메뉴 건너뛰기




Volumn 36, Issue 5, 1999, Pages 375-389

The efficiency concept in pharmacodynamics

Author keywords

[No Author keywords available]

Indexed keywords

15 DEOXYSPERGUALIN; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; BLOOD CLOTTING FACTOR 8; BUMETANIDE; CHELATING AGENT; CHLOROTHIAZIDE; CIMETIDINE; FUROSEMIDE; LOOP DIURETIC AGENT; METHYLPREDNISOLONE; OPIATE; TORASEMIDE;

EID: 0033015970     PISSN: 03125963     EISSN: None     Source Type: Journal    
DOI: 10.2165/00003088-199936050-00005     Document Type: Review
Times cited : (21)

References (58)
  • 1
    • 0019785890 scopus 로고
    • Understanding the dose-effect relationship: Clinical application of pharmacokinetic-pharmacodynamic models
    • 1. Holford NHG, Sheiner LB. Understanding the dose-effect relationship: clinical application of pharmacokinetic-pharmacodynamic models. Clin Pharmacokinet 1981; 6: 429-53
    • (1981) Clin Pharmacokinet , vol.6 , pp. 429-453
    • Holford, N.H.G.1    Sheiner, L.B.2
  • 2
    • 0014318562 scopus 로고
    • Kinetics of pharmacological response I: Proposed relationships between response and drug concentration in the intact animal and man
    • 2. Wagner JG. Kinetics of pharmacological response I: proposed relationships between response and drug concentration in the intact animal and man. J Theor Biol 1968; 20: 171-201
    • (1968) J Theor Biol , vol.20 , pp. 171-201
    • Wagner, J.G.1
  • 3
    • 0019969409 scopus 로고
    • The time course of delivery of furosemide into urine: An independent determinant of overall response
    • 3. Kaojarern S, Day B, Brater DC. The time course of delivery of furosemide into urine: an independent determinant of overall response. Kidney Int 1982; 22: 69-74
    • (1982) Kidney Int , vol.22 , pp. 69-74
    • Kaojarern, S.1    Day, B.2    Brater, D.C.3
  • 4
    • 0017225050 scopus 로고
    • Tubular chloride transport and the mode of action of some diuretics
    • 4. Burg MB. Tubular chloride transport and the mode of action of some diuretics. Kidney Int 1976; 9: 189-97
    • (1976) Kidney Int , vol.9 , pp. 189-197
    • Burg, M.B.1
  • 6
    • 0018886475 scopus 로고
    • Renal tubular secretion and effects of furosemide
    • 6. Odlind B, Beermann B. Renal tubular secretion and effects of furosemide. Clin Pharmacol Ther 1980; 27: 784-90
    • (1980) Clin Pharmacol Ther , vol.27 , pp. 784-790
    • Odlind, B.1    Beermann, B.2
  • 7
    • 0016737501 scopus 로고
    • Effect of dosage regimen on natriuretic response to furosemide
    • 7. Wilson TW, Falk KJ, Labelle JL, et al. Effect of dosage regimen on natriuretic response to furosemide. Clin Pharmacol Ther 1975; 18: 165-9
    • (1975) Clin Pharmacol Ther , vol.18 , pp. 165-169
    • Wilson, T.W.1    Falk, K.J.2    Labelle, J.L.3
  • 8
    • 0020263708 scopus 로고
    • Kinetics and dynamics of furosemide and slow-acting furosemide
    • 8. Beermann B. Kinetics and dynamics of furosemide and slow-acting furosemide. Clin Pharmacol Ther 1982; 32: 584-91
    • (1982) Clin Pharmacol Ther , vol.32 , pp. 584-591
    • Beermann, B.1
  • 9
    • 0021954756 scopus 로고
    • Acute tolerance to furosemide diuresis in humans: Pharmacokinetic-pharmacodynamic modeling
    • 9. Hammarlund MM, Odlind B, Paalzow LK. Acute tolerance to furosemide diuresis in humans: pharmacokinetic-pharmacodynamic modeling. J Pharmacol Exp Ther 1985; 233: 447-53
    • (1985) J Pharmacol Exp Ther , vol.233 , pp. 447-453
    • Hammarlund, M.M.1    Odlind, B.2    Paalzow, L.K.3
  • 10
    • 0023701453 scopus 로고
    • Increased nonrenal clearance and increased diuretic efficiency of furosemide in cystic fibrosis
    • 10. Alván G, Beermann B, Hjelte L, et al. Increased nonrenal clearance and increased diuretic efficiency of furosemide in cystic fibrosis. Clin Pharmacol Ther 1988; 44: 436-41
    • (1988) Clin Pharmacol Ther , vol.44 , pp. 436-441
    • Alván, G.1    Beermann, B.2    Hjelte, L.3
  • 11
    • 0025911452 scopus 로고
    • Diuretic effect and disposition of furosemide in cystic fibrosis
    • 11. Prandota J, Smith IJ, Hilman BC, et al. Diuretic effect and disposition of furosemide in cystic fibrosis. Eur J Clin Pharmacol 1991; 40: 333-41
    • (1991) Eur J Clin Pharmacol , vol.40 , pp. 333-341
    • Prandota, J.1    Smith, I.J.2    Hilman, B.C.3
  • 12
    • 0017652767 scopus 로고
    • Effects of probenecid on furosemide kinetics and natriuresis in man
    • 12. Honari J, Blair AD, Cutler RE. Effects of probenecid on furosemide kinetics and natriuresis in man. Clin Pharmacol Ther 1977; 22: 395-401
    • (1977) Clin Pharmacol Ther , vol.22 , pp. 395-401
    • Honari, J.1    Blair, A.D.2    Cutler, R.E.3
  • 13
    • 0017757983 scopus 로고
    • Influence of probenecid and spironolactone on furosemide kinetics and dynamics in man
    • 13. Homeida M, Roberts C, Branch RA. Influence of probenecid and spironolactone on furosemide kinetics and dynamics in man. Clin Pharmacol Ther 1977; 22: 402-9
    • (1977) Clin Pharmacol Ther , vol.22 , pp. 402-409
    • Homeida, M.1    Roberts, C.2    Branch, R.A.3
  • 14
    • 0018725963 scopus 로고
    • Pharmacodynamic analysis of the furosemide-probenecid interaction in man
    • 14. Chennavasin P, Seiwell R, Brater DC, et al. Pharmacodynamic analysis of the furosemide-probenecid interaction in man. Kidney Int 1979; 16: 187-95
    • (1979) Kidney Int , vol.16 , pp. 187-195
    • Chennavasin, P.1    Seiwell, R.2    Brater, D.C.3
  • 16
    • 0030451776 scopus 로고    scopus 로고
    • Theophylline improves measurements of respiratory muscle efficiency
    • 16. Sherman MS. Theophylline improves measurements of respiratory muscle efficiency. Chest 1996; 110: 1437-42
    • (1996) Chest , vol.110 , pp. 1437-1442
    • Sherman, M.S.1
  • 17
    • 0025268382 scopus 로고
    • Diuretic effect and diuretic efficiency after intravenous dosage of frusemide
    • 17. Alván G, Helleday L, Lindholm A, et al. Diuretic effect and diuretic efficiency after intravenous dosage of frusemide. Br J Clin Pharmacol 1990; 29: 215-9
    • (1990) Br J Clin Pharmacol , vol.29 , pp. 215-219
    • Alván, G.1    Helleday, L.2    Lindholm, A.3
  • 18
    • 0002025584 scopus 로고
    • Parametric models of the time course of drug action
    • van Boxtel CJ, Holford NHG, Danhof M, editors. Amsterdam: Elsevier
    • 18. Holford NHG. Parametric models of the time course of drug action. In: van Boxtel CJ, Holford NHG, Danhof M, editors. The in vivo study of drug action. Amsterdam: Elsevier; 1992: 61-70
    • (1992) The in Vivo Study of Drug Action , pp. 61-70
    • Holford, N.H.G.1
  • 19
    • 0026695456 scopus 로고
    • Discrepancy between bioavailability as estimated from urinary recovery of frusemide and total diuretic effect
    • 19. Alván G, Paintaud G, Eckernäs S-A, et al. Discrepancy between bioavailability as estimated from urinary recovery of frusemide and total diuretic effect. Br J Clin Pharmacol 1992; 34: 47-52
    • (1992) Br J Clin Pharmacol , vol.34 , pp. 47-52
    • Alván, G.1    Paintaud, G.2    Eckernäs, S.-A.3
  • 20
    • 0028912982 scopus 로고
    • The influence of food intake on the effect of two controlled release formulations of furosemide
    • 20. Paintaud G, Alván G, Eckernäs S-A, et al. The influence of food intake on the effect of two controlled release formulations of furosemide. Biopharm Drug Dispos 1995; 16: 221-32
    • (1995) Biopharm Drug Dispos , vol.16 , pp. 221-232
    • Paintaud, G.1    Alván, G.2    Eckernäs, S.-A.3
  • 21
    • 0026598062 scopus 로고
    • Diuretic efficiency of furosemide during continuous administration versus bolus injection in healthy volunteers
    • 21. van Meyel JJ, Smits P, Russel FG, et al. Diuretic efficiency of furosemide during continuous administration versus bolus injection in healthy volunteers. Clin Pharmacol Ther 1992; 51: 440-4
    • (1992) Clin Pharmacol Ther , vol.51 , pp. 440-444
    • Van Meyel, J.J.1    Smits, P.2    Russel, F.G.3
  • 22
    • 0025830945 scopus 로고
    • Loop diuretics for chronic renal insufficiency: A continuous infusion is more efficacious than bolus therapy
    • 22. Rudy DW, Voelker JR, Greene PK, et al. Loop diuretics for chronic renal insufficiency: a continuous infusion is more efficacious than bolus therapy. Ann Intern Med 1991; 115: 360-6
    • (1991) Ann Intern Med , vol.115 , pp. 360-366
    • Rudy, D.W.1    Voelker, J.R.2    Greene, P.K.3
  • 23
    • 0030868982 scopus 로고    scopus 로고
    • Role of duration of diuretic effect in preventing sodium retention
    • 23. Ferguson JA, Sundblad KJ, Becker PK, et al. Role of duration of diuretic effect in preventing sodium retention. Clin Pharmacol Ther 1997; 62: 203-8
    • (1997) Clin Pharmacol Ther , vol.62 , pp. 203-208
    • Ferguson, J.A.1    Sundblad, K.J.2    Becker, P.K.3
  • 24
    • 0021018418 scopus 로고
    • Diuresis with continuous infusion of furosemide after cardiac surgery
    • 24. Copeland JG, Campbell DW, Plachetka JR. Diuresis with continuous infusion of furosemide after cardiac surgery. Am J Surg 1983; 146: 796-9
    • (1983) Am J Surg , vol.146 , pp. 796-799
    • Copeland, J.G.1    Campbell, D.W.2    Plachetka, J.R.3
  • 25
    • 0026671225 scopus 로고
    • Intermittent administration of furosemide vs continuous infusion preceded by a loading dose for congestive heart failure
    • 25. Lahav M, Regev A, Ra'anani P, et al. Intermittent administration of furosemide vs continuous infusion preceded by a loading dose for congestive heart failure. Chest 1992; 102: 725-31
    • (1992) Chest , vol.102 , pp. 725-731
    • Lahav, M.1    Regev, A.2    Ra'anani, P.3
  • 26
    • 0030221335 scopus 로고    scopus 로고
    • Diuretic efficacy of high dose furosemide in severe heart failure: Bolus injection versus continuous infusion
    • 26. Dormans TPJ, van Meyel JJM, Gerlag PGG, et al. Diuretic efficacy of high dose furosemide in severe heart failure: bolus injection versus continuous infusion. J Am Coll Cardiol 1996; 28: 376-82
    • (1996) J Am Coll Cardiol , vol.28 , pp. 376-382
    • Dormans, T.P.J.1    Van Meyel, J.J.M.2    Gerlag, P.G.G.3
  • 27
    • 0031456487 scopus 로고    scopus 로고
    • Protocol-guided diuretic management comparison of furosemide by continuous infusion and intermittent bolus
    • 27. Schuller D, Lynch JP, Fine D. Protocol-guided diuretic management comparison of furosemide by continuous infusion and intermittent bolus. Crit Care Med 1997; 25: 1969-75
    • (1997) Crit Care Med , vol.25 , pp. 1969-1975
    • Schuller, D.1    Lynch, J.P.2    Fine, D.3
  • 28
    • 0030852034 scopus 로고    scopus 로고
    • Effect of bolus injection versus continuous infusion of furosemide on diuresis and neurohormonal activation in patients with severe congestive heart failure
    • 28. Aaser E, Gullestad L, Tølløfsrud S, et al. Effect of bolus injection versus continuous infusion of furosemide on diuresis and neurohormonal activation in patients with severe congestive heart failure. Scand J Clin Lab Invest 1997; 57: 361-7
    • (1997) Scand J Clin Lab Invest , vol.57 , pp. 361-367
    • Aaser, E.1    Gullestad, L.2    Tølløfsrud, S.3
  • 29
    • 0031975662 scopus 로고    scopus 로고
    • Comparison of 6-hour infusion versus bolus furosemide in premature infants
    • 29. Reiter PD, Makhlouf R, Stiles AD. Comparison of 6-hour infusion versus bolus furosemide in premature infants. Pharmacotherapy 1998; 18: 63-8
    • (1998) Pharmacotherapy , vol.18 , pp. 63-68
    • Reiter, P.D.1    Makhlouf, R.2    Stiles, A.D.3
  • 30
    • 0029984505 scopus 로고    scopus 로고
    • Pharmacodynamics of torsemide administered as an intravenous injection and as a continuous infusion to patients with congestive heart failure
    • 30. Kramer WG, Smith WB, Ferguson J, et al. Pharmacodynamics of torsemide administered as an intravenous injection and as a continuous infusion to patients with congestive heart failure. J Clin Pharmacol 1996; 36: 265-70
    • (1996) J Clin Pharmacol , vol.36 , pp. 265-270
    • Kramer, W.G.1    Smith, W.B.2    Ferguson, J.3
  • 31
    • 0031029101 scopus 로고    scopus 로고
    • Severe musculoskeletal symptoms during continuous infusion of bumetanide
    • 31. Howard PA, Dunn MI. Severe musculoskeletal symptoms during continuous infusion of bumetanide. Chest 1997; 111: 359-64
    • (1997) Chest , vol.111 , pp. 359-364
    • Howard, P.A.1    Dunn, M.I.2
  • 32
    • 0030919195 scopus 로고    scopus 로고
    • Natriuretic efficiency of frusemide as a consequence of drug input rate
    • 32. Wakelkamp M, Alván G, Paintaud G. Natriuretic efficiency of frusemide as a consequence of drug input rate. Br J Clin Pharmacol 1997; 43: 481-91
    • (1997) Br J Clin Pharmacol , vol.43 , pp. 481-491
    • Wakelkamp, M.1    Alván, G.2    Paintaud, G.3
  • 33
    • 0026014532 scopus 로고
    • The influence of co-administered organic acids on the kinetics and dynamics of frusemide
    • 33. Sommers DK, Meyer EC, Moncrieff J. The influence of co-administered organic acids on the kinetics and dynamics of frusemide. Br J Clin Pharmacol 1991; 32: 489-93
    • (1991) Br J Clin Pharmacol , vol.32 , pp. 489-493
    • Sommers, D.K.1    Meyer, E.C.2    Moncrieff, J.3
  • 34
    • 0027769745 scopus 로고
    • Comparison of four basic models of indirect pharmacodynamic responses
    • 34. Dayneka NL, Garg V, Jusko WJ. Comparison of four basic models of indirect pharmacodynamic responses. J Pharmacokinet Biopharm 1993; 21: 457-78
    • (1993) J Pharmacokinet Biopharm , vol.21 , pp. 457-478
    • Dayneka, N.L.1    Garg, V.2    Jusko, W.J.3
  • 35
    • 0033023485 scopus 로고    scopus 로고
    • Interchangeability and predictive performance of empirical tolerance models
    • Feb
    • 35. Gårdmark M, Brynne L, Hammarlund-Udenaes M, et al. Interchangeability and predictive performance of empirical tolerance models. Clin Pharmacokinet 1999 Feb; 36 (2): 145-67
    • (1999) Clin Pharmacokinet , vol.36 , Issue.2 , pp. 145-167
    • Gårdmark, M.1    Brynne, L.2    Hammarlund-Udenaes, M.3
  • 36
    • 0031730651 scopus 로고    scopus 로고
    • The influence of drug input rate on the development of tolerance to frusemide
    • 36. Wakelkamp M, Alván G, Scheinin H, et al. The influence of drug input rate on the development of tolerance to frusemide. Br J Clin Pharmacol 1998; 46: 479-87
    • (1998) Br J Clin Pharmacol , vol.46 , pp. 479-487
    • Wakelkamp, M.1    Alván, G.2    Scheinin, H.3
  • 37
    • 0029758870 scopus 로고    scopus 로고
    • Pharmacodynamic modeling of furosemide tolerance after multiple intravenous administration
    • 37. Wakelkamp M, Alván G, Gabrielsson J, et al. Pharmacodynamic modeling of furosemide tolerance after multiple intravenous administration. Clin Pharmacol Ther 1996; 60: 75-88
    • (1996) Clin Pharmacol Ther , vol.60 , pp. 75-88
    • Wakelkamp, M.1    Alván, G.2    Gabrielsson, J.3
  • 38
    • 0027955093 scopus 로고
    • Urinary iron excretion depends on the mode of administration of the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one in patients with homozygous β-thalassemia
    • 38. Fassos FF, Klein J, Fernandes D, et al. Urinary iron excretion depends on the mode of administration of the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one in patients with homozygous β-thalassemia. Clin Pharmacol Ther 1994; 55: 70-5
    • (1994) Clin Pharmacol Ther , vol.55 , pp. 70-75
    • Fassos, F.F.1    Klein, J.2    Fernandes, D.3
  • 39
    • 0025873389 scopus 로고
    • Pharmacokinetic optimisation of anti-cancer therapy
    • 39. Liliemark J, Peterson C. Pharmacokinetic optimisation of anti-cancer therapy. Clin Pharmacokinet 1991; 21: 213-31
    • (1991) Clin Pharmacokinet , vol.21 , pp. 213-231
    • Liliemark, J.1    Peterson, C.2
  • 40
    • 0030892991 scopus 로고    scopus 로고
    • Pharmacokinetic optimisation of cancer chemotherapy
    • 40. Masson E, Zamboni WC. Pharmacokinetic optimisation of cancer chemotherapy. Clin Pharmacokinet 1997; 32: 324-43
    • (1997) Clin Pharmacokinet , vol.32 , pp. 324-343
    • Masson, E.1    Zamboni, W.C.2
  • 41
    • 0024417601 scopus 로고
    • A randomized trial to evaluate the effect of schedule on the activity of etoposide in small-cell lung cancer
    • 41. Slevin ML, Clark PI, Joel SP, et al. A randomized trial to evaluate the effect of schedule on the activity of etoposide in small-cell lung cancer. J Clin Oncol 1989; 7: 1333-40
    • (1989) J Clin Oncol , vol.7 , pp. 1333-1340
    • Slevin, M.L.1    Clark, P.I.2    Joel, S.P.3
  • 42
    • 0029802508 scopus 로고    scopus 로고
    • Curative chemotherapy for acute myeloid leukemia: The development of high-dose ara-c from the laboratory to bedside
    • 42. Capizzi RL. Curative chemotherapy for acute myeloid leukemia: the development of high-dose ara-C from the laboratory to bedside. Invest New Drugs 1996; 14: 249-56
    • (1996) Invest New Drugs , vol.14 , pp. 249-256
    • Capizzi, R.L.1
  • 43
    • 0025788960 scopus 로고
    • Treatment schedule dependency of antitumor effect of deoxyspergualin
    • 43. Nishikawa K, Shibasaki C, Takahashi KT, et al. Treatment schedule dependency of antitumor effect of deoxyspergualin. Jpn J Antibiot 1991; 44: 917-25
    • (1991) Jpn J Antibiot , vol.44 , pp. 917-925
    • Nishikawa, K.1    Shibasaki, C.2    Takahashi, K.T.3
  • 44
    • 0021828667 scopus 로고
    • Pharmacokinetics of 1-beta-D-arabinofuranosylcytosine 5′-triphosphate in leukemic cells after intravenous and subcutaneous administration of 1-beta-D-arabinofuranosylcytosine
    • 44. Liliemark JO, Paul CY, Gahrton CG, et al. Pharmacokinetics of 1-beta-D-arabinofuranosylcytosine 5′-triphosphate in leukemic cells after intravenous and subcutaneous administration of 1-beta-D-arabinofuranosylcytosine. Cancer Res 1985; 45: 2373-5
    • (1985) Cancer Res , vol.45 , pp. 2373-2375
    • Liliemark, J.O.1    Paul, C.Y.2    Gahrton, C.G.3
  • 45
    • 0024580678 scopus 로고
    • Increasing the accumulation of daunorubicin in human leukemic cells by prolonging the infusion time
    • 45. Paul C, Tidefelt U, Liliemark J, et al. Increasing the accumulation of daunorubicin in human leukemic cells by prolonging the infusion time. Leuk Res 1989; 13: 191-6
    • (1989) Leuk Res , vol.13 , pp. 191-196
    • Paul, C.1    Tidefelt, U.2    Liliemark, J.3
  • 47
    • 0020585001 scopus 로고
    • Opposing effects of apomorphine on pain in rats. Evaluation of the dose-response curve
    • 47. Paalzow G, Paalzow L. Opposing effects of apomorphine on pain in rats. Evaluation of the dose-response curve. Eur J Pharmacol 1983; 88: 27-35
    • (1983) Eur J Pharmacol , vol.88 , pp. 27-35
    • Paalzow, G.1    Paalzow, L.2
  • 48
    • 0025907775 scopus 로고
    • Electroencephalographic quantitation of opioid effect: Comparative pharmacodynamics of fentanyl and sufentanil
    • 48. Scott JC, Cooke JE, Stanski DR. Electroencephalographic quantitation of opioid effect: comparative pharmacodynamics of fentanyl and sufentanil. Anesthesiology 1991; 74: 34-42
    • (1991) Anesthesiology , vol.74 , pp. 34-42
    • Scott, J.C.1    Cooke, J.E.2    Stanski, D.R.3
  • 49
    • 0027938305 scopus 로고
    • Pharmacokinetic-pharmacodynamic modeling in drug development: Application to the investigational opioid trefentanil
    • 49. Lemmens HJM, Dyck JB, Shafer SL, et al. Pharmacokinetic-pharmacodynamic modeling in drug development: application to the investigational opioid trefentanil. Clin Pharmacol Ther 1904; 56: 261-71
    • (1904) Clin Pharmacol Ther , vol.56 , pp. 261-271
    • Lemmens, H.J.M.1    Dyck, J.B.2    Shafer, S.L.3
  • 51
    • 0026447603 scopus 로고
    • Continuous infusion of β-lactam antibiotics
    • 51. Craig WA, Ebert SC. Continuous infusion of β-lactam antibiotics. Antimicrob Agents Chemother 1992; 36: 2577-83
    • (1992) Antimicrob Agents Chemother , vol.36 , pp. 2577-2583
    • Craig, W.A.1    Ebert, S.C.2
  • 52
    • 0030793840 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic models of the antistaphylococcal effects of meropenem and cloxacillin in vitro and in experimental infection
    • 52. Matti H, Zhang L-C, van Strijen E, et al. Pharmacokinetic and pharmacodynamic models of the antistaphylococcal effects of meropenem and cloxacillin in vitro and in experimental infection. Antimicrob Agents Chemother 1997; 41: 2083-8
    • (1997) Antimicrob Agents Chemother , vol.41 , pp. 2083-2088
    • Matti, H.1    Zhang, L.-C.2    Van Strijen, E.3
  • 53
    • 0030985564 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic modeling of activity of ceftazidime during continuous and intermittent infusion
    • 53. Mouton JW, Vinks AATMM, Punt NC. Pharmacokinetic-pharmacodynamic modeling of activity of ceftazidime during continuous and intermittent infusion. Antimicrob Agents Chemother 1997; 41: 733-8
    • (1997) Antimicrob Agents Chemother , vol.41 , pp. 733-738
    • Mouton, J.W.1    Vinks, A.A.T.M.M.2    Punt, N.C.3
  • 54
    • 0027145071 scopus 로고
    • Pharmacokinetic dosing in prophylactic treatment of hemophilia A
    • 54. Carlsson M, Berntorp E, Bjorkman S, et al. Pharmacokinetic dosing in prophylactic treatment of hemophilia A. Eur J Haematol 1993; 51: 247-52
    • (1993) Eur J Haematol , vol.51 , pp. 247-252
    • Carlsson, M.1    Berntorp, E.2    Bjorkman, S.3
  • 55
    • 0032494116 scopus 로고    scopus 로고
    • Role of dosage regimen in controlling indirect pharmacodynamic responses
    • 55. Gobburu JVS, Jusko WJ. Role of dosage regimen in controlling indirect pharmacodynamic responses. Adv Drug Deliv Rev 1998; 33: 221-33
    • (1998) Adv Drug Deliv Rev , vol.33 , pp. 221-233
    • Gobburu, J.V.S.1    Jusko, W.J.2
  • 56
    • 0023145387 scopus 로고
    • Rate of increase in the plasma concentration of nifedipine as a major determinant of its hemodynamic effects in humans
    • 56. Kleinbloesem CH, van Brummelen P, Danhof M, et al. Rate of increase in the plasma concentration of nifedipine as a major determinant of its hemodynamic effects in humans. Clin Pharmacol Ther 1987; 41: 26-30
    • (1987) Clin Pharmacol Ther , vol.41 , pp. 26-30
    • Kleinbloesem, C.H.1    Van Brummelen, P.2    Danhof, M.3
  • 57
    • 85069244245 scopus 로고    scopus 로고
    • Early tolerance with immediate-release isosorbide mononitrate
    • 57. Nyberg G, Gudnason T. Early tolerance with immediate-release isosorbide mononitrate. Physiologist 1998; 41: 281
    • (1998) Physiologist , vol.41 , pp. 281
    • Nyberg, G.1    Gudnason, T.2
  • 58
    • 0025924471 scopus 로고
    • The validity of the sigmoid Emax model and efficiency concept in diuretic studies
    • 58. Alván G, Hammarlund-Udenaes MM, Odlind B. The validity of the sigmoid Emax model and efficiency concept in diuretic studies. Br J Clin Pharmacol 1991; 31: 210-1
    • (1991) Br J Clin Pharmacol , vol.31 , pp. 210-211
    • Alván, G.1    Hammarlund-Udenaes, M.M.2    Odlind, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.