Efficacy and Safety of Tacrolimus Versus Cyclosporine in Children With Steroid-Resistant Nephrotic Syndrome: A Randomized Controlled Trial

American Journal of Kidney Diseases

Volumn 53, Issue 5, 2009, Pages 760-769

  Choudhry, Swati ^a   Bagga, Arvind ^a   Hari, Pankaj ^a   Sharma, Sonika ^a   Kalaivani, Mani ^a   Dinda, Amit ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

cyclosporine; Focal segmental glomerulosclerosis; minimal change disease; steroid resistant nephrotic syndrome; tacrolimus

Indexed keywords

AMLODIPINE; CALCIUM CARBONATE; CHOLESTEROL; CREATININE; CYCLOSPORIN A; ENALAPRIL; PANGRAF; PANIMUN BIORAL; PREDNISOLONE; SERUM ALBUMIN; TACROLIMUS; UNCLASSIFIED DRUG; VITAMIN D;

ACNE; ADOLESCENT; ALBUMIN BLOOD LEVEL; ARTICLE; CHILD; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DRUG BLOOD LEVEL; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; FEMALE; FOLLOW UP; GINGIVA HYPERTROPHY; GLOMERULOSCLEROSIS; GLOMERULUS FILTRATION RATE; GLUCOSE BLOOD LEVEL; HEADACHE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYPERTENSION; HYPERTRICHOSIS; MALE; MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS; NEPHROTIC SYNDROME; NEPHROTOXICITY; NUCLEOTIDE SEQUENCE; PARESTHESIA; PATIENT COMPLIANCE; PNEUMONIA; PRESCHOOL CHILD; PROTEIN URINE LEVEL; RANDOMIZED CONTROLLED TRIAL; RELAPSE; REMISSION; SCHOOL CHILD; SEPSIS; SIDE EFFECT; SKIN INFECTION; TERTIARY HEALTH CARE; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT RESPONSE;

ADOLESCENT; BIOPSY; CHILD; CHILD, PRESCHOOL; CREATININE; CYCLOSPORINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE; FEMALE; FOLLOW-UP STUDIES; GLUCOCORTICOIDS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFANT; MALE; MICROSCOPY, FLUORESCENCE; NEPHROTIC SYNDROME; REMISSION INDUCTION; RETROSPECTIVE STUDIES; TACROLIMUS; TIME FACTORS; TREATMENT OUTCOME;

EID: 64749088681     PISSN: 02726386     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.ajkd.2008.11.033     Document Type: Article

References (32)

1. Bagga A., and Mantan M. Nephrotic syndrome in children. Indian J Med Res 122 (2005) 13-28
2. Hodson E.M., Habashy D., and Craig J.C. Interventions for idiopathic steroid-resistant nephrotic syndrome in children. Cochrane Database Syst Rev 2 (2006) CD003594
3. Tarshish P., Tobin J.N., Bernstein J., and Edelmann Jr. C.M. Cyclophosphamide does not benefit patients with focal segmental glomerulosclerosis. A report for the International Study of Kidney Disease in Children. Pediatr Nephrol 10 (1996) 590-593
4. Prospective, controlled trial of cyclophosphamide therapy in children with the nephrotic syndrome. Report of the International Study of Kidney Disease in Children. No authors listed:. Lancet 2 (1974) 423-427
5. Hari P., Bagga A., and Mantan M. Short term efficacy of intravenous dexamethasone and methylprednisolone therapy in steroid resistant nephrotic syndrome. Indian Pediatr 41 (2004) 993-1000
6. Bajpai A., Bagga A., Hari P., Dinda A., and Srivastava R.N. Intravenous cyclophosphamide in steroid-resistant nephrotic syndrome. Pediatr Nephrol 18 (2003) 351-356
7. Niaudet P., Habib R., Tete M.J., Hinglais N., and Broyer M. Cyclosporin in the treatment of idiopathic nephrotic syndrome in children. Pediatr Nephrol 1 (1987) 566-573
8. Ponticelli C., Rizzoni G., Edefonti A., et al. A randomized trial of cyclosporine in steroid-resistant idiopathic nephrotic syndrome. Kidney Int 43 (1993) 1377-1384
9. Cattran D.C., Appel G.B., Hebert L.A., et al. A randomized trial of cyclosporine in patients with steroid-resistant focal segmental glomerulosclerosis. North America Nephrotic Syndrome Study Group. Kidney Int 56 (1999) 2220-2226
10. Mahmoud I., Basuni F., Sabry A., et al. Single centre experience with cyclosporine in 106 children with idiopathic focal segmental glomerulosclerosis. Nephrol Dial Transplant 20 (2005) 735-742
11. Lieberman K.V., and Tejani A. A randomized double-blind placebo controlled trial of cyclosporine in steroid-resistant idiopathic focal segmental glomerulosclerosis in children. J Am Soc Nephrol 7 (1996) 56-63
12. Denton M.D., Magee C.C., and Sayegh M.H. Immunosuppressive strategies in transplantation. Lancet 353 (1999) 1083-1091
13. Webster A., Taylor R.S., Chapman J.R., and Craig J.C. Tacrolimus versus cyclosporin as primary immunosuppression for kidney transplant recipients. Cochrane Database Syst Rev 4 (2005) CD003961
14. McCauley J., Shapiro R., Ellis D., Igdal H., Tzakis A., and Starzl T.E. Pilot trial of FK-506 in the management of steroid-resistant nephrotic syndrome. Nephrol Dial Transplant 8 (1993) 1286-1290
15. Segarra A., Vila J., Pou L., et al. Combined therapy of tacrolimus and corticosteroids in cyclosporin-resistant or -dependent idiopathic focal glomerulosclerosis: A preliminary uncontrolled study with prospective follow up. Nephrol Dial Transplant 17 (2002) 655-662
16. Loeffler K., Gowrishanker M., and Yiu V. Tacrolimus therapy in pediatric patients with treatment-resistant nephrotic syndrome. Pediatr Nephrol 19 (2004) 281-287
17. Schwartz G.J., Haycock G.B., Edelman C.M., and Spitzer A. A simple measure of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatrics 58 (1976) 259-263
18. Srivastava R.N., and Bagga A. Nephrotic syndrome. In: Srivastava R.N., and Bagga A. (Eds). Pediatric Nephrology. (ed 4) (2005), Jaypee, New Delhi, India 161-200
19. Boute N., Gribouval O., Roselli S., et al. NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome. Nat Genet 24 (2000) 349-354
20. Mucha B., Ozaltin F., Hinkes B.G., et al. Mutations in the Wilms' tumor 1 gene cause isolated steroid resistant nephrotic syndrome and occur in exons 8 and 9. Pediatr Res 59 (2006) 325-331
21. Ganguly A., Rock M.J., and Prockop D.J. Conformation-sensitive gel electrophoresis for rapid detection of single-base differences in double-stranded PCR products and DNA fragments: Evidence for solvent induced bends in DNA heteroduplexes. Proc Natl Acad Sci U S A 90 (1993) 10325-10329
22. Tsukaguchi H., Sudhakar A., Le T.C., et al. NPHS2 mutations in late-onset focal segmental glomerulosclerosis: R229Q is a common disease-associated allele. J Clin Invest 110 (2002) 1659-1666
23. National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The Fourth Report on the Diagnosis, Evaluation and Treatment of High Blood Pressure in Children and Adolescents. Pediatrics 114 suppl 2 (2004) S555-S576
24. Gomez E., Sanchez-Nunez M., Sanchez J.E., et al. Treatment of cyclosporin-induced gingival hyperplasia with azithromycin. Nephrol Dial Transplant 12 (1997) 2694-2697
25. Vercauteren S.B., Bosmans J.L., Elseviers M.M., Verpooten G.A., and Broe E.D. A meta-analysis and morphological review of cyclosporine-induced nephrotoxicity in auto-immune diseases. Kidney Int 54 (1998) 536-545
26. Ehrich J.H.H., Geerlings C., Zivicnjak M., Franke D., Geerlings H., and Gellermann J. Steroid-resistant idiopathic childhood nephrosis: Overdiagnosed and undertreated. Nephrol Dial Transplant 22 (2007) 2183-2193
27. Bhimma R., Adhikari M., Asharam K., and Connolly C. Management of steroid-resistant focal segmental glomerulosclerosis in children using tacrolimus. Am J Nephrol 26 (2006) 544-551
28. Gulati S., Prasad N., Sharma R.K., Kumar A., Gupta A., and Baburaj V.P. Tacrolimus: A new therapy for steroid-resistant nephrotic syndrome in children. Nephrol Dial Transplant 23 (2008) 910-913
29. Ruf R.G., Lichtenberger A., Karle S.M., et al. Patients with mutations in NPHS2 (podocin) do not respond to standard steroid treatment of nephrotic syndrome. J Am Soc Nephrol 15 (2004) 722-732
30. Caridi G., Bertelli R., Di Duca M., et al. Broadening the spectrum of diseases related to podocin mutations. J Am Soc Nephrol 14 (2003) 1278-1286
31. Schwaderer P., Knüppel T., Konrad M., et al. Clinical course and NPHS2 analysis in patients with late steroid-resistant nephrotic syndrome. Pediatr Nephrol 23 (2008) 251-256
32. Sinha M.D., MacLeod R., Rigby E., and Clark A.G.B. Treatment of severe steroid dependent nephrotic syndrome (SDNS) in children with tacrolimus. Nephrol Dial Transplant 21 (2006) 1848-1854