Y-27632 augments the isoflurane-induced relaxation of bronchial smooth muscle in rats

Journal of Smooth Muscle Research

Volumn 44, Issue 6, 2008, Pages 189-193

  Hanazaki, Motohiko ^a   Chiba, Yoshihiko ^b   Yokoyama, Masataka ^a   Morita, Kiyoshi ^a   Kohjitani, Atsushi ^c   Sakai, Hiroyasu ^b   Misawa, Miwa ^b  

^a OKAYAMA UNIVERSITY   (Japan)

^b HOSHI UNIVERSITY   (Japan)

^c KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

Acetylcholine; Bronchial smooth muscle; Isoflurane; Rat; Y 27632

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ACETYLCHOLINE; AMIDE; ENZYME INHIBITOR; INHALATION ANESTHETIC AGENT; ISOFLURANE; PYRIDINE DERIVATIVE; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL; ARTICLE; ASTHMA; BRONCHUS; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG COMBINATION; DRUG EFFECT; MALE; METABOLISM; MUSCLE RELAXATION; PATHOPHYSIOLOGY; PHYSIOLOGY; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE; WISTAR RAT;

ACETYLCHOLINE; AMIDES; ANESTHETICS, INHALATION; ANIMALS; ASTHMA; BRONCHI; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; ENZYME INHIBITORS; ISOFLURANE; MALE; MUSCLE RELAXATION; MUSCLE, SMOOTH; PYRIDINES; RATS; RATS, WISTAR; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION;

EID: 65449117297     PISSN: 09168737     EISSN: 18848796     Source Type: Journal    
DOI: 10.1540/jsmr.44.189     Document Type: Article

References (18)

1. 2+ sensitivity during muscarinic receptor stimulation of airway smooth muscle. Am. J. Physiol. 271: L719-L725.
2. 2+ availability involved in antigen-induced airway hyperresponsiveness in rats. Eur. J. Pharmacol. 278: 79-82.
3. Chiba, Y., Takada, Y., Miyamoto, S., Mitsui-Saito, M., Karaki, H. and Misawa, M. (1999). Augmented acetylcholine-induced, Rho-mediated Ca2+ sensitization of bronchial smooth muscle contraction in antigen-induced airway hyperresponsive rats. Br. J. Pharmacol. 127: 597-600.
4. Chiba, Y., Takeyama, H., Sakai, H. and Misawa, M. (2001). Effects of Y-27632 on acetylcholine-induced contraction of intact and permeabilized intrapulmonary bronchial smooth muscles in rats. Eur. J. Pharmacol. 427: 77-82.
5. Chiba, Y., Ueno, A., Shinozaki, K., Takeyama, H., Nakazawa, S., Sakai, H. and Misawa, M. (2005). Involvement of RhoA-mediated Ca2+ sensitization in antigen-induced bronchial smooth muscle hyperresponsiveness in mice. Respir. Res. 6: Art. No. 4.
6. Gosens, R., Schaafsma, D., Nelemans, S.A. and Halayko, A.J. (2006). Rho-kinase as a drug target for the treatment of airway hyperresponsiveness in asthma. Mini Rev. Med. Chem. 6: 339-348.
7. Hanazaki, M., Jones, K.A., Perkins, W.J. and Warner, D.O. (2001). Halothane increases smooth muscle protein phosphatase in airway smooth muscle. Anesthesiology 94: 129-136.
8. 2+ sensitivity in canine tracheal smooth muscle. Anesthesiology 92: 133-139.
9. Hanazaki, M., Yokoyama, M., Morita, K., Kohjitani, A., Sakai, H., Chiba, Y. and Misawa, M. (2008). Rhokinase (ROCK) inhibitors augment the inhibitory effect of propofol on rat bronchial smooth muscle contraction. Anesth. Analg. 106: 1765-1771.
10. 2+ sensitization and mobilization by MCh in tracheal smooth muscle. Am. J. Physiol. Lung Cell. Mol. Physiol. 280: L1218-L1224.
11. Kai, T., Bremerich, D.H., Jones, K.A. and Warner, D.O. (1998). Drug-specific effects of volatile anesthetics on Ca2+ sensitization in airway smooth muscle. Anesth. Analg. 87: 425-429.
12. Maltais, F., Sovilj, M., Goldberg, P. and Gottfried, S.B. (1994). Respiratory mechanics in status asthmaticus. Effects of inhalational anesthesia. Chest 106: 1401-1406.
13. Martin, J.G., Duguet, A. and Eidelman, D.H. (2000). The contribution of airway smooth muscle to airway narrowing and airway hyperresponsiveness in disease. Eur. Respir. J. 16: 349-354.
14. Mercier, F.J., Naline, E., Bardou, M., Georges, O., Denjean, A., Benhamou, D. and Advenier, C. (2002). Relaxation of proximal and distal isolated human bronchi by halothane, isoflurane and desflurane. Eur. Respir. J. 20: 286-292.
15. Seow, C.Y., Schellenberg, R.R. and Pare, P.D. (1998). Structural and functional changes in the airway smooth muscle of asthmatic subjects. Am. J. Respir. Crit. Care Med. 158: S179-S186.
16. Uehata, M., Ishizaki, T., Satoh, H., Ono, T., Kawahara, T., Morishita, T., Tamakawa, H., Yamagami, K., Inui, J., Maekawa, M. and Narumiya, S. (1997). Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 389: 990-994.
17. 2+ concentration. Anesth. Analg. 77: 67-72.
18. 2+ sensitization. Am. J. Respir. Cell Mol. Biol. 20: 1190-1200.