burchfield DJ, Sun Y, and Smith CB. Rates of local cerebral protein synthesis in fetal and neonatal sheep. Am J Physiol Regul Integr Comp Physiol 272: R1235-R1244, 1997.
2. Adam K. Sleep as a restorative process and a theory to explain why. Prog Brain Res 53: 289-305, 1980.
3. Battaglia FC and Meschia G. Fetal and placental metabolism. II. Amino acids and lipids. In: An Introduction to Fetal Physiology. Orlando, FL: Academic, 1986, p. 100-135.
4. Chao CR, Hohimer AR, and Bissonnette JM. The effect of electrocortical state on cerebral carbohydrate metabolism in fetal sheep. Dev Brain Res 49: 1-5, 1989.
5. Davis SR, Barry TN, and Hughson GA. Protein synthesis in tissues of growing lambs. Br J Nutr 46: 409-419, 1981.
6. Dunlop DS, van Elden W, and Lajtha A. Protein degradation rates in regions of the central nervous system in vivo during development. Biochem J 170: 637-642, 1978.
7. Grant DA, Franzini C, Wild J, and Walker AM. Continuous measurements of blood flow in the superior sagittal sinus of the lamb. Am J Physiol Regul Integr Comp Physiol 269: R274-R279, 1995.
8. 11C]leucine and PET: Methods, model and results in animals and humans. J Cereb Blood Flow Metab 9: 446-460, 1989.
9. Heitman RN and Bergman EN. Transport of amino acids in whole blood and plasma of sheep. Am J Physiol Endocrinol Metab 239: E242-E247, 1980.
10. Horber FF, Horber-Feyder CM, Krayder S, Schwenk WF, and Haymond MW. Plasma reciprocal pool specific activity predicts that of intracellular free leucine for protein synthesis. Am J Physiol Endocrinol Metab 257: E385-E399, 1989.
11. Jones MC, Burd LI, Makowski EL, Meschia G, and Battaglia FC. Cerebral metabolism in sheep: A comparative study of the adult, the lamb and the fetus. Am J Physiol 229: 235-239, 1975.
12. Lajtha A, Latzkovits L, and Toth J. Comparison of turnover rates of proteins of the brain, liver and kidney in mouse in vivo following long term labeling. Biochim Biophys Acta 425: 511-520, 1976.
13. Madsen PL and Vorstrup S. Cerebral blood flow and metabolism during sleep. Cerebrovasc Brain Metab Rev 3: 281-296, 1991.
14. McIntosh GH, Baghurst KI, Potter BJ, and Hetzel BS. Foetal brain development in the sheep. Neuropathol Appl Neurobiol 5: 103-114, 1979.
15. Milley JR and Sweeley JC. High-performance liquid chromatographic measurement of leucine and α-ketoisocaproate in whole blood: Application to fetal protein metabolism. J Chromatogr 613: 23-33, 1993.
16. Nakanishi H, Sun Y, Nakamura RK, Mori K, Ito M, Suda S, Nambe H, Storch FI, Dang TP, Mendelson W, Mishkin M, Kennedy C, Gillen JC, Smith CB, and Sokoloff L. Positive correlations between cerebral protein synthesis rates and deep sleep in Macaca mulatta. Eur J Neurosci 9: 271-279, 1997.
17. Oldendorf WH. Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. Am J Physiol 221: 1629-1639, 1971.
18. Pell JM and Bergman EN. Cerebral metabolism of amino acids and glucose in fed and fasted sheep. Am J Physiol Endocrinol Metab 244: E282-E289, 1983.
19. Ramm P and Smith CT. Rates of cerebral protein synthesis are linked to slow wave sleep in the rat. Physiol Behav 48: 749-753, 1990.
20. Richardson BS. Metabolism of the fetal brain: Biological and pathological development. In: The Fetal and Neonatal Brain Stem, edited by Hanson MA. Cambridge, UK: Cambridge Univ. Press, 1991, p. 87-105.
21. Richardson BS. The effect of behavioural state on fetal metabolism and blood flow circulation. Semin Perinatol 16: 227-233, 1992.
22. Richardson BS. Ontogeny of behavioural states in the fetus. In: Textbook of Fetal Physiology, edited by Thornburn G and Harding R. Oxford, UK: Oxford Univ. Press, 1994, p. 322-328.
23. Richardson B, Carmichael L, Homan J, Morrison J, and Rupar T. The uptake of amino acids by the ovine fetal brain: Relationship to electrocortical state. J Soc Gynecol Investig 2: P267, 1995.
24. Schaefer AL and Krishnamurti CR. Whole body and tissue fractional protein synthesis in the ovine fetus in utero. Br J Nutr 52: 359-369, 1984.
25. Smith CB. The measurement of regional rates of cerebral protein synthesis in vivo. Neurochem Res 16: 1037-1045, 1991.
26. Sun Y, Deibler GE, Jehle J, Macedonia J, Dumont I, Dang T, and Smith CB. Rates of local cerebral protein synthesis in the rat during normal postnatal development. Am J Physiol Regul Integr Comp Physiol 268: R549-R561, 1995.
27. Szeto HH and Hinman DJ. Prenatal development of sleep-wake patterns in sheep. Sleep 8: 347-355, 1985.