Evaluation of liver biopsy in Egyptian HBeAg-negative chronic hepatitis B patients at initial presentation: Implications for therapy

American Journal of Gastroenterology

Volumn 104, Issue 4, 2009, Pages 906-911

  El Zayadi, Abdel Rahman ^a,g   Badran, Hanaa Mostafa ^b   Saied, Ahmed ^c   Shawky, Sherine ^d   Attia, Mohy El Deen ^e   Zalata, Khaled ^f  

^a AIN SHAMS UNIVERSITY   (Egypt)

^b MENOUFIA UNIVERSITY   (Egypt)

^c Cairo Liver Center   (Egypt)

^d Social Research Center of the American University in Cairo   (Egypt)

^e THEODOR BILHARZ RESEARCH INSTITUTE   (Egypt)

^f MANSOURA UNIVERSITY   (Egypt)

^g Hepatology and Gastroenterology   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; HEPATITIS B(E) ANTIGEN; VIRUS DNA; INTERFERON;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; CLINICAL FEATURE; EGYPT; FEMALE; HEPATITIS B; HEPATITIS VIRUS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LIVER BIOPSY; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SCORING SYSTEM; SCREENING TEST; TREATMENT INDICATION; TREATMENT PLANNING; COMPARATIVE STUDY; DIFFERENTIAL DIAGNOSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; EVALUATION STUDY; GENETICS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; IMMUNOLOGY; INCIDENCE; LIVER; MIDDLE AGED; NEEDLE BIOPSY; PATHOLOGY; POLYMERASE CHAIN REACTION; PREVALENCE; PROCEDURES; REPRODUCIBILITY; RETROSPECTIVE STUDY; VIROLOGY; YOUNG ADULT;

ADULT; BIOPSY, NEEDLE; DIAGNOSIS, DIFFERENTIAL; DNA, VIRAL; EGYPT; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HEPATITIS B E ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; INCIDENCE; INTERFERONS; LIVER; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; PREVALENCE; REPRODUCIBILITY OF RESULTS; RETROSPECTIVE STUDIES; YOUNG ADULT;

EID: 65449126322     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1038/ajg.2009.30     Document Type: Article

References (27)

1. Attia MA . Prevalence of hepatitis B and C in Egypt and Africa . Antivir their 1998;3 (Suppl 3):1-9.
2. Hyams KC , Osman NM , Khaled EM et al. Maternal-infant transmission of hepatitis B in Egypt . J Med Virol 1988;24:191-7.
3. El-Zayadi A , Saber M , Lavanchy D et al. High Frequency of HBeAgminus Chronic HBsAg-positive liver disease in Egypt . Int Hepatol Commun 1995;3:178-83.
4. Chu CJ , KeeB e EB , Han SH et al. Prevalence of HBV precore/core promoter variants in the United States . Hepatology 2003; 38: 619-28.
5. Funk ML , Rosenberg DM , Lok AS . World-wide epidemiology of HBeAgnegative chronic hepatitis B and associated precore and core promoter variants . JViral Hepat 2002;9:52-16.
6. Bonino F , Rosina F , Rizzetto M et al. Chronic hepatitis in HBsAg carriers with serum HBV-DNA and anti-HBe . Gastroenterology 1986; 90 (5 Pt 1):1268-73.
7. Brunetto MR , Oliveri F , Coco B et al. Outcome of anti-HBe positive chronic hepatitis B in alpha-interferon treated and untreated patients: a long-term cohort study . JHepatol 2002; 36:263-70.
8. Laras A , Koskinas J , Avgidis K et al. Incidence and clinical signiO cance of hepatitis B virus precore gene translation initiation mutations in e antigennegative patients . J Viral Hepat 1998; 5:241-8.
9. Thakur V , Guptan RC , Kazim SN et al. ProO le, spectrum and signiO cance of HBV genotypes in chronic liver disease patients in the Indian subcontinent. J Gastroenterol Hepatol 2002; 17:165-70.
10. Sanchez-Tapias JM, Costa I, Mas A et al. Influence ofhepatftis B virus genotype on the long-term outcome of chronic hepathis B in western patients. Gastroenterology 2002;123:1848-56.
11. de Franchis R, Hadengue A, Lau Get al. EASL International Consensus Conference on Hepatitis B. 13-14 September, 2002 Geneva, Swftzerland. I Hepatol 2003;39 (Suppl 1): S3-25.
12. Keeffe EB, Dieterich DT, Han SH et al. A treatment algorithm for the management of chronic hepatitis B virus infection in the United States: an update. Cljn Gasroenerol Hepatol 2006;4:936-62.
13. Liaw YF, Leung N, Guan R et al. Asian-Pacific consensus saement on the management of chronic hepatitis B: a 2005 update. Liver Tnt 2005;25:472-89.
14. Lok AS, McMahon BJ. Chronic hepatitis B. Hepatology 2007;45:507-39.
15. Lau G, Marcellin P, Peters M. Chronic hepatitis B: a global health problem requiring coherent worldwide treatment strategies. Hep Intl 2007;1:316-25.
16. Iloeje UH, Yang HI, Su J et al. Predicting cirrhosis risk based on the level of circulating hepathis B viral load. Gastroenerology 2006;1 30:678-86.
17. Lai M, Hyali BJ, Nasser I et al. The clinical significance of persisenly normal ALT in chronic hepatitis B infection. J Hepatol 2007;47:760-7.
18. Tsang PS, Trinh H, Garcia RT et at. Significant prevalence of histologic disease in paiens wfth chronic hepatitis B and mildly elevated serum alanine aminotransferase leels. Clin Gasroenerol Hepatol 2008;6:569-74.
19. Wang CC, Lim LY, Deubner H et al. Factors predictive of significant hepatic fibrosis in adults with chronic hepatitis B and normal serum ALT. J Clin Gastroenterol 2008:42:820-6.
20. Hadziyannis SJ, Vassilopoulos D. Hepatitis B e an̈gen-negative chronic hepatitis B. Hepatology200l;34 (4 Pt 1): 617-24.
21. Chu CI, Hussain M, Lok AS. Quantitative serum HBV DNA levels during different stages of chronic hepatitis B infection. Hepaology 2002;36:1408-15.
22. Yuen MF, Ng TO, Fan ST et al. Significance of HBV DNA levels in lier histology of HBeAg and Anti-HBe positive patients with chronic hepatitis B. Am J Gastroenterol 2004;99:2032-7.
23. Lindh M, Horal P, Dhillon AP et al. Hepatitis B virus DNA leels, precore mutations, genotypes and hismlogical activity in chronic hepatitis B. J Viral Hepat 2000;7:258-67.
24. Zavaglia C, Mondazzi L, Maggi G et al. Are alanine aminotransferase, hepathis B virus DNA or 1gM antibody to hepathis B core antigen serum levels predictors of histological grading in chronic hepathis B? Lier 1997;17:83-7.
25. Ter Borg F, Ten Kate FL Cuypers HT et at. Relation between laboratory test results and histological hepatitis activity in individuals positive for hepathis B surface antigen and antibodies to hepatitis B e antigen. Lancet 1998;351:1914-8.
26. Crockett SD, Keeffe EB. Natural history and treatment of hepatitis B virus and hepatitis C virus coinfection. Ann Clin Microbiol Antimicrob 2005;4;13.
27. Weilman MD, Brorndihardjo A, Crewe EB et al. Confection with hepathis B and C or B, C and delia viruses results in severe chronic liver disease and responds poorly to interferon-alpha treatment. I Viral Hepat 1995;2:39-45.