Optimization of lipospheres production by factorial design and their performances on a dielectrophoretic lab-on-a-chip platform

Colloids and Surfaces A: Physicochemical and Engineering Aspects

Volumn 340, Issue 1-3, 2009, Pages 77-85

  Tosi, A ^a   Mazzitelli, S ^a   Capretto, L ^a   Guerrieri, R ^b   Nastruzzi, C ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

DEParray; Experimental design; Lab on a chip; Lipospheres

Indexed keywords

DESIGN OF EXPERIMENTS; EMULSIFICATION; STATISTICS;

AQUEOUS PHASE; DEPARRAY; DIELECTROPHORETIC; EXPERIMENTAL DESIGN; EXPERIMENTAL PARAMETERS; FACTORIAL DESIGNS; LAB-ON-A-CHIP; LIPID COMPOSITIONS; LIPID MIXTURES; LIPOSPHERES; MELT DISPERSIONS; PREPARATION PARAMETERS; SELECTION OF THE BESTS;

LABORATORIES;

LIPID; NANOSPHERE;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL COMPOSITION; CHEMICAL REACTION; CONTROLLED STUDY; ELECTROPHORESIS; EMULSION; MELTING POINT; PRIORITY JOURNAL; PRODUCT DEVELOPMENT; SEPARATION TECHNIQUE; SYNTHESIS;

EID: 64849112831     PISSN: 09277757     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.colsurfa.2009.03.005     Document Type: Article

References (26)

1. Wrobel G., Schlingemann J., Hummerich L., Kramer H., Lichter P., and Hahn M. Optimization of high-density cDNA-microarray protocols by "Design of Experiments". Nucleic Acid Res. 31 (2003) 1-7
2. Bertucci F., Viens P., Hingamp P., Nasser V., Houlgatte R., and Birnbaum D. Breast cancer revisited using DNA array-based gene expression profiling. Int. J. Cancer 103 (2003) 565-571
3. El-Ali J., Sorger P.K., and Jensen K.F. Cells on chips. Nature 442 (2006) 403-411
4. Chin C.D., Linder V., and Sia S.K. Lab-on-a-chip devices for global health: past studies and future opportunities. Lab. Chip 7 (2007) 41-57
5. West J., Becker M., Tombrinik S., and Manz A. Micrototal anlaysis systems: latest achievements. Anal. Chem. 12 (2008) 4403-4419
6. Fair R.B., Khlystov A., Tailor T.D., Ivanov V., Evans R.D., Srinivasan V., Pamula V., Pollack M.G., Griffin P.B., and Zhou J. Chemical and biological applications of digital-microfluidic devices. IEEE Des. Test Comput. 1 (2007) 10-24
7. Muller T., Pfennig A., Klein P., Gradl G., Jager M., and Schnelle T. The potential of dielectrophoresis for single-cell experiments. IEEE Eng. Med. Biol. 22 (2003) 51-61
8. Yang J., Huang Y., Wang X.B., Becker F.F., and Gascoyne P.R. Cell separation on microfabricated electrodes using dielectrophoretic/gravitational field-flow fractionation. Anal. Chem. 71 (1999) 911-918
9. Gascoyne P.R., and Vykoukal J. Particle separation by dielectrophoresis. Electrophoresis 23 (2002) 1973-1983
10. Schnelle T., Müller T., Gradl G., Shirley G., and Fuhr G. Paired microelectrode system: dielectrophoretic particle sorting and force calibration. J. Electrostat. 47 (1999) 121-132
11. Manaresi N., Romani A., Medoro G., Altomare L., Leonardi A., Tartagni M., and Guerrieri R. A lab-on-a-chip for cell detection and manipulation. IEEE J. Solid-State Circ. 38 (2003) 2297-2305
12. Borgatti M., Altomare L., Abonnec M., Fabbri E., Manaresi N., Medoro G., Romani A., Tartagni M., Nastruzzi C., Di Croce S., Tosi A., Mancini I., Guerrieri R., and Gambari R. Dielectrophoresis-based 'Lab-on-a-chip' devices for programmable binding of microspheres to target cells. Int. J. Oncol. 27 (2005) 1559-1566
13. Lucas L.J., Chesler J.N., and Yoon J. Lab-on-a-chip immunoassay for multiple antibodies using microsphere light scattering and quantum dot emission. Biosens. Bioelectron. 23 (2007) 675-681
14. Cortesi R., Esposito E., Luca G., and Nastruzzi C. Production of lipospheres as carriers for bioactive compounds. Biomaterials 23 (2002) 2283-2294
15. Almeida A.J., and Souto E. Solid lipid nanoparticles as a drug delivery system for peptides and proteins. Adv. Drug Del. Rev. 59 (2007) 478-490
16. Reithmeier H., Herrmann J., and Gopferich A. Lipid microparticles as a parenteral controlled release device for peptides. J. Control. Release 73 (2001) 339-350
17. Könnings S., and Göpferich A. Lipospheres as delivery systems for peptides and proteins. In: Nastruzzi C C. (Ed). Lipospheres in Drug Targets and Delivery (2005), CRC Press, Boca Raton 67-86
18. Schäfer-Korting M., and Mehnert M. Delivery of lipophilic compounds with lipid nanoparticles-applications in dermatics and for transdermal therapy. In: Nastruzzi C C. (Ed). Lipospheres in Drug Targets and Delivery (2005), CRC Press, Boca Raton 127-142
19. Domb A.J., Ezra A., and Mizrahi B. Lipospheres for bioactive compound delivery. In: Nastruzzi C C. (Ed). Lipospheres in Drug Targets and Delivery (2005), CRC Press, Boca Raton 143-159
20. Fabbri E., Borgatti M., Manaresi N., Medoro G., Nastruzzi C., Di Croce S., Tosi A., Mazzitelli S., Mancini I., Guerrieri R., and Gambari R. Levitation and movement of tripalmitin based cationic lipospheres on a dielectrophoresis (DEP) based 'Lab-on-a-chip' device. J. Appl. Polym. Sci. 109 (2008) 3484-3491
21. Medoro G., Manaresi N., Tartagli M., and Guerrieri R. CMOS-only sensors and manipulator for microorganisms. Proc. IEDM (2000) 415-418
22. Pohl H.A., and Crane J.S. Theoretical models of cellular dielectrophoresis. Theor. Biol. 37 (1972) 15-41
23. Crews N., Darabi J., Voglewede P., Guo F., and Bayoumi A. An analysis of interdigitated electrode geometry for dielectrophoretic particle transport in micro-fluidics. Sensors Actuat. B 125 (2007) 672-679
24. Iliescu C., Yu L., Tay F.E.H., and Chen B. Bidirectional field-flow particle separation method in a dielectrophoretic chip with 3D electrodes. Sensors Actuat. B 129 (2008) 491-496
25. Behnam M., Kaigala G.V., Khorasani M., Marshall P., Backhouse C.J., and Elliott D.G. An integrated CMOS high voltage supply for lab-on-a-chip systems. Lab. Chip 8 (2008) 1524-1529
26. Wang K.L., Jones T.B., and Raisanen A. DEP actuated nanoliter droplet dispensing using feedback control. Lab. Chip 9 (2009) 901-909