Collaborative work on evaluation of ovarian toxicity 16) Effects of 2 or 4 weeks repeated dose studies and fertility study of chlorpromazine hydrochloride in rats

Journal of Toxicological Sciences

Volumn 34, Issue 1 SPEC. ISS., 2009, Pages

  Izumi, Yuko ^a   Watanabe, Takeshi ^a   Awasaki, Naoko ^a   Hikawa, Kenji ^a   Minagi, Takashi ^a   Chatani, Fumio ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

Chlorpromazine hydrochloride; Large atretic follicle; Ovarian toxicity; Rat

Indexed keywords

CHLORPROMAZINE; CYCLINE; NEUROLEPTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATROPHY; BREAST HYPERPLASIA; CONTROLLED STUDY; COPULATION; ESTRUS CYCLE; FEMALE; FEMALE FERTILITY; HISTOPATHOLOGY; MATING; NONHUMAN; ORGAN WEIGHT; OVARY; OVARY FOLLICLE ATRESIA; RAT; REPRODUCTIVE TOXICITY; UTERUS; UTERUS WEIGHT; VAGINA; VAGINA EPITHELIUM; ANIMAL; CHEMICALLY INDUCED DISORDER; DRUG ADMINISTRATION; DRUG EFFECT; DRUG SURVEILLANCE PROGRAM; FERTILITY; HEALTH CARE ORGANIZATION; JAPAN; MALE; METABOLISM; METHODOLOGY; MOTOR ACTIVITY; ORAL DRUG ADMINISTRATION; ORGAN SIZE; OVARY FOLLICLE; PATHOLOGY; PREGNANCY; PTOSIS; SPRAGUE DAWLEY RAT; TOXICITY TESTING; UDDER; WEIGHT GAIN;

RATTUS;

ADMINISTRATION, ORAL; ANIMALS; ANTIPSYCHOTIC AGENTS; BLEPHAROPTOSIS; CHLORPROMAZINE; DRUG ADMINISTRATION SCHEDULE; ESTROUS CYCLE; FEMALE; FERTILITY; JAPAN; MALE; MAMMARY GLANDS, ANIMAL; MOTOR ACTIVITY; NO-OBSERVED-ADVERSE-EFFECT LEVEL; ORGAN SIZE; OVARIAN FOLLICLE; OVARY; PREGNANCY; PROLIFERATING CELL NUCLEAR ANTIGEN; PUBLIC-PRIVATE SECTOR PARTNERSHIPS; RATS; RATS, SPRAGUE-DAWLEY; SOCIETIES, SCIENTIFIC; TOXICITY TESTS; UTERUS; VAGINA; WEIGHT GAIN;

EID: 64949192631     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.34.s167     Document Type: Article

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