Studies on synthesis and pharmacological activities of 1,2,4- triazolo[3,4-b]1,3,4-thiadiazoles and their dihydro analogues

Archiv der Pharmazie

Volumn 342, Issue 4, 2009, Pages 210-222

  Mathew, Vinod ^a   Giles, Devasahayam ^a   Keshavayya, Jathi ^b   Vaidya, Vijaya P ^b  

^a ACHARYA AND B M REDDY COLLEGE OF PHARMACY   (India)

^b KUVEMPU UNIVERSITY   (India)

Author keywords

Analgesic; Anti inflammatory; Antimicrobial screening; Dihydro triazolothiadiazoles; Phosphorous oxychloride

Indexed keywords

1,2,4 TRIAZOLO[3,4 B]1,3,4 THIADIAZOLE DERIVATIVE; 3 (NAPHTHALEN 1 YL METHYL) 6 [(1H INDOL 3 YL)METHYL] 1,2,4 TRIAZOLO[3,4 B] 1,3,4 THIADIAZOLE; 3 (NAPHTHALEN 1 YL METHYL) 6 [(5 METHOXY 2 METHYL 1H INDOL 3 YL)METHYL] 1,2,4 TRIAZOLO[3,4 B] 1,3,4 THIADIAZOLE; 3 (NAPHTHALEN 1 YLMETHYL) 6 [(5 METHOXY 1H INDOL 3 YL)METHYL] 1,2,4 TRIAZOLO[3,4 B] 1,3,4 THIADIAZOLE; 3 (NAPHTHYL 1 METHYL) 6 (5 CHLORO 2 FURANYL) 5,6 DIHYDRO 1,2,4 TRIAZOLO[3,4 B] 1,3,4 THIADIAZOLE; 3 (NAPHTHYL 1 METHYL) 6 (5 NITRO 2 FURANYL) 5,6 DIHYDRO 1,2,4 TRIAZOLO[3,4 B] 1,3,4 THIADIAZOLE; 3 [2 (N METHYLAMINO) PHENYL] 6 (1H PYRROL 2 YL) 5,6 DIHYDRO 1,2,4 TRIAZOLO[3,4 B] 1,3,4 THIADIAZOLE; 3 [2 (N METHYLAMINO)PHENYL] 6 (2 FLUOROPYRIDIN 4 YL) 1,2,4 TRIAZOLO[3,4 B] 1,3,4 THIADIAZOLE; 3 [2 (N METHYLAMINO)PHENYL] 6 (5 CHLORO 2 FURANYL) 5,6 DIHYDRO 1,2,4 TRIAZOLO[3,4 B] 1,3,4 THIADIAZOLE; 3 [2 (N METHYLAMINO)PHENYL] 6 (5 NITRO 2 FURANYL) 5,6 DIHYDRO 1,2,4 TRIAZOLO[3,4 B] 1,3,4 THIADIAZOLE; 3 [2 (N METHYLAMINO)PHENYL] 6 [(1H INDOL 3 YL)METHYL] 1,2,4 TRIAZOLO[3,4 B] 1,3,4 THIADIAZOLE; 3 [2 (N METHYLAMINO)PHENYL] 6 [(5 METHOXY 1H INDOL 3 YL)METHYL] 1,2,4 TRIAZOLO[3,4 B] 1,3,4 THIADIAZOLE; 3 [2 (N METHYLAMINO)PHENYL] 6 [(5 METHOXY 2 METHYLINDOL 3 YL)METHYL] 1,2,4 TRIAZOLO[3,4 B] 1,3,4 THIADIAZOLE; 3 [4 (N,N DIMETHYLAMINO)PHENYL] 6 (2 FLUOROPYRIDIN 4 YL) 1,2,4 TRIAZOLO[3,4 B] 1,3,4 THIADIAZOLE; 3 [4 (N,N DIMETHYLAMINO)PHENYL] 6 (5 NITRO 2 FURANYL) 5,6 DIHYDRO 2,4 TRIAZOLO[3,4 B] 1,3,4 THIADIAZOLE; 3 [4 (N,N DIMETHYLAMINO)PHENYL] 6 [(1H INDOL 3 YL)METHYL] 1,2,4 TRIAZOLO[3,4 B] 1,3,4 THIADIAZOLE; 3 [4 (N,N DIMETHYLAMINO)PHENYL] 6 [(5 METHOXY 1H INDOL 3 YL)METHYL] 1,2,4 TRIAZOLO[3,4 B] 1,3,4 THIADIAZOLE; 3 [4 (N,N DIMETHYLAMINO)PHENYL] 6 [(5 METHOXY 2 METHYL 1H INDOL 3 YL)METHYL] 1,2,4 TRIAZOLO[3,4 B] 1,3,4 THIADIAZOLE; 3 [4 (N,N DIMETHYLAMINO)PHENYL] 6 [5 CHLORO 2 FURANYL] 5,6 DIHYDRO 1,2,4 TRIAZOLO[3,4 B] 1,3,4 THIADIAZOLE; 5,6 DIHYDROTRIAZOLOTHIADIAZOLE DERIVATIVE; ANALGESIC AGENT; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; HETEROCYCLIC COMPOUND; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; HOT PLATE TEST; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; MOUSE; NONHUMAN; PAW EDEMA; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

ANALGESICS, NON-NARCOTIC; ANIMALS; ANTI-INFECTIVE AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BACTERIA; CARRAGEENAN; EDEMA; FEMALE; FUNGI; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; MICE; MICROBIAL SENSITIVITY TESTS; PAIN MEASUREMENT; RATS; RATS, WISTAR; SPECTROPHOTOMETRY, INFRARED; THIADIAZOLES;

EID: 64849106876     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.200800073     Document Type: Article

References (29)

1. N. Demirbas, A. Demirbas, S. A. Karaoglu, E. Celik, ARKI- VOC 2005, (i), 75-91.
2. M. M. Ghorab, A. M. Sh. El-Sharief, Y. A. Ammar, Sh. I. Mohamed, Phosphorus Sulfur Silicon Relat. Elem. 2001, 173, 223-233.
3. Z. Wang, S. Haoxin, S. Haijian, J. Heterocycl. Chem. 2001, 38, 355-357.
4. E. Palaska, G. Sahin, P. Kelicen, N. T. Durlu, G. Altinok, Farmaco 2002, 57, 101-107.
5. L. Labanauskas, V. Kalcas, E. Udrenaite, P. Gaidelis, et al., Pharmazie 2001, 56, 617-619.
6. A. Foroumadi, M. Mirzaei, A. Shafiee, Pharmazie 2001, 56, 610-612.
7. X.-W. Sun, Y. Zhang, W. Q. Zhang, S.-F. Wang, Indian J. Chem. 1999, 38B(3), 380-383.
8. R. H. Udupi, G. V. Suresh, S. R. Setty, A. R. Bhat, J. Indian Chem. Soc. 2000, 77, 302-304.
9. Nizamuddin, M. Gupta, M. H. Khan, M. K. Srivastava, J. Sci. Ind. Res. 1999, 58, 538-542.
10. F. P. Invidiata, D. Simoni, F. Scintu, N. Pinna, Farmaco 1996, 51, 659-664.
11. B. S. Holla, N. K. Poorjary, S. B. Rao, M. K. Shivananda, Eur. J. Med. Chem. 2002, 37, 511-517.
12. B. S. Holla, P. M. Akberali, M. K. Shivananda, Farmaco 2001, 56, 919-927.
13. G. Turan-Zitouni, Z. A. Kaplancikli, K. Erol, F. S. Kilic, Farmaco 1999, 54, 218-223.
14. B. S. Holla, R. Gonsalves, S. Shenoy, Farmaco 1998, 53, 574- 578.
15. B. S. Holla, B. Sarojini, S. B. Rao, P. M. Akberali, et al., Farmaco 2001, 56, 565-570.
16. J. R. Reid, N. D. Heindel, J. Heterocycl. Chem. 1976, 13, 925- 926.
17. S. N. Swamy, Basappa, B. S. Priya, B. Prabhuswamy, et al., Eur. J. Med. Chem. 2006, 41, 531-538.
18. L.-X. Zhang, A.-J. Zhang, X.-X. Chen, X.-X. Lei, et al., Molecules 2002, 7, 681-689.
19. F. M. Liu, B. L. Wang, Chin. J. Org. Chem. 2000, 20, 738-742.
20. X. Zhang, Tan, L. Zhang, M. Xiao, Chin. J. Pest. Sci. 2005, 7, 353-356.
21. A. J. Zhang, L. X. Zhang Ding, Chin. J. Org. Chem. 2003, 25, 442-444.
22. K. H. Zou, L. X. Zhang, S. N. Zhou, A. J. Zhang, et al., Chin. J. Struct. Chem. 2006, 25, 1517.
23. N. Ergeuc, E. Ilhan, G. Otuk, Pharmazie 1992, 47, 59-60.
24. S. Rollas, N. Kalyoncuoglu, D. Sur-Altiner, Y. Yegenoglu, Pharmazie 1993, 48, 308-309.
25. A. J. Zhang, L. X. Zhang, Y. Xiong, D. J. Xu, X. J. Li, Chin. J. Org. Chem. 2003, 23, 456-460.
26. R. S. Verma, S. A. Imam, Indian J. Microbiol. 1973, 13, 45.
27. C. A. Winter, E. T. Risley, G. W. Nuss, Proc. Soc. Exp. Biol. Med. 1962, 3, 544-547.
28. rd Ed., p. 128.
29. N. B. Eddy, D. J. Leimbach, J. Pharmacol. Exp. Ther. 1953, 385-393.