Micro-CT analysis of alveolar bone healing using a rat experimental model of critical-size defects

Oral Diseases

Volumn 15, Issue 4, 2009, Pages 273-280

  Ebina, H ^a,b   Hatakeyama, J ^c   Onodera, M ^d   Honma, T ^a   Kamakura, S ^a   Shimauchi, H ^b   Sasano, Y ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b Divisions of Periodontology and Endodontology ^*  (Japan)

^c FUKUOKA DENTAL COLLEGE   (Japan)

^d IWATE MEDICAL UNIVERSITY   (Japan)

Author keywords

Alveolar bone; Defect; Micro CT; Rats; Repair

Indexed keywords

COLLAGEN TYPE 1;

ALVEOLAR BONE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE REMODELING; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; FRACTURE HEALING; HISTOPATHOLOGY; IN SITU HYBRIDIZATION; MALE; NONHUMAN; OSTEOBLAST; OSTEOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; THREE DIMENSIONAL IMAGING;

ALVEOLAR BONE LOSS; ALVEOLAR PROCESS; ANIMALS; BONE MATRIX; BONE REGENERATION; COLLAGEN TYPE I; CONNECTIVE TISSUE; DISEASE MODELS, ANIMAL; IMAGING, THREE-DIMENSIONAL; IN SITU HYBRIDIZATION; MALE; MANDIBULAR DISEASES; MOLAR; OSTEOBLASTS; OSTEOCYTES; PERIODONTAL LIGAMENT; RATS; RATS, WISTAR; TIME FACTORS; TOOTH ROOT; WOUND HEALING; X-RAY MICROTOMOGRAPHY;

EID: 64549145509     PISSN: 1354523X     EISSN: 16010825     Source Type: Journal    
DOI: 10.1111/j.1601-0825.2009.01522.x     Document Type: Article

References (18)

1. Cowan CM, Shi YY, Aalami OO et al (2004). Adisose-derived adult stromal cells heal critical-size mouse calvarial defects. Nat Biotechnol 22 : 560 567.
2. Cowan CM, Soo C, Ting K, Wu B (2005). Evolving concepts in bone tissue engineering. Curr Top Dev Biol 66 : 239 285.
3. Fritz ME, Jeffcoat MK, Reddy M et al (2000). Guided bone regeneration of large mandibular defects in a primate model. J Periodontol 71 : 1484 1491.
4. Honma T, Itagaki T, Nakamura M et al (2008). Bone formation in rat calvaria ceases within a limited period regardless of completion of defect repair. Oral Dis 14 : 457 464.
5. Itagaki T, Honma T, Takahashi I, Echigo S, Sasano Y (2008). Quantitative analysis and localization of mRNA transcripts of type I collagen, osteocalcin, MMP 2, MMP 8 and MMP 13 during bone healing in a rat calvarial experimental defect model. Anat Rec 291 : 1038 1046.
6. Kamakura S, Sasano Y, Homma H, Suzuki O, Kagayama M, Motegi K (1999). Implantation of octacalcium phosphate(OCP) in rat skull defects enhances bone repair. J Dent Res 78 : 1682 1687.
7. Kamakura S, Nakajo S, Suzuki O, Sasano Y (2004). New scaffold for recombinant human bone morphogenetic protein-2. J Biomed Mater Res 71A : 299 307.
8. Kamakura S, Sasaki K, Honda Y, Anada T, Suzuki O (2006). Octacalcium phosphate combined with collagen orthotopically enhances bone regeneration. J Biomed Mater Res B 79 : 210 217.
9. King GN, King N, Cruchley AT, Wozney JM, Hughes FJ (1997). Recombinant human bone morphogenetic protein-2 promotes wound healing in rat periodontal fenestration defects. J Dent Res 76 : 1460 1470.
10. Lutolf MP, Weber FE, Schmoekel HG et al (2003). Repair of bone defects using synthetic mimetics of collagenous extracellular matrices. Nat Biotechnol 21 : 513 518.
11. Mavropoulos A, Kiliaridis S, Bresin A, Ammann P (2004). Effect of different masticatory functional and mechanical demands on the structural adaptation of the mandibular alveolar bone in young growing rats. Bone 35 : 191 197.
12. Misch KA, Yi ES, Sarment DP (2006). Accuracy of cone beam computed tomography for periodontal defect measurements. J Periodontol 77 : 1261 1266.
13. Nakamura M, Sone S, Takahashi I, Mizoguchi I, Echigo S, Sasano Y (2005). Expression of versican and ADAMTS1,4, and 5 during bone development in the rat mandible and hind limb. J Histochem Cytochem 53 : 1553 1562.
14. Park CH, Abramson ZR, Taba M Jr. et al (2007). Three-dimensional micro-computed tomographic imaging of alveolar bone in experimental bone loss or repair. J Periodontol 78 : 273 281.
15. Sasano Y, Zhu JX, Tsubota M et al (2002). Gene expression of MMP8 and MMP13 during embryonic development of bone and cartilage in the rat mandible and hind limb. J Histochem Cytochem 50 : 325 332.
16. Wikesjö UME, Lim WH, Thomson RC, Cook AD, Wozney JM, Hardwick WR (2003). Periodontal repair in dogs: evaluation of a bioabsorbable space-providing macro-porous membrane with recombinant human bone morphogenetic protein-2. J Periodontol 74 : 635 647.
17. Wilensky A, Gabet Y, Yumoto H, Houri-Haddad Y, Shapira L (2005). Three-dimensional quantification of alveolar bone loss in Porphyromonas gingivalis-infected mice using micro-computed tomography. J Periodontol 76 : 1282 1286.
18. Zhao M, Jin Q, Berry JE, Nociti FH Jr., Giannobile WV, Somerman MJ (2004). Cementoblast delivery for periodontal tissue engineering. J Periodontol 75 : 154 161.