Advances in radiobiological studies using a microbeam

Journal of Radiation Research

Volumn 50, Issue SUPPL. A, 2009, Pages

  Hei, Tom K ^a,b,c   Ballas, Leslie K ^b   Brenner, David J ^a,c   Geard, Charles R ^a  

^a Center for Radiological Research   (United States)

^b College of Physicians and Surgeons ^*  (United States)

^c Department of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHARGED PARTICLES; IMAGE ENHANCEMENT; IONIZING RADIATION; RADIATION EFFECTS;

BYSTANDER EFFECTS; HIT CELLS; IMAGES PROCESSING; LOW DOSE EFFECTS; MICRO BEAMS; NON-TARGETED; PARADIGM SHIFTS; PARTICLE MICROBEAM; RADIATION-INDUCED; RADIOBIOLOGICAL STUDY;

DEMONSTRATIONS;

EID: 65349131975     PISSN: 04493060     EISSN: 13499157     Source Type: Journal    
DOI: 10.1269/jrr.08135S     Document Type: Article

References (25)

1. Munro, T. R. (1970) The relative radiosensitivity of the nucleus and cytoplasm of Chinese hamster fibroblasts. Radiation Research 42: 451-470.
2. Wu, L. J., Randers-Pehrson, G., Waldren, C. A., Geard, C. R., Yu, Z. Y. and Hei, T. K. (1999) Targeted cytoplasmic irradiation by alpha particles induces gene mutations. Proc. National Academy Science (U.S.A.) 96: 4959-4964.
3. Zhou, H., Randers-Pehrson, G., Waldren, C. A., Vannais, D., Hall, E. J. and Hei, T. K. (2000) Induction of a bystander mutagenic effect of alpha particles in mammalian cells. Proc. National Academy Science (U.S.A.) 97: 2099-2104.
4. Shao, C. L., Folkard, M., Michael, B. D. and Prise, K. M. (2004) Targeted cytoplasmic irradiation induces bystander responses. Proc. National Academy Science (U.S.A.) 101: 13495-13500.
5. Belyakov, O. V., Mitchell, S. A., Parikh, D., Randers-Pehrson, G., Marino, S. A., Amundson, S. A., Geard, C. R. and Brenner, D. J. (2005) Biological effects in unirradiated human tissue induced by radiation damage up to 1 mm away. Proc. National Academy Science (U.S.A.) 102(40): 14203-14208.
6. Yang, G., Wu, L. J., Chen, L. Y., Pei, B., Wang, Y. G., Zhan, F., Wu, Y. J. and Yu, Z. Y. (2007) Targeted irradiation of shoot apical meristem of Arabidopsis embryos induces long distance bystander/ abscopal effects. Radiation Research 167: 298-305.
7. Morgan, W. F. (2003) Non-targeted and delayed effects of exposure to ionizing radiation I: Radiation induced genomic instability and bystander effects in vitro. Radiation Research 159: 567-580.
8. Loeb, L. A., Loeb, K. R. and Anderson, J. P. (2003) Multiple mutations and cancer. Proc. National Academy Science (U.S.A.) 100(40): 776-781.
9. Grady, W. M. and Carethers, J. M. (2008) Genomic and epigenetic instability in colorectal cancer pathogenesis. Gastroenterology 135: 1079-1099.
10. Azzam, E. I., deToledo, S. M., Gooding, T. and Little, J. B. (1998) Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles. Radiation Research 150: 497-504.
11. Nagasawa, H., Huo, L. and Little, J. B. (2003) Increased bystander mutagenic effect in DNA double-strand break repair deficient mammalian cells. Int. J. Radiation Biology 79: 35-41.
12. Hei, T. K., Zhou, H., Ivanov, V. N., Mei, H., Lieberman, H. B., Brenner, D. J., Amundson, S. A. and Geard, C. R. (2008) Mechanism of radiation induced bystander effects: A unifying model. Journal of Pharmacy and Pharmacology 60: 943-950.
13. Persaud, R., Zhou, H., Baker, S. E., Hei, T. K. and Hall, E. J. (2005) Assessment of low linear energy transfer radiation-induced bystander mutagenesis in a three-dimensional culture model. Cancer Research 65: 9876-9882.
14. Zhou, H., Suzuki, M., Randers-Pehrson, G., Vannais, D., Trosko, J., Waldren, C. A. and Hei, T. K. (2001) Radiation risk at low doses may be greater than we thought. Proc. National Academy Science (U.S.A) 98: 14410-14415.
15. Azzam, E. I., deToledo, S. M. and Little, J. B. (2001) Direct evidence for the participation of gap junction mediated intercellular communication in the transmission of damage signals from alpha particle irradiated to non-irradiated cells. Proc. National Academy Science (U.S.A) 98: 473-478.
16. Zhou, H., Ivanov, V. N., Gillespie, J., Geard, C. R., Amundson, S. A., Brenner, D. J., Yu, Z., Lieberman, H. B. and Hei, T. K. (2005) Mechanism of radiation-induced bystander effect: role of Cox-2 signaling pathway. Proc Natl Acad Sci (USA) 102:14641-14646.
17. Lyng, F. M., Maguire, P., McClean, B., Seymour, C. and Mothersill, C. (2006) The involvement of calcium and MAP kinase signaling pathways in the production of radiation-induced bystander effects. Radiation Research 165: 400-409.
18. Zhou, H., Ivanov, V. N., Lien, Y. C., Davidson, M. and Hei, T. K. (2008) Mitochondrial function and NFκB mediated signaling in radiation induced bystander effects. Cancer Research 68: 2233-2240.
19. Azzam, E. I., deToledo, S. M., Spitz, D. R. and Little, J. B.(2002) Oxidative metabolism modulates signal transduction and micronucleus formation in bystander cells from alpha-particle-irradiated normal human fibroblast cultures. Cancer Res. 62: 5436-5442.
20. Narayanan, P. K., Goodwin, E. H. and Lehnert, B. E. (1997) Alpha Particles initiate biological production of superoxide anions and hydrogen peroxide in human cells, Cancer Research 57: 3963-3971.
21. Koyama, S., Kodama, K., Suzuki, K., Matsumoto, T., Miyazaki, T. and Watanabe, M. (1998) Radiation induced long lived radicals which cause mutation and transformation. Mutation Research 421: 45-54.
22. Shao, C., Stewart, V., Folkard, M., Michael, B. D. and Prise, K. M. (2003) Nitric oxide-mediated signaling in the bystander response of individually targeted glioma cells. Cancer Research 63: 8437-8442.
23. Yang, H., Asaad, N. and Held, K. D. (2005) Medium-mediated intercellular communication is involved in bystander responses of X-ray-irradiated normal human fibroblasts. Oncogene 24: 2096-2103.
24. Belyakov, O. V., Folkard, M., Mothersill, M., Prise, K. M. and Michael, B. D. (2006) Bystander induced differentiation: A major response to targeted irradiation of a urothelial explant model. Mutation Research 597: 43-49.
25. Coates, P. J., Lorimore, S. A. and Wright, E. G. (2004) Damaging and protective cell signaling in the untargeted effects of ionizing radiation. Mutation Research 568: 5-20.