A bioavailability/bioequivalence and pharmacokinetic study of two oral doses of torasemide (5 and 10 mg): Prolonged-release versus the conventional formulation

Clinical and Experimental Pharmacology and Physiology

Volumn 36, Issue 5-6, 2009, Pages 469-477

  Barbanoj, M J ^a,b   Ballester, M R ^a,b   Antonijoan, R M ^a   Puntes, M ^a   Gropper, S ^c   Santos, B ^c   Albet, C ^c   Guglietta, A ^c  

^a HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c Ferrer Internacional SA   (Spain)

Author keywords

Absorption; Bioavailability; Controlled release preparation; Efficiency; Healthy volunteers; Pharmacokinetics; Torasemide

Indexed keywords

TORASEMIDE;

ADULT; AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; BLOOD LEVEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIURESIS; DIURETIC ACTIVITY; DRUG BIOAVAILABILITY; DRUG DOSAGE FORM COMPARISON; DRUG EXCRETION; DRUG FORMULATION; ELECTROLYTE URINE LEVEL; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; KIDNEY CONCENTRATING CAPACITY; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PHARMACODYNAMICS; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; TIME TO MAXIMUM PLASMA CONCENTRATION; URINE VOLUME;

ADMINISTRATION, ORAL; ADULT; BIOLOGICAL AVAILABILITY; CROSS-OVER STUDIES; DELAYED-ACTION PREPARATIONS; DIURETICS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MALE; SINGLE-BLIND METHOD; SULFONAMIDES; THERAPEUTIC EQUIVALENCY; YOUNG ADULT;

EID: 65349145755     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2008.05089.x     Document Type: Article

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