Effects of β-adrenergic receptor blockers on cardiac function: A comparative study in male versus female rats

Canadian Journal of Physiology and Pharmacology

Volumn 87, Issue 4, 2009, Pages 310-317

  Tuncay, Erkan ^a   Seymen, Ali Aytac ^a   Sam, Pinar ^a   Gurdal, Hakan ^a   Turan, Belma ^a  

^a ANKARA UNIVERSITY   (Turkey)

Author keywords

Beta blockers; Heart function; Propranolol; Sex differences; Timolol

Indexed keywords

ISOPRENALINE; PROPRANOLOL; TIMOLOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; FEMALE; HEART FUNCTION; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE POTENTIAL; HEART PAPILLARY MUSCLE; HEART REPOLARIZATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEX DIFFERENCE;

ACTION POTENTIALS; ADRENERGIC BETA-ANTAGONISTS; ANIMALS; CALCIUM; FEMALE; HEART; MALE; PROPRANOLOL; RATS; RATS, WISTAR; SEX CHARACTERISTICS; TIMOLOL; VENTRICULAR FUNCTION, LEFT;

EID: 65249086231     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/Y09-015     Document Type: Article

References (40)

1. Anwar, A., Schlüter, K.D., Heger, J., Piper, H.M., and Euler, G. 2008. Enhanced SERCA2A expression improves contractile performance of ventricular cardiomyocytes of rat under adrenergic stimulation. Pflugers Arch.. doi:10.1007/s00424-008-0520-7. PMID:18581135.
2. Bedinghaus, J., Leshan, L., and Diehr, S. 2001. Coronary artery disease prevention: what's different for women? Am. Fam. Physician, 63(7): 1393-1400, 1405-1406. PMID:11310652.
3. Bidoggia, H., Maciel, J.P., Capalozza, N., Mosca, S., Blaksley, E.J., Valverde, E., et al. 2000. Sex differences on the electrocardiographic pattern of cardiac repolarization: possible role of testosterone. Am. Heart J. 140(4): 678-683. doi:10.1067/mhj.2000. 109918. PMID:11011345.
4. Bouzamondo, A., Hulot, J.S., Sanchez, P., Cucherat, M., and Le- chat, P. 2001. Beta-blocker treatment in heart failure. Fundam. Clin. Pharmacol. 15(2): 95-109. doi:10.1046/j.1472-8206.2001. 00019.x. PMID:11468019.
5. Bristow, M.R., Ginsburg, R., Umans, V., Fowler, M., Minobe, W., Rasmussen, R., et al. 1986. Beta 1- and beta 2-adrenergic- receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure. Circ. Res. 59(3): 297-309. PMID:2876788.
6. Bristow, M.R., Port, J.D., Hershberger, R.E., Gilbert, E.M., and Feldman, A.M. 1989. The beta-adrenergic receptor- adenylate cyclase complex as a target for therapeutic intervention in heart failure. Eur. Heart J. 10 Suppl. B: 45-54. PMID:2572420.
7. Brodde, O.E. 2007. Beta- adrenoceptor blocker treatment and the cardiac beta- adrenoceptor-G-protein(s)-adenylyl cyclase system in chronic heart failure. Naunyn Schmiedebergs Arch. Pharmacol. 374(5-6): 361-372. doi:10.1007/s00210-006-0125-7. PMID:17216434.
8. Brodde, O.E., and Michel, M.C. 1999. Adrenergic and muscarinic receptors in the human heart. Pharmacol. Rev. 51(4): 651-690. PMID:10581327.
9. Buxton, I.L., and Brunton, L.L. 1985. Direct analysis of beta- adrenergic receptor subtypes on intact adult ventricular myocytes of the rat. Circ. Res. 56(1): 126-132. PMID:2857116.
10. Chalothorn, D., McCune, D.F., Edelmann, S.E., García -Cazarín, M.L., Tsujimoto, G., and Piascik, M.T. 2002. Differences in the cellular localization and agonist-mediated internalization proper-ties of the alpha(1)-adrenoceptor subtypes. Mol. Pharmacol. 61(5): 1008-1016. doi:10.1124/mol.61.5.1008. PMID:11961118.
11. Davis, S.N., Galassetti, P., Wasserman, D.H., and Tate, D. 2000. Effects of gender on neuroendocrine and metabolic counter- regulatory responses to exercise in normal man. J. Clin. Endo- crinol. Metab. 85(1): 224-230. doi:10.1210/jc.85.1.224. PMID:10634391.
12. Dirksen, R.T., and Sheu, S.S. 1990. Modulation of ventricular action potential by alpha 1-adrenoceptors and protein kinase C. Am. J. Physiol. 258(3 Pt 2): H907-H911. PMID:2156457.
13. Dupré, D.J., Robitaille, M., Ethier, N., Villeneuve, L.R., Mamarba- chi, A.M., and Heibert, T.E. 2006. Seven transmembrane receptor core signaling complexes are assembled prior to plasma membrane trafficking. J. Biol. Chem. 281(45): 34561-34573. doi:10.1074/jbc.M605012200. PMID:16959776.
14. Haeusler, G. 1990. Pharmacology of beta-blockers: classical aspects and recent developments. J. Cardiovasc. Pharmacol. 5:S1-S9.
15. Horinouchi, T., Morishima, S., Tanaka, T., Suzuki, F., Tanaka, Y., Koike, K., et al. 2007. Different changes of plasma membrane beta -adrenoceptors in rat heart after chronic administration of propranolol, atenolol and bevantolol. Life Sci. 81(5): 399-404. doi:10.1016/j.lfs.2007.06.003. PMID:17628611.
16. Johnson, B.E., and Johnson, C.A. 2001. Cardiovascular disease and differences between the sexes. Am. Fam. Physician, 63(7): 1290, 1292. PMID:11310645.
17. Juberg, E.N., Minneman, K.P., and Abel, P.W. 1985. Beta 1- and beta 2-adrenoceptor binding and functional response in right and left atria of rat heart. Naunyn Schmiedebergs Arch. Pharmacol. 330(3): 193-202. doi:10.1007/BF00572434. PMID:2865685.
18. Kuznetsov, V., Pak, E., Robinson, R.B., and Steinberg, S.F. 1995. Beta 2-adrenergic receptor actions in neonatal and adult rat ventricular myocytes. Circ. Res. 76(1): 40-52. PMID:8001277.
19. 2+ in adult rat ventricular myocytes? Am. J. Physiol. 274(4 Pt 2): H1308-H1314. PMID:9575936.
20. Limmroth, V., and Michel, M.C. 2001. The prevention of migraine: a critical review with special emphasis on beta -adrenoceptor blockers. Br. J. Clin. Pharmacol. 52(3): 237-243. doi:10.1046/j. 0306-5251.2001.01459.X. PMID:11560555.
21. Linck, B., Boknfk, P., Baba, H.A., Eschenhagen, T., Haverkamp, U., Jackel, E., et al. 1998. Long-term beta adrenoceptor- mediated alteration in contractility and expression of phospho- lamban and sarcoplasmic reticulum Ca(++)-ATPase in mammalian ventricle. J. Pharmacol. Exp. Ther. 286(1): 531-538. PMID:9655899.
22. Lowe, M.D., Lynham, J.A., Grace, A.A., and Kaumann, A.J. 2002. Comparison of the affinity of beta-blockers for two states of the beta 1-adrenoceptor in ferret ventricular myocardium. Br. J. Pharmacol. 135(2): 451-461. doi:10.1038/sj.bjp.0704450. PMID:11815381.
23. Luzier, A.B., Nawarskas, J.J., Añonuevo, J., Wilson, M.F., and Kazierad, D.J. 1998. The effects of gender on adrenergic receptor responsiveness. J. Clin. Pharmacol. 38(7): 618-624. PMID:9702846.
24. Madden, K.M., Levy, W.C., and Stratton, J.R. 2006. Normal aging impairs upregulation of the beta-adrenergic but not the alpha- adrenergic response: aging and adrenergic upregulation. J. Car- diovasc. Pharmacol. 48(4): 153-159. doi:10.1097/01.fjc. 0000246405.89380.48. PMID:17086093.
25. Mendelsohn, M.E., and Karas, R.H. 2005. Molecular and cellular basis of cardiovascular gender differences. Science, 308(5728):1583-1587. doi:10.1126/science.1112062. PMID:15947175.
26. Pham, T.V., Robinson, R.B., Danilo, P., and Rosen, M.R. 2002. Effects of gonadal steroids on gender-related differences in trans- mural dispersion of L- type calcium current. Cardiovasc. Res. 53(3): 752-762. doi:10.1016/S0008-6363(01)00449-7. PMID: 11861045.
27. Poole-Wilson, P.A., Swedberg, K., Cleland, J.G.F., Di Lenarda, A., Hanrath, P., Komajda, M., et al. 2003. Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol or Metoprolol European Trial (COMET). Lancet, 362: 7-13. doi:10.1016/S0140-6736(03) 13800-7. PMID:12853193.
28. Prichard, B.N. 1988. Risk-benefits of antihypertensive drugs-beta- blockers. Clin. Exp. Pharmacol. Physiol. 15(3): 203-213. doi:10.1111/j.1440-1681.1988.tb01063.x. PMID:2908432.
29. Schwertz, D.W., Vizgirda, V., Solaro, R.J., Piano, M.R., and Ry- jewski, C. 1999. Sexual dimorphism in rat left atrial function and response to adrenergic stimulation. Mol. Cell. Biochem. 200(1- 2): 143-153. doi:10.1023/A:1007011807383. PMID:10569194.
30. Steinberg, S.F. 1999. The molecular basis for distinct beta- adrenergic receptor subtype actions in cardiomyocytes. Circ. Res. 85(11): 1101-1111. PMID:10571542.
31. Stone, P.H., Thompson, B., Anderson, H.V., Kronenberg, M.W., Gibson, R.S., Rogers, W.J., et al. 1996. Influence of race, sex, and age on management of unstable angina and non-Q-wave myocardial infarction: the TIMI III registry. JAMA, 275(14): 1104-1112. doi:10.1001/jama.275.14.1104. PMID:8601930.
32. The BEST Steering Committee. 1995. Design of the Beta- Blocker Evaluation Survival Trial (BEST). Am. J. Cardiol. 75(17): 1224-1228. doi:10.1016/S0002-9149(99)80766-8. PMID:7778543.
33. The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial. 1999. Lancet, 353(9146): 9-13. doi:10.1016/S0140- 6736(98)11181-9. PMID:10023943.
34. Uitti, R.J. 1998. Medical treatment of essential tremor and Parkinson's disease. Geriatrics, 53(5): 46-48, 53-57. PMID:9597979.
35. Verkerk, A.O., Wilders, R., Geringel, W., and Tan, H.L. 2006. Cellular basis of sex disparities in human cardiac electrophysiology. Acta Physiol. (Oxf.), 187(4): 459-477. doi:10.1111/j.1748-1716. 2006.01586.x. PMID:16866777.
36. Vizgirda, V.M., Wahler, G.M., Sondgeroth, K.L., Ziolo, M.T., and Schwertz, D.W. 2002. Mechanisms of sex differences in rat cardiac myocyte response to beta-adrenergic stimulation. Am. J. Physiol. Heart Circ. Physiol. 282(1): H256-H263. PMID:11748070.
37. Wang, T., Kaumann, A.J., and Brown, M.J. 1996. (-)-Timolol is a more potent antagonist of the positive inotropic effects of (-)- adrenaline than of those of (-)-noradrenaline in human atrium. Br. J. Clin. Pharmacol. 42(2): 217-223. doi:10.1046/j.1365-2125.1996.39412.x. PMID:8864321.
38. White, M., Roden, R., Minobe, W., Khan, M.F., Larrabee, P., Wollmering, M., et al. 1994. Age-related changes in beta-adre- nergic neuroeffector systems in the human heart. Circulation, 90(3): 1225-1238. PMID:8087932.
39. i in ventricular myocytes compared with those of timolol and atenolol. Circ. J. 67(1): 83-90. doi:10.1253/circj.67.83. PMID:12520158.
40. Yaras, N., Tuncay, E., Purali, N., Sahinoglu, B., Vassort, G., and Turan, B. 2007. Sex-related effects on diabetes-induced alterations in calcium release in the rat heart. Am. J. Physiol. Heart Circ. Physiol. 293(6): H3584-H3592. doi:10.1152/ajpheart. 00619.2007. PMID:17890429.