Usefulness of p16 for differentiating primary pulmonary squamous cell carcinoma from cervical squamous cell carcinoma metastatic to the lung

American Journal of Clinical Pathology

Volumn 131, Issue 5, 2009, Pages 715-722

  Wang, Chih Wei ^a   Wu, Tzu I ^a   Yu, Chih Teng ^a   Wu, Yi Cheng ^a   Teng, Yun Hui ^a   Chin, Szu Ying ^a   Lai, Chyong Huey ^a   Chen, Tse Ching ^a,b  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Cervix; Lung; Metastasis; P16; Squamous cell carcinoma

Indexed keywords

GENOMIC DNA; PROTEIN P16; TUMOR MARKER; CYCLIN DEPENDENT KINASE INHIBITOR 2A; VIRUS DNA;

ARTICLE; CANCER STAGING; CELL DIFFERENTIATION; CERVICAL SQUAMOUS CELL CARCINOMA; DIFFERENTIAL DIAGNOSIS; DNA DETERMINATION; DNA EXTRACTION; FEMALE; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LUNG; LUNG CARCINOMA; METASTASIS; POLYMERASE CHAIN REACTION; PRIMARY PULMONARY SQUAMOUS CELL CARCINOMA; PRIMARY TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; TUMOR LOCALIZATION; UTERINE CERVIX CANCER; WART VIRUS; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; ISOLATION AND PURIFICATION; LUNG TUMOR; METABOLISM; PAPILLOMA VIRUS; PATHOLOGY; PREDICTION AND FORECASTING; UTERINE CERVIX TUMOR;

CARCINOMA, SQUAMOUS CELL; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DIAGNOSIS, DIFFERENTIAL; DNA, VIRAL; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, DIRECT; HUMANS; LUNG NEOPLASMS; PAPILLOMAVIRIDAE; PREDICTIVE VALUE OF TESTS; TUMOR MARKERS, BIOLOGICAL; UTERINE CERVICAL NEOPLASMS;

EID: 65349098727     PISSN: 00029173     EISSN: None     Source Type: Journal    
DOI: 10.1309/AJCPTPBC6V5KUITM     Document Type: Article

References (46)

1. Moore DH. Cervical cancer. Obstet Gynecol. 2006;107:1152-1161.
2. Takemura M, Yamasaki M, Shimizu H, et al. A clinicopatho- logical study of pulmonary metastases in carcinoma of the uterine cervix [in Japanese]. Nippon Gan Chiryo Gakkai Shi. 1990;25:776-780.
3. Imachi M, Tsukamoto N, Matsuyama T, et al. Pulmonary metastasis from carcinoma of the uterine cervix. Gynecol Oncol. 1989;33:189-192.
4. Tellis CJ, Beechler CR. Pulmonary metastasis of carcinoma of the cervix: a retrospective study. Cancer. 1982;49:1705-1709.
5. Michalides RJ. Cell cycle regulators: mechanisms and their role in etiology, prognosis, and treatment of cancer. J Clin Pathol. 1999;52:555-568.
6. Tjalma WA, Van Waes TR, Van den Eeden LE, et al. Role of human papillomavirus in the carcinogenesis of squamous cell carcinoma and adenocarcinoma of the cervix. Best Pract Res Clin Obstet Gynaecol. 2005;19:469-483.
7. Tringler B, Gup CJ, Singh M, et al. Evaluation of p16INK4a and pRb expression in cervical squamous and glandular neoplasia. Hum Pathol. 2004;35:689-696.
8. Gazzeri S, Gouyer V, Vour'ch C. Mechanisms of p16INK4A inactivation in non small-cell lung cancers. Oncogene. 1998;16:497-504.
9. Sekido Y, Fong KM, Minna JD. Molecular genetics of lung cancer. Annu Rev Med. 2003;54:73-87.
10. Sato M, Shames DS, Gazdar AF, et al. A translational view of the molecular pathogenesis of lung cancer. J Thorac Oncol. 2007;2:327-343.
11. Akin H, Yilmazbayhan D, Kilicaslan Z, et al. Clinical significance of P16INK4A and retinoblastoma proteins in non-small-cell lung carcinoma. Lung Cancer. 2002;38:253-260.
12. Brambilla E, Moro D, Gazzeri S, et al. Alterations of expression of Rb, p16(INK4A) and cyclin D1 in non-small cell lung carcinoma and their clinical significance. J Pathol. 1999;188:351-360.
13. Dessy E, Rossi E, Berenzi A, et al. Chromosome 9 instability and alterations of p16 gene in squamous cell carcinoma of the lung and in adjacent normal bronchi: FISH and immunohistochemical study. Histopathology. 2008;52:475-482.
14. Huang HJ, Huang SL, Lin CY, et al. Human papillomavirus genotyping by a polymerase chain reaction-based genechip method in cervical carcinoma treated with neoadjuvant chemotherapy plus radical surgery. Int J Gynecol Cancer. 2004;14:639-649.
15. Stenhouse G, Fyfe N, King G, et al. Thyroid transcription factor 1 in pulmonary adenocarcinoma. J Clin Pathol. 2004;57:383-387.
16. Pelosi G, Fraggetta F, Pasini F. Immunoreactivity for thyroid transcription factor-1 in stage I non-small cell carcinomas of the lung. Am J Surg Pathol. 2001;25:363-372.
17. Tsubokawa F, Nishisaka T, Takeshima Y, et al. Heterogeneity of expression of cytokeratin subtypes in squamous cell carcinoma of the lung: with special reference to CK14 overexpression in cancer of high-proliferative and lymphogenous metastatic potential. Pathol Int. 2002;52:286-293.
18. Jerome Marson V, Mazieres J, Groussard O, et al. Expression of TTF-1 and cytokeratins in primary and secondary epithelial lung tumours: correlation with histological type and grade. Histopathology. 2004;45:125-134.
19. Ivanyi D, Groeneveld E, Van Doornewaard G, et al. Keratin subtypes in carcinomas of the uterine cervix: implications for histogenesis and differential diagnosis. Cancer Res. 1990;50:5143-5152.
20. Heatley MK. Cytokeratin 10/13, 14, 7, 8, and 18 in invasive squamous cell carcinoma and adenocarcinoma of the uterine cervix [letter]. J Clin Pathol. 1999;52:789.
21. Wang HL, Lu DW. Detection of human papillomavirus DNA and expression of p16, Rb, and p53 proteins in small cell carcinomas of the uterine cervix. Am J Surg Pathol. 2004;28:901-908.
22. Horn LC, Reichert A, Oster A, et al. Immunostaining for p16INK4a used as a conjunctive tool improves interobserver agreement of the histologic diagnosis of cervical intraepithelial neoplasia. Am J Surg Pathol. 2008;32:502-512.
23. Monsonego J, Pollini G, Evrard MJ, et al. P16(INK4a) immunocytochemistry in liquid-based cytology samples in equivocal Pap smears: added value in management of women with equivocal Pap smear. Acta Cytol. 2007;51:755-766.
24. Ansari-Lari MA, Staebler A, Zaino RJ, et al. Distinction of endocervical and endometrial adenocarcinomas: immunohistochemical p16 expression correlated with human papillomavirus (HPV) DNA detection. Am J Surg Pathol. 2004;28:160-167.
25. Vang R, Gown AM, Farinola M, et al. p16 Expression in primary ovarian mucinous and endometrioid tumors and metastatic adenocarcinomas in the ovary: utility for identification of metastatic HPV-related endocervical adenocarcinomas. Am J Surg Pathol. 2007;31:653-663.
26. Beasley MB, Lantuejoul S, Abbondanzo S, et al. The p16/ cyclin D1/Rb pathway in neuroendocrine tumors of the lung. Hum Pathol. 2003;34:136-142.
27. Calson JW, Nucci MR, Brodsky J, et al. Biomarker-assisted diagnosis of ovarian, cervical and pulmonary small cell carcinomas: the role of TTF-1, WT-1 and HPV analysis. Histopathology. 2007;51:305-312.
28. Murphy N, Ring M, Heffron CC, et al. P16INK4A, CDC6, and MCM5: predictive biomarkers in cervical preinvasive neoplasia and cervical cancer. J Clin Pathol. 2005;58:525-534.
29. Ishikawa M, Fujii T, Saito M, et al. Overexpression of p16 INK4a as an indicator for human papillomavirus oncogenic activity in cervical squamous neoplasia. Int J Gynecol Cancer. 2006;16:347-353.
30. Sano T, Masuda N, Oyama T, et al. Overexpression of p16 and p14ARF is associated with human papillomavirus infection in cervical squamous cell carcinoma and dysplasia. Pathol Int. 2002;52:375-383.
31. Plaza JA, Ramirez NC, Nuovo GJ. Utility of HPV analysis for evaluation of possible metastatic disease in women with cervical cancer. Int J Gynecol Pathol. 2004;23:7-12.
32. Nagai Y, Maehama T, Asato T, et al. Detection of human papillomavirus DNA in primary and metastatic lesions of carcinoma of the cervix in women from Okinawa, Japan. Am J Clin Oncol. 2001;24:160-166.
33. Huang CC, Kashima ML, Chen H, et al. HPV in situ hybridization with catalyzed signal amplification and polymerase chain reaction in establishing cerebellar metastasis of a cervical carcinoma. Hum Pathol. 1999;30:587-591.
34. Yanuck MD, Kaufman RH, Woods KV. Cervical carcinoma metastatic to the skull, heart, and lungs: analysis for human papillomavirus DNA. Gynecol Oncol. 1991;42:94-97.
35. Nuovo GJ. The surgical and cytopathology of viral infections: utility of immunohistochemistry, in situ hybridization, and in situ polymerase chain reaction amplification. Ann Diagn Pathol. 2006;10:117-131.
36. Syrjanen KJ. HPV infections and lung cancer. J Clin Pathol. 2002:55:885-891.
37. Coissard CJ, Besson G, Polette MC, et al. Prevalence of human papillomavirus in lung carcinomas: a study of 218 cases. Mod Pathol. 2005;18:1606-1609.
38. Brouchet L, Valmary S, Dahan M, et al. Detection of oncogenic virus genomes and gene products in lung carcinoma. Br J Cancer. 2005;92:743-746.
39. Miyagi J, Tsuhako K, Kinjo T, et al. Recent striking changes in histological differentiation and rate of human papillomavirus infection in squamous cell carcinoma of the lung in Okinawa, a subtropical island in southern Japan. J Clin Pathol. 2000;53:676-684.
40. Soini Y, Nuorva K, Kamel D, et al. Presence of human papillomavirus DNA and abnormal p53 protein accumulation in lung carcinoma. Thorax. 1996;51:887-893.
41. Papadopoulou K, Labropoulou V, Davaris P, et al. Detection of human papillomavirus in squamous cell carcinomas of the lung. Virchows Arch. 1998;433:49-54.
42. Hirayasu T, Iwamasa T, Kamada Y, et al. Human papillomavirus DNA in squamous cell carcinoma of the lung. J Clin Pathol. 1996;49:810-817.
43. Qingquan L, Ke H, Xianguang P, et al. Detection of human papillomavirus type 16, 18 DNA related sequences in bronchogenic carcinoma by polymerase chain reaction. Chin Med J (Engl). 1995;108:610-614.
44. Cheng YW, Chiou HL, Sheu GT, et al. The association of human papillomavirus 16/18 infection with lung cancer among nonsmoking Taiwanese women. Cancer Res. 2001;61:2799-2803.
45. Cheng YW, Chiou HL, Chen JT, et al. Gender difference in human papillomavirus infection for non-small cell lung cancer in Taiwan. Lung Cancer. 2004;46:165-170.
46. Wu MF, Cheng YW, Lai JC, et al. Frequent p16INK4a promoter hypermethylation in human papillomavirus-infected female lung cancer in Taiwan. Int J Cancer. 2005;113:440-445.