Activation of Orexin B receptors in the pontine Kölliker-Fuse nucleus modulates pre-inspiratory hypoglossal motor activity in rat

Respiratory Physiology and Neurobiology

Volumn 159, Issue 2, 2007, Pages 232-235

  Dutschmann, Mathias ^a   Kron, Miriam ^a   Mörschel, Michael ^a   Gestreau, Christian ^b  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b AIX MARSEILLE UNIVERSITY   (France)

Author keywords

Obstructive sleep apnoea; Respiratory rhythm generation; Upper airway

Indexed keywords

NEUROPEPTIDE; OREXIN B; OREXIN B RECEPTOR; UNCLASSIFIED DRUG;

ADOLESCENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AROUSAL; ARTICLE; BREATHING RATE; CARDIOVASCULAR RESPONSE; CONTROLLED STUDY; FEMALE; HEART; HYPOGLOSSAL NERVE; MALE; MOTOR ACTIVITY; NARCOLEPSY; NONHUMAN; NUTRITION; PHRENIC NERVE; PRIORITY JOURNAL; RAT; RESPIRATION CENTER; SLEEP DISORDERED BREATHING; UPPER AIRWAY RESISTANCE SYNDROME;

ACTION POTENTIALS; ANIMALS; ANIMALS, NEWBORN; FEMALE; HYPOGLOSSAL NERVE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MOTOR NEURONS; NEUROPEPTIDES; PHRENIC NERVE; PONS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE; RESPIRATORY CENTER; SYMPATHOMIMETICS;

EID: 35248884442     PISSN: 15699048     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resp.2007.06.004     Document Type: Article

References (10)

1. Chemelli R.M., Willie J.T., Sinton C.M., Elmquist J.K., Scammell T., Lee C., Richardson J.A., Williams S.C., Xiong Y., Kisanuki Y., Fitch T.E., Nakazato M., Hammer R.E., Saper C.B., and Yanagisawa M. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98 (1999) 437-451
2. Dutschmann M., and Herbert H. The Kolliker-Fuse nucleus gates the postinspiratory phase of the respiratory cycle to control inspiratory off-switch and upper airway resistance in rat. Eur. J. Neurosci. 24 (2006) 1071-1084
3. Gestreau C., Dutschmann M., Obled S., and Bianchi A.L. Activation of XII motoneurons and premotor neurons during various oropharyngeal behaviors. Respir. Physiol. Neurobiol. 147 (2005) 159-176
4. Marcus J.N., Aschkenasi C.J., Lee C.E., Chemelli R.M., Saper C.B., Yanagisawa M., and Elmquist J.K. Differential expression of orexin receptors 1 and 2 in the rat brain. J. Comp. Neurol. 435 (2001) 6-25
5. Mörschel M., Kron M., Gestreau C., and Dutschmann M. Orexin B evoked modulation of respiratory activity in rat. FASEB J. 19 (2005) A653-A1653
6. Nakamura A., Zhang W., Yanagisawa M., Fukuda Y., and Kuwaki T. Vigilance state-dependent attenuation of hypercapnic chemoreflex and exaggerated sleep apnea in orexin knockout mice. J. Appl. Physiol. 102 (2007) 241-248
7. Peyron C., Tighe D.K., van den Pol A.N., de Lecea L., Heller H.C., Sutcliffe J.G., and Kilduff T.S. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J. Neurosci. 18 (1998) 9996-10015
8. Sakurai S., Nishijima T., Takahashi S., Yamauchi K., Arihara Z., and Takahashi K. Clinical significance of daytime plasma orexin-A-like immunoreactivity concentrations in patients with obstructive sleep apnea hypopnea syndrome. Respiration 71 (2004) 380-384
9. Willie J.T., Chemelli R.M., Sinton C.M., and Yanagisawa M. To eat or to sleep? Orexin in the regulation of feeding and wakefulness. Annu. Rev. Neurosci. 24 (2001) 429-458
10. Young J.K., Wu M., Manaye K.F., Kc P., Allard J.S., Mack S.O., and Haxhiu M.A. Orexin stimulates breathing via medullary and spinal pathways. J. Appl. Physiol. 98 (2005) 1387-1395