Timing of induction of cardiomyocyte differentiation for in vitro cultured mesenchymal stem cells: A perspective for emergencies

Canadian Journal of Physiology and Pharmacology

Volumn 87, Issue 2, 2009, Pages 143-150

  Tokcaer Keskin, Zeynep ^a   Akar, A Ruchan ^b   Ayaloglu Butun, Fatma ^a   Terzioglu Kara, Ece ^a   Durdu, Serkan ^b   Ozyurda, Umit ^b   Ugur, Mehmet ^b   Akcali, Kamil C ^a  

^a BILKENT UNIVERSITY   (Turkey)

^b ANKARA UNIVERSITY   (Turkey)

Author keywords

Cardiomyocytes; Differentiation; Gene expression; In vitro; Mesenchymal stem cells; Rat

Indexed keywords

ALPHA ACTIN; AZACITIDINE; CALCIUM; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MYOCYTE ENHANCER FACTOR 2; MYOCYTE ENHANCER FACTOR 2D; TROPONIN I; UNCLASSIFIED DRUG;

ANIMAL CELL; CALCIUM CELL LEVEL; CELL DIFFERENTIATION; CELL ISOLATION; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GENE EXPRESSION; HEART INFARCTION; HEART MUSCLE CELL; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN VITRO STUDY; MESENCHYMAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANTIGENS, CD34; ANTIGENS, THY-1; AZACITIDINE; BIOLOGICAL MARKERS; BONE MARROW CELLS; CAFFEINE; CALCIUM; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; CELLS, CULTURED; FEMALE; MEMBRANE POTENTIALS; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; MYOCYTES, CARDIAC; POTASSIUM CHLORIDE; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

EID: 65249120766     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/Y08-111     Document Type: Conference Paper

References (28)

1. Akar, A.R., Durdu, S., Corapcioglu, T., and Ozyurda, U. 2006. Regenerative medicine for cardiovascular disorders-new milestones: adult stem cells. Artif. Organs, 30: 213-232. doi:10. 1111/j.1525-1594.2006.00209.x. PMID:16643380.
2. Antonitsis, P., Ioannidou-Papagiannaki, E., Kaidoglou, A., and Pa- pakonstantinou, C. 2007. In vitro cardiomyogenic differentiation of adult human bone marrow mesenchymal stem cells: the role of 5-azacytidine. Interact. Cardiovasc. Thorac. Surg. 6: 593597. doi:10.1510/icvts.2007.157875. PMID:17670726.
3. Atsma, D.E., Fibbe, W.E., and Rabelink, T.J. 2007. Opportunities and challenges for mesenchymal stem cell-mediated heart repair. Curr. Opin. Lipidol. 18: 645-649. PMID:17993810.
4. Baksh, D., Song, L., and Tuan, R.S. 2004. Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy. J. Cell. Mol. Med. 8: 301-316. doi:10. 1111/j.1582-4934.2004.tb00320.x. PMID:15491506.
5. Barry, F.P., and Murphy, J.M. 2004. Mesenchymal stem cells: clinical applications and biological characterization. Int. J. Biochem. Cell Biol. 36: 568-584. doi:10.1016/j.biocel.2003.11.001. PMID:15010324.
6. Bartunek, J., Wijns, W., Heyndrickx, G.R., and Vanderheyden, M. 2006. Timing of intracoronary bone marrow-derived stem cell transplantation after ST-elevation myocardial infarction. Nat. Clin. Pract. Cardiovasc. Med. 3(Suppl 1): S52-S56. doi:10. 1038/ncpcardio0417. PMID:16501632.
7. Brazelton, T.R., Rossi, F.M., Keshet, G.I., and Blau, H.M. 2000. From marrow to brain: expression of neuronal phenotypes in adult mice. Science, 290: 1775-1779. doi:10.1126/science.290. 5497.1775. PMID:11099418.
8. Caplan, A.I., and Bruder, S.P. 2001. Mesenchymal stem cells: building blocks for molecular medicine in the 21st century. Trends Mol. Med. 7: 259-264. doi:10.1016/S1471-4914(01) 02016-0. PMID:11378515.
9. Edelberg, J.M., Tang, L., Hattori, K., Lyden, D., and Rafii, S. 2002. Young adult bone marrow-derived endothelial precursor cells restore aging-impaired cardiac angiogenic function. Circ. Res. 90: E89-E93. doi:10.1161/01.RES.0000020861.20064.7E. PMID:12039806.
10. Friedenstein, A.J., Deriglasova, U.F., Kulagina, N.N., Panasuk, A.F., Rudakowa, S.F., Luria, E.A., and Ruadkow, I.A. 1974. Precursors for fibroblasts in different populations of hematopoie- tic cells as detected by the in vitro colony assay method. Exp. Hematol. 2: 83-92. PMID:4455512.
11. Friedenstein, A.J., Gorskaja, J.F., and Kulagina, N.N. 1976. Fibro- blast precursors in normal and irradiated mouse hematopoietic organs. Exp. Hematol. 4: 267-274. PMID:976387.
12. Ivanova, N.B., Dimos, J.T., Schaniel, C., Hackney, J.A., Moore, K.A., and Lemischka, I.R. 2002. A stem cell molecular signature. Science, 298: 601-604. doi:10.1126/science.1073823. PMID:12228721.
13. Jackson, K.A., Majka, S.M., Wang, H., Pocius, J., Hartley, C.J., Majesky, M.W., et al. 2001. Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J. Clin. Invest. 107: 1395-1402. doi:10.1172/JCI12150. PMID:11390421.
14. Laflamme, M.A., and Murry, C.E. 2005. Regenerating the heart. Nat. Biotechnol. 23: 845-856. doi:10.1038/nbt1117. PMID:16003373.
15. Makino, S., Fukuda, K., Miyoshi, S., Konishi, F., Kodama, H., Pan, J., et al. 1999. Cardiomyocytes can be generated from marrow stromal cells in vitro. J. Clin. Invest. 103: 697-705. doi:10. 1172/JCI5298. PMID:10074487.
16. Mezey, E., Chandross, K.J., Harta, G., Maki, R.A., and McKercher, S.R. 2000. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science, 290: 1779-1782. doi:10.1126/science.290. 5497.1779. PMID:11099419.
17. Morrison, S.J., Shah, N.M., and Anderson, D.J. 1997. Regulatory mechanisms in stem cell biology. Cell, 88: 287-298. doi:10. 1016/S0092-8674(00)81867-X. PMID:9039255.
18. Muscari, C., Bonafe, F., Carboni, M., Govoni, M., Stanic, I., Gam- berini, C., et al. 2008. Difluoromethylornithine stimulates early cardiac commitment of mesenchymal stem cells in a model of mixed culture with cardiomyocytes. J. Cell. Biochem. 103: 1046-1052. doi:10.1002/jcb.21683. PMID:18240140.
19. Ohnishi, S., and Nagaya, N. 2007. Prepare cells to repair the heart: mesenchymal stem cells for the treatment of heart failure. Am. J. Nephrol. 27: 301-307. doi:10.1159/000102000. PMID:17460394.
20. Orlic, D., Kajstura, J., Chimenti, S., Jakoniuk, I., Anderson, S.M., Li, B., et al. 2001. Bone marrow cells regenerate infarcted myocardium. Nature, 410: 701-705. doi:10.1038/35070587. PMID:11287958.
21. Petersen, B.E., Bowen, W.C., Patrene, K.D., Mars, W.M., Sullivan, A.K., Murase, N., et al. 1999. Bone marrow as a potential source of hepatic oval cells. Science, 284: 1168-1170. doi:10. 1126/science.284.5417.1168. PMID:10325227.
22. Pittenger, M.F., Mackay, A.M., Beck, S.C., Jaiswal, R.K., Douglas, R., Mosca, J.D., et al. 1999. Multilineage potential of adult human mesenchymal stem cells. Science, 284: 143-147. doi:10. 1126/science.284.5411.143. PMID:10102814.
23. Shake, J.G., Gruber, P.J., Baumgartner, W.A., Senechal, G., Meyers, J., Redmond, J.M., et al. 2002. Mesenchymal stem cell implantation in a swine myocardial infarct model: engraftment and functional effects. Ann. Thorac. Surg. 73: 1919-1926. doi:10.1016/S0003-4975(02)03517-8. PMID:12078791.
24. Toma, C., Pittenger, M.F., Cahil, K.S., Byrne, B.J., and Kessler, P.D. 2002. Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation, 105: 93-98. doi:10.1161/hc0102. 101442. PMID:11772882.
25. Tomita, S., Mickle, D.A., Weisel, R.D., Jia, Z.Q., Tumiati, L.C., Allidina, Y., et al. 2002. Improved heart function with myogen- esis and angiogenesis after autologous porcine bone marrow stromal cell transplantation. J. Thorac. Cardiovasc. Surg. 123: 1132-1140. doi:10.1067/mtc.2002.120716. PMID:12063460.
26. Tousoulis, D., Briasoulis, A., Antoniades, C., Stefanadi, E., and Stefanadis, C. 2008. Heart regeneration: what cells to use and how? Curr. Opin. Pharmacol. 8: 211-218. doi:10.1016/j.coph. 2008.01.001. PMID:18291721.
27. Wang, X.J., and Li, Q.P. 2007. The roles of mesenchymal stem cells (MSCs) therapy in ischemic heart diseases. Biochem. Biophys. Res. Commun. 359: 189-193. doi:10.1016/j.bbrc.2007.05. 112. PMID:17543286.
28. Zhang, F.B., Li, L., Fang, B., Zhu, D.L., Yang, H.T., and Gao, P.J. 2005. Passage-restricted differentiation potential of mesenchy- mal stem cells into cardiomyocyte-like cells. Biochem. Biophys. Res. Commun. 336: 784-792. doi:10.1016/j.bbrc.2005.08.177. PMID:16143296.