Cytoplasmic Prep1 interacts with 4EHP inhibiting Hoxb4 translation

PLoS ONE

Volumn 4, Issue 4, 2009, Pages

  Villaescusa, J Carlos ^a,d   Buratti, Claudia ^a   Penkov, Dmitry ^a   Mathiasen, Lisa ^a   Planagumà, Jesús ^b   Ferretti, Elisabetta ^c,e   Blasi, Francesco ^a,c  

^a FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^b UNIVERSITY OF BERGEN   (Norway)

^c VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^d KAROLINSKA INSTITUTE   (Sweden)

^e WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HOMEODOMAIN PROTEIN; HOX PROTEIN; HOXB4 PROTEIN; INITIATION FACTOR 4E; LUCIFERASE; MESSENGER RNA; MICRORNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PREP1; UNCLASSIFIED DRUG; HOXB4 PROTEIN, MOUSE; HYBRID PROTEIN; PKNOX1 PROTEIN, MOUSE;

3' UNTRANSLATED REGION; ANIMAL CELL; ARTICLE; CELL FATE; CELL GROWTH; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; CYTOSOL; EMBRYO DEVELOPMENT; EMBRYO PATTERN FORMATION; FEMALE; GEL MOBILITY SHIFT ASSAY; GENE OVEREXPRESSION; GERM CELL; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IN VITRO STUDY; INHIBITION KINETICS; MAMMAL; MOUSE; MUTAGENESIS; NONHUMAN; OOCYTE DEVELOPMENT; PROTEIN BINDING; PROTEIN DENATURATION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN SYNTHESIS; RNA STRUCTURE; TRANSCRIPTION REGULATION; TRANSLATION REGULATION; ZYGOTE; AMINO ACID SEQUENCE; ANIMAL; ANIMAL EMBRYO; C57BL MOUSE; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HISTOLOGY; METABOLISM; MOLECULAR GENETICS; OOCYTE; OVARY; PHYSIOLOGY; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY;

EUKARYOTA; MAMMALIA;

3' UNTRANSLATED REGIONS; AMINO ACID SEQUENCE; ANIMALS; EMBRYO, MAMMALIAN; EUKARYOTIC INITIATION FACTOR-4E; FEMALE; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; OOCYTES; OVARY; PROTEIN BIOSYNTHESIS; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION FACTORS;

EID: 65249118749     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0005213     Document Type: Article

References (43)

1. Moens CB, Selleri L (2006) Hox cofactors in vertebrate development. Dev Biol 291: 193-206.
2. Di Rosa P, Villaescusa JC, Longobardi E, Iotti G, Ferretti E, et al. (2007) The homeodomain transcription factor Prep1 (pKnox1) is required for hematopoietic stem and progenitor cell activity. Dev Biol.
3. Ferretti E, Villaescusa JC, Di Rosa P, Fernandez-Diaz LC, Longobardi E, et al. (2006) Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype. Mol Cell Biol 26: 5650-5662.
4. Penkov D, Di Rosa P, Fernandez Diaz L, Basso V, Ferretti E, et al. (2005) Involvement of Prep1 in the alphabeta T-cell receptor T-lymphocytic potential of hematopoietic precursors. Mol Cell Biol 25: 10768-10781.
5. Waskiewicz AJ, Rikhof HA, Moens CB (2002) Eliminating zebrafish pbx proteins reveals a hindbrain ground state. Dev Cell 3: 723-733.
6. Deflorian G, Tiso N, Ferretti E, Meyer D, Blasi F, et al. (2004) Prep1.1 has essential genetic functions in hindbrain development and cranial neural crest cell differentiation. Development 131: 613-627.
7. Brend T, Gilthorpe J, Summerbell D, Rigby PW (2003) Multiple levels of transcriptional and post-transcriptional regulation are required to define the domain of Hoxb4 expression. Development 130: 2717-2728.
8. Small S, Levine M (1991) The initiation of pair-rule stripes in the Drosophila blastoderm. Curr Opin Genet Dev 1: 255-260.
9. Small S, Kraut R, Hoey T, Warrior R, Levine M (1991) Transcriptional regulation of a pair-rule stripe in Drosophila. Genes Dev 5: 827-839.
10. Driever W, Nusslein-Volhard C (1989) The bicoid protein is a positive regulator of hunchback transcription in the early Drosophila embryo. Nature 337: 138-143.
11. Cho PF, Poulin F, Cho-Park YA, Cho-Park IB, Chicoine JD, et al. (2005) A new paradigm for translational control: inhibition via 59-39 mRNA tethering by Bicoid and the eIF4E cognate 4EHP. Cell 121: 411-423.
12. Topisirovic I, Borden KL (2005) Homeodomain proteins and eukaryotic translation initiation factor 4E (eIF4E): an unexpected relationship. Histol Histopathol 20: 1275-1284.
13. Niessing D, Blanke S, Jackle H (2002) Bicoid associates with the 5′-cap-bound complex of caudal mRNA and represses translation. Genes Dev 16: 2576-2582.
14. Bachvarova R (1981) Synthesis, turnover, and stability of heterogeneous RNA in growing mouse oocytes. Dev Biol 86: 384-392.
15. Bachvarova R, De Leon V, Johnson A, Kaplan G, Paynton BV (1985) Changes in total RNA, polyadenylated RNA, and actin mRNA during meiotic maturation of mouse oocytes. Dev Biol 108: 325-331.
16. Bachvarova R, Cohen EM, De Leon V, Tokunaga K, Sakiyama S, et al. (1989) Amounts and modulation of actin mRNAs in mouse oocytes and embryos. Development 106: 561-565.
17. Kuliev A, Kukharenko V, Morozov G, Freidine M, Rechitsky S, et al. (1996) Expression of homebox-containing genes in human preimplantation development and in embryos with chromosomal aneuploidies. J Assist Reprod Genet 13: 177-181.
18. Villaescusa JC, Verrotti AC, Ferretti E, Farookhi R, Blasi F (2004) Expression of Hox cofactor genes during mouse ovarian follicular development and oocyte maturation. Gene 330: 1-7.
19. Sedarat F, Lin E, Moore ED, Tibbits GF (2004) Deconvolution of confocal images of dihydropyridine and ryanodine receptors in developing cardiomyocytes. J Appl Physiol 97: 1098-1103.
20. Angenstein F, Evans AM, Ling SC, Settlage RE, Ficarro S, et al. (2005) Proteomic characterization of messenger ribonucleoprotein complexes bound to nontranslated or translated poly(A) mRNAs in the rat cerebral cortex. J Biol Chem 280: 6496-6503.
21. Stauber M, Jackle H, Schmidt-Ott U (1999) The anterior determinant bicoid of Drosophila is a derived Hox class 3 gene. Proc Natl Acad Sci U S A 96: 3786-3789.
22. Murtha MT, Leckman JF, Ruddle FH (1991) Detection of homeobox genes in development and evolution. Proc Natl Acad Sci U S A 88: 10711-10715.
23. Ponsuksili S, Wimmers K, Adjaye J, Schellander K (2001) Expression of homeobox-containing genes in cDNA libraries derived from cattle oocytes and preimplantation stage embryo. Mol Reprod Dev 60: 297-301.
24. Tee AR, Tee JA, Blenis J (2004) Characterizing the interaction of the mammalian eIF4E-related protein 4EHP with 4E-BP1. FEBS Lett 564: 58-62.
25. Zuberek J, Kubacka D, Jablonowska A, Jemielity J, Stepinski J, et al. (2007) Weak binding affinity of human 4EHP for mRNA cap analogs. RNA 13: 691-697.
26. Chawengsaksophak K, Beck F (1996) Chromosomal localization of cdx2, a murine homologue of the Drosophila gene caudal, to mouse chromosome 5. Genomics 34: 270-271.
27. Ferretti E, Marshall H, Popperl H, Maconochie M, Krumlauf R, et al. (2000) Segmental expression of Hoxb2 in r4 requires two separate sites that integrate cooperative interactions between Prep1, Pbx and Hox proteins. Development 127: 155-166.
28. Ferretti E, Cambronero F, Tumpel S, Longobardi E, Wiedemann LM, et al. (2005) Hoxb1 enhancer and control of rhombomere 4 expression: complex interplay between PREP1-PBX1-HOXB1 binding sites. Mol Cell Biol 25: 8541-8552.
29. Diaz VM, Mori S, Longobardi E, Menendez G, Ferrai C, et al. (2007) p160 myb-binding-protein interacts with Prep1 and inhibits its transcriptional activity. Mol Cell Biol.
30. Berthelsen J, Kilstrup-Nielsen C, Blasi F, Mavilio F, Zappavigna V (1999) The subcellular localization of PBX1 and EXD proteins depends on nuclear import and export signals and is modulated by association with PREP1 and HTH. Genes Dev 13: 946-953.
31. Rom E, Kim HC, Gingras AC, Marcotrigiano J, Favre D, et al. (1998) Cloning and characterization of 4EHP, a novel mammalian eIF4E-related cap-binding protein. J Biol Chem 273: 13104-13109.
32. Semotok JL, Lipshitz HD (2007) Regulation and function of maternal mRNA destabilization during early Drosophila development.Differentiation 75: 482-506.
33. Kuersten S, Goodwin EB (2003) The power of the 39 UTR: translational control and development. Nat Rev Genet 4: 626-637.
34. Oh B, Hwang S, McLaughlin J, Solter D, Knowles BB (2000) Timely translation during the mouse oocyte-to-embryo transition. Development 127: 3795-3803.
35. Gebauer F, Xu W, Cooper GM, Richter JD (1994) Translational control by cytoplasmic polyadenylation of c-mos mRNA is necessary for oocyte maturation in the mouse. Embo J 13: 5712-5720.
36. Huarte J, Belin D, Vassalli A, Strickland S, Vassalli JD (1987) Meiotic maturation of mouse oocytes triggers the translation and polyadenylation of dormant tissue-type plasminogen activator mRNA. Genes Dev 1: 1201-1211.
37. Brun AC, Bjornsson JM, Magnusson M, Larsson N, Leveen P, et al. (2004) Hoxb4-deficient mice undergo normal hematopoietic development but exhibit a mild proliferation defect in hematopoietic stem cells. Blood 103: 4126-4133.
38. Niranjanakumari S, Lasda E, Brazas R, Garcia-Blanco MA (2002) Reversible cross-linking combined with immunoprecipitation to study RNA-protein interactions in vivo. Methods 26: 182-190.
39. Costes SV, Daelemans D, Cho EH, Dobbin Z, Pavlakis G, et al. (2004) Automatic and quantitative measurement of protein-protein colocalization in live cells. Biophys J 86: 3993-4003.
40. Thomson AM, Rogers JT, Walker CE, Staton JM, Leedman PJ (1999) Optimized RNA gel-shift and UV cross-linking assays for characterization of cytoplasmic RNA-protein interactions. Biotechniques 27: 1032-1039, 1042.
41. Schultz RM, Montgomery RR, Belanoff JR (1983) Regulation of mouse oocyte meiotic maturation: implication of a decrease in oocyte cAMP and protein dephosphorylation in commitment to resume meiosis. Dev Biol 97: 264-273.
42. Schultz RM, Montgomery RR, Ward-Bailey PF, Eppig JJ (1983) Regulation of oocyte maturation in the mouse: possible roles of intercellular communication, cAMP, and testosterone. Dev Biol 95: 294-304.
43. Chatot CL, Ziomek CA, Bavister BD, Lewis JL, Torres I (1989) An improved culture medium supports development of random-bred 1-cell mouse embryos in vitro. J Reprod Fertil 86: 679-688.