Procalcitonin (PCT) as diagnostic tool for the monitoring of spondylodiscitis;Procalcitonin (PCT) als Verlaufsparameter der Spondylodiszitis

Zeitschrift fur Orthopadie und Unfallchirurgie

Volumn 147, Issue 1, 2009, Pages 59-64

  Maus, U ^a   Andereya, S ^a   Gravius, S ^b   Ohnsorge, J A K ^a   Miltner, O ^c   Niedhart, C ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b UNIVERSITY OF BONN   (Germany)

^c Orthopädische Gemeinschaftspraxis für Ganzheitliche Orthopadie die Priv Doz Dr Med O Miltner   (Germany)

Author keywords

CRP; Infection; Procalcitonin; Spondylodiscitis

Indexed keywords

C REACTIVE PROTEIN; CALCITONIN; FIBRINOGEN; LEUKOCYTE ELASTASE;

ADOLESCENT; ADULT; AGED; ARTICLE; BACTERIAL INFECTION; BLOOD; COMPUTER ASSISTED TOMOGRAPHY; DIFFERENTIAL DIAGNOSIS; DISKITIS; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; HUMAN; LEUKOCYTE COUNT; MALE; METABOLISM; MIDDLE AGED; PREDICTION AND FORECASTING; REFERENCE VALUE; SPONDYLITIS;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BACTERIAL INFECTIONS; BLOOD SEDIMENTATION; C-REACTIVE PROTEIN; CALCITONIN; DIAGNOSIS, DIFFERENTIAL; DISCITIS; FEMALE; FIBRINOGEN; HUMANS; LEUKOCYTE COUNT; LEUKOCYTE ELASTASE; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; REFERENCE VALUES; SPONDYLITIS; TOMOGRAPHY, X-RAY COMPUTED; YOUNG ADULT;

EID: 64749098660     PISSN: 1864-669     EISSN: 18646743     Source Type: Journal    
DOI: 10.1055/s-2008-1038974     Document Type: Article

References (51)

1. Klöti M, Ludwig C. Infectious spondylodiscitis an important differential diagnosis in backache. Schweiz Rundsch Med Prax 1998 87 753-758
2. Grane P, Josephsson A, Seferlis A, Tullberg T. Septic and aseptic post-operative discitis in the lumbar spine evaluation by MR imaging. Acta Radiol 1998 39 108-115
3. Hatherill M, Tibby S M., Turner C, Ratnavel N, Murdoch I A. Procalcitonin and cytokine levels: relationship to organ failure and mortality in pediatric septic shock. Crit Care Med 2000 28 2591-2594
4. Delèvaux I, André M, Colombier M, Albuisson E, Meylheuc F, Bègue R J., Piette J C., Aumaître O. Can procalcitonin measurement help in differentiating between bacterial infection and other kinds of inflammatory processes? Ann Rheum Dis 2003 62 337-340
5. Jacobs J W., Lund P K., Potts J T. Jr, Bell N H., Habener J F. Procalcitonin is a glycoprotein. J Biol Chem 1981 256 2803-2807
6. Oberhoffer M, Karzai W, Meier-Hellmann A, Reinhart K. Procalcitonin. A new diagnostic parameter for severe infections and sepsis. Anaesthesist 1998 47 581-587
7. Assicot M, Gendrel D, Carsin H, Raymond J, Guilbaud J, Bohuon C. High serum procalcitonin concentrations in patients with sepsis and infection. Lancet 1993 341 515-518
8. Nijsten M W., Olinga P, The T H., de Vries E G., Koops H S., Groothuis G M., Limburg P C., ten Duis H J., Moshage H, Hoekstra H J., Bijzet J, Zwaveling J H. Procalcitonin behaves as a fast responding acute phase protein in vivo and in vitro. Crit Care Med 2000 28 458-461
9. Nylen E S., Whang K T., Snider R H. Jr, Steinwald P M., White J C., Becker K L. Mortality is increased by procalcitonin and decreased by an antiserum reactive to procalcitonin in experimental sepsis. Crit Care Med 1998 26 1001-1006
10. Nylén E S., Snider R H. Jr, Thompson K A., Rohatgi P, Becker K L. Pneumonitis-associated hyperprocalcitoninemia. Am J Med Sci 1996 312 12-18
11. Oberhoffer M, Stonans I, Russwurm S, Stonane E, Vogelsang H, Junker U, Jäger L, Reinhart K. Procalcitonin expression in human peripheral blood mononuclear cells and its modulation by lipopolysaccharides and sepsis-related cytokines in vitro. J Lab Clin Med 1999 134 49-55
12. Becker K L., O'Neil W J., Snider R H. Jr, Nylen E S., Moore C F., Jeng J, Silva O L., Lewis M S., Jordan M H. Hypercalcitonemia in inhalation burn injury: a response of the pulmonary neuroendocrine cell? Anat Rec 1993 236 136-138
13. Cate C C., Pettengill O S., Sorenson G D. Biosynthesis of procalcitonin in small cell carcinoma of the lung. Cancer Res 1986 46 812-818
14. Chiesa C, Panero A, Rossi N, Stegagno M, De Giusti M, Osborn J F., Pacifico L. Reliability of procalcitonin concentrations for the diagnosis of sepsis in critically ill neonates. Clin Infect Dis 1998 26 664-672
15. Gendrel D, Raymond J, Coste J, Moulin F, Lorrot M, Guérin S, Ravilly S, Lefèvre H, Royer C, Lacombe C, Palmer P, Bohuon C. Comparison of procalcitonin with C-reactive protein, interleukin 6 and interferon-alpha for differentiation of bacterial vs. viral infections. Pediatr Infect Dis J 1999 18 875-881
16. Gendrel D, Raymond J, Assicot M, Moulin F, Iniguez J L., Lebon P, Bohuon C. Measurement of procalcitonin levels in children with bacterial or viral meningitis. Clin Infect Dis 1997 24 1240-1242
17. Smolkin V, Koren A, Raz R, Colodner R, Sakran W, Halevy R. Procalcitonin as a marker of acute pyelonephritis in infants and children. Pediatr Nephrol 2002 17 409-412
18. Butbul-Aviel Y, Koren A, Halevy R, Sakran W. Procalcitonin as a diagnostic aid in osteomyelitis and septic arthritis. Pediatr Emerg Care 2005 21 828-832
19. Wirtz D C., Genius I, Wildberger J E., Adam G, Zilkens K W., Niethard F U. Diagnostic and therapeutic management of lumbar and thoracic spondylodiscitis an evaluation of 59 cases. Arch Orthop Trauma Surg 2000 120 245-251
20. Peters K M., Koberg K, Rosendahl T, Haubeck H D. PMN elastase in bone and joint infections. Int Orthop 1994 18 352-355
21. Peters K M., Koberg K, Kehren H, Zilkens K W. PMN-elastase as a marker in diagnosis and follow-up of bone and joint infections. Unfallchirurg 1991 94 376-379
22. Rothoerl R D., Woertgen C, Holzschuh M, Rueschoff J, Brawanski A. Is there a clinical correlate to the histologic evidence of inflammation in herniated lumbar disc tissue? Spine 1998 23 1197-1200
23. Rothoerl R, Woertgen C, Holzschuh M, Brehme K, Rüschoff J, Brawanski A. Macrophage tissue infiltration, clinical symptoms, and signs in patients with lumbar disc herniation. A clinicopathological study on 179 patients. Acta Neurochir (Wien) 1998 140 1245-1248
24. Rothoerl R D., Woertgen C, Brawanski A. Pain resolution after lumbar disc surgery is influenced by macrophage tissue infiltration. A prospective consecutive study on 177 patients. J Clin Neurosci 2002 9 633-636
25. Wood G W. Infections of spine. Canale ST, ed. Campbell's operative orthopaedics. St.Louis Mosby 1998 3093-3124
26. Rieneck K, Hansen S E., Karle A, Gutschick E. Microbiologically verified diagnosis of infectious spondylitis using CT-guided fine needle biopsy. APMIS 1996 104 755-762
27. Chew F S., Kline M J. Diagnostic yield of CT-guided percutaneous aspiration procedures in suspected spontaneous infectious diskitis. Radiology 2001 218 211-214
28. Müller E J., Russe O J., Muhr G. Osteomyelitis der Wirbelsäule. Orthopaede 2004 33 305-315
29. Huttner B, Opravil M. Die infektiöse Spondylitis. Z Rheumatol 2006 65 7-11
30. Bhagat S, Mathieson C, Jandhyala R, Johnston R. Spondylodiscitis (disc space infection) associated with negative microbiological tests: comparison of outcome of suspected disc space infections to documented non-tuberculous pyogenic discitis. Br J Neurosurg 2007 21 473-477
31. Bontoux D, Codello L, Debiais F, Lambert de Cursay G, Azais I, Alcalay M. Infectious spondylodiscitis. Analysis of a series of 105 cases. Rev Rhum Mal Osteoartic 1992 59 401-407
32. Frangen T M., Kälicke T, Gottwald M, Andereya S, Andress H J., Russe O J., Müller E J., Muhr G, Schinkel C. Die operative Therapie der Spondylodiszitis. Unfallchirurg 2006 109 743-753
33. Lucio E, Adesokan A, Hadjipavlou A G., Crow W N., Adegboyega P A. Pyogenis spondylodiscitis, a radiologic/pathologic and culture correlation study. Arch Pathol Lab Med 2000 124 712-716
34. Krogsgaard M R., Wagn P, Bengtsson J. Epidemiology of acute vertebral osteomyelitis in Denmark: 137 cases in Denmark 19781982, compared to cases reported to the National Patient Register 19911993. Acta Orthop Scand 1998 69 513-517
35. Khan I A., Vaccaro A R., Zlotolow D A. Management of vertebral diskitis and osteomyelitis. Orthopedics 1999 22 758-765
36. Tali E T. Spinal infections. Eur J Radiol 2004 50 120-133
37. Al-Nawas B, Krammer I, Shah P M. Procalcitonin in diagnosis of severe infections. Eur J Med Res 1996 1 331-333
38. Karzai W, Oberhoffer M, Meier-Hellmann A, Reinhart K. Procalcitonin a new indicator of the systemic response to severe infections. Infection 1997 25 329-334
39. Bernard L, Ferrière F, Casassus P, Malas F, Lévêque S, Guillevin L, Lortholary O. Procalcitonin as an early marker of bacterial infection in severely neutropenic febrile adults. Clin Infect Dis 1998 27 914-915
40. Wanner G A., Keel M, Steckholzer U, Beier W, Stocker R, Ertel W. Relationship between procalcitonin plasma levels and severity of injury, sepsis, organ failure, and mortality in injured patients. Crit Care Med 2000 28 950-957
41. Sauerland S, Hensler T, Bouillon B, Rixen D, Raum M R., Andermahr J, Neugebauer E A. Plasma levels of procalcitonin and neopterin in multiple trauma patients with or without brain injury. J Neurotrauma 2003 20 953-960
42. Meisner M, Adina H, Schmidt J. Correlation of procalcitonin and C-reactive protein to inflammation, complications, and outcome during the intensive care unit course of multiple-trauma patients. Crit Care 2006 10 R1-R1
43. Hensler T, Sauerland S, Lefering R, Nagelschmidt M, Bouillon B, Andermahr J, Neugebauer E A. The clinical value of procalcitonin and neopterin in predicting sepsis and organ failure after major trauma. Shock 2003 20 420-426
44. Ruokonen E, Nousiainen T, Pulkki K, Takala J. Procalcitonin concentrations in patients with neutropenic fever. Eur J Clin Microbiol Infect Dis 1999 18 283-285
45. Eberhard O K., Haubitz M, Brunkhorst F M., Kliem V, Koch K M., Brunkhorst R. Usefulness of procalcitonin for differentiation between activity of systemic autoimmune disease (systemic lupus erythematosus/systemic antineutrophil cytoplasmic antibody-associated vasculitis) and invasive bacterial infection. Arthritis Rheum 1997 40 1250-1256
46. Shin K C., Lee Y J., Kang S W., Baek H J., Lee E B., Kim H A., Song Y W. Serum procalcitonin measurement for detection of intercurrent infection in febrile patients with SLE. Ann Rheum Dis 2001 60 988-989
47. Reinhart K, Karzai W, Meisner M. Procalcitonin as a marker of the systemic inflammatory response to infection. Intensive Care Med 2000 26 1193-1200
48. Staatz G, Adam G B., Keulers P, Vorwerk D, Günther R W. Spondylodiscitic abscesses: CT-guided percutaneous catheter drainage. Radiology 1998 208 363-367
49. Rhoten R L., Murphy M A., Kalfas I H., Hahn J F., Washington J A. Antibiotic penetration into cervical discs. Neurosurgery 1995 37 418-421
50. Schulitz K P., Assheuer J, Wiesner L. Early diagnosis of postoperative discitis. Z Orthop Ihre Grenzgeb 1995 133 148-153
51. Costerton J W., Stewart P S., Greenberg E P. Bacterial biofilms: a common cause of persistent infections. Science 1999 284 1318-1322