Fospropofol assay: Issues and impact on pharmacokinetic and pharmacodynamic evaluation

European Journal of Anaesthesiology

Volumn 26, Issue 1, 2009, Pages 81-

  Shah, Ajit ^a   Mistry, Bipin ^b   Gibiansky, Ekaterina ^b,c   Gibiansky, Leonid ^d  

^a GUILFORD PHARMACEUTICALS INC   (United States)

^b MGI Pharma   (United States)

^c ICON Development Solutions   (United States)

^d Metrum Research Group LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOSPROPOFOL; PROPOFOL; VANADATE SODIUM; DRUG DERIVATIVE;

DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG METABOLISM; HUMAN; LETTER; PHARMACODYNAMICS; BIOASSAY; METHODOLOGY; CLINICAL PRACTICE;

BIOLOGICAL ASSAY; HUMANS; PROPOFOL;

EID: 64849103977     PISSN: 02650215     EISSN: 13652346     Source Type: Journal    
DOI: 10.1097/EJA.0b013e32831bc285     Document Type: Letter

References (6)

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2. Fechner J, Ihmsen H, Hatterscheid D, et al. Comparative pharmacokinetics and pharmacodynamics of the new propofol prodrug GPI 15715 and propofol emulsion. Anesthesiology 2004; 101: 626-639.
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4. Gibiansky E, Struys M, Gibiansky L, et al. AQUAVAN Injection, a water- soluble prodrug of propofol as bolus injection: a phase I dose escalation comparison with DIPRIVAN. Part 1: pharmacokinetics. Anesthesiology 2005; 103: 718-729.
5. Schywalsky M, Ihmsen H, Tzabazis A, et al. Pharmacokinetics and pharmacodynamics of the new propofol prodrug GPI 15715 in rats. Eur J Anaesthesiol 2003; 20: 182-190. (Pubitemid 36286285)
6. Fechner J, Ihmsen H, Schiessl C, et al. Sedation with GPI 15715, a water- soluble prodrug of propofol, using target-controlled infusion in volunteers. Anesth Analg 2005; 100: 701 -706.