Characterization of two distinct binding modes between syntaxin 4 and Munc18c

Biochemical Journal

Volumn 419, Issue 3, 2009, Pages 655-660

  Aran, Veronica ^a   Brandie, Fiona M ^a   Boyd, Alasdair R ^a   Kantidakis, Theodoros ^a   Rideout, Elizabeth J ^a   Kelly, Sharon M ^a   Gould, Gwyn W ^a   Bryant, Nia J ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Membrane fusion; Munc18c; Sec1 Munc18 protein (SM protein); Soluble N ethylmaleimide sensitive fusion protein attachment protein receptor (SNARE); Syntaxin 4; Vacuolar protein sorting 45 (Vps45p)

Indexed keywords

MEMBRANE FUSION; MUNC18C; SEC1/MUNC18 PROTEIN (SM PROTEIN); SOLUBLE N-ETHYLMALEIMIDE-SENSITIVE FUSION PROTEIN-ATTACHMENT PROTEIN RECEPTOR (SNARE); SYNTAXIN 4; VACUOLAR PROTEIN SORTING 45 (VPS45P);

AMINES; BINDING ENERGY; PROTEINS; SORTING;

CELL MEMBRANES;

GLUCOSE TRANSPORTER 4; MEMBRANE PROTEIN; MUNC18 PROTEIN; MUTANT PROTEIN; SNARE PROTEIN; SYNTAXIN 16; SYNTAXIN 1A; SYNTAXIN 4; UNCLASSIFIED DRUG; VACUOLAR PROTEIN SORTING 45; HYBRID PROTEIN; PEPTIDE HYDROLASE; SYNTAXIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; ANIMAL; METABOLISM;

ANIMALS; MUNC18 PROTEINS; MUTANT PROTEINS; PEPTIDE HYDROLASES; PROTEIN BINDING; QA-SNARE PROTEINS; RECOMBINANT FUSION PROTEINS;

EID: 64849097626     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20082293     Document Type: Article

References (23)

1. Jahn, R. and Scheller, R. H. (2006) SNAREs: engines for membrane fusion. Nat. Rev. Mol. Cell Biol. 7, 631-643
2. Toonen, R. F. and Verhage, M. (2003) Vesicle trafficking: pleasure and pain from SM genes. Trends Cell Biol. 13, 177-186
3. Jahn, R. (2000) Sec1/Munc18 proteins: mediators of membrane fusion moving to center stage. Neuron 27, 201-204
4. Dulubova, I., Sugita, S., Hill, S., Hosaka, M., Fernandez, I., Sudhof, T. C. and Rizo, J. (1999) A conformational switch in syntaxin during exocytosis: role of munc18. EMBO J. 18, 4372-4382
5. Misura, K. M. S., Scheller, R. H. and Weis, W. I. (2000) Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex. Nature 404, 355-362
6. Hata, Y., Slaughter, C. A. and Sudhof, T. C. (1993) Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin. Nature 366, 347-351
7. Pevsner, J., Hsu, S. C., Braun, J. E., Calakos, N., Ting, A. E., Bennett, M. K. and Scheller, R. H. (1994) Specificity and regulation of a synaptic vesicle docking complex. Neuron 13, 353-361
8. Bracher, A. and Weissenhorn, W. (2002) Structural basis for the Golgi membrane recruitment of Sly1p by Sed5p. EMBO J. 21, 6114-6124
9. Dulubova, I., Yamaguchi, T., Arac, D., Li, H., Huryeva, I., Min, S.-W., Rizo, J. and Sudhof, T. C. (2003) Convergence and divergence in the mechanism of SNARE binding by Sec1/Munc18-like proteins. Proc. Natl. Acad. Sci. U.S.A. 100, 32-37
10. Dulubova, I., Yamaguchi, T., Gao, Y., Min, S.-W., Huryeva, I., Sudhof, T. C. and Rizo, J. (2002) How Tlg2p/syntaxin 16 'snares' Vps45. EMBO J. 21, 3620-3631
11. Hu, S.-H., Latham, C. F., Gee, C. L., James, D. E. and Martin, J. L. (2007) Structure of the Munc18c/Syntaxin4 N-peptide complex defines universal features of the N-peptide binding mode of Sec1/Munc18 proteins. Proc. Natl. Acad. Sci. U.S.A. 104, 8773-8778
12. Latham, C. F., Lopez, J. A., Hu, S.-H., Gee, C. L., Westbury, E., Blair, D. H., Armishaw, C. J., Alewood, P. F., Bryant, N. J., James, D. E. and Martin, J. L. (2006) Molecular dissection of the Munc18c/Syntaxin4 interaction: implications for regulation of membrane trafficking. Traffic 7, 1408-1419
13. Yamaguchi, T., Dulubova, I., Min, S.-W., Chen, X., Rizo, J. and Sudhof, T. C. (2002) Sly1 binds to Golgi and ER syntaxins via a conserved N-terminal peptide motif. Dev. Cell 2, 295-305
14. Bryant, N. J. and James, D. E. (2001) Vps45p stabilizes the syntaxin homologue Tlg2p and positively regulates SNARE complex formation. EMBO J. 20, 3380-3388
15. Carpp, L. N., Ciufo, L. F., Shanks, S. G., Boyd, A. and Bryant, N. J. (2006) The Sec1p/Munc18 protein Vps45p binds its cognate SNARE proteins via two distinct modes. J. Cell Biol. 173, 927-936
16. Yang, B., Steegmaier, M., Gonzalez, Jr, L. C. and Scheller, R. H. (2000) nSec1 binds a closed conformation of syntaxin 1A. J. Cell Biol. 148, 247-252
17. Burkhardt, P., Hattendorf, D. A., Weis, W. I. and Fasshauer, D. (2008) Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide. EMBO J. 27, 923-933
18. Rickman, C., Medine, C. N., Bergmann, A. and Duncan, R. R. (2007) Functionally and spatially distinct modes of munc18-syntaxin 1 interaction. J. Biol. Chem. 282, 12097-12103
19. Khvotchev, M., Dulubova, I., Sun, J., Dai, H., Rizo, J. and Sudhof, T. C. (2007) Dual modes of Munc18-1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus. J. Neurosci. 27, 12147-12155
20. Shen, J., Tareste, D. C., Paumet, F., Rothman, J. E. and Melia, T. J. (2007) Selective activation of cognate SNAREpins by Sec1/Munc18 proteins. Cell 128, 183-195
21. Bryant, N. J., Govers, R. and James, D. E. (2002) Regulated trafficking of the glucose transporter, Glut4. Nat. Rev. Mol. Cell Biol. 3, 267-277
22. Graham, M. E., Barclay, J. W. and Burgoyne, R. D. (2004) Syntaxin/Munc18 interactions in the late events during vesicle fusion and release in exocytosis. J. Biol. Chem. 279, 32751-32760
23. D'Andrea-Merrins, M., Chang, L., Lam, A. D., Ernst, S. A. and Stuenkel, E. L. (2007) Munc18c interaction with syntaxin4 monomers and SNARE complex intermediates in GLUT4 vesicle trafficking. J. Biol. Chem. 282, 16553-16566