Fumonisin inhibition of ceramide synthase: A possible risk factor for human neural tube defects

Sphingolipid Biology

Volumn , Issue , 2006, Pages 345-361

  Riley, Ronald T ^a   Voss, Kenneth A ^a   Speer, Marcy ^b   Stevens, Victoria L ^c   Gelineau Van Waes, Janee ^d  

^a U S DEPARTMENT OF AGRICULTURE   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c AMERICAN CANCER SOCIETY   (United States)

^d UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Ceramide Synthase; Folate; Fumonisin; Neural Tube Defects

Indexed keywords

EID: 64749084270     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/4-431-34200-1_28     Document Type: Chapter

References (58)

1. Bolger M, Coker RD, Dinovi M, Gaylor D, Gelderblom MO, Paster N, Riley RT, Shephard G, and Speijers JA (2001) Fumonisins. In: Safety evaluation of cer tain mycotoxins in food. Food and Agriculture Organization of the United Nations, paper 74. World Health Organization Food Additives, Series 47, 103-279.
2. Brown DA and London E (1998) Functions of lipid rafts in biological membranes. Annu Rev Cell Dev Biol, 14, 111-136.
3. Campbell LR, Dayton DH and Sohal GS (1986) Neural tube defects: A review of human and animal studies on the etiology and neural tube defects. Teratology, 34, 171-187.
4. CDC (2000) Neural tube defect surveillance and folic acid intervention- Texas-Mexico border, 1993-1998. Morbidity and Mortality Weekly Report, 49(1), 1-4.
5. Cifuentes G (2002) Perfil epidemiologico de las anomalias del tubo neural en Guatemala, durante el afio 2000. in Graduation Thesis of the School of Medicine of Universidad San Carlos de Guatemala.
6. Collins TFX, Sprando RL, Black TN, Olejnik N, Eppley RM, Shackelford ME, Howard PC, Rorie JI, Bryant M, Ruggles DI (2005) Effects of aminopentol on in utero development in rats. Food Chem Toxicol, in press.
7. Constable PD, Riley RT, Waggoner AL, Hsiao S-H, Foreman J H, Tumbleson ME and. Haschek WM (2005)Serum sphingosine-l-phosphate and sphinganine- l-phosphate are elevated in horses exposed to Fumonisin B]. in AOAC International Midwest Section Final Program, pp. 63-64.
8. Czeizel AE and Dudas I (1992) Prevention of the first occurrence of neural-tube defects by periconceptual vitamin supplementation. N Engl J ivied, 327, 1832-1835.
9. da Costa M, Sequeira JM, Rothenberg SP, Weedon J. (2003) Antibodies to folate receptors impair embryogenesis and fetal development in the rat. Birth Defects Res Part A Clin Mol Teratol, 67, 837-847.
10. Detrait ER, George TM, Etchevers HC, Gilbert JR, Vekemans M, Speer MC (2005) Human neural tube defects: Developmental biology, epidemiology, and genetics. Neurotoxicology and Teratology, 27, 515-524.
11. Enongene EN, Sharma RP, Bhandari N, Meredith FI, Voss KA and Riley RT (2002) Persistence and reversibility of the elevation in free sphingoid bases induced by fumonisin inhibition of ceramide synthase. Tox Sci, 67, 173-181.
12. Feuchtbaum LB, Currier RJ, Riggle S, Robertson M, Lorey FW, Cunningham GC (1999) Neural tube defect prevalence in California (1990-1994): Eliciting patterns by type of defect and maternal race/ethnicity. Genetic Testing, 3(3), 265-272.
13. Figueroa Cardenas JD, Acero Godinez MG, Vasco Mendez NL, Lozano Guzman A, Flores Acosta LM, Gonzalez-Hernandez J (2001) Fortification and evaluation of the nixtamal tortillas. Arch Latinoam Nutr, 51,293-302.
14. Flynn TJ, Pritchard D, Bradlaw J, Eppley R and Page S (1996) In vivo embryotoxicity of fumonisin B∼ evaluated with cultured postimplantation staged rat embryos. In vitro Toxicology, 9, 271-279.
15. Flynn TJ, Stack ME, Troy AL and Chirtel SJ (1997) Assessment of the embryotoxic potential of the total hydrolysis product of fumonisin B 1 using cultured organogenesis-staged rat embryos. Food Chem Toxicol, 35, 1135-1141.
16. Gelderblom WCA, Kriek NPJ, Marasas WFO, and Thiel PG (1991) Toxicity and carcinogenicity of the Fusarium moniliforme metabolite, fumonisin B∼, in rats. Carcinogenesis, 12, 1247-1251.
17. Gelineau-van Waes J, Starr L, Maddox JR, Aleman F, Voss KA, Wilberding J and Riley RT (2005) Maternal fumonisin exposure and risk for neural tube defects: Disruption of sphingolipid metabolism and folate transport in an in vivo mouse model. Birth Defects Research (A), 73, 487-497.
18. Gelineau-van Waes J, Maddox J, Starr L, Wilberding J, Bauer L, Voss K, and Riley R (2006) Maternal fumonisin exposure and neural tube defects: Mechanisms in a mouse model. Tox Sci (Suppl. The Toxicologist), 85 (S1), accepted.
19. Green NS (2002) Folic acid supplementation and prevention of birth defects. J Nutr, 132, 2356S-2360S.
20. Hendricks K (1999) Fumonisins and neural tube defects in South Texas. Epidemiol, 10, 198-200.
21. Hansen, DK, Streck, RD and Antony, AC (2003) Antisense modulation of the coding or regulatory sequence of the folate receptor (folate binding protein-I) in mouse embryos leads to neural tube defects. Birth Defects Res Part A Clin. Mol Teratol, 67, 475-487.
22. Humpf H-U, and Voss KA (2004) Effects of food processing on the chemical structure and toxicity of fumonisin mycotoxins. Mol Nutr Food Res, 48, 255-269.
23. IARC (2002) (International Agency for Research on Cancer). Fumonisin B1. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: Some Traditional Medicines, Some Mycotoxins, Naphthalene and Styrene. IARC, 82, 301-366.
24. IPCS (International Programme on Chemical Safety). (2000) Fumonisin B1, Environmental Health Criteria 219. World Health Organization, Geneva, 150 pp.
25. Kromberg JG and Jenkins T. (1982) Common birth defects in South African Blacks. S Afr Med J, 62(17), 599-602.
26. Lian Z-H, Yang H-Y and Li Z (1987) Neural tube defects in Beijing-Tianjin area of China. Urban-rural distribution and some other epidemiological characteristics. J Epidemiol Community Health, 41,259-262.
27. Luhrs CA and Slomiany BL (1989) A human membrane-associated folate binding protein is anchored by a glycosyl-phosphatidylinositol tail. J Biol Chem, 264, 21446-21449.
28. Marasas WFO, Riley RT, Hendricks KA, Stevens VL, Sadler TW, Gelineau-van Waes J, Missmer, SA, Cabrera Valverde J, Torres OL, Gelderblom W, Allegood J, Martfnez de Figueroa AC, Maddox J, Miller JD, Starr L, Sullards MC, Roman Trigo AV, Voss KA, Wang E, Merrill AH, Jr (2004) Fumonisins disrupt sphingolipid metabolism, folate transport and development of neural crest cells in embryo culture and in vivo: A risk factor for human neural tube defects among populations consuming fumonisin-contaminated maize? J Nutr, 134, 711-716. March of Dimes Perinatal Data Center (2001) Maternal, Infant, and Child Health in the United States.
29. Melnick M and Marazita ML (1998). Neural tube defects, methylenetetrahydrofolate reductase mutation, and north/south dietary differences in China. J Craniofac Genet Dev Biol, 18, 233-235.
30. Meredith F I, Torres O R, Saenz de Tejada S, Riley R T and Merrill A H Jr (1999) Fumonisin B∼ and hydrolyzed fumonisin B∼ levels in nixtamalized maize (Zea mays L.) and tortillas from two different geographical locations in Guatemala. J Food Prot, 62, 1218-1222.
31. Merrill AH Jr, Sullards MC, Wang E, Voss KA and Riley RT (2001) Sphingolipid metabolism:Roles in signal transduction and disruption by fumonisins. Environ Health Perspect, 109, 283-289.
32. Merrill Jr. A.H. (2002) De novo sphingolipid biosynthesis: A necessary, but dangerous, pathway. J Biol Chem, 277, 25843-25846.
33. Mitchell LE (2005) Epidemiology of neural tube defects. American Journal of Medical Genetics Part C, 135C, 88-94.
34. Moore CA, Li S, Gu H, Berry RJ, Mulinare J and Erickson JD (1997) Elevated rates of severe neural tube defects in a high-prevalence area in Northern China. Amer J Med Genetics, 73, 113-118.
35. MRC (1991) MRC Vitamin Study Research Group Prevention of neural tube defects: results of the Medical Research Council vitamin study. Lancet II, 131-137.
36. NTP (2001) (National Toxicology Program Technical Report). (2002) Toxicology and Carcinogenesis Studies of Fumonisin B I in F344/N rats and B6C3F1 mice. Publication no. 99-3955, NIH, Washington, DC
37. Ncayiyana DJ (1986) Neural tube defects among rural blacks in a Transkei district. S A Med J, 69, 618-620.
38. Palencia E, Tortes O, Hagler W, Meredith FI, Williams L D, and Riley RT (2003) Total fumonisins are reduced in tortillas using the traditional nixtamalization method of Mayan communities. J Nutr, 133, 3200-3203.
39. Piva A, Casadei G, Pagliuca G, Cabassi E, Galvano F, Solfrizzo M, Riley RT and Diaz DE (2005) Inability of activated carbon to prevent the toxicity of culture material containing fumonisin B I when fed to weaned piglets. J Animal Sci, 83, 1939-1947
40. Piedrahita JA, Oetama B, Bennett GD, van Waes J, Kamen BA, Richardson J, Lacey SW, Anderson RG and Finnell RH (1999) Mice lacking the folic acid-binding protein Folbpl are defective in early embryonic development. Nature Genetics, 23, 228-232.
41. Rheeder J P, Marasas W F O, Thiel P G, Sydenham E W, Shephard G S and Van Schalkwyk D J (1992) Fusarium monili/brme and fumonisins in corn in relation to human esophageal cancer in Transkei. Phytopathology, 82, 353-357.
42. Riley RT, Enongene E, Voss KA, Norred WP, Meredith FI, Sharma RP, Spitsbergen J, Williams DE, Carlson DB and Merrill AH Jr (2001) Sphingolipid perturbations as mechanisms for fumonisin carcinogenesis. Envirotl Health Perspect, 109, 301-308.
43. Riley RT, Showker JL, Voss KA (2005a) Time- and dose-dependent changes in sphingoid base 1 phosphates in tissues from rats fed diets containing fumonisins. Tox Sci (Suppl. Tlle Toxicologist), 84 (S1), 284-285.
44. Riley RT, Torres OA, Palencia E, Lopez de Pratdesaba L, Glenn AE, O'Donnell K and Fuentes M. (2005b) Fumonisins in highland and lowland maize in Guatemala and a preliminary exposure estimate. AOAC International Midwest Section Final Program, pp. 34-35.
45. Rothenberg SP, Da Costa MP, Sequeira JM, Cracco J, Roberts JL, Weedon J, and Quadros EV (2004) Autoantibodies against folate receptors in women with a pregnancy complicated by a neural tube defect. Obstet Gynecol Surv, 59, 410-411.
46. Sadler TW, Merrill AH, Jr, Stevens VL, Sullards MC, Wang E and Wang P (2002) Prevention of fumonisin Bl-induced neural tube defects by folic acid. Teratology, 66, 169-176.
47. Shaw GM, Schaffer D, Velie E, Morland KM and Harris JA (1995) Periconceptional vitamin use, dietary folate, and the occurrence of neural tube defects. Epidemiol, 6, 219-226.
48. Shephard GS (2004). Mycotoxins worldwide: Current issues in Africa.In Barug D, Van Egmond, H.P., Lopez Garci∼., R., Van Osenbruggen, W.A. and Visconti, A. Meeting the mycotoxin menace. Wageningen Academic Publishers, the Netherlands, pp. 81-88.
49. Stevens VL and Tang J (1997) Fumonisin B∼-induced sphingolipid depletion inhibits vitamin uptake via the glycosylphosphatidylinositol-anchored folate receptor. J Biol Chem, 272, 18020-18025.
50. Venter PA, Christianson AL, Hutamo CM, Makhura MP and Gericke GS (1995) Congenital anomalies in rural black South African neonates-a silent epidemic? S A Med J, 83, 15-20.
51. Voss KA, Riley RT, and Gelineau-van Waes J (2005a) Trends in fumonisin research: Recent studies on the developmental effects of fumonisins and Fusarium verticillioides. Mycotoxins, 55, 91-100.
52. Voss KA, Gelineau van-Waes JB, Riley RT, Burns TD, Bacon CW. (2005b) Developmental toxicity of diets containing fumonisin BI to LM/Bc and CD1 mice: a comparative study. Tox Sci (Suppl. The Toxicologist), 84 (S1), 1396.
53. Wang E, Norred WP, Bacon CW, Riley RT, and Merrill AH Jr (1991) Inhibition of sphingolipid biosynthesis by fumonisins: Implications for diseases associated with Fusarium moniliforme. J Biol Chem, 266, 14486-14490.
54. Wang E, Riley RT, Meredith FI and Merrill AH Jr (1999) Time course, dose-dependence, and reversibility of increases in urinary sphinganine and sphingosine in animals fed defined diets containing fumonisin B∼: characteristics of urinary biomarkers for exposure to fumonisins. J Nutr, 129, 214-220.
55. Werler MM, Sharpio S and Mitchell AA (1993) Periconceptual folic acid exposure and risk of occurrent neural tube defects. JAMA, 269, 1257-1261.
56. WHO (2001) World Health Organization. Evaluation of Certain Mycotoxins in Food. Fifty-sixth Report of the Joint FAO/WHO Expert Committee on Food Additives (JECFA). WHO Technical Report, 906, 16-27.
57. Xiao KZ, Zhang ZY, Su YM, Liu FQ, Yan ZZ, Jiang ZQ, Zhou SF, He WG, Wang BY, Jiang HP, (1990). Central nervous system congenital malformations, especially neural tube defects in 29 provinces, metropolitan cities and autonomous regions of China: Chinese Birth Defects Monitoring Program. lnt J Epidemiol, 19,978-982.
58. Yoshizawa T, Yamashita A and Luo Y (1994) Fumonisin occurrence in corn from high- and low-risk areas for human esophageal cancer in China. Appl Environ Microbiol, 60, 1626-1629.