The inhibitory mechanism of a novel cationic glucosamine derivative against MMP-2 and MMP-9 expressions

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 10, 2009, Pages 2755-2759

  Mendis, Eresha ^a   Kim, Moon Moo ^b   Rajapakse, Niranjan ^a   Kim, Se Kwon ^c  

^a UNIVERSITY OF PERADENIYA   (Sri Lanka)

^b Dong Eui University   (South Korea)

^c Pukyong National University   (South Korea)

Author keywords

Activating protein 1 (AP 1); Gelatinases; Glucosamine (Glc); Mitogen activated protein kinases (MAPKs); Nuclear transcription factor B (NF B); Quaternized amino glucosamine (QAGlc)

Indexed keywords

ACTIN; DOXYCYCLINE; GELATINASE A; GELATINASE B; GLUCOSAMINE DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN C FOS; STRESS ACTIVATED PROTEIN KINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR RELA;

ARTICLE; CANCER CELL CULTURE; CANCER INVASION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; ENZYME REPRESSION; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; NUCLEAR LOCALIZATION SIGNAL; PROTEIN EXPRESSION; REPORTER GENE; TRANSCRIPTION INITIATION; WESTERN BLOTTING;

CELL LINE, TUMOR; GELATINASES; GENES, REPORTER; GLUCOSAMINE; HUMANS; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; NF-KAPPA B; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION, GENETIC;

EID: 65349120747     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.03.126     Document Type: Article

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