The ethics of thrombolytic trials beyond 3 (or 4.5) hours randomized controlled trials are required to change clinical practice

Stroke

Volumn 40, Issue 4, 2009, Pages 1545-

  Donnan, Geoffrey A ^a   Davis, Stephen M ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; PLACEBO; TISSUE PLASMINOGEN ACTIVATOR;

BLOOD CLOT LYSIS; BRAIN EDEMA; CLINICAL DECISION MAKING; CLINICAL PRACTICE; CLINICAL TRIAL; CRANIECTOMY; HEALTH PRACTITIONER; HUMAN; MIDDLE CEREBRAL ARTERY OCCLUSION; PRACTICE GUIDELINE; PRIORITY JOURNAL; REPERFUSION; SHORT SURVEY; STROKE; TREATMENT OUTCOME; ETHICS; FIBRINOLYTIC THERAPY; METHODOLOGY; PHASE 3 CLINICAL TRIAL; RANDOMIZED CONTROLLED TRIAL; REVIEW; TIME;

CLINICAL TRIALS, PHASE III AS TOPIC; HUMANS; PLACEBOS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; STROKE; THROMBOLYTIC THERAPY; TIME FACTORS;

EID: 65249113199     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/STROKEAHA.108.520684     Document Type: Short Survey

References (4)

1. Donnan GA, Fisher M, Macleod M, Davis SM. Stroke Lancet. 2008;371: 1612-1623.
2. Hacke W, Kaste M, Bluhmki E, Brozman M, Davalos A, Guidetti D, Larrue V, Lees KR, Medeghri Z, Machnig T, Schneider D, von Kummer R, Wahlgren N, Toni D. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med. 2008;359:1317-1329.
3. Furlan A, Higashida R, Wechsler L, Gent M, Rowley H, Kase C, Pessin M, Ahuja A, Callahan F, Clark WM, Silver F, Rivera F, for the PROACT investigators. Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: A randomized controlled trial. JAMA 1999;282:2003-2011.
4. Davis SM, Donnan GA, Parsons MW, Levi C, Butcher KS, Peeters A, Barber PA, Bladin C, De Silva DA, Byrnes G, Chalk JB, Fink JN, Kimber TE, Schultz D, Hand PJ, Frayne J, Hankey G, Muir K, Gerraty R, Tress BM, Desmond PM. Effects of alteplase beyond 3 hours after stroke in the echoplanar imaging thrombolytic evaluation trial (EPITHET): A placebo-controlled randomised trial. Lancet Neurol. 2008;7:299-309.