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Volumn 35, Issue 2, 2009, Pages 443-457

Antipsychotic combinations vs monotherapy in schizophrenia: A meta-analysis of randomized controlled trials

Author keywords

All cause discontinuation; Antipsychotics; Combination; Efficacy; Monotherapy; Polypharmacy; Schizophrenia; Side effects; Trial methodology

Indexed keywords

CHLORPROMAZINE; CLOZAPINE; FLUPHENAZINE; HALOPERIDOL; LEVOMEPROMAZINE; NEUROLEPTIC AGENT; OLANZAPINE; PIMOZIDE; RESERPINE; SULPIRIDE; THIORIDAZINE; TRIFLUOPERAZINE;

EID: 65349112410     PISSN: 05867614     EISSN: 17451701     Source Type: Journal    
DOI: 10.1093/schbul/sbn018     Document Type: Article
Times cited : (320)

References (64)
  • 1
    • 0028022630 scopus 로고
    • One hundred years of schizophrenia: A meta-analysis of the outcome literature
    • Hegarty JD, Baldessarini RJ, Tohen M, Waternaux C, Oepen G. One hundred years of schizophrenia: a meta-analysis of the outcome literature. Am J Psychiatry. 1994;151(10): 1409-1416.
    • (1994) Am J Psychiatry , vol.151 , Issue.10 , pp. 1409-1416
    • Hegarty, J.D.1    Baldessarini, R.J.2    Tohen, M.3    Waternaux, C.4    Oepen, G.5
  • 2
    • 33749321169 scopus 로고    scopus 로고
    • Randomized controlled trial of the effect on Quality of Life of second- vs first-generation antipsychotic drugs in schizophrenia: Cost Utility of the Latest Antipsychotic Drugs in Schizophrenia Study (CUtLASS 1)
    • Jones PB, Barnes TR, Davies L, et al. Randomized controlled trial of the effect on Quality of Life of second- vs first-generation antipsychotic drugs in schizophrenia: cost Utility of the Latest Antipsychotic Drugs in Schizophrenia Study (CUtLASS 1). Arch Gen Psychiatry. 2006;63(10):1079-1087.
    • (2006) Arch Gen Psychiatry , vol.63 , Issue.10 , pp. 1079-1087
    • Jones, P.B.1    Barnes, T.R.2    Davies, L.3
  • 3
    • 25144456112 scopus 로고    scopus 로고
    • Clinical Antipsy-chotic Trials of Intervention Effectiveness (CATIE) Investigators. Effectiveness of antipsychotic drugs in patients with chronic schizophrenia
    • Lieberman JA, Stroup TS, McEvoy JP, et al. Clinical Antipsy-chotic Trials of Intervention Effectiveness (CATIE) Investigators. Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. New Engl J Med. 2005;353(12):1209-1223.
    • (2005) New Engl J Med , vol.353 , Issue.12 , pp. 1209-1223
    • Lieberman, J.A.1    Stroup, T.S.2    McEvoy, J.P.3
  • 4
    • 1542313966 scopus 로고    scopus 로고
    • Symptomatic and functional recovery from a first episode of schizophrenia or schizoaffective disorder
    • Robinson DG, Woerner MG, McMeniman M, Mendelowitz A, Bilder RM. Symptomatic and functional recovery from a first episode of schizophrenia or schizoaffective disorder. Am J Psychiatry. 2004;161(3):473-479.
    • (2004) Am J Psychiatry , vol.161 , Issue.3 , pp. 473-479
    • Robinson, D.G.1    Woerner, M.G.2    McMeniman, M.3    Mendelowitz, A.4    Bilder, R.M.5
  • 6
    • 85047698267 scopus 로고    scopus 로고
    • Effectiveness of clozapine versus olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia who did not respond to prior atypical antipsychotic treatment
    • McEvoy JP, Lieberman JA, Stroup TS, et al. Effectiveness of clozapine versus olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia who did not respond to prior atypical antipsychotic treatment. Am J Psychiatry. 2006;163(4):600-610.
    • (2006) Am J Psychiatry , vol.163 , Issue.4 , pp. 600-610
    • McEvoy, J.P.1    Lieberman, J.A.2    Stroup, T.S.3
  • 7
    • 33748768220 scopus 로고    scopus 로고
    • Randomized controlled trial of effect of prescription of clozapine versus other second-generation antipsychotic drugs in resistant schizophrenia
    • Lewis SW, Barnes TR, Davies L, et al. Randomized controlled trial of effect of prescription of clozapine versus other second-generation antipsychotic drugs in resistant schizophrenia. Schizophr Bull. 2006;32(4):715-723.
    • (2006) Schizophr Bull , vol.32 , Issue.4 , pp. 715-723
    • Lewis, S.W.1    Barnes, T.R.2    Davies, L.3
  • 9
    • 65349171690 scopus 로고    scopus 로고
    • Carbamazapine for Schizophrenia and Schizoaffective Psychoses
    • The Cochrane Library
    • Leucht S, McGrath J, White P, Kissling W. Carbamazapine for Schizophrenia and Schizoaffective Psychoses (Cochrane Review). The Cochrane Library. Issue 2.
    • Cochrane Review , Issue.2
    • Leucht, S.1    McGrath, J.2    White, P.3    Kissling, W.4
  • 10
    • 3142713738 scopus 로고    scopus 로고
    • Valproate as an adjunct to antipsychotics for schizophrenia: A systematic review of randomized trials
    • Basan A, Kissling W, Leucht S. Valproate as an adjunct to antipsychotics for schizophrenia: a systematic review of randomized trials. Schizophr Res. 2004;70(1):33-37.
    • (2004) Schizophr Res , vol.70 , Issue.1 , pp. 33-37
    • Basan, A.1    Kissling, W.2    Leucht, S.3
  • 12
    • 65349126061 scopus 로고    scopus 로고
    • Supplementing standard drug treatment of those with schizophrenia with beta-blocking medication (Cochrane Review)
    • Cheine M, Ahonen J, Wahlbeck K. Supplementing standard drug treatment of those with schizophrenia with beta-blocking medication (Cochrane Review). The Cochrane Library. 2001; Issue 2.
    • (2001) The Cochrane Library , Issue.2
    • Cheine, M.1    Ahonen, J.2    Wahlbeck, K.3
  • 13
    • 33750106155 scopus 로고    scopus 로고
    • Antidepressants for the negative symptoms of schizophrenia
    • CD005581
    • Rummel C, Kissling W, Leucht S. Antidepressants for the negative symptoms of schizophrenia. Cochrane Database Syst Rev. 2006;(3):CD005581
    • (2006) Cochrane Database Syst Rev , Issue.3
    • Rummel, C.1    Kissling, W.2    Leucht, S.3
  • 14
    • 31344446924 scopus 로고    scopus 로고
    • COX-2 inhibitors as adjunctive therapy in schizophrenia: Rationale for use and evidence to date
    • Riedel M, Strassnig M, Schwarz MJ, Muller N. COX-2 inhibitors as adjunctive therapy in schizophrenia: rationale for use and evidence to date. CNS Drugs. 2005;19(10):805-819.
    • (2005) CNS Drugs , vol.19 , Issue.10 , pp. 805-819
    • Riedel, M.1    Strassnig, M.2    Schwarz, M.J.3    Muller, N.4
  • 16
    • 77950235397 scopus 로고    scopus 로고
    • Electroconvulsive therapy for schizophrenia (Cochrane Review)
    • Tharyan P, Adams CE. Electroconvulsive therapy for schizophrenia (Cochrane Review). The Cochrane Library. 2003;Issue 2.
    • (2003) The Cochrane Library , Issue.2
    • Tharyan, P.1    Adams, C.E.2
  • 17
    • 33845320133 scopus 로고    scopus 로고
    • Does an-tipsychotic polypharmacy increase the risk for metabolic syndrome?
    • Correll CU, Frederickson AM, Kane JM, Manu P. Does an-tipsychotic polypharmacy increase the risk for metabolic syndrome? Schizophr Res. 2007;89(1-3):91-100.
    • (2007) Schizophr Res , vol.89 , Issue.1-3 , pp. 91-100
    • Correll, C.U.1    Frederickson, A.M.2    Kane, J.M.3    Manu, P.4
  • 18
    • 12944304694 scopus 로고    scopus 로고
    • Prevalence, trends, and factors associated with antipsychotic polypharmacy among Medicaid-eligible schizophrenia patients, 1998-2000
    • Ganguly R, Kotzan JA, Miller LS, Kennedy K, Martin BC. Prevalence, trends, and factors associated with antipsychotic polypharmacy among Medicaid-eligible schizophrenia patients, 1998-2000. J Clin Psychiatry. 2004;65(10):1377-1388.
    • (2004) J Clin Psychiatry , vol.65 , Issue.10 , pp. 1377-1388
    • Ganguly, R.1    Kotzan, J.A.2    Miller, L.S.3    Kennedy, K.4    Martin, B.C.5
  • 19
    • 26844433208 scopus 로고    scopus 로고
    • An-tipsychotic monotherapy and polypharmacy in the naturalistic treatment of schizophrenia with atypical antipsychotics
    • Faries D, Ascher-Svanum H, Zhu B, Correll C, Kane J. An-tipsychotic monotherapy and polypharmacy in the naturalistic treatment of schizophrenia with atypical antipsychotics. BMC Psychiatry. 2005;5(1):26.
    • (2005) BMC Psychiatry , vol.5 , Issue.1 , pp. 26
    • Faries, D.1    Ascher-Svanum, H.2    Zhu, B.3    Correll, C.4    Kane, J.5
  • 20
    • 33646690029 scopus 로고    scopus 로고
    • Long-term combination antipsychotic treatment in VA patients with schizophrenia
    • Kreyenbuhl J, Valenstein M, McCarthy JF, Ganoczy D, Blow FC. Long-term combination antipsychotic treatment in VA patients with schizophrenia. Schizophr Res. 2006; 84(1):90-99.
    • (2006) Schizophr Res , vol.84 , Issue.1 , pp. 90-99
    • Kreyenbuhl, J.1    Valenstein, M.2    McCarthy, J.F.3    Ganoczy, D.4    Blow, F.C.5
  • 22
    • 0035988519 scopus 로고    scopus 로고
    • Recent trends in antipsychotic combination therapy of schizophrenia and schizoaffective disorder: Implications for state mental health policy
    • Clark RE, Bartels SJ, Mellman TA, Peacock WJ. Recent trends in antipsychotic combination therapy of schizophrenia and schizoaffective disorder: implications for state mental health policy. Schizophr Bull. 2002;28:75-84.
    • (2002) Schizophr Bull , vol.28 , pp. 75-84
    • Clark, R.E.1    Bartels, S.J.2    Mellman, T.A.3    Peacock, W.J.4
  • 23
    • 2442473932 scopus 로고    scopus 로고
    • The Texas Medication Algorithm Project antipsychotic algorithm for schizophrenia: 2003 update
    • Miller AL, Hall CS, Buchanan RW, et al. The Texas Medication Algorithm Project antipsychotic algorithm for schizophrenia: 2003 update. J Clin Psychiatry. 2004;65(4):500-508.
    • (2004) J Clin Psychiatry , vol.65 , Issue.4 , pp. 500-508
    • Miller, A.L.1    Hall, C.S.2    Buchanan, R.W.3
  • 24
    • 1642283731 scopus 로고    scopus 로고
    • Lehman AF, Lieberman JA, Dixon LB, et al. Practice guideline for the treatment of patients with schizophrenia. 2nd edition. Am J Psychiatry. 2004;161(2 Suppl):1-56.
    • Lehman AF, Lieberman JA, Dixon LB, et al. Practice guideline for the treatment of patients with schizophrenia. 2nd edition. Am J Psychiatry. 2004;161(2 Suppl):1-56.
  • 25
    • 0036838758 scopus 로고    scopus 로고
    • Antipsychotic combination therapy in schizophrenia. A review of efficacy and risks of current combinations
    • Freudenreich O, Goff DC. Antipsychotic combination therapy in schizophrenia. A review of efficacy and risks of current combinations. Acta Psychiatr Scand. 2002;106(5):323-330.
    • (2002) Acta Psychiatr Scand , vol.106 , Issue.5 , pp. 323-330
    • Freudenreich, O.1    Goff, D.C.2
  • 26
    • 0036839285 scopus 로고    scopus 로고
    • Antipsychotic polypharmacy: Evidence based or eminence based?
    • Stahl SM. Antipsychotic polypharmacy: evidence based or eminence based? Acta Psychiatr Scand. 2002;106(5):321-322.
    • (2002) Acta Psychiatr Scand , vol.106 , Issue.5 , pp. 321-322
    • Stahl, S.M.1
  • 27
    • 4444286682 scopus 로고    scopus 로고
    • Relationship between antipsychotic medication treatment and new cases of diabetes among psychiatric inpatients
    • Citrome L, Jaffe A, Levine J, Allingham B, Robinson J. Relationship between antipsychotic medication treatment and new cases of diabetes among psychiatric inpatients. Psychiatr Serv. 2004;55(9):1006-1013.
    • (2004) Psychiatr Serv , vol.55 , Issue.9 , pp. 1006-1013
    • Citrome, L.1    Jaffe, A.2    Levine, J.3    Allingham, B.4    Robinson, J.5
  • 28
    • 0031668084 scopus 로고    scopus 로고
    • Mortality in schizophrenia. Antipsychotic polypharmacy and absence of adjunctive anticholinergics over the course of a 10-year prospective study
    • Waddington JL, Youssef HA, Kinsella A. Mortality in schizophrenia. Antipsychotic polypharmacy and absence of adjunctive anticholinergics over the course of a 10-year prospective study. Br J Psychiatry. 1998;173:325-329.
    • (1998) Br J Psychiatry , vol.173 , pp. 325-329
    • Waddington, J.L.1    Youssef, H.A.2    Kinsella, A.3
  • 30
    • 0030691937 scopus 로고    scopus 로고
    • Sulpiride augmentation in people with schizophrenia partially responsive to clozapine. A double-blind, placebo-controlled study
    • Shiloh R. Sulpiride augmentation in people with schizophrenia partially responsive to clozapine. A double-blind, placebo-controlled study. Br J Psychiatry. 1997;569-573.
    • (1997) Br J Psychiatry , pp. 569-573
    • Shiloh, R.1
  • 31
    • 11844304940 scopus 로고    scopus 로고
    • Clozapine augmented with risperidone in the treatment of schizophrenia: A randomized, double-blind, placebo-controlled trial
    • Josiassen R, Joseph A, Kohegyi E, et al. Clozapine augmented with risperidone in the treatment of schizophrenia: a randomized, double-blind, placebo-controlled trial. Am J Psychiatry. 2005;162:130-136.
    • (2005) Am J Psychiatry , vol.162 , pp. 130-136
    • Josiassen, R.1    Joseph, A.2    Kohegyi, E.3
  • 32
    • 13844311144 scopus 로고    scopus 로고
    • A double-blind controlled study of adjunctive treatment with risperidone in schizophrenic patients partially responsive to clozapine: Efficacy and safety
    • Anil Yagcioglu AE, Kivircik Akdede BB, Turgut TI, et al. A double-blind controlled study of adjunctive treatment with risperidone in schizophrenic patients partially responsive to clozapine: efficacy and safety. J Clin Psychiatry. 2005;66(1): 63-72.
    • (2005) J Clin Psychiatry , vol.66 , Issue.1 , pp. 63-72
    • Anil Yagcioglu, A.E.1    Kivircik Akdede, B.B.2    Turgut, T.I.3
  • 33
    • 32044464964 scopus 로고    scopus 로고
    • Clozapine alone versus clozapine and risperidone with refractory schizophrenia
    • Honer WG, Thornton AE, Chen EY, et al. Clozapine alone versus clozapine and risperidone with refractory schizophrenia. New Engl J Med. 2006;354(5):472-482.
    • (2006) New Engl J Med , vol.354 , Issue.5 , pp. 472-482
    • Honer, W.G.1    Thornton, A.E.2    Chen, E.Y.3
  • 35
    • 85100415918 scopus 로고    scopus 로고
    • Cochrane handbook for systematic reviews of interventions 4.2.5
    • Chi-chester, UK: Wiley and Sons
    • Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions 4.2.5. The Cochrane Library. Chi-chester, UK: Wiley and Sons, 2005.
    • (2005) The Cochrane Library
    • Higgins, J.P.T.1    Green, S.2
  • 40
    • 0030922816 scopus 로고    scopus 로고
    • Egger M, Davey mith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629-634.
    • Egger M, Davey mith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629-634.
  • 41
    • 1642283731 scopus 로고    scopus 로고
    • Lehman AF, Lieberman JA, Dixon LB, et al. Practice guideline for the treatment of patients with schizophrenia. 2nd edition. Am J Psychiatry. 2004;161(2 Suppl):1-56.
    • Lehman AF, Lieberman JA, Dixon LB, et al. Practice guideline for the treatment of patients with schizophrenia. 2nd edition. Am J Psychiatry. 2004;161(2 Suppl):1-56.
  • 43
    • 0038266756 scopus 로고    scopus 로고
    • Chlorpromazine equivalent doses for the newer atypical antipsychotics
    • Woods SW. Chlorpromazine equivalent doses for the newer atypical antipsychotics. J Clin Psychiatry. 2003;64(6):663-667.
    • (2003) J Clin Psychiatry , vol.64 , Issue.6 , pp. 663-667
    • Woods, S.W.1
  • 44
    • 65349152680 scopus 로고    scopus 로고
    • RevMan Analyses [Computer program, Version 1.0 for Windows. Review Manager, RevMan, Version 4.2 for Windows. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration; 2003
    • RevMan Analyses [Computer program]. Version 1.0 for Windows. Review Manager. (RevMan). Version 4.2 for Windows. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration; 2003.
  • 45
    • 65349127198 scopus 로고
    • Study of the differential behavioral effects of reserpine, chlorpromazine, and a combination of these drugs in chronic schizophrenic patients
    • Barrett WW, Elsworth RB, Clark LD, Ennis J. Study of the differential behavioral effects of reserpine, chlorpromazine, and a combination of these drugs in chronic schizophrenic patients. Dis Nerv Syst. 1957;18(6):209-215.
    • (1957) Dis Nerv Syst , vol.18 , Issue.6 , pp. 209-215
    • Barrett, W.W.1    Elsworth, R.B.2    Clark, L.D.3    Ennis, J.4
  • 46
    • 0024443180 scopus 로고
    • Clozapine in China: A review and preview of US/PRC collaboration
    • Potter WZ, Ko GN, Zhang LD, Yan W. Clozapine in China: a review and preview of US/PRC collaboration. Psychophar-macology. 1989;99:87-91.
    • (1989) Psychophar-macology , vol.99 , pp. 87-91
    • Potter, W.Z.1    Ko, G.N.2    Zhang, L.D.3    Yan, W.4
  • 47
    • 27744544316 scopus 로고
    • A double-blind controlled study on the usefulness of carpipramine-chlorpromazine combination in the pharmaco-therapy of chronic schizophrenic patients
    • Yagi G. A double-blind controlled study on the usefulness of carpipramine-chlorpromazine combination in the pharmaco-therapy of chronic schizophrenic patients. Clin Eval. 1976;3: 351-403.
    • (1976) Clin Eval , vol.3 , pp. 351-403
    • Yagi, G.1
  • 48
    • 65349083932 scopus 로고
    • A comparison study on treatment effect of clozapine, chlorpromazine and the combination of clozapine and chlorpromazine in schizophrenia
    • Zhang L, Xu Y. A comparison study on treatment effect of clozapine, chlorpromazine and the combination of clozapine and chlorpromazine in schizophrenia. Chin J Nerv Ment Dis. 1989;5(5):306-308.
    • (1989) Chin J Nerv Ment Dis , vol.5 , Issue.5 , pp. 306-308
    • Zhang, L.1    Xu, Y.2
  • 49
    • 34147137079 scopus 로고    scopus 로고
    • Risperidone augmentation for schizophrenia partially responsive to clozapine: A double-blind, placebo-controlled trial
    • Freudenreich O. Risperidone augmentation for schizophrenia partially responsive to clozapine: a double-blind, placebo-controlled trial. Schizophr Res. 2007;92(1-3):90-94.
    • (2007) Schizophr Res , vol.92 , Issue.1-3 , pp. 90-94
    • Freudenreich, O.1
  • 50
    • 65349153282 scopus 로고    scopus 로고
    • The treatment effect of combined clozapine and sulpiride on negative symptoms of schizophrenia. Chin
    • Liu Q, Li X, Zhang Y, et al. The treatment effect of combined clozapine and sulpiride on negative symptoms of schizophrenia. Chin J Psychiatry. 1996;29:87-90.
    • (1996) J Psychiatry , vol.29 , pp. 87-90
    • Liu, Q.1    Li, X.2    Zhang, Y.3
  • 51
    • 65349100744 scopus 로고    scopus 로고
    • A control study of risperidone in combination with clozapine in treating refractory schizophrenia
    • Peng H, Kuang Y, Huang X. A control study of risperidone in combination with clozapine in treating refractory schizophrenia. J Mod Clin Med Bioeng. 2001;7(2):100-102.
    • (2001) J Mod Clin Med Bioeng , vol.7 , Issue.2 , pp. 100-102
    • Peng, H.1    Kuang, Y.2    Huang, X.3
  • 52
    • 65349097534 scopus 로고
    • A clinical effect and following-up study about sulpiride and clozapine for 105 cases of the schizophrenia type
    • Wang CH, Qin TF, Lin YL, Zhao XF. A clinical effect and following-up study about sulpiride and clozapine for 105 cases of the schizophrenia type. J Xinxiang Med Coll. 1994;11(2):148-151.
    • (1994) J Xinxiang Med Coll , vol.11 , Issue.2 , pp. 148-151
    • Wang, C.H.1    Qin, T.F.2    Lin, Y.L.3    Zhao, X.F.4
  • 53
    • 65349103172 scopus 로고    scopus 로고
    • The compared study of treating schizophrenia with risperidone combining clozapine
    • Xie C, Ni XL. The compared study of treating schizophrenia with risperidone combining clozapine. J Prev Med Inform. 2001;17(4):245.
    • (2001) J Prev Med Inform , vol.17 , Issue.4 , pp. 245
    • Xie, C.1    Ni, X.L.2
  • 54
    • 65349166482 scopus 로고    scopus 로고
    • A controlled trial comparing chlorimipramine and sulpiride as adjunct to clozapine in the treatment of negative symptoms of schizophrenia
    • Zhu Y, Zhang S, Zhang D. A controlled trial comparing chlorimipramine and sulpiride as adjunct to clozapine in the treatment of negative symptoms of schizophrenia. J Clin Psychol Med. 1999;9(4):204-205.
    • (1999) J Clin Psychol Med , vol.9 , Issue.4 , pp. 204-205
    • Zhu, Y.1    Zhang, S.2    Zhang, D.3
  • 55
    • 0015546153 scopus 로고
    • Depot phenothiazine treatment in acute psychosis: A sequential comparative clinical study
    • Chien CP, Cole JO. Depot phenothiazine treatment in acute psychosis: a sequential comparative clinical study. Am J Psychiatry. 1973;130(1):13-18.
    • (1973) Am J Psychiatry , vol.130 , Issue.1 , pp. 13-18
    • Chien, C.P.1    Cole, J.O.2
  • 56
    • 4444345535 scopus 로고    scopus 로고
    • Combined therapy with low-potency neuroleptic levomepromazine as an adjunct to haloperidol for agitated patients with acute exacerbation of schizophrenia
    • Higashima M, Takeda T, Nagasawa T, et al. Combined therapy with low-potency neuroleptic levomepromazine as an adjunct to haloperidol for agitated patients with acute exacerbation of schizophrenia. Eur Psychiatry. 2004;19(6): 380-381.
    • (2004) Eur Psychiatry , vol.19 , Issue.6 , pp. 380-381
    • Higashima, M.1    Takeda, T.2    Nagasawa, T.3
  • 57
    • 0022206136 scopus 로고
    • Prophylactic effects of neuroleptics in symptom-free schizophrenics: Roles of dopaminergic and noradrenergic blockers
    • Nishikawa T. Prophylactic effects of neuroleptics in symptom-free schizophrenics: roles of dopaminergic and noradrenergic blockers. Biol Psychiatry. 1985;11:1161-1166.
    • (1985) Biol Psychiatry , vol.11 , pp. 1161-1166
    • Nishikawa, T.1
  • 58
    • 65349164367 scopus 로고
    • Are tranquilizer combinations more effective than a single tranquilizer?
    • Talbot DR. Are tranquilizer combinations more effective than a single tranquilizer? Am J Psychiatry. 1964;121:597-600.
    • (1964) Am J Psychiatry , vol.121 , pp. 597-600
    • Talbot, D.R.1
  • 59
    • 1642534546 scopus 로고    scopus 로고
    • Sulpiride augmentation of olanzapine in the management of treatment-resistant chronic schizophrenia: Evidence for improvement of mood symptomatology
    • Kotler M, Strous RD, Reznik I, Shwartz S, Weizman A, Spivak B. Sulpiride augmentation of olanzapine in the management of treatment-resistant chronic schizophrenia: evidence for improvement of mood symptomatology. Int Clin Psychopharmacol. 2004;19(1):23-26.
    • (2004) Int Clin Psychopharmacol , vol.19 , Issue.1 , pp. 23-26
    • Kotler, M.1    Strous, R.D.2    Reznik, I.3    Shwartz, S.4    Weizman, A.5    Spivak, B.6
  • 60
    • 34247156726 scopus 로고    scopus 로고
    • Augmentation with a second antipsychotic in patients with schizophrenia who partially respond to clozapine: A meta-analysis
    • Paton C, Whittington C, Barnes TR. Augmentation with a second antipsychotic in patients with schizophrenia who partially respond to clozapine: a meta-analysis. J Clin Psycho-pharmacology. 2007;27(2):198-204.
    • (2007) J Clin Psycho-pharmacology , vol.27 , Issue.2 , pp. 198-204
    • Paton, C.1    Whittington, C.2    Barnes, T.R.3
  • 61
    • 33644750716 scopus 로고    scopus 로고
    • An exploratory open-label trial of aripiprazole as an adjuvant to clozapine therapy in chronic schizophrenia
    • Henderson DC, Kunkel L, Nguyen DD, et al. An exploratory open-label trial of aripiprazole as an adjuvant to clozapine therapy in chronic schizophrenia. Acta Psychiatr Scand. 2006;113(2):142-147.
    • (2006) Acta Psychiatr Scand , vol.113 , Issue.2 , pp. 142-147
    • Henderson, D.C.1    Kunkel, L.2    Nguyen, D.D.3
  • 62
    • 34447570718 scopus 로고    scopus 로고
    • Is clozapine-aripiprazole combination a useful regime in the management of treatment-resistant schizophrenia?
    • Karunakaran K, Tungaraza TE, Harborne GC. Is clozapine-aripiprazole combination a useful regime in the management of treatment-resistant schizophrenia? J Psychopharmacol. 2007;21(4):453-456.
    • (2007) J Psychopharmacol , vol.21 , Issue.4 , pp. 453-456
    • Karunakaran, K.1    Tungaraza, T.E.2    Harborne, G.C.3
  • 63
    • 1842435000 scopus 로고    scopus 로고
    • Correll CU, Malhotra AK, Kaushik S, McMeniman M, Kane JM. Early prediction of antipsychotic response in schizophrenia. Am J Psychiatry. 2003;160(11):2063-2065. Erratum in: Am J Psychiatry 2005;162(9):1774.
    • Correll CU, Malhotra AK, Kaushik S, McMeniman M, Kane JM. Early prediction of antipsychotic response in schizophrenia. Am J Psychiatry. 2003;160(11):2063-2065. Erratum in: Am J Psychiatry 2005;162(9):1774.
  • 64
    • 33947729638 scopus 로고    scopus 로고
    • Early prediction of antipsychotic nonresponse among patients with schizophrenia
    • Leucht S, Busch R, Kissling W, Kane JM. Early prediction of antipsychotic nonresponse among patients with schizophrenia. J Clin Psychiatry. 2007;68(3):352-360.
    • (2007) J Clin Psychiatry , vol.68 , Issue.3 , pp. 352-360
    • Leucht, S.1    Busch, R.2    Kissling, W.3    Kane, J.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.