CDK4 IVS4-nt40 AA genotype and obesity-associated tumors/cancer in Italians - A case-control study

Journal of Experimental and Clinical Cancer Research

Volumn 28, Issue 1, 2009, Pages

  Meenakshisundaram, Ramachandran ^a   Gragnoli, Claudia ^a,b,c,d  

^a PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

^c Temple University   (United States)

^d Bios Biotech Multi Diagnostic Health Center   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 4; CDK4 PROTEIN, HUMAN;

ADULT; ARTICLE; BENIGN TUMOR; BODY MASS; CANCER DIAGNOSIS; CASE CONTROL STUDY; CYCLIN DEPENDENT KINASE 4 IVS4 NT40 GENE; DISEASE ASSOCIATION; GENE; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HUMAN; ITALY; MAJOR CLINICAL STUDY; MALIGNANT NEOPLASTIC DISEASE; OBESITY; PRIORITY JOURNAL; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL SIGNIFICANCE; GENETICS; NEOPLASM;

CASE-CONTROL STUDIES; CYCLIN-DEPENDENT KINASE 4; GENOTYPE; HUMANS; ITALY; NEOPLASMS; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 64649107441     PISSN: None     EISSN: 17569966     Source Type: Journal    
DOI: 10.1186/1756-9966-28-42     Document Type: Article

References (16)

1. Cancer and the cell cycle. HL Ford AB Pardee, J Cell Biochem 1999 Suppl 32-33 166 72
2. The role of glucose in the in vitro regulation of cell cycle kinetics and proliferation of fetal pancreatic B-cells. I Swenne, Diabetes 1982 31 9 754 60 6761212
3. Regulation of CDK4. L Bockstaele K Coulonval H Kooken S Paternot PP Roger, Cell Div 2006 1 25 17092340
4. Induction of beta-cell proliferation and retinoblastoma protein phosphorylation in rat and human islets using adenovirus-mediated transfer of cyclin-dependent kinase-4 and cyclin D1. I Cozar-Castellano KK Takane R Bottino AN Balamurugan AF Stewart, Diabetes 2004 53 1 149 59 14693709
5. Genetic variants in cell cycle control pathway confer susceptibility to bladder cancer. Y Ye H Yang HB Grossman C Dinney X Wu J Gu, Cancer 2008 112 11 2467 74 18361427
6. Genome-wide screen in obese pedigrees with type 2 diabetes mellitus from a defined Dutch population. JH van Tilburg LA Sandkuijl L Franke E Strengman PL Pearson TW van Haeften C Wijmenga, Eur J Clin Invest 2003 33 12 1070 4 14636289
7. Genetic profile of gliosarcomas. RM Reis D Konu-Lebleblicioglu JM Lopes P Kleihues H Ohgaki, Am J Pathol 2000 156 2 425 32 10666371
8. Altered apoptosis pathways in mantle cell lymphoma. MJ Rummel S de Vos D Hoelzer HP Koeffler WK Hofmann, Leuk Lymphoma 2004 45 1 49 54 15061196
9. Association of CDK4 and CCND1 mRNA overexpression in laryngeal squamous cell carcinomas occurs without CDK4 amplification. A Nadal P Jares M Pinyol L Conde C Romeu PL Fernandez E Campo A Cardesa, Virchows Arch 2007 450 2 161 7 17139501
10. Cancer prevalence in Italian cancer registry areas: the ITAPREVAL study. ITAPREVAL Working Group. A Micheli S Francisci V Krogh AG Rossi P Crosignani, Tumori 1999 85 5 309 69 10665852
11. Prevalence of cancer in Italian obese patients referred for bariatric surgery. C Boru G Silecchia A Pecchia G Iacobellis F Greco M Rizzello N Basso, Obes Surg 2005 15 8 1171 6 16197792
12. Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. H Matsushime MF Roussel RA Ashmun CJ Sherr, Cell 1991 65 4 701 13 1827757
13. Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia. SG Rane P Dubus RV Mettus EJ Galbreath G Boden EP Reddy M Barbacid, Nat Genet 1999 22 1 44 52 10319860
14. Modifiable risk factors for colorectal neoplasms and hyperplastic polyps. F Omata WR Brown Y Tokuda O Takahashi T Fukui F Ueno T Mine, Intern Med 2009 48 3 123 8 19182421
15. Lifestyle, genes, and cancer. YM Coyle, Methods Mol Biol 2009 472 25 56 19107428
16. Risk factors for benign serous and mucinous epithelial ovarian tumors. SJ Jordan AC Green DC Whiteman PM Webb, Obstet Gynecol 2007 109 3 647 54 17329516