New antituberculotics originated from salicylanilides with promising in vitro activity against atypical mycobacterial strains

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 10, 2009, Pages 3572-3579

  Imramovský, Aleš ^a   Vinšová, Jarmila ^b   Férriz, Juana Monreal ^b   Doležal, Rafael ^b   Jampílek, Josef ^c,d   Kaustová, Jarmila ^e   Kunc, Filip ^f,g  

^a UNIVERSITY OF PARDUBICE   (Czech Republic)

^b Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^c Zentiva Prague   (Czech Republic)

^d UNIVERSITY OF VETERINARY AND PHARMACEUTICAL SCIENCES   (Czech Republic)

^e Zdravotniho ustavu se sidlem v Ostrave   (Czech Republic)

^f CHARLES UNIVERSITY   (Czech Republic)

^g GENERI BIOTECH sro   (Czech Republic)

Author keywords

Amino acid esterification; Artificial neural networks; Cytotoxicity, hydrolytic stability, QSAR; In vitro antimycobacterial activity; Lipophilicity; Salicylanilides

Indexed keywords

SALICYLANILIDE DERIVATIVE; TUBERCULOSTATIC AGENT;

ARTICLE; ATYPICAL MYCOBACTERIUM; BACTERIAL MEMBRANE; BACTERIAL STRAIN; BACTERIUM ISOLATE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; LIPOPHILICITY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM AVIUM; MYCOBACTERIUM KANSASII; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SIMULATOR;

ANTITUBERCULAR AGENTS; ESTERIFICATION; HYDROPHOBICITY; MYCOBACTERIA, ATYPICAL; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SALICYLANILIDES;

MYCOBACTERIUM AVIUM; MYCOBACTERIUM KANSASII; MYCOBACTERIUM TUBERCULOSIS;

EID: 65349142609     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.04.008     Document Type: Article

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