Randomized, controlled study of continuous 5-FU infusion starting immediately after curative surgery for advanced colorectal cancer

Hepato-Gastroenterology

Volumn 56, Issue 89, 2009, Pages 116-119

  Koda, Keiji ^a   Saito, Norio ^b   Ochiai, Takenori ^c   Miyazaki, Masaru ^c   Sarashina, Hiromi ^d   Nakajima, Nobuyuki ^c  

^a TEIKYO UNIVERSITY CHIBA MEDICAL CENTER   (Japan)

^b NATIONAL CANCER CENTER HOSPITAL EAST   (Japan)

^c CHIBA UNIVERSITY   (Japan)

^d CHIBA AOBA MUNICIPAL HOSPITAL   (Japan)

Author keywords

5 FU infusion; Colorectal cancer; HCFU; Perioperative chemotherapy; Randomized clinical trial

Indexed keywords

CARMOFUR; FLUOROURACIL;

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER ADJUVANT THERAPY; CANCER PATIENT; CANCER STAGING; CLINICAL TRIAL; COLON CANCER; COLORECTAL CANCER; COLORECTAL SURGERY; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DISEASE FREE SURVIVAL; DRUG EFFICACY; DRUG ERUPTION; DRUG SAFETY; EDEMA; EXTRAPYRAMIDAL SYMPTOM; FEMALE; HUMAN; ILEUS; LIVER DYSFUNCTION; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; POSTOPERATIVE CARE; PRIORITY JOURNAL; PROGNOSIS; RANDOMIZED CONTROLLED TRIAL; RECTUM CANCER; VOMITING;

ADULT; AGED; CHEMOTHERAPY, ADJUVANT; COLORECTAL NEOPLASMS; FEMALE; FLUOROURACIL; HUMANS; INFUSIONS, INTRAVENOUS; MALE; MIDDLE AGED; PROPORTIONAL HAZARDS MODELS; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 64949110686     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. O'Connell MJ, Mailliard JA, Kahn MJ, Macdonald JS, Haller DG, Mayer RJ and Wieand HS: Controlled trial of fluorouracil and low-dose leucovorin given for 6 months as postoperative adjuvant therapy for colon cancer. J Clin Oncol 1997; 15:246-250.
2. Colorectal cancer collaborative group: Adjuvant radiotherapy for rectal cancer: a systematic overview of 8507 patinets from 22 randomised trial. Lancet 2001; 358:1291-1304.
3. Willett CG, Czito BG, and Tyler DS: Intraoperative radiation therapy. JClin Oncol 2007; 25:971-977.
4. Wiig JN, Tveit KM, Poulsen JP, Olsen DR, and Giercksky KE: Preoperative irradiation and surgery for recurrent rectal cancer. Will intraoperative radiotherapy (IORT) be of additional benefit? A prospective study. Radiother Oncol 2002; 62:207-213.
5. Lokich JJ, Ahlgren JD, Gullo JJ, Philips JA, and Fryer JG: A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: a Mid-Atlantic Oncology Program Study. J Clin Oncol 1989; 7:425-432.
6. Meta-analysis group in cancer: Efficacy of intravenous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer. J Clin Oncol 1998; 16:301-308.
7. Meta-analysis group of the Japanese society for cancer of the colon and rectum. Efficacy of oral adjuvant therapy after resection of colorectal cancer: 5-year results from three randomized trials. J Clin Oncol 2004; 22:484-492.