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Volumn 29, Issue 4, 2009, Pages 1143-1150

Rapamycin effects on mTOR signaling in benign, premalignant and malignant human breast epithelial cells

Author keywords

Biomarkers of resistance; Early events in breast tumorigenesis; Human breast epithelial cells; Human breast premalignant and tumor epithelial cells; mTOR phosphorylation; mTOR signaling; p70s6 and Rs6P; Rapamycin; STATEt3 phosphorylation

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; RAPAMYCIN; STAT3 PROTEIN;

EID: 64949114063     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (20)

References (21)
  • 1
    • 0034722888 scopus 로고    scopus 로고
    • The rapamycin-sensitive signal transduction pathway as a target for cancer therapy
    • Hidalgo M and Rowinsky EK: The rapamycin-sensitive signal transduction pathway as a target for cancer therapy. Oncogene 19: 6680-6686, 2000.
    • (2000) Oncogene , vol.19 , pp. 6680-6686
    • Hidalgo, M.1    Rowinsky, E.K.2
  • 3
    • 0042197413 scopus 로고    scopus 로고
    • Mammalian target of rapamycin: A new molecular target for breast cancer
    • Mita MM, Mita A and Rowinsky EK: Mammalian target of rapamycin: a new molecular target for breast cancer. Clin Breast Cancer 4: 126-137,2003.
    • (2003) Clin Breast Cancer , vol.4 , pp. 126-137
    • Mita, M.M.1    Mita, A.2    Rowinsky, E.K.3
  • 4
    • 0032973572 scopus 로고    scopus 로고
    • Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation
    • Dufner A, Andjelkovic M, Burgering BM, Hemmings BA and Thomas G: Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation. Mol Cell Biol 19: 4525-4534, 1999.
    • (1999) Mol Cell Biol , vol.19 , pp. 4525-4534
    • Dufner, A.1    Andjelkovic, M.2    Burgering, B.M.3    Hemmings, B.A.4    Thomas, G.5
  • 6
    • 0033968596 scopus 로고    scopus 로고
    • Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR
    • Yokogami K, Wakisaka S, Avruch J and Reeves SA: Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR. Curr Biol 10: 47-50, 2000.
    • (2000) Curr Biol , vol.10 , pp. 47-50
    • Yokogami, K.1    Wakisaka, S.2    Avruch, J.3    Reeves, S.A.4
  • 7
    • 7244245445 scopus 로고    scopus 로고
    • Roles and regulation of STAT family transcription factors in human breast cancer
    • Clevenger CV: Roles and regulation of STAT family transcription factors in human breast cancer. Am J Pathol 165: 1449-1460,2004.
    • (2004) Am J Pathol , vol.165 , pp. 1449-1460
    • Clevenger, C.V.1
  • 9
    • 0030044330 scopus 로고    scopus 로고
    • MCF10AT: A model for the evolution of cancer from proliferative breast disease
    • Dawson PJ, Wolman SR, Tait L, Heppner GH and Miller FR: MCF10AT: a model for the evolution of cancer from proliferative breast disease. Am J Pathol 148: 313-319, 1996.
    • (1996) Am J Pathol , vol.148 , pp. 313-319
    • Dawson, P.J.1    Wolman, S.R.2    Tait, L.3    Heppner, G.H.4    Miller, F.R.5
  • 10
    • 0035897536 scopus 로고    scopus 로고
    • Progressive resistance to apoptosis in a cell lineage model of human proliferative breast disease
    • Starcevic SL, Elferink C and Novak RF: Progressive resistance to apoptosis in a cell lineage model of human proliferative breast disease. J Natl Cancer Institute 93: 776-782, 2001.
    • (2001) J Natl Cancer Institute , vol.93 , pp. 776-782
    • Starcevic, S.L.1    Elferink, C.2    Novak, R.F.3
  • 11
    • 0041380874 scopus 로고    scopus 로고
    • Oxidative DNA damage and repair in a cell lineage model of human proliferative breast disease (PBD)
    • Starcevic SL, Diotte NM, Zukowski KL, Cameron MJ and Novak RF: Oxidative DNA damage and repair in a cell lineage model of human proliferative breast disease (PBD). Toxicol Sci 75: 74-81,2003.
    • (2003) Toxicol Sci , vol.75 , pp. 74-81
    • Starcevic, S.L.1    Diotte, N.M.2    Zukowski, K.L.3    Cameron, M.J.4    Novak, R.F.5
  • 13
    • 0025763647 scopus 로고
    • Morphological expression of cell transformation induced c-Ha-ras oncogene in human breast epithelial cells
    • Russo J, Tait L and Russo IH: Morphological expression of cell transformation induced c-Ha-ras oncogene in human breast epithelial cells. J Cell Sci 99: 453-463, 1991.
    • (1991) J Cell Sci , vol.99 , pp. 453-463
    • Russo, J.1    Tait, L.2    Russo, I.H.3
  • 17
    • 0037134480 scopus 로고    scopus 로고
    • 4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to rapamycin
    • Dilling MB, Germain GS, Dudkin L, Jayaraman AL, Zhang X, Harwood FC and Houghton PJ: 4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to rapamycin. J Biol Chem 277: 13907-13917, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 13907-13917
    • Dilling, M.B.1    Germain, G.S.2    Dudkin, L.3    Jayaraman, A.L.4    Zhang, X.5    Harwood, F.C.6    Houghton, P.J.7
  • 18
    • 0030849455 scopus 로고    scopus 로고
    • Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation
    • Knudsen ES and Wang JY: Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation. Mol Cell Biol 17: 5771-5783, 1997.
    • (1997) Mol Cell Biol , vol.17 , pp. 5771-5783
    • Knudsen, E.S.1    Wang, J.Y.2
  • 19
    • 23844438209 scopus 로고    scopus 로고
    • Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition
    • Sun SY, Rosenberg LM, Wang X, Zhou Z, Yue P, Fu H and Khuri FR: Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition. Cancer Res 65: 7052-7058, 2005.
    • (2005) Cancer Res , vol.65 , pp. 7052-7058
    • Sun, S.Y.1    Rosenberg, L.M.2    Wang, X.3    Zhou, Z.4    Yue, P.5    Fu, H.6    Khuri, F.R.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.