Tinidazole for bacterial vaginosis

Expert Review of Anti-Infective Therapy

Volumn 5, Issue 3, 2007, Pages 343-348

  Nailor, Michael D ^a   Sobel, Jack D ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bacterial vaginosis; Gardnerella vaginalis; Metronidazole; Tinidazole

Indexed keywords

ALCOHOL; AZANIDAZOLE; CIMETIDINE; CIPROFLOXACIN; CLINDAMYCIN; CYCLOSPORIN; DISULFIRAM; FLUCONAZOLE; FLUOROURACIL; ITRACONAZOLE; KETOCONAZOLE; LITHIUM; METRONIDAZOLE; NIMORAZOLE; NITROIMIDAZOLE DERIVATIVE; ORAL CONTRACEPTIVE AGENT; ORNIDAZOLE; PHENOBARBITAL; PHENYTOIN; PLACEBO; RIFAMPICIN; SECNIDAZOLE; SULFANILAMIDE; TACROLIMUS; TINIDAZOLE; ANTIINFECTIVE AGENT;

AEROBIC BACTERIUM; ANAEROBIC BACTERIUM; ANTIBIOTIC RESISTANCE; AREA UNDER THE CURVE; ARTICLE; BACTERIAL STRAIN; BACTERIUM DETECTION; BACTERIUM ISOLATION; BONE MARROW TOXICITY; CLINICAL TRIAL; CONCENTRATION RESPONSE; DIZZINESS; DOSAGE SCHEDULE COMPARISON; DRUG ABSORPTION; DRUG ANTAGONISM; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CONTRAINDICATION; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG EXCRETION; DRUG HALF LIFE; DRUG HYPERSENSITIVITY; DRUG INDICATION; DRUG MECHANISM; DRUG METABOLISM; DRUG POTENTIATION; DRUG PROTEIN BINDING; DRUG SAFETY; DRUG TISSUE LEVEL; DRUG TOLERABILITY; GASTROINTESTINAL TOXICITY; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; IN VITRO STUDY; LOW DRUG DOSE; MAXIMUM PLASMA CONCENTRATION; MICROBIOLOGICAL EXAMINATION; MINIMUM INHIBITORY CONCENTRATION; NAUSEA; NEUROTOXICITY; NONHUMAN; OPTIMAL DRUG DOSE; PERIPHERAL NEUROPATHY; SHORT COURSE THERAPY; SINGLE DRUG DOSE; TASTE DISORDER; TREATMENT DURATION; VAGINITIS; VOMITING; FEMALE; REVIEW;

ANTI-BACTERIAL AGENTS; FEMALE; HUMANS; MICROBIAL SENSITIVITY TESTS; TINIDAZOLE; VAGINOSIS, BACTERIAL;

EID: 34447258398     PISSN: 14787210     EISSN: 17448336     Source Type: Journal    
DOI: 10.1586/14787210.5.3.343     Document Type: Article

References (57)

1. Sobel JD. Vaginitis. N. Engl. J. Med. 337(26), 1896-1903 (1997).
2. Fredricks DN, Fiedler TL, Marrazzo JM. Molecular identification of bacteria associated with bacterial vaginosis. N. Engl. J. Med. 353, 1899-1911 (2005).
3. Ferris MJ, Masztal A, Aldridge KE, Fortenberry JD, Fidel PL Jr, Martin DH. Association of Atopobium vaginae, a recently described metronidazole resistant anaerobe, with bacterial vaginosis. BMC Infect. Dis. 13(4), 5 (2004).
4. Amsel R, Totten PA, Spegel CA et al. Nonspecific vaginitis: diagnostic criteria and microbial and epidemiologic associations. Am. J. Med. 74, 14-22 (1983).
5. Morbidity and Mortality Weekly Report. Sexually transmitted diseases treatment guidelines. MMWR Morb. Mortal. Wkly Rep. 55, RR-11 (2006).
6. Fung HB, Doan T. Tinidazole: a nitroimidazole antiprotozoal agent. Clin. Ther. 27(12), 1859-1884 (2005).
7. Nord CE, Kager L. Tinidazole - microbiology, pharmacology and efficacy in anaerobic infections. Infection 11(1), 54-60 (1983).
8. Lamp KC, Freeman CD, Klutman NE, Lacy MK. Pharmacokinetics and pharmacodynamics of the nitroimidazole antimicrobials. Clin. Pharmacokinet. 36(5), 353-373 (1999).
9. Mattila J, Mannisto PT, Mantyla R, Nykanen S, Lamminsivu U. Comparative pharmacokinetics of metronidazole and tinidazole as influenced by administration route. Antimicrob. Agents Chemother. 23(5), 721-725 (1983).
10. Mannisto P, Karhunen M, Mattila J et al. Concentrations of metronidazole and tinidazole in female reproductive organs after a single intravenous infusion and after repeated oral administration. Infection 12, 197-201 (1984).
11. Carmona O, Silva H, Acosta H. Vaginitis due to Gardnerella vaginalis: treatment with tinidazole. Curr. Ther. Res. 22, 898-904 (1983).
12. Mohanty KC, Deighton R. Comparison of 2 g single dose of metronidazole, nimorazole and tinidazole in the treatment of vaginitis associated with Gardnerella vaginalis. J. Antimicrob. Chemother. 19, 393-399 (1987).
13. Austin MN, Meyn LA, Hillier SL. Susceptibility of vaginal bacteria to metronidazole and tinidazole. Anaerobe 12(5-6), 227-230 (2006).
14. Milani M, Barcellona E, Agnello A. Efficacy of the combination of 2 g oral tinidazole and acidic buffering vaginal gel in comparison with vaginal clindamycin alone in bacterial vaginosis: a randomized, investigator-blinded, controlled trial. Eur. J. Obstet. Gynecol. Reprod. Biol. 109, 67-71 (2003).
15. Buranawarodomkul P, Chandeying V, Sutthijumroon S. Seven day metronidazole versus single dose tinidazole as therapy for nonspecific vaginitis. J. Med. Assoc. Thai. 73, 283-287 (1990).
16. Sanz-Sanz F, Hernanz AD, Sancher EA, Alvarez CG, Muelas M, Rodriguez-Noriega A. Controlled comparative study of metronidazole (Flagyl) versus tinidazole (Tricolan) in the treatment of nonspecific vaginitis (vaginitis due to Gardnerella vaginalis). Rev. Gynecol. Obstet. 44, 717-720 (1985).
17. Schindler EM, Thamm H, Ansmann EB, Sarnow E, Schindler AE. Treatment of bacterial vaginitis. Multicenter, randomized, open study with tinidazole in comparison with metronidazole. Fortschr. Med. 109(5), 138-140 (1991).
18. Sanz-Sanz F, Arreaza L, Vidriales I, Miranda P, Grande J, Valle R. Concerning the different therapeutic options for bacterial vaginosis. Progresos Obstet. Ginecol. 39, 669-674 (1996).
19. Milani M, Baldoni A, Guerro B, Spinillo A. The "talent" multicenter trial: efficacy of tinidazole, metronidazole, and tinidazole + acidic vaginal gel in the treatment of B. vaginosis. Abstracts of the 86th World Congress for Infectious and Immunological Diseases in Obstetrics and Gynecology. Venice, Italy, November (2003).
20. Ekgren J, Norling BK, Degre M, Midtvedt T. Comparison of tinidazole given as a single dose and on 2 consecutive days for the treatment of nonspecific bacterial vaginosis. Gynecol. Obstet. Invest. 26, 313-317 (1988).
21. Paavonen J, Vesterinen E, Purola E et al. Single dose of tinidazole in the treatment of vaginal discharge. Scand. J. Urol. Nephrol. Suppl. 86, 237-240 (1984).
22. van der Meijden WI. Treatment of nonspecific vaginitis with a single dose of tinidazole. Scand. J. Infect. Dis. Suppl. 40, 85-89 (1983).
23. Bagnoli VR, Kesselring GL. Multicenter, double-blind, randomized, comparative study between secnidazole (single dose of 2g) and tinidazole (single dose of 2g) in the treatment of nonspecific vagiitis. RBM Ginecologia E Obstetricia 3, 198-202 (1992).
24. Vutyavanich T, Pongsuthirak P, Vannareumol P, Ruangsri RA, Luangsook P. A randomized double-blind trial of tinidazole treatment of the sexual partners of females with bacterial vaginosis. Obstet. Gynecol. 82, 550-554 (1993).
25. Bardi M, Manenti G, Mattioni D, Lasala L. Activity of some metronidazole analogs on vaginitis caused by Haemophilus vaginalis: comparative clinical study. Gior. It. Ost. Gin. 4, 503-506 (1982).
26. Martins N. Ambulatory diagnosis of vaginitis: evaluation of 4903 patients treated with tinidazole with a single oral dose. Rev. Bras. Clin. Terap. 14, 94-98 (1985).
27. Improda L, Nobler L, Chierego C, Iacono A, Sica C, Rullo F. Is it necessary to treat the partner of a woman affected by bacterial vaginosis? Gior. It. Ost Gin. 7-8, 371-373 (1994).
28. Villagrana-Zesati R, Reyna-Figueroa J, Ortiz-Ibarra J. Short-term therapy for mixed vaginal infections. Int. J. Gynaecol. Obstet. 92, 149-150 (2006).
29. Bardi M, Manenti G, Mattioni D, Lasala L. Activity of some metronidazole analogs on vaginitis caused by Haemophilus vaginalis: comparative clinical study. Gior. It. Ost. Gin. 4, 503-506 (1982).
30. de la Cabada FJ. Treatment of vaginitis due to Gardnerella vaginalis with tinidazole. Invest. Med. Int. 15, 66-71 (1988).
31. Sanz-Sanz F, Del Palacio Hernanz A, Sanchez E et al. Double-blind randomized comparative trial: ornidazole (Tiberal®) versus tinidazole (Falsigin®) for the treatment of non-specific vaginitis. Chemioterapla 4(3), 218-221 (1998).
32. Piot P, Van Dyck E, Godts P, Vanderheyden J. A placebo-controlled, double-blind comparison of tinidazole and triple sulfonamide cream for the treatment of nonspecific vaginitis. Am. J. Obstet. Gynecol. 147, 85-89 (1983).
33. Heikkinen J, Vuopala S. Anaerobic vaginosis: treatment with tinidazole vaginal tablets. Gynecol. Obstet. Invest. 28, 98-100 (1989).
34. Baylson FA, Nyirjesy P, Weitz MV. Treatment of recurrent bacterial vaginosis with tinidazole. Obstet. Gynecol. 104, 931-932 (2004).
35. Schwebke JR, Provan A, Barrientes F. Treatment of resistant Trichomonas vaginalis and bacterial vaginosis with tinidazole. Abstract 0021 of the International Society of Sexuay Transmitted Diseases Research 15th Biennial Congress. Ontario, Canada, July (2003).
36. Package insert. Tindamax®, Presutti Laboratories, IL, USA.
37. Sanz-Sanz F, Hernanz AD, Sancher EA, Alvarez CG, Muelas M, Rodriguez-Noriega A. Controlled comparative study of metronidazole (Flagyl) versus tinidazole (Tricolan) in the treatment of nonspecific vaginitis (vaginitis due to Gardnerella vaginalis). Rev. Gynecol. Obstet. 44, 717-720 (1985).
38. Schindler EM, Thamm H, Ansmann EB, Sarnow E, Schindler AE. Treatment of bacterial vaginitis. Multicenter, randomized, open study with tinidazole in comparison with metronidazole. Fortschr. Med. 109(5), 138-140 (1991).
39. Sanz-Sanz F, Arreaza L, Vidriales I, Miranda P, Grande J, Valle R. Concerning the different therapeutic options for bacterial vaginosis. Progresos Obstet. Ginecol. 39, 669-674 (1996).
40. Milani M, Baldoni A, Guerro B, Spinillo A. The "talent" multicenter trial: efficacy of tinidazole, metronidazole, and tinidazole + acidic vaginal gel in the treatment of B. vaginosis. Abstracts of the 86th World Congress for Infectious and Immunological Diseases in Obstetrics and Gynecology. Venice, Italy, November (2003).
41. Ekgren J, Norling BK, Degre M, Midtvedt T. Comparison of tinidazole given as a single dose and on 2 consecutive days for the treatment of nonspecific bacterial vaginosis. Gynecol. Obstet. Invest. 26, 313-317 (1988).
42. Paavonen J, Vesterinen E, Purola E et al. Single dose of tinidazole in the treatment of vaginal discharge. Scand. J. Urol. Nephrol. Suppl. 86, 237-240 (1984).
43. van der Meijden WI. Treatment of nonspecific vaginitis with a single dose of tinidazole. Scand. J. Infect. Dis. Suppl. 40, 85-89 (1983).
44. Bagnoli VR, Kesselring GL. Multicenter, double-blind, randomized, comparative study between secnidazole (single dose of 2g) and tinidazole (single dose of 2g) in the treatment of nonspecific vagiitis. RBM Ginecologia E Obstetricia 3, 198-202 (1992).
45. Vutyavanich T, Pongsuthirak P, Vannareumol P, Ruangsri RA, Luangsook P. A randomized double-blind trial of tinidazole treatment of the sexual partners of females with bacterial vaginosis. Obstet. Gynecol. 82, 550-554 (1993).
46. Bardi M, Manenti G, Mattioni D, Lasala L. Activity of some metronidazole analogs on vaginitis caused by Haemophilus vaginalis: comparative clinical study. Gior. It. Ost. Gin. 4, 503-506 (1982).
47. Martins N. Ambulatory diagnosis of vaginitis: evaluation of 4903 patients treated with tinidazole with a single oral dose. Rev. Bras. Clin. Terap. 14, 94-98 (1985).
48. Improda L, Nobler L, Chierego C, Iacono A, Sica C, Rullo F. Is it necessary to treat the partner of a woman affected by bacterial vaginosis? Gior. It. Ost Gin. 7-8, 371-373 (1994).
49. Villagrana-Zesati R, Reyna-Figueroa J, Ortiz-Ibarra J. Short-term therapy for mixed vaginal infections. Int. J. Gynaecol. Obstet. 92, 149-150 (2006).
50. Bardi M, Manenti G, Mattioni D, Lasala L. Activity of some metronidazole analogs on vaginitis caused by Haemophilus vaginalis: comparative clinical study. Gior. It. Ost. Gin. 4, 503-506 (1982).
51. de la Cabada FJ. Treatment of vaginitis due to Gardnerella vaginalis with tinidazole. Invest. Med. Int. 15, 66-71 (1988).
52. Sanz-Sanz F, Del Palacio Hernanz A, Sanchez E et al. Double-blind randomized comparative trial: ornidazole (Tiberal®) versus tinidazole (Falsigin®) for the treatment of non-specific vaginitis. Chemioterapla 4(3), 218-221 (1998).
53. Piot P, Van Dyck E, Godts P, Vanderheyden J. A placebo-controlled, double-blind comparison of tinidazole and triple sulfonamide cream for the treatment of nonspecific vaginitis. Am. J. Obstet. Gynecol. 147, 85-89 (1983).
54. Heikkinen J, Vuopala S. Anaerobic vaginosis: treatment with tinidazole vaginal tablets. Gynecol. Obstet. Invest. 28, 98-100 (1989).
55. Baylson FA, Nyirjesy P, Weitz MV. Treatment of recurrent bacterial vaginosis with tinidazole. Obstet. Gynecol. 104, 931-932 (2004).
56. Schwebke JR, Provan A, Barrientes F. Treatment of resistant Trichomonas vaginalis and bacterial vaginosis with tinidazole. Abstract 0021 of the International Society of Sexuay Transmitted Diseases Research 15th Biennial Congress. Ontario, Canada, July (2003).
57. Package insert. Tindamax®, Presutti Laboratories, IL, USA.