3D QSAR of novel estrogen-RGD peptide conjugates: Getting insight into structural dependence of anti-osteoporosis activity and side effect of estrogen in ERT

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 10, 2009, Pages 3680-3689

  Zhao, Ming ^a   Liu, Jiangyuan ^a   Zhang, Xiaoyi ^a   Peng, Li ^a   Li, Chunyu ^a   Peng, Shiqi ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

3D QSAR; Anti osteoporosis; Estrogen; Estrogen RGD peptide; Side effect

Indexed keywords

ALKALINE PHOSPHATASE; ARGINYLGLYCYLASPARTIC ACID; ESTRADIOL; ESTRADIOL 3,17 DI(ARGINYLGLYCYLASPARTIC ACID); ESTROGEN; ESTROGEN ARGINYLGLYCYLASPARTIC ACID; ESTRONE; ESTRONE 17 ARGINYLGLYCYLASPARTIC ACID; OCTAPEPTIDE; TETRAPEPTIDE; UNCLASSIFIED DRUG;

ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEEDING TIME; CALCIUM BLOOD LEVEL; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; ENDOMETRIUM HYPERPLASIA; ESTROGEN THERAPY; FEMALE; FEMUR; MOUSE; NONHUMAN; OSTEOPOROSIS; OVARIECTOMY; PEPTIDE SYNTHESIS; PHOSPHATE BLOOD LEVEL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; THREE DIMENSIONAL IMAGING; THROMBOEMBOLISM; UTERUS WEIGHT;

AMINO ACID SEQUENCE; ANIMALS; BONE AND BONES; COMPUTER SIMULATION; ESTROGEN REPLACEMENT THERAPY; ESTROGENS; FEMALE; HUMANS; MICE; MODELS, CHEMICAL; OLIGOPEPTIDES; OSTEOPOROSIS; PEPTIDES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 65349137550     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.03.057     Document Type: Article

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