A novel diketopiperazine improves functional recovery given after the onset of 6-OHDA-induced motor deficit in rats

British Journal of Pharmacology

Volumn 156, Issue 4, 2009, Pages 662-672

  Krishnamurthi, R V M ^a   Mathai, S ^a   Kim, A H ^a   Zhang, R ^a   Guan, J ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Diketopiperazine; Forelimb akinesia; Functional recovery; Parkinson's disease; Rats and 6 OHDA lesion

Indexed keywords

CYCLOGLYCYL 2 PROLINE; DOPAMINE; NNZ 2591; OXIDOPAMINE; PIPERAZINEDIONE; UNCLASSIFIED DRUG; CYCLO L GLYCYL L 2 ALLYLPROLINE; CYCLO-L-GLYCYL-L-2-ALLYLPROLINE; CYCLOPEPTIDE; NEUROPROTECTIVE AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR CHANGE; CONTROLLED STUDY; CONVALESCENCE; CORPUS STRIATUM; DISEASE MODEL; DRUG BLOOD LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG EFFECT; DRUG EFFICACY; DRUG PENETRATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOHISTOCHEMISTRY; MALE; MASS SPECTROMETRY; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; NEUROBLAST; NEUROCHEMISTRY; NEUROPROTECTION; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; SUBVENTRICULAR ZONE; ANIMAL; ANIMAL BEHAVIOR; METABOLISM; PARKINSONISM; PATHOPHYSIOLOGY; SUBSTANTIA NIGRA; WISTAR RAT;

ANIMALS; BEHAVIOR, ANIMAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CORPUS STRIATUM; DIKETOPIPERAZINES; IMMUNOHISTOCHEMISTRY; MOVEMENT DISORDERS; NEUROPROTECTIVE AGENTS; OXIDOPAMINE; PARKINSONIAN DISORDERS; PEPTIDES, CYCLIC; RATS; RATS, WISTAR; RECOVERY OF FUNCTION; SUBSTANTIA NIGRA;

EID: 65349162774     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2008.00064.x     Document Type: Article

References (34)

1. Aoi M, Date I, Tomita S, Ohmoto T (2000). The effect of intrastriatal single injection of GDNF on the nigrostriatal dopaminergic system in hemiparkinsonian rats: behavioural and histological studies using two different dosages. Neurosci Res Suppl 36 : 319 325.
2. Baker SA, Baker KA, Hagg T (2004). Dopaminergic nigrostriatal projections regulate neural precursor proliferation in the adult mouse subventricular zone. Eur J Neurosci 20 : 575 579.
3. Bezard E, Gross CE (1998). Compensatory mechanisms in experimental and human parkinsonism: towards a dynamic approach. Prog Neurobiol 55 : 93 116.
4. Blandini F, Nappi G, Tassorelli C, Martignoni E (2000). Functional changes of the basal ganglia circuitry in Parkinson's disease. Prog Neurobiol 62 : 63 88.
5. Blandini F, Levandis G, Bazzini E, Nappi G, Armentero MT (2007). Time-course of nigrostriatal damage, basal ganglia metabolic changes and behavioural alterations following intrastriatal injection of 6-hydroxydopamine in the rat: new clues from an old model. Eur J Neurosci 25 : 397 405.
6. Borta A, Hoglinger GU (2007). Dopamine and adult neurogenesis. J Neurochem 100 : 587 595.
7. Faden AI, Knoblach SM, Cernak I, Fan L, Vink R, Araldi GL et al. (2003). Novel diketopiperazine enhances motor and cognitive recovery after traumatic brain injury in rats and shows neuroprotection in vitro and in vivo. J Cereb Blood Flow Metab 23 : 342 354.
8. Geraerts M, Krylyshkina O, Debyser Z, Baekelandt V (2007). Concise review: therapeutic strategies for Parkinson disease based on the modulation of adult neurogenesis. Stem Cells 25 : 263 270.
9. Guan J, Williams C, Gunning M, Mallard C, Gluckman P (1993). The effects of IGF-1 treatment after hypoxic-ischemic brain injury in adult rats. J Cereb Blood Flow Metab 13 : 609 616.
10. Guan J, Krishnamurthi R, Waldvogel HJ, Faull RL, Clark R, Gluckman P (2000). N-terminal tripeptide of IGF-1 (GPE) prevents the loss of TH positive neurons after 6-OHDA induced nigral lesion in rats. Brain Res 859 : 286 292.
11. Guan J, Bennet L, Gluckman PD, Gunn AJ (2003). Insulin-like growth factor-1 and post-ischemic brain injury. Prog Neurobiol 70 : 443 462.
12. Guan J, Thomas GB, Lin H, Mathai S, Bachelor DC, George S et al. (2004). Neuroprotective effects of the N-terminal tripeptide of insulin-like growth factor-1, glycine-proline-glutamate (GPE) following intravenous infusion in hypoxic-ischemic adult rats. Neuropharmacology 47 : 892 903.
13. Guan J, Mathai S, Harris AP, Wen JY, Zhang R, Brimble MA et al. (2007). Peripheral administration of a novel diketopiperazine, NNZ-2591, prevents brain injury and improves somatosensory-motor funcion following hypoxia-ischemia in adult rats. Neuropharmacology 53 : 749 762.
14. Hanrott K, Gudmunsen L, O'Neill MJ, Wonnacott S (2006). 6-hydroxydopamine-induced apoptosis is mediated via extracellular auto-oxidation and caspase 3-dependent activation of protein kinase Cdelta. J Biol Chem 281 : 5373 5382.
15. Hodaie M, Neimat JS, Lozano AM (2007). The dopaminergic nigrostriatal system and Parkinson's disease: molecular events in development, disease, and cell death, and new therapeutic strategies. Neurosurgery 60 : 17 28.
16. Ikegami H, Prasad C (1990). Neuropeptide-dopamine interactions. V. Cyclo(His-Pro) regulation of striatal dopamine transporter complex. Peptides 11 : 145 148.
17. Kase H, Aoyama S, Ichimura M, Ikeda K, Ishii A, Kanda T et al. (2003). Progress in pursuit of therapeutic A2A antagonists: the adenosine A2A receptor selective antagonist KW6002: research and development toward a novel nondopaminergic therapy for Parkinson's disease. Neurology 61 : S97 S100.
18. Kirik D, Rosenblad C, Bjorklund A (1998). Characterization of behavioural and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat. Exp Neurol 152 : 259 277.
19. Kirik D, Georgievska B, Rosenblad C, Bjorklund A (2001). Delayed infusion of GDNF promotes recovery of motor function in the partial lesion model of Parkinson's disease. Eur J Neurosci 13 : 1589 1599.
20. Krishnamurthi R, Stott S, Maingay M, Faull RL, McCarthy D, Gluckman P et al. (2004). N-terminal tripeptide of IGF-1 improves functional deficits after 6-OHDA lesion in rats. Neuroreport 15 : 1601 1604.
21. Mizuma H, Shimizu I, Hilton C, Prasad C (1994). Does cyclo(His-Pro) act like amphetamine? Life Sci 54 : 1625 1633.
22. Mohapel P, Frielingsdorf H, Haggblad J, Zachrisson O, Brundin P (2005). Platelet-derived growth factor (PDGF-BB) and brain-derived neurotrophic factor (BDNF) induce striatal neurogenesis in adult rats with 6-hydroxydopamine lesions. Neuroscience 132 : 767 776.
23. Okano H, Sakaguchi M, Ohki K, Suzuki N, Sawamoto K (2007). Regeneration of the central nervous system using endogenous repair mechanisms. J Neurochem 102 : 1459 1465.
24. Olsson M, Nikkhah G, Bentlage C, Bjorklund A (1995). Forelimb akinesia in the rat Parkinson model: differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test. J Neurosci 15 (2 3863 3875.
25. Partridge WM (2002). Drug and gene delivery to the brain: the vascular route. Neuron 36 : 555 558.
26. Paxinos G, Watson C (1982). The Rat Brain in Stereotaxic Coordinates. Academic Press : New York.
27. Pinna A, Pontis S, Borsini F, Morelli M (2007). Adenosine A2A receptor antagonists improve deficits in initiation of movement and sensory motor integration in the unilateral 6-hydroxydopamine rat model of Parkinson's disease. Synapse 61 : 606 614.
28. Samonina G, Ashmarin I, Lyapina L (2002). Glyproline peptide family: review on bioactivity and possible origins. Pathophysiology 8 : 229 234.
29. Schwarting RK, Huston JP (1996). The unilateral 6-hydroxydopamine lesion model in behavioural brain research. Analysis of functional deficits, recovery and treatments. Prog Neurobiol 50 : 275 331.
30. Svedin P, Guan J, Mathai S, Zhang R, Wang X, Gustavsson M et al. (2007). Delayed peripheral administration of a GPE analogue induces astrogliosis and angiogenesis and reduces inflammation and brain injury following hypoxia-ischemia in the neonatal rat. Dev Neurosci 29 : 393 402.
31. Urakawa S, Hida H, Masuda T, Misumi S, Kim TS, Nishino H (2007). Environmental enrichment brings a beneficial effect on beam walking and enhances the migration of doublecortin-positive cells following striatal lesions in rats. Neuroscience 144 : 920 933.
32. Whone AL, Moore RY, Piccini PP, Brooks DJ (2003). Plasticity of the nigropallidal pathway in Parkinson's disease. Ann Neurol 53 : 206 213.
33. Xu XH, Zheng XX, Zhou Q, Li H (2007). Inhibition of excitatory amino acid efflux contributes to protective effects of puerarin against cerebral ischemia in rats. Biomed Environ Sci 20 : 336 342.
34. Zhao M, Momma S, Delfani K, Carlen M, Cassidy RM, Johansson CB et al. (2003). Evidence for neurogenesis in the adult mammalian substantia nigra. Proc Natl Acad Sci USA 100 : 7925 7930.