Osteoblasts stimulated with pulsed electromagnetic fields increase HUVEC proliferation via a VEGF-A independent mechanism

Bioelectromagnetics

Volumn 30, Issue 3, 2009, Pages 189-197

  Hopper, Richard A ^a,e   Verhalen, Jon P ^a   Tepper, Oren T ^b   Mehrara, Babek J ^b,d   Detch, Robert ^b   Chang, Edward I ^b   Baharestani, Samuel ^b   Simon, Bruce J ^b   Gurtner, Geoffrey C ^c  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b NEW YORK UNIVERSITY   (United States)

^c LP   (United States)

^d STANFORD UNIVERSITY   (United States)

^e SEATTLE CHILDREN S HOSPITAL   (United States)

Author keywords

Bone fracture; Co culture; Endothelial cells; Mitogen

Indexed keywords

BONE; CELL ENGINEERING; CYTOLOGY; ELECTROMAGNETIC FIELDS; OSTEOBLASTS;

BONE FRACTURE; CO-CULTURES; ENDOTHELIAL CELL PROLIFERATION; ENDOTHELIAL-CELLS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; LOWER FREQUENCIES; MITOGENIC EFFECTS; MITOGENS; PULSED ELECTROMAGNETIC FIELDS; VASCULAR ENDOTHELIAL GROWTH FACTOR;

ENDOTHELIAL CELLS;

THYMIDINE; VASCULOTROPIN A;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; CELL COMMUNICATION; CELL PROLIFERATION; CELL STIMULATION; ELECTROMAGNETIC FIELD; ENDOTHELIUM CELL; FRACTURE HEALING; HUMAN; HUMAN CELL; MITOGENESIS; NONHUMAN; OSTEOBLAST; PARACRINE SIGNALING; PRIORITY JOURNAL; RAT;

RATTUS;

EID: 65349089024     PISSN: 01978462     EISSN: 1521186X     Source Type: Journal    
DOI: 10.1002/bem.20459     Document Type: Article

References (36)

1. Aaron RK, Ciombor DM, Jolly G. 1989. Stimulation of experimental endochondral ossification by low-energy pulsing electromagnetic fields. J Bone Miner Res 4(2):227- 233.
2. AshiharaT, KagawaK, KamachiM. 1979. In: Brighton CT, BlackJ, Pollack SR, editors. Electrical properties of bone and cartilage. New York: Grune and Stratton. pp. 401 -426.
3. Bassett CA, Chockshi HR, Hernandez E. 1979. In: Brighton CT, Black J, Pollack SR, editors. Electrical properties of bone and cartilage. New York: Grune and Stratton. pp. 424-441.
4. Bassett CA, Schink-Ascani M, Lewis SM. 1989. Effects of pulsed electromagnetic fields on Steinberg ratings of femoral head osteonecrosis. Clin Orthop Relat Res 246:172-185.
5. Bodamyali T, Bhatt B, Hughes FJ, Winrow VR, Kanczler JM, Simon B, Abbott J, Blake DR, Stevens CR. 1998. Pulsed electromagnetic fields simultaneously induce osteogenesis and upregulate transcription of bone morphogenetic proteins 2 and 4 in rat osteoblasts in vitro. Biochem Biophys Res Commun 250(2):458-461.
6. Canalis E, Lorenzo J, Burgess WH, Maciag T. 1987. Effects of endothelial cell growth factor on bone remodeling in vitro. J Clin Invest 79(1):52-58.
7. Carano RA, Filvaroff EH. 2003. Angiogenesis and bone repair. Drug Discov Today 8(21):980-989.
8. Colacicco G, Pilla AA. 1983. Electromagnetic modulation of biological processes: Bicarbonate effect and mechanistic considerations in the Ca-uptake by embryonal chick tibia in vitro. Z Naturforsch [C] 38(5-6):465-467.
9. Conn G, Bayne ML, Soderman DD, Kwok PW, Sullivan KA, Palisi TM, Hope DA, Thomas KA. 1990. Amino acid and cDNA sequences of a vascular endothelial cell mitogen that is homologous to platelet-derived growth factor. Proc Natl Acad Sci USA 87(7):2628-2632.
10. Deckers MM, Karperien M, van der Bent C, Yamashita T, Papapoulos SE, Lowik CW. 2000. Expression of vascular endothelial growth factors and their receptors during osteoblast differentiation. Endocrinology 141(5):1667- 1674.
11. Deckers MM, van Bezooijen RL, van der Horst G, Hoogendam J, van Der Bent C, Papapoulos SE, Lowik CW. 2002. Bone morphogenetic proteins stimulate angiogenesis through osteoblast-derived vascular endothelial growth factor A. Endocrinology 143(4):1545 -1553.
12. Delle Monache S, Alessandro R, Iorio R, Gualtieri R, Colonna R. 2008. Extremely low frequency electromagnetic fields (ELF-EMFs) induce in vitro angiogenesis process in human endothelial cells. Bioelectromagnetics Pub Online 30 May 2008. 10.1002/bem.20430. http://www3.interscience.wiley. com/journal/119635786/abstract.
13. Farndale RW, Murray JC. 1985. Pulsed electromagnetic fields promote collagen production in bone marrow fibroblasts via athermal mechanisms. Calcif Tissue Int 37(2):178- 182.
14. Goad DL, Rubin J, Wang H, Tashjian AH, Jr., Patterson C. 1996. Enhanced expression of vascular endothelial growth factor in human SaOS-2 osteoblast-like cells and murine osteoblasts induced by insulin-like growth factor I. Endocrinology 137(6):2262 -2268.
15. Guenther HL, Fleisch H, Sorgente N. 1986. Endothelial cells in culture synthesize a potent bone cell active mitogen. Endocrinology 119(1):193 -201.
16. Guerkov HH, Lohmann CH, Liu Y, Dean DD, Simon BJ, Heckman JD, Schwartz Z, Boyan BD. 2001. Pulsed electromagnetic fields increase growth factor release by nonunion cells. Clin Orthop Relat Res 384:265-279.
17. Kaigler D, Krebsbach PH, Polverini PJ, Mooney DJ. 2003. Role of vascular endothelial growth factor in bone marrow stromal cell modulation of endothelial cells. Tissue Eng 9(1):95- 103.
18. Kueng W, Silber E, Eppenberger U. 1989. Quantification of cells cultured on 96-well plates. Anal Biochem 182(1):16-19.
19. Levy NS, Goldberg MA, Levy AP. 1997. Sequencing of the human vascular endothelial growth factor (VEGF) 3' untranslated region (UTR): Conservation of five hypoxia-inducible RNA- protein binding sites. Biochim Biophys Acta 1352(2):167- 173.
20. J, Perrella MA, Tsai JC, Yet SF, Hsieh CM, Yoshizumi M, Patterson C, Endege WO, Zhou F, Lee ME. 1995. Induction of vascular endothelial growth factor gene expression by interleukin-1 beta in rat aortic smooth muscle cells. J Biol Chem 270(1):308- 312.
21. Lohmann CH, Schwartz Z, Liu Y, Guerkov H, Dean DD, Simon B, Boyan BD. 2000. Pulsed electromagnetic field stimulation of MG63 osteoblast-like cells affects differentiation and local factor production. J Orthop Res 18(4):637-646.
22. Lohmann CH, Schwartz Z, Liu Y, Li Z, Simon BJ, Sylvia VL, Dean DD, Bonewald LF, Donahue HJ, Boyan BD. 2003. Pulsed electromagnetic fields affect phenotype and connexin 43 protein expression in MLO-Y4 osteocyte-like cells and ROS 17/2.8 osteoblast-like cells. J Orthop Res 21(2):326-334.
23. Mehrara BJ, Steinbrech DS, Saadeh PB, Gittes GK, Longaker MT. 1999. Expression of high-affinity receptors for TGF-beta during rat cranial suture fusion. Ann Plast Surg 42(5):502- 508.
24. Millauer B, Wizigmann-Voos S, Schnurch H, Martinez R, Moller NP, Risau W, Ullrich A. 1993. High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 72:835846.
25. Norton LA, Bourret LA, Majeska RJ. 1979. In: Brighton CT, Black J, Pollack SR, editors. Electrical properties of bone and cartilage. New York: Grune and Stratton. pp. 443 -454.
26. Norton LA, Witt DW, Rovetti LA. 1988. Pulsed electromagnetic fields alter phenotypic expression in chondroblasts in tissue culture. J Orthop Res 6(5):685-689.
27. Parfitt AM. 2000. The mechanism of coupling: A role for the vasculature. Bone 26(4):319-323.
28. Rubin CT, McLeod KJ, Lanyon LE. 1989. Prevention of osteoporosis by pulsed electromagnetic fields. J Bone Joint Surg Am 71(3):411 -417.
29. Saadeh PB, Mehrara BJ, Steinbrech DS, Dudziak ME, Greenwald JA, Luchs JS, Spector JA, Ueno H, Gittes GK, Longaker MT. 1999. Transforming growth factor-β1 modulates the expression of vascular endothelial growth factor by osteoblasts. Am J Physiol 277(4 Pt 1):C628-C637.
30. Saadeh PB, Mehrara BJ, Steinbrech DS, Spector JA, Greenwald JA, Chin GS, Ueno H, Gittes GK, Longaker MT. 2000. Mechanisms of fibroblast growth factor-2 modulation of vascular endothelial growth factor expression by osteoblastic cells. Endocrinology 141(6):2075-2083.
31. Spector JA, Mehrara BJ, Greenwald JA, Saadeh PB, Steinbrech DS, Bouletreau PJ, Smith LP, Longaker MT. 2001. Osteoblast expression of vascular endothelial growth factor is modulated by the extracellular microenvironment. Am J Physiol Cell Physiol 280(1):C72-C80.
32. Steinbrech DS, Mehrara BJ, Saadeh PB, Chin G, Dudziak ME, Gerrets RP, Gittes GK, Longaker MT. 1999. Hypoxia regulates VEGF expression and cellular proliferation by osteoblasts in vitro. Plast Reconstr Surg 104(3):738-747.
33. Tepper OM, Callaghan MJ, Chang EI, Galiano RD, Bhatt KA, Baharestani S, Gan J, Simon B, Hopper RA, Levine JP, Gurtner GC. 2004. Electromagnetic fields increase in vitro and in vivo angiogenesis through endothelial release of FGF-2. FASEB J 18(11):1231- 1233.
34. Villars F, Bordenave L, Bareille R, Amedee J. 2000. Effect of human endothelial cells on human bone marrow stromal cell phenotype: Role of VEGF? J Cell Biochem 79(4):672- 685.
35. von Schroeder HP, Veillette CJ, Payandeh J, Qureshi A, Heersche JN. 2003. Endothelin-1 promotes osteoprogenitor proliferation and differentiation in fetal rat calvarial cell cultures. Bone 33(4):673-684.
36. Yen-Patton GP, Patton WF, Beer DM, Jacobson BS. 1988. Endothelial cell response to pulsed electromagnetic fields: Stimulation of growth rate and angiogenesis in vitro. J Cell Physiol 134(1):37-46.